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Data related to article "Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients"

THE DATASET CONTAINS RAW DATA UNDERLYING  ARTICLE FIG N.6

Dataset related to article "IN REPLY FORECASTING SEIZURE FREEDOM AFTER EPILEPSY SURGERY ASSESSING CONCORDANCE BETWEEN NONINVASIVE AND STEREOEEG FINDINGS"

.XLS DATASET CONTAINING CLINICAL AND NEUROIMAGING DATA

Data set from the article Malavazos AE, Capitanio G, Milani V, Ambrogi F, Matelloni IA, Basilico S, Dubini C, Sironi FM, Stella E, Castaldi S, Secchi F, Menicanti L, Iacobellis G, Corsi Romanelli MM, Carruba MO, Morricone LF. Tri-Ponderal Mass Index vs body Mass Index in discriminating central obesity and hypertension in adolescents with overweight. Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1613-1621. doi: 10.1016/j.numecd.2021.02.013. Epub 2021 Feb 23. Erratum in: Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3247-3248. PMID: 33741212.

Data set from the article Malavazos AE, Capitanio G, Milani V, Ambrogi F, Matelloni IA, Basilico S, Dubini C, Sironi FM, Stella E, Castaldi S, Secchi F, Menicanti L, Iacobellis G, Corsi Romanelli MM, Carruba MO, Morricone LF. Tri-Ponderal Mass Index vs body Mass Index in discriminating central obesity and hypertension in adolescents with overweight. Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1613-1621. doi: 10.1016/j.numecd.2021.02.013. Epub 2021 Feb 23. Erratum in: Nutr Metab Cardiovasc Dis. 2021 Oct 28;31(11):3247-3248. PMID: 33741212.   Astract

Dataset related to article "A novel MRPS34 gene mutation with combined OXPHOS deficiency in an adult patient with Leigh syndrome"

data set contains ngs RAW DATA (vcf, abi files) related to article mentioned at title

Dataset related to article "Current and New Next-Generation Sequencing Approaches to Study Mitochondrial DNA"

Dataset contain raw data relate to article mentioned at title

data set from the article De Marco F, Casenghi M, Spagnolo P, Popolo Rubbio A, Brambilla N, Testa L, Bedogni F. A patient-specific algorithm to achieve commissural alignment with Acurate Neo: The sextant technique. Catheter Cardiovasc Interv. 2021 Nov 15;98(6):E847-E854. doi: 10.1002/ccd.29737. Epub 2021 May 7. PMID: 33960624.

data set from the article De Marco F, Casenghi M, Spagnolo P, Popolo Rubbio A, Brambilla N, Testa L, Bedogni F. A patient-specific algorithm to achieve commissural alignment with Acurate Neo: The sextant technique. Catheter Cardiovasc Interv. 2021 Nov 15;98(6):E847-E854. doi: 10.1002/ccd.29737. Epub 2021 May 7. PMID: 33960624 abstract: Aims: The aim of this proof-of-concept study was to investigate safety and efficacy of a CT-scan based patient-specific algorithm to maximize coronary clearance and secondarily to achieve anatomically correct commissural alignment with the Acurate Neo device. Method and results: A total of 45 consecutive patients undergoing TAVR with the Acurate Neo THV were prospectively enrolled in the study. Mean age was 81.6 ± 5.5 years, mean STS score was 6.1 ± 3.7. Device success rate was 100%. Aim of the technique was to rotationally deploy the TAVR device with a commissure lying on the bisector between the coronary ostia as calculated on the pre-procedural CT-scan. At post-TAVR CT-scan, coronary clearance was achieved in 98% of patients with no cases of severe coronary artery overlap. In 42 out of 45 patients, THV was aligned or, at most, mildly misaligned; there were 2 cases of moderate misalignment without any case of severe misalignment. Post-TAVR selective coronary artery engagement was attempted and succeeded in all patients (100%). Conclusion: Our CT-scan based patient-specific algorithm is safe and proven to be effective in avoiding coronary artery overlap and providing commissural alignment with Acurate Neo in all treated patients.

