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5,330
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Dataset results
5,330 results for “MicroRNAs”
The gene vitellogenin affects microRNA regulation in honey bee (Apis mellifera) fat body and brain
GEO Series GSE44917. Apis mellifera. 24 samples. Type: Non-coding RNA profiling by array.
Systematic assessment of blood-borne microRNAs highlights molecular profiles of endurance sport and carbohydrate uptake
GEO Series GSE133910. Homo sapiens. 90 samples. Type: Non-coding RNA profiling by array.
Patterns of microRNA Expression in Non-Human Primate
GEO Series GSE22920. Pan paniscus; Ateles geoffroyi; Gorilla gorilla; Saguinus labiatus; Chlorocebus aethiops; Macaca mulatta; Pan troglodytes; Pongo pygmaeus; Lemur catta; Lagothrix lagotricha; Macaca nemestrina; Homo sapiens. 9 samples. Type: Non-coding RNA profiling by array.
Identification of microRNA-dependent gene regulatory networks driving human pancreatic endocrine cell differentiation [RNA-Seq III]
GEO Series GSE135197. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Inhibitory effect of a human microRNA, miR-6133-5p, on the fibrotic activity of hepatic stellate cells in culture
GEO Series GSE158478. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA-221 promotes cell proliferation and inhibit apoptosis in osteosarcoma cells via directly targeting FBXW11 and regulating the Wnt signaling
<p><strong>Figure 1.</strong> miR-221 expression is significantly high in human clinical tissues and cell lines of OS. The expression levels of miR-221 in 30 pairs of OS tissues and their adjacent, non-cancerous normal bone tissues (Normal) (A) and the human osteoblastic cell line hFOB 1.19 and OS cell lines (B) are detected by qRT-PCR. U6 is used as the internal control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 2. </strong>Attenuating miR-221 expression inhibits OS cell proliferation and increase apoptosis. MiR-221 inhibitor is transfected into MG-63-A16 (A) or U2OS cells (B) and induces an obviously lower proliferation rate compared with that in control groups. Further, miR-221 inhibitor is transfected into MG-63-A16 (C) and U2OS cells (D) and triggers a significantly higher apoptosis than controls. And that, the significantly down-regulated Ki67 expression in MG-63-A16 (E) and U2OS cells (F) were observed compared with that in the controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 3. </strong>FBXW11 can directly target to miR-221. (A) An potential target of miR-221, called as FBXW11 has been predicted by bioinformatics-based target prediction analysis, and the binding site is on the 3’UTR of FBXW11. (B) RT-PCR analysis of FBXW11 expression in the OS tumor tissues and noncancerous counterparts. (C) The obviously down-regulated expression levels of FBXW11 mRNA are observed in OS cell lines compared with those in hFOB 1.19 cells. (D) A negative Spearman’s correlation between miR-221 and FBXW11 mRNA levels was observed in 30 OS tumor tissues. (E) The significantly decreased luciferase activity driven by 3’UTR of FBXW11 is observed in the miR-211 mimic group and the 3’UTR-MUT group and negative control are as control. (F) The down-regulation of miR-221 induces a dramatic overexpression of FBXW11 protein. (G) A distinctly lower cell proliferation rate is observed in the group of pcDNA-FBXW11 compared with control. (H) An obviously higher apoptosis is observed in the group of pcDNA-FBXW11 than control. (I) The significantly decreased Ki67 expression is detected in the pcDNA-FBXW11 group than control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 4.</strong> miR-221 and FBXW11 regulate cell proliferation and apoptosis in OS through inhibiting Wnt signaling. (A) The markedly down-regulated expression levels of β-catenin, cyclin D1 and c-myc were detected in the group of miR-221 inhibitor compared with controls. (B) The obviously decreased expression levels of β-catenin, cyclin D1 and c-myc were determined in the pcDNA-FBXW11 group compared with controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 5. </strong>The effect of Wnt signaling on the cell proliferation and apoptosis of OS cell lines. A distinctly lower cell proliferation rate (A and B) and an obviously higher apoptosis rate (C and D) were detected in the Wnt1 siRNA groups (siRNA1, siRNA2) than si-control, and similar results were observed in the CGP049090 group. (E and F) The obviously decreased Ki67 expression were detected in the Wnt1 siRNA groups compared with si-control, and similar results were observed in the CGP049090 group. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p>
