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2,551 results for “complication”
Blood immunomonitoring uncovers pregnancy-induced immune programs and their dysregulation in lupus pregnancy destined for complications
GEO Series GSE108497. Homo sapiens. 512 samples. Type: Expression profiling by array.
LncRNA LYPLAL1-DT screening from type 2 diabetes with macrovascular complication contributes protective effects on human umbilical vein endothelial cells via regulating the miR-204-5p/SIRT1 axis.
GEO Series GSE202151. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene-expression profiles of whole blood cells from a Han Chinese population with or without Type-2 Diabetes Mellitus or/and its complications in nephropathy and retinopathy
GEO Series GSE189007. synthetic construct; Homo sapiens. 130 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
A genome-wide CRISPR/Cas phenotypic screen for modulators of DUX4 cytotoxicity reveals screen complications
GEO Series GSE155034. synthetic construct; Homo sapiens. 6 samples. Type: Other.
Hepatocyte nuclear factor 4β protect zebrafish from dexamethasone-induced hepatobiliary syndrome and hepatobiliary syndrome complicated with GCRV-II infection by targeting Hsp70 and inhibiting autopha
GEO Series GSE303991. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification of long noncoding RNAs involved in clinicopathological features of papillary thyroid carcinoma complicated with Hashimoto's thyroiditis
GEO Series GSE192560. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by array; Expression profiling by array.
Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients
<p>This record contains raw data related to the article "Platelet and Endothelial Activation as Potential Mechanisms Behind the Thrombotic Complications of COVID-19 Patients"</p> <p>The authors hypothesized that the cytokine storm described in COVID-19 patients may lead to consistent cell-<br> based tissue factor (TF)-mediated activation of coagulation, procoagulant microvesicles (MVs) release, and<br> massive platelet activation. COVID-19 patients have higher levels of TFþ platelets, TFþ granulocytes, and TFþ<br> MVs than healthy subjects and coronary artery disease patients. Plasma MV-associated thrombin generation is<br> present in prophylactic anticoagulated patients. A sustained platelet activation in terms of P-selectin expression<br> and platelet–leukocyte aggregate formation, and altered nitric oxide/prostacyclin synthesis are also observed.<br> COVID-19 plasma, added to the blood of healthy subjects, induces platelet activation similar to that observed<br> in vivo. This effect was blunted by pre-incubation with tocilizumab, aspirin, or a P2Y12 inhibitor.</p>
Dataset related to article "Long term follow-up after balloon expandable covered stents implantation for management of transcatheter aortic valve replacement related vascular access complications"
<p>This record contains raw data related to article “Long term follow-up after balloon expandable covered stents implantation for management of transcatheter aortic valve replacement related vascular access complications"</p> <p>Abstract</p> <p><strong>Objectives: </strong> To report the experience of a high-volume center with balloon-expandable (BE) stents implantation to manage vascular complications after transcatheter aortic valve replacement (TAVR).</p> <p><strong>Background: </strong> Despite increased operator experience and better devices, vascular complications after TAVR are still a major issue and covered stent implantation is often required.</p> <p><strong>Methods: </strong> We retrospectively collected baseline and procedural data about 78 consecutive patients who underwent BE stent implantation to manage a vascular complication after transfemoral TAVR. Primary endpoints were technical success, incidence of new-onset claudication and need for vascular interventions during long-term follow-up. Secondary endpoints included length of hospitalization, in-hospital and 30-day mortality, and major postoperative complications.</p> <p><strong>Results: </strong> BE stents implantation to manage vascular complications after TAVR was successfully performed in 96.2% of the cases, with bailout surgery required in two cases. One patient suffered in-hospital death. Predischarge Doppler Ultrasound revealed no cases of in-stent occlusion or fracture. At a median follow-up of 429 days (interquartile range, 89-994 days), no cases of symptomatic leg ischemia were reported and only one patient experienced new-onset claudication.</p> <p><strong>Conclusions: </strong> Our experience showed good periprocedural and long-term results of BE covered stent implantation to manage vascular complication after TAVR. Their great radial outward force may guarantee effective hemostasis without necessarily being associated with stent deformation/fracture resulting in restenosis or further interventions. More research is needed to define the role of BE covered stents in this setting.</p>
: Dataset related to the article "Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study"