Dataset related to the article "Leadless pacemaker implant, anticoagulation status, and outcomes: Results from the Micra Transcatheter Pacing System Post-Approval Registry"

This record contains raw data related to the article "Leadless pacemaker implant, anticoagulation status, and outcomes: Results from the Micra Transcatheter Pacing System Post-Approval Registry".    Abstract Background: Early results from the Micra investigational trial and Micra Post-Approval Registry (PAR) demonstrated excellent safety and device performance; however, outcomes based on anticoagulation (AC) status at implant have not been evaluated. Objective: The purpose of this study was to report implant characteristics, perforation rate, and vascular-related events based on perioperative oral AC strategy in patients undergoing Micra implant. Methods: We compared procedure characteristics, major complications, and vascular events, including pericardial effusion, stratified by any adverse event (including major complications, minor complications, and observations) or major complication only according to AC status in the Micra PAR. Results: Among 1795 patients with AC status available, 585 were not on AC, 795 had AC interrupted, and 415 had AC continued during Micra implant. Non-AC patients tended to be younger, with less history of atrial fibrillation and chronic obstructive pulmonary disease, and more history of dialysis than interrupted and continued patients. The implant success rate was similar for all groups (99.1%-99.8%). Through 30 days postimplant, the overall major complication rate was 3.1% for the non-AC group, 2.6% for the interrupted group, and 1.5% for the continued group. The combined rate for any vascular or pericardial effusion adverse event did not differ significantly among AC strategies (6.5%, 4.8%, and 3.6%, respectively). Conclusion: Implant of Micra seems to be safe and feasible regardless of an interrupted or continued periprocedural oral AC strategy, with no increased risk of perforation or vascular complications. Trial registration: ClinicalTrials.gov <a href="http://clinicaltrials.gov/show/NCT02536118">NCT02536118</a>.

restrictedApr 2022View details →

Link to dataset related to article "mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients"

This record contains raw data related to article “mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients" SARS-CoV-2 vaccination has proven effective in inducing an immune response in healthy individuals and is progressively us allowing to overcome the pandemic. Recent evidence has shown that response to vaccination in some vulnerable patients may be diminished, and it has been proposed a booster dose. We tested the kinetic of development of serum antibodies to the SARS-CoV-2 Spike protein, their neutralizing capacity, the CD4 and CD8 IFN-γ T-cell response in 328 subjects, including 131 immunocompromised individuals (cancer, rheumatologic, and hemodialysis patients), 160 health-care workers (HCW) and 37 subjects older than 75 yr, after vaccination with two or three doses of mRNA vaccines. We stratified the patients according to the type of treatment. We found that immunocompromised patients, depending on the type of treatment, poorly respond to SARS-CoV-2 mRNA vaccines. However, an additional booster dose of vaccine induced a good immune response in almost all of the patients except those receiving anti-CD20 antibody. Similarly to HCW, previously infected and vaccinated immunocompromised individuals demonstrate a stronger SARS-CoV-2-specific immune response than those who are vaccinated without prior infection.

restrictedApr 2022View details →

Dataset related to the article "Computed tomography predictors of structural valve degeneration in patients undergoing transcatheter aortic valve implantation with balloon-expandable prostheses"

