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12,799 results for “Immunization”
Complete and early response to cemiplimab associated to severe immune toxicity in advanced cervical cancer: a case report
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Data from: CRISPR-based herd immunity limits phage epidemics in bacterial populations
Herd immunity, a process in which resistant individuals limit the spread of a pathogen among susceptible hosts has been extensively studied in eukaryotes. Even though bacteria have evolved multiple immune systems against their phage pathogens, herd immunity in bacteria remains unexplored. Here we experimentally demonstrate that herd immunity arises during phage epidemics in structured and unstructured Escherichia coli populations consisting of differing frequencies of susceptible and resistant cells harboring CRISPR immunity. In addition, we develop a mathematical model that quantifies how herd immunity is affected by spatial population structure, bacterial growth rate, and phage replication rate. Using our model we infer a general epidemiological rule describing the relative speed of an epidemic in partially resistant spatially structured populations. Our experimental and theoretical findings indicate that herd immunity may be important in bacterial communities, allowing for stable coexistence of bacteria and their phages and the maintenance of polymorphism in bacterial immunity.
OrganoIDNetData: A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models
<p>OrganoIDNetData encompasses 180 images with 34113 organoids of human and murine Pancreatic Ductal Adenocarcinoma co-cultured with immune cells.</p> <p><strong>For further information and to cite this dataset, please refer to:</strong></p> <p>Kulkarni, A., Ferreira, N., Scodellaro, R. <em>et al.</em> A Curated Cell Life Imaging Dataset of Immune-enriched Pancreatic Cancer Organoids with Pre-trained AI Models. <em>Sci Data</em> <strong>11</strong>, 820 (2024). https://doi.org/10.1038/s41597-024-03631-3</p>
Characterization of the tumor-immune microenvironment in hepatocellular carcinoma patients undergoing immune checkpoint inhibitor therapy by highly multiplexed imaging mass cytometry
<p>Imaging mass cytometry data of 42 HCC patients that received immune checkpoint inhibtor therapy after tumor biopsy or resection. </p> <ul> <li>ICI_img_normalized: Preprocessed and normalized multistack .tiff images. Each stack represents one channel. Channel annotations are stored in the ICICohort_panel.csv file.</li> <li>ICI_cellmasks: Masks identifying individual cells on the images.</li> <li>ICI_stromamasks: Masks identifying stromal and parenchymal regions on the image.</li> <li>ICICohort_panel.csv: table containing channel information (metal tag and marker).</li> </ul> <p>Patient etadata may be found in the supplementary table 3 of DOI <a href="https://doi.org/10.1136/gutjnl-2024-332837" target="_blank" rel="noopener noreferrer">10.1136/gutjnl-2024-332837</a>.</p>
Post-resolution macrophages shape long-term tissue immunity and integrity in a mouse model of Streptococcus pneumonia.
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Supplementary data for "Profiling the peripheral immune landscape of metastatic HER2+ breast cancer"
<p>Supplementary data (Supplementary Table III.1) and high-resolution versions of figures III.3 - III.9 for Chapter III of the PhD thesis "The effect of dual HER2 blockade on anti-tumor immune cells" (ITQB-NOVA, Oeiras, Portugal).</p>
Immune repertoires for Bionumpy Blogpost
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Learning the sequence code for protein abundance in human immune cells
<p><span>Protein abundance is defined by </span><span>transcriptional, post-transcriptional and post-translational regulatory mechanisms. Understanding the code for gene expression could inform novel therapies. Here, we developed a machine learning pipeline, termed SONAR, to decipher the endogenous sequence code that defines the abundance of protein in human cells. SONAR predicts up to 63% of protein abundance independently of promoter or enhancer information. Our analysis reveals a strong - yet dynamic - </span><span>cell-type specific sequence code<span>. The deep knowledge of SONAR provides a map of biologically active sequence features (SFs), which we leveraged to </span></span><span>manipulate protein expression and tailored to a specific cell-type. </span><span>Beyond providing fundamental insights in gene expression regulation, our study offers novel means to improve therapeutic and biotechnology applications.</span></p> <p><span>Datasets of the protein models (with gamma=1) are included in this repository. Please refer to GitHub for more details on how the models were generated. </span></p>
Infection of HSV1 in innate lymphoid cells leads to alienation of the mechanism of T/B-cell activation in the adaptive immune response-image
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Therapeutic Potential of Lianli Decoction in Ulcerative Colitis: Role of Intestinal Microbiota and Immune Regulation
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Recognition Mechanism of RNA by TLR13: Structural Insights and Implications for Immune Activation
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Identifying Key Targets and Immune Environment in Wound Healing Based on Iron Overload-Related Genes
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raw data - Causal relationship of immune cells and primary open-angle glaucoma: A Mendelian randomization study
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THE ROLE OF CULTURE AND ART IN RAISING SPIRITUAL AND EDUCATIONAL IMMUNITY IN YOUTH
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The battle between gut bacteria, immune system and Cry1Ac toxin in Plutella xylostella.