<p>This record contains raw data related to the article “Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study”.</p> <p><em><strong>Abstract</strong></em></p> <p><strong>Background: </strong>Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced glycation end-products (RAGE) play a pivotal role in the development and progression of type 2 diabetes. In this retrospective cohort study, we explored the association of circulating levels of soluble RAGE (sRAGE) isoforms, i.e., endogenous secretory esRAGE and cleaved cRAGE, AGEs and their respective ratios with 15-year all-cause mortality in type 2 diabetes. <strong>Methods: </strong>Baseline AGEs and sRAGE isoforms concentration were measured by ELISA in 362 patients with type 2 diabetes and in 125 age- and gender-matched healthy control subjects (CTR). Independent predictors of mortality were determined using Cox proportional-hazards models and used to build and validate a nomogram for all-cause mortality prediction in type 2 diabetes. <strong>Results: </strong>AGEs, total sRAGE, cRAGE and the AGEs/sRAGE and AGEs/esRAGE ratios were significantly increased in patients with type 2 diabetes compared to CTR (p < 0.001). In CTR subjects, but not in type 2 diabetes patients, a significant negative correlation between cRAGE and age was confirmed (p = 0.003), whereas the AGEs/sRAGE (p = 0.032) and AGEs/cRAGE (p = 0.006) ratios were positively associated with age. At an average follow-up of 15 years (4,982 person-years), 130 deaths were observed. The increase in the AGEs/cRAGE ratio was accompanied by a higher risk of all-cause mortality in patients with type 2 diabetes (HR per each SD increment = 1.30, 95% CI 1.15-1.47; p < 0.001). Moreover, sRAGE was associated with the development of major adverse cardiovascular events (MACE) in type 2 diabetes patients without previous MACE (OR for each SD increase: 1.48, 95% CI 1.11-1.89). A nomogram based on age, sex, HbA1c, systolic blood pressure, and the AGEs/cRAGE ratio was built to predict 5-, 10- and 15-year survival in type 2 diabetes. Patients were categorized into quartiles of the monogram scores and Kaplan-Meier survival curves confirmed the prognostic accuracy of the model (log-rank p = 6.5 × 10<sup>- 13</sup>). <strong>Conclusions: </strong>The ratio between AGEs and the cRAGE isoform is predictive of 15-year survival in patients with type 2 diabetes. Our data support the assessment of circulating AGEs and soluble RAGE isoforms in patients with type 2 diabetes as predictors of MACE and all-cause mortality.</p> Enable Ginger<em>Cannot connect to Ginger</em> Check your internet connection<br> or reload the browserDisable in this text fieldRephraseRephrase current sentence<span class="ginger-floatingG-bar-tool-mistakes-count">26</span>Log in to edit with Ginger×
Expanded Access to REGN4461 for Patients With Lipodystrophy or Monogenic Obesity With Complications of Leptin Deficiency or Deficient Leptin Signaling
ClinicalTrials.gov study NCT04710056. IPD Sharing: Not stated. Countries: 0. Publications: 0.
To Evaluate the Treatment Effect of an Anti-Infective Agent for Complicated Infections (0826-053)
ClinicalTrials.gov study NCT00397956. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Probiotic Therapy in Preventing Gastrointestinal Complications in Patients Undergoing Chemotherapy and Pelvic Radiation Therapy
ClinicalTrials.gov study NCT01473290. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Expanded Access Use of Sulopenem Etzadroxil/Probenecid for Complicated Urinary Tract Infection
ClinicalTrials.gov study NCT04682834. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Supplemental deinoxanthin protects mice from irradiation-mediated systemic impairments by recovering hematopoietic and degenerative complications
GEO Series GSE301666. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
miRNA expression profiles of whole blood cells from a Han Chinese population with or without Type-2 Diabetes Mellitus or/and its complications in nephropathy and retinopathy
GEO Series GSE189002. Homo sapiens; synthetic construct. 45 samples. Type: Non-coding RNA profiling by array.
Gene expression profiling in endothelial precursor cells of patients protected from microvascular complications
GEO Series GSE43950. Homo sapiens. 14 samples. Type: Expression profiling by array.
RNA expression profiles of whole blood cells from a Han Chinese population with or without Type-2 Diabetes Mellitus or/and its complications in nephropathy and retinopathy
GEO Series GSE189005. Homo sapiens. 45 samples. Type: Expression profiling by array.
Erucic acid improves the pregnancy complicated with systemic lupus erythematosus by inhibiting the effector function of CD8+ T cell
GEO Series GSE222565. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Myosteatosis Is Not Associated with Complications or Survival in HCC Patients Undergoing Trans Arterial Embolization"
<p>This record contains raw data related to article "Myosteatosis Is Not Associated with Complications or Survival in HCC Patients Undergoing Trans Arterial Embolization"</p><p> <strong>Abstract</strong></p><p>Alterations in nutritional status, in particular sarcopenia, have been extensively associated with a poor prognosis in cirrhotic patients regardless of the etiology of liver disease. Less is known about the predictive value of myosteatosis, defined as pathological fat infiltration into the skeletal muscle. We retrospectively analyzed a cohort of 151 cirrhotic patients with unresectable hepatocellular carcinoma (HCC) who underwent their first trans-arterial embolization (TAE) between 1 March 2011 and 1 July 2019 at our Institution. Clinical and biochemical data were collected. Sarcopenia was assessed using the L3-SMI method while myosteatosis with a dedicated segmentation suite (3D Slicer), using a single slice at an axial plane located at L3 and calculating the IMAC (Intramuscular Adipose Tissue Content Index). The sex-specific cut-off values for defining myosteatosis were IMAC > −0.44 in males and >−0.31 in females. In our cohort, 115 (76%) patients were included in the myosteatosis group; 128 (85%) patients had a coexistent diagnosis of sarcopenia. Patients with myosteatosis were significantly older and showed higher BMI than patients without myosteatosis. In addition, male gender and alcoholic- or metabolic-related cirrhosis were most represented in the myosteatosis group. Myosteatosis was not associated with a different HCC burden, length of hospitalization, complication rate, and readmission in the first 30 days after discharge. Overall survival was not influenced by the presence of myosteatosis</p>
Peribulbar vs. incisionless sub-Tenon's blocks: analysis of complication profiles: a retrospective cohort study
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.