This record contains raw data related to the article "Computed tomography predictors of structural valve degeneration in patients undergoing transcatheter aortic valve implantation with balloon-expandable prostheses" Objectives: Computed tomography (CT) provides excellent anatomy assessment of the aortic annulus (AoA) and is utilized for pre-procedural planning of transcatheter aortic valve implantation (TAVI). We sought to investigate if geometrical characteristics of the AoA determined by CT may represent predictors of structural valve degeneration (SVD) in patients undergoing TAVI with balloon-expandable valves. Methods: Retrospective study on 124 consecutive patients (mean age:79±7 years; female: 61%) undergoing balloon-expandable TAVI prospectively enrolled in a registry. AoA maximum diameter (Dmax), minimum diameter (Dmin), and area were assessed using pre-procedural CT.  SVD was identified during follow-up with transthoracic echocardiography documenting structural prosthetic valve abnormalities with or without hemodynamic changes.   Results: The mean follow up was 5.9±1.7 years. SVD was found in 48 out of 124 patients (38%). AoA Dmax, Dmin and area were significantly smaller in patients with SVD compared to patients without SVD (25.6±2.2 mm  vs. 27.1±2.8 mm , p=0.012; 20.5±2.1 mm vs. 21.8±2.1 mm ,p=0.001 and 419±77 mm2  vs. 467±88 mm2,p=0.002, respectively). At univariable analysis, female sex, BSA, 23-mm prosthetic valve size, Dmax <27.1 mm and a Dmin < 19.9 mm were associated with SVD whereas at multivariable analysis, only Dmin <19.9 mm (OR=2.873, 95% CI: 1.191-6.929,p=0.019) and female sex (OR=2.659, 95% CI: 1.095-6.458, p=0.031) were independent predictors of SVD. Conclusions: Female sex and AoA Dmin < 19.9 mm are associated with SVD in patients undergoing TAVI with balloon expandable valves. When implanting large prostheses in order to avoid paraprosthetic regurgitation, caution should be observed due to the risk of excessive stretching of the AoA Dmin, which may play a role in SVD.

restrictedMay 2022View details →

Dataset related to article "Chemotherapy after PD-1 inhibitors in relapsed/refractory Hodgkin lymphoma: Outcomes and clonal evolution dynamics"

This record contains raw data related to article  "Chemotherapy after PD-1 inhibitors in relapsed/refractory Hodgkin lymphoma: Outcomes and clonal evolution dynamics" Checkpoint inhibitors (CPIs) are routinely employed in relapsed/refractory classical Hodgkin lymphoma. Nonetheless, persistent long-term responses are uncommon, and one-third of patients are refractory. Several reports have suggested that treatment with CPIs may re-sensitize patients to chemotherapy, however there is no consensus on the optimal chemotherapy regimen and subsequent consolidation strategy. In this retrospective study we analysed the response to rechallenge with chemotherapy after CPI failure. Furthermore, we exploratively characterized the clonal evolution profile of a small sample of patients (n = 5) by employing the CALDER approach. Among the 28 patients included in the study, 17 (71%) were primary refractory and 26 (92%) were refractory to the last chemotherapy prior to CPIs. Following rechallenge with chemotherapy, response was recorded in 23 (82%) patients experiencing complete remission and 3 (11%) patients experiencing partial remission. The tumour evolution of the patients inferred by CALDER seemingly occurred prior to the first cycle of therapy and was characterized either by linear or branching evolution patterns.Twenty-five patients proceeded to allogeneic stem cell transplantation. At a median follow-up of 21 months, median PFS and OS were not reached. In conclusion, patients who fail CPIs can be effectively rescued by salvage chemotherapy and bridged to allo-SCT/ auto-SCT.

restrictedMay 2022View details →

Dataset related to article "Different Personality Profiles In Patients With Chronic Cluster Headache: A Data-Driven Approach"

dataset contains clinical information on patient involved in the study described at article at title

Dataset relate to article: "Alteration of the immunophenotype and cytokine profiles in patients affected by neuroendocrine neoplasms"