<p><span>Research into the interaction between </span><em><span>Bacillus thuringiensis</span></em> <span>(Bt) and pest has primarily focused on the Cry toxin receptor, relatively less attention has been paid towards the role of the gut bacteria, particularly the mechanism on how insect gut bacteria affect its sensitivity to Bt. Addressing this gap could provide valuable insights for pest control strategies. This study analyzed the variances of gut microbiota between Cry1Ac-resistant and sensitive strains of </span><em><span>Plutella xylostella</span></em><span>, as well as field populations. From their gut microbiota, one strain (</span><em><span>Enterobacter asburiae</span></em><span>, PxG1) that significantly increased and another strain (</span><em><span>Enterobacter hormaechei</span></em><span>, PxG15) that significantly decreased the Cry1Ac susceptibility of </span><em><span>P. xylostella</span></em> <span>were isolated and cultured. PxG15 degraded Cry1Ac protoxin and activated the proPO-AS and JNK pathway, which reduced Cry1Ac</span><span>’</span><span>s damage to the midgut while limiting the invasion of gut bacteria into the hemolymph. Although PxG1 rapidly activated the proPO-AS, the JNK pathway was activated in a much slower and weaker mode when compared to PxG15, which attenuated the repairing efficiency of midgut under the treatment of Cry1Ac, leading to death resulted from sepsis from the quick invasion of gut bacteria into the hemolymph. This study illustrates the intricate interrelationships among Cry1Ac toxins, the pest's midgut bacteria, and its immune system. Different midgut bacteria exhibited distinct interactions with the Cry1Ac toxin and the immune system, resulting in opposing effects on the virulence of Cry1Ac on pests. These findings provide new insights into the role of gut bacteria in influencing the survival of Lepidoptera pest after exposure to Cry1Ac.</span></p>
COVID-19 PHAC Agent-Based Model for age-stratified intervention and herd immunity study
<p>The PHAC agent-based model was used to explore the progression of the COVID-19 epidemic under three intervention scenarios (infection-preventing vaccination, illness-preventing vaccination and shielding) in individuals above three age thresholds (≥45, ≥55 and ≥65 years) while lifting shutdowns and physical distancing in the community. This data repository contains the PHAC modelling code in Anylogic used for this study. </p>
Berberine protects against sepsis-related acute lung injury in rats via the upregulation of the PPAR - Υ signaling pathway, with amelioration at the cellular level - A functional, immune-histological and biochemical study
<p>Aim: To assess the therapeutic effects of berberine in experimentally induced lung sepsis. Examining its effects on selected cytokines, gene and protein expression and the histopathological findings.</p> <p>Results: Berberine significantly reduced the wet/dry lung ratio, the BALF protein, cell, and neutrophils percentage & the BALF cytokines levels. In addition, pretreatment with berberine decreases the myeloperoxidase and MDA levels and decreases gene expression of NFKB, MCP -1 and the ICAM - 1 by RT - PCR analysis. Thus, suggesting an antioxidant and anti-inflammatory mode of the action. Western blot analysis revealed increased PPAR – Υ expression in the berberine pretreated group compared to the CLP group. Histopathological examination revealed improved histopathological parameters, in the berberine pretreated group, compared to the CLP group.</p> <p>Conclusion: Berberine improves the outcome in sepsis via antioxidant and anti-inflammatory effects, modulation of cytokine levels, upregulation of PPAR - Υ protein expression, and histopathological amelioration.</p>
Correlations between components of the immune system
