Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,532
datasets available to search
ShareScore release 0.9.0
Dataset results
2,532 results for “at present”
Endothelial cells present an innate resistance to glucocorticoid treatment: implications for therapy of primary vasculitis
GEO Series GSE25269. Homo sapiens. 4 samples. Type: Expression profiling by array.
Mycobacterial cord factor reprograms the macrophage response to IFN-gamma towards enhanced inflammation yet impaired antigen presentation and expression of Gbp1
GEO Series GSE137150. Mus musculus. 42 samples. Type: Expression profiling by array.
SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs
GEO Series GSE159191. Homo sapiens; Severe acute respiratory syndrome coronavirus 2. 16 samples. Type: Expression profiling by high throughput sequencing.
Keratinocyte-secreted SAA1 induces a population of long-lived antigen-presenting neutrophils that drives Sweet Syndrome
GEO Series GSE291004. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Measured data presented in: Domes and Semi-Capsules as Model Systems for Infrared Microspectroscopy of Biological Cells
<p>The data is the measured presented in the article: Domes and Semi-Capsules as Model Systems for Infrared Microspectroscopy of Biological Cells.</p> <p>It contains the following:</p> <ul> <li>Measured spectra and AFM measurement of lung cancer cell</li> <li>Matrigle spectra</li> <li>Measured spectra of 3D printed samples</li> </ul>
Dataset used in "The present-day Yangtze River became established in the Late Miocene: evidence from detrital zircon ages"
<p>A large number of detrial zircon U-Pb ages from the offshore basins of China are presented in this dataset. You may find details of this dataset from the original paper "The present-day Yangtze River became established in the Late Miocene: evidence from detrital zircon ages".</p>
Raw data_Evaluation of the prognostic role of NLR, CAR, and PLR in patients with the co-presentation of coronary artery disease and COVID-19
<p>Raw data </p>
Overexpression of miR-155-5p can upregulate antigen processing and presentation pathway via targeting tapasin
<p><strong>Background </strong>Dysregulation of major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) components in the tumor as one main molecular mechanism of immune escape leading to deactivation of T cell immune surveillance could be due to post-transcriptional regulation via immune-modulatory microRNAs (miRNA). It is now well established from a variety of studies that several miRNAs could effectively modulate the expression of some MHC class I APM components in tumors. Tapasin is an important APM molecule involved in the association of MHC class I with transporter associated with antigen processing (TAP) and peptide loading. Since so far no detailed investigation of the posttranscriptional regulation of tapasin exists, the aim of this study is to identify and functionally characterize miRNAs targeting tapasin in melanoma.</p> <p><strong>Methods </strong>Using miRNA trapping by RNA <em>in vitro</em> affinity purification (miTRAP) and <em>in silico </em>as well as small RNA sequencing, miRNAs will be identified, which bind to the 3'untranslated region (3' UTR) of tapasin. Dual luciferase assays will be performed to determine binding of the miRNA. <em>In silico</em> analysis was performed to predict the effect of miRNAs on the survival of melanoma patients in correlation to tapasin. RT-qPCR, Western blot, flow cytometry and other functional assays were performed after transfecting miRNA mimics in three melanoma cell lines.</p> <p><strong>Results </strong>Using the combination strategy of miTRAP and RNA seq we identified miR-155-5p to bind to the 3’UTR of tapasin, which was further confirmed by <em>in silico analysis</em> and dual luciferase reporter assay. Transfection of miR-155-5p mimics demonstrated that miR-155-5p upregulate tapasin protein level, which was accompanied by an upregulation of the MHC class I (HLA-ABC) surface expression. Simultaneously, in several different types of cancer, including melanoma, the expression of miR-155-5p is significantly positively correlated with the patient's survival and HLA-A protein.</p>
Kids First: Expanded Ewing sarcoma cohort for tumor genomics and association with DNA repair deficiencies, clinical presentation, and outcome
Namespace hosted on the Kids First DRC FHIR services at fhir.kidsfirstdrc.org
ILASALF presentation
<p>ILASALF</p>
Video-presentations at NATURAL-ARSENAL meetings
<p>Video-presentations at NATURAL-ARSENAL meetings</p>
Present Crustal Vertical Movement of Dabie Mountain and Surrounding Area
<p>Data</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.