This record contains data related to article "Alteration of the immunophenotype and cytokine profiles in patients affected by neuroendocrine neoplasms" Abstract: Neuroendocrine neoplasms (NENs) are tumors that arise from cells of the endocrine system and are most common in the gastrointestinal tract, the pancreas, and the lungs. Their incidence is rapidly increasing and the therapeutic options available are limited, as NENs frequently show resistance to pharmacological therapy. Since the immune system can interfere with tumor growth and response to therapy, using flow cytometry we investigated the immunophenotype in samples of peripheral blood leukocytes from patients with pancreatic (Pan-NEN, n = 45) and pulmonary (Lung-NEN, n = 19) neuroendocrine neoplasm and from 17 healthy donors. Moreover, we performed a multiplex analysis of 13 key cytokines and growth factors essential for the immune response in the plasma of NEN patients and controls. Patients presented with a higher percentage of granulocytes, a lower percentage of lymphocytes and an increase in the granulocytes to lymphocytes ratio (GLR) compared to healthy donors. These alterations were more marked in patients presenting metastasis. Since somatostatin analogs (SSAs) represented the main treatment modality in our cohort of patients, we analyzed its impact on the immunophenotype. SSAs restored the immunophenotype of patients to that seen in healthy donors. Finally, Pan-NEN patients showed a higher plasma concentration of IP-10, MCP-1, and IL-8 compared to healthy donors, suggesting a potential role for these cytokines as diagnostic biomarkers. In conclusion, this study demonstrates profound differences in the immunophenotype of patients with Pan- and Lung-NENs compared to healthy individuals; these alterations were partially restored by therapy.

Original image data contributed to the JASN article

Original image data contributed to the JASN article to “Macrophage Dectin-1 mediates angiotensin II-induced renal injury by activating neutrophil migration and TGF-β1 secretion”

Dataset related to article "Is the Instability Severity Index Score a Valid Tool for Predicting Failure After Primary Arthroscopic Stabilization for Anterior Glenohumeral Instability?"

This record contains raw data related to article “Is the Instability Severity Index Score a Valid Tool for Predicting Failure After Primary Arthroscopic Stabilization for Anterior Glenohumeral Instability?”. Abstract Purpose: To assess the validity of the Instability Severity Index Score in predicting the rate of recurrence of dislocation in patients undergoing arthroscopic Bankart repair. Methods: The inclusion criteria were recurrent anterior traumatic glenohumeral instability and a minimum follow-up of 5 years. According to the preoperative Instability Severity Index Score, patients were divided into the following groups: ≤3 points (A), 4 to 6 points (B), and >6 points (C). The recurrence rate was determined by telephone interviews. The estimated overall rate of success at 5 years was defined as the estimated overall percentage of patients free of recurrence at 5 years. Results: Six hundred seventy patients (572 men and 98 women) were included. The average age was 27 years (range, 18 to 39 years) at the time of surgery. One hundred fourteen of 670 patients had a recurrence of instability, with an overall recurrence rate of 17% (95% confidence interval [CI] 14.2%-19.9%). The Instability Severity Index Score had a significant association with recurrence. Compared with patients in group A, those in group B had double the risk of recurrence (hazard ratio [HR] = 2.43, 95% CI 1.38-4.28, P = .002), and patients in group C a 9 times greater risk of recurrence (HR = 9.42, 95% CI 5.20-17.7, P < .001). The estimated overall rate of success at 5 years was 84.8% (95% CI 81.8-87.3). The rate of success with an Instability Severity Index Score ≤3 points was 93.7% (95% CI 89.6-96.2), but it dropped to 85.7% (95% CI 81.7-88.9) in those with an Instability Severity Index Score of 4 to 6 points and became 54.6% (95% CI 42.8-64.9) in those with an Instability Severity Index Score >6 points. On multivariable analysis, the Instability Severity Index Score was found to significantly affect the risk of recurrence, corrected by type of sport and glenoid bone loss. Conclusions: The Instability Severity Index Score is a validated tool with which to assess the recurrence rate of dislocation after arthroscopic surgery in patients with shoulder instability. Arthroscopic stabilization in patients with an Instability Severity Index Score ≤3 is associated with a significantly lower risk of recurrence of glenohumeral instability compared with that in patients with an Instability Severity Index Score >3 points. Level of evidence: III, case-control study.

Dataset related to article ''Complications, readmission and reoperation rates in one‑stage bilateral versus unilateral total hip arthroplasty: a high‑volume single center case–control study''.

