Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
12,799
datasets available to search
ShareScore release 0.9.0
Dataset results
12,799 results for “Immunization”
Oviposition preference and performance of Plutella xylostella are modulated by natural enemies, larval odours and immune status
<p>Insect herbivores frequently must balance host plant quality and the risk of attack by their natural enemies when making oviposition decisions. Yet, which factor is more important remains unresolved in plant-insect ecology. Here, we report the oviposition preference and larval performance of the brassicaceous specialist <em>Plutella xylostella</em>, in the context of plant quality (cabbage <em>Brassica oleracea</em>, vs. mustard <em>B. juncea</em>) and associated natural enemies. <a name="_Hlk95552650"></a>Despite the greater larval weight and adult life-span on cabbage, ovipositing females strongly preferred mustard. Both the egg parasitoid <em>Trichogrammatoidea bactrae</em> and the larval ectoparasitoid <em>Bracon brevicornis</em> are more likely to attack <em>P. xylostella</em> that feed on cabbage; thus, mustard represents enemy-reduced space from these two parasitoids. However, larval diet had no impact on the parasitization rate of specialist <em>Cotesia vestalis</em>. Feeding on mustard improved larval immunity. The total hemocytes number, diversity and phenoloxidase activity was higher on mustard-fed larvae that increased their survival against the entomopathogen, <em>Bacillus thuringiensis. </em>Interestingly, host plants altered the larval body odour profile. Mustard fed larvae emitted allyl isothiocyanate (AITC) and butyl isothiocyanate (BITC) while cabbage fed larvae emitted dimethyl disulphide (DMDS) and dimethyl trisulphide (DMTS) that served as short-range cues for larval parasitoids. For <em>B. brevicornis</em>, host body odour guided oviposition choice was crucial as their fitness was affected by the host larval diet. Although, <em>C. vestalis</em> showed a clear preference towards volatiles emitted by mustard fed larvae, their fitness was unaltered. Taken together, our results illustrate that <em>P. xylostella</em> prefers to lay eggs on mustard plants providing enemy-reduced space from some, but not all, natural enemies.</p>
Multimodal single cell analysis of the paediatric lower airway reveals novel immune cell phenotypes in early life health and disease
<p>RDS files of SingleCellExperiment objects containing raw single cell RