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795 results for “Drug Safety”
A large-scale Twitter dataset for drug safety applications mined from publicly existing resources
<p>This dataset consists of 1,181,993 Tweet Ids, obtained as a result from the paper - A large-scale Twitter dataset for drug safety applications mined from publicly existing resources.</p> <p>The Tweet Ids can be hydrated using <strong>twarc</strong>, a command line tool and Python library for archiving Twitter JSON data. Please follow these instructions to install twarc - <a href="https://github.com/DocNow/twarc">https://github.com/DocNow/twarc</a></p> <p>It will take less than 4 hours to hydrate the tweet ids using twarc. </p> <p>If you intend to use the dataset, please cite the paper. </p>
Data from: Comparison of the efficacy and safety of drug therapies for macular edema secondary to central retinal vein occlusion
Objectives: To evaluate the efficacy and safety of anti-vascular endothelial growth factor (VEGF) agents and corticosteroids for the treatment of macular edema (ME) secondary to central retinal vein occlusion (CRVO). Design: Systematic review and network meta-analysis. Participants: Patients from previously reported randomized controlled trials (RCTs) comparing anti-VEGF and corticosteroids for the treatment of ME secondary to CRVO. Methods: Literature searches were conducted using PubMed, Medline, Embase, Cochrane Library, and clinicaltrials.gov until March 2017. Therapeutic effects were estimated using the proportions of patients gaining/losing ≥15 letters, best-corrected visual acuity (BCVA), and central retinal thickness (CRT). Treatment safety was estimated using the proportions of adverse events, namely increased intraocular pressure (IOP), cataracts, vitreous hemorrhage (VH), and retinal tear. The software ADDIS (version 1.16.8) was used for analysis. Treatment effect and safety of different drugs could be ranked based on simulation. Results: Eleven RCTs comprising 2060 patients were identified. Regarding patients gaining ≥15 letters, aflibercept and ranibizumab were significantly more effective than sham/placebo at 6 months. Regarding patients losing ≥15 letters at 6 months, ranibizumab showed significant improvement compared to dexamethasone. Aflibercept, bevacizumab, or ranibizumab showed greater improvements in BCVA than sham/placebo at 6 months. Intravitreal ranibizumab injection demonstrated greater CRT reduction than both sham and dexamethasone did. Dexamethasone had a higher risk of increased IOP than aflibercept and ranibizumab. Ranibizumab demonstrated a greater risk of cataracts than dexamethasone. Aflibercept and ranibizumab demonstrated low incidence of VH and retinal tear, respectively. Aflibercept had a slight advantage over ranibizumab as assessed by benefit-risk analysis. Conclusions: Anti-VEGF agents have advantages in the treatment of ME secondary to CRVO. Aflibercept and ranibizumab showed marked BCVA improvement and CRT reduction. Aflibercept may have a slight advantage over ranibizumab. The results of this study can serve as a reference for clinicians to provide patient-tailored treatment.
Study of Efficacy and Safety of Drugs BCD-033 and Rebif for Treatment of Patients With Multiple Sclerosis
ClinicalTrials.gov study NCT02727907. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of a Glaucoma Drug Delivery System
ClinicalTrials.gov study NCT00824720. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Single and Multiple Dose Study to Assess How the Drug Enters, Moves Through and Exits the Body, Safety and Tolerability of Safinamide in Healthy Adult Chinese Volunteers
ClinicalTrials.gov study NCT03887221. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis
ClinicalTrials.gov study NCT04179500. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Evaluation of Safety, Tolerability, Pharmacokinetics, Drug-Drug and Food Interactions of Single and Multiple Doses of S-648414 in Healthy Adults
ClinicalTrials.gov study NCT04147715. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Safety Extension Study to Evaluate the Biodegradation of the Brimonidine Tartrate Posterior Segment Drug Delivery System
ClinicalTrials.gov study NCT01080209. IPD Sharing: Not stated. Countries: 12. Publications: 0.
Efficacy and Safety Study of Linagliptin (5 mg Administered Orally Once Daily) Over 24 Weeks, in Drug naïve or Previously Treated Type 2 Diabetic Patients With Insufficient Glycaemic Control
ClinicalTrials.gov study NCT01214239. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Safety and Tolerability Study of Drug to Treat Schizophrenia
ClinicalTrials.gov study NCT00044005. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Open Label, Safety and Efficacy Study of Topical Investigational Drug to Treat Patients With Psoriasis
ClinicalTrials.gov study NCT00617994. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy Study of the Amaranth Medical FORTITUDE Bioresorbable Drug-Eluting Coronary Stent
ClinicalTrials.gov study NCT02255864. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients.
ClinicalTrials.gov study NCT03775421. IPD Sharing: YES. Countries: 11. Publications: 0.
Effectiveness and Safety of COVID-19 Vaccine in Patients With IBD Treated With Immunomodulatory or Biological Drugs (ESCAPE-IBD)
ClinicalTrials.gov study NCT04769258. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Safety and Efficacy of the SurVeil™ Drug-Coated Balloon (AVess FIH)
ClinicalTrials.gov study NCT03734679. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A Monoclonal Antibody With Antiangiogenic Features) In Combination With Best Supportive Care Versus Placebo Plus Be
ClinicalTrials.gov study NCT01911273. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia)
ClinicalTrials.gov study NCT03939104. IPD Sharing: YES. Countries: 2. Publications: 0.
A Study to Investigate the Safety of the Drugs Topiramate and Levetiracetam in Treating Children Recently Diagnosed With Epilepsy
ClinicalTrials.gov study NCT02201251. IPD Sharing: Not stated. Countries: 14. Publications: 0.
A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066)
ClinicalTrials.gov study NCT00250445. IPD Sharing: Not stated. Countries: 0. Publications: 7.
Clinical Trial of Safety and Efficacy of Various Dosage Schedules for Dietressa Drug in Treatment of Obese Patients
ClinicalTrials.gov study NCT01535014. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.