This record contains raw data related to article: ''Complications, readmission and reoperation rates in one‑stage bilateral versus unilateral total hip arthroplasty: a high‑volume single center case–control study''. Abstract The study aimed to assess the safety of one-stage bilateral total hip arthroplasty (THA) compared with unilateral THA. In this retrospective observational case-control study were included patients undergoing unilateral (group 1) and one-stage bilateral (group 2) THA in a high-volume center. The groups were matched for gender, age at surgery, and pre-operative American Society of Anesthesiology score. The following variables were assessed: local and systemic complications, postoperative anemia, 30-day and 1-year readmission and reoperation rates, length of hospital stay, and ambulation time. Group 1 reported a significantly higher rate of local and systemic complications compared with group 2 (5.4% versus 3.9% and 29.6% versus 4.7%, respectively). Postoperative anemia was significantly lower in group 1 compared with group 2 (8.1% versus 30%). There was no significant difference in terms of 30-day and 1-year readmission rates between the two groups. The average length of hospital stay was 5.1 ± 2.3 days in group 1, and 5.3 ± 1.9 days in group 2 (p = 0.78). Ambulation time was significantly lower for group 1 (day 0.9 ± 0.9 in group 1, and day 1 ± 0.8 in group 2, p = 0.03). In a high-volume center, one-stage bilateral THA is a safe procedure compared with unilateral THA in terms of postoperative local and systemic complications, 30-day readmission and 1-year reoperation rates, and length of hospital stay.

restrictedMay 2022View details →

Dataset related to article "Epithelioid pleural mesothelioma is characterized by tertiary lymphoid structures in long survivors: results from the MATCH study"

This record contains data related to article “Epithelioid pleural mesothelioma is characterized by tertiary lymphoid structures in long survivors: results from the MATCH study”. The abstract is not yet available.

restrictedJul 2022View details →

Dataset related to article "Diffusion weighted magnetic resonance imaging for kidney cyst volume quantification and non-cystic tissue characterization in ADPKD"

Kidney volumes, demographic features, and median DWI-based parameters related to the individual patients and healthy volunteers included in the study

restrictedJul 2022View details →

Dataset related to article "Sport Activity and Clinical Outcomes after Hip Arthroscopy with Acetabular Microfractures at a Minimum 2-Year Follow-Up: A Matched-Pair Controlled Study".

This record contains raw data related to article “ Sport Activity and Clinical Outcomes after Hip Arthroscopy with Acetabular Microfractures at a Minimum 2-Year Follow-Up: A Matched-Pair Controlled Study" Abstract: Background: Acetabular microfractures for cartilage lesions have been shown to be a safe procedure able to improve patient reported outcomes (PROs). Nevertheless, the return to sport activity rate represents a crucial outcome to be investigated in these young athletic patients. Methods: Patients undergoing acetabular microfracture for full chondral acetabular lesions were compared to a 1:1 matched-pair by age and gender control group undergoing hip arthroscopy without microfractures. Clinical assessment was performed with PROs and participation in sports in terms of type and level of activities was evaluated preoperatively and at 2-years follow-up. Results: A total of 62 patients with an average age of 35.1 ± 8.1 (microfracture group) and 36.4 ± 6.3 (control group) were included. In both groups, the average values of PROs significantly increased from preoperatively to the last follow-up. There was no significant difference between the two groups in the number of patients playing at the amateur and elite level preoperatively and at the last follow-up. Conclusions: Microfractures for the management of full-thickness acetabular chondral defect provides good clinical results at a minimum follow-up of two years, which are not inferior to a matched-pair control group. Patients undergoing this procedure are likely able to return at the same level of sport before surgery.

restrictedAug 2022View details →

Dateset relate to article "Why are type II focal cortical dysplasias frequently located at the bottom of sulcus? A neurodevelopmental hypothesis"

dataset contains MRI images and an .xls file describing clinical variable of patients involved in the study