<p><span><span><b>Background:</b></span></span></p> <p><span><span>No evidence of the possibility to alter a constituent of the immune system without directly affecting one of its associated components has been shown yet. </span></span></p> <p><span><span><b>Methods:</b> </span></span></p> <p><span><span><span>A schematic model was developed in which two triggers, fasting and splenectomy, were studied for their ability to affect the expression of cell membrane epitopes and the cytokine secretion of out-of-body autogeneic and syngeneic lymphocytes. </span></span></span></p> <p><span><span><b>Results</b>: </span></span></p> <p><span><span><span>Fasting decreased expression of CD8 and CD25 and increased TNFα levels. The effect of splenectomy as a trigger was investigated in non-fasting mice by comparing splenectomized and non-splenectomized mice. An increase in the CD8 expression and in TNFα, IFNg, and IL10 secretion was noted. The effect of splenectomy as a trigger was investigated in fasting mice by comparing splenectomized and non-splenectomized mice. Splenectomy had a significant effect on expression of CD25 and CD4 CD25 and on secretion of TNFα, IFNg, and IL10. To determine the effect of keeping the cells in an out-of-body location on the expression of lymphocyte epitopes, tubes kept on top of the cages of the fasting mice were compared with tubes kept on top of empty cages. A significant change in the CD8 expression was noted. To determine the effect of keeping cells in an out-of-body location on cytokine secretion, tubes kept on top of cages were tested for cytokine levels. A significant decrease was noted for the secretion of TNFα and IFNg.</span></span></span></p> <p><span><span><b>Conclusions:</b> </span></span></p> <p><span><span>The data obtained from this study characterized a system for induction of correlations between two components of the immune system without a transfer of mediators. The study showed that a mouse could affect cells at a distance and alter the expression of surface markers and cytokine secretion following two types of triggers: fasting and/or splenectomy. Thus, an out-of-body correlation can be induced between two components of the immune system.</span></span></p>
Figure 6 from: Demkovych A, Bondarenko Y, Shcherba V, Luchynskyi V, Vitkovskyy V, Machogan V (2021) Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis. Pharmacia 68(4): 877-882. https://doi.org/10.3897/pharmacia.68.e70883
Figure 6 Dynamics of the natural killers content in the rat's blood on the 14th day of the research in conditions of experimental bacterial-immune periodontitis development and treatment by quercetin (% of control). Notes. * – significant of differences in relation to the intact animals (p<0.01); ● – significant of differences in relation to the intact animals (p<0.05); # – significant of differences in relation to the animals with periodontitis on the 14th day of the experiment without treatment (p<0.01).
Figure 1 from: Demkovych A, Bondarenko Y, Shcherba V, Luchynskyi V, Vitkovskyy V, Machogan V (2021) Quercetin effects on adaptive immune response in experimental periodontitis of bacterial-immune genesis. Pharmacia 68(4): 877-882. https://doi.org/10.3897/pharmacia.68.e70883
Figure 1 Dynamics of the content of common mature T-lymphocytes in the rat's blood on the 14th day of the research in conditions of experimental bacterial-immune periodontitis development and treatment by quercetin (% of control). Notes: * – significant of differences in relation to the intact animals (p<0.01); # – significant of differences in relation to the animals with periodontitis on the 14th day of the experiment without treatment (p<0.01).
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.