Supplementary Materials for "MicroRNAs associated with biological pathways of left- and right-sided colorectal cancer"
<p>Supplementary materials for the paper entitled "MicroRNAs associated with biological pathways of left- and right-sided colorectal cancer".</p>
Data from: Conservation and novelty in the microRNA genomic landscape of hyperdiverse cichlid fishes
MicroRNAs (miRNAs) play crucial roles in the post-transcriptional control of messenger RNA (mRNA). These miRNA-mRNA regulatory networks are present in nearly all organisms and contribute to development, phenotypic divergence, and speciation. To examine the miRNA landscape of cichlid fishes, one of the most species-rich families of vertebrates, we profiled the expression of both miRNA and mRNA in a diverse set of cichlid lineages. Among these, we found that conserved miRNAs differ from recently arisen miRNAs (i.e. lineage specific) in average expression levels, number of target sites, sequence variability, and physical clustering patterns in the genome. Furthermore, conserved miRNA target sites tend to be enriched at the 5' end of protein-coding gene 3'UTRs. Consistent with the presumed regulatory role of miRNAs, we detected more negative correlations between the expression of miRNA-mRNA functional pairs than in random pairings. Finally, we provide evidence that novel miRNA targets sites are enriched in genes involved in protein synthesis pathways. Our results show how conserved and evolutionarily novel miRNAs differ in their contribution of the genomic landscape and highlight their particular evolutionary roles in the adaptive diversification of cichlids.
MiRLog and dbmiR: prioritization and functional annotation tools to study human microRNA sequence variants
<p>dbmiR is a comprehensive database for functional annotation of miRNA SNVs (Single Nucleotide Variants). It includes a precompiled list of all possible miRNA allelic SNVs, providing their biological annotations at nucleotide and miRNA levels. In dbmiR we also integrated MiRLog, a new meta-predictor we implemented to predict the functional effect of miRNA SNVs.</p> <p>dbmiR can be used only for non-commercial purposes because of the licenses associated with some of the included tools and databases.</p>
The Effect of Tongguan Capsule for MicroRNA Profiles in Coronary Heart Disease Patients
ClinicalTrials.gov study NCT02850627. IPD Sharing: YES. Countries: 1. Publications: 0.
The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation
ClinicalTrials.gov study NCT03591367. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer
ClinicalTrials.gov study NCT04149613. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Endometrial Luteal Phase Characteristics and Luteal Phase Support in Controlled Ovarian Stimulation Protocols With GnRH Antagonists:Focusing on MicroRNA
ClinicalTrials.gov study NCT01510054. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity
ClinicalTrials.gov study NCT06368154. IPD Sharing: Not stated. Countries: 1. Publications: 0.
miRNA (microRNA) and FGF21 (Fibroblast Growth Factor-21) Profile in First Trimester and Gestational Diabetes Prediction
ClinicalTrials.gov study NCT05632055. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Quantification of microRNAs in Diagnosis of Pulmonary Nodules
ClinicalTrials.gov study NCT03293433. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Correlating MicroRNA Changes With Sepsis Outcomes
ClinicalTrials.gov study NCT03929159. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Role of Circulating MicroRNAs in Differentiating Psychological Disorders Among Women With Chronic Toxoplasmosis
ClinicalTrials.gov study NCT07346833. IPD Sharing: Not stated. Countries: 1. Publications: 0.
microRNA Expression in Renal Cell Carcinoma
ClinicalTrials.gov study NCT00743054. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility
ClinicalTrials.gov study NCT05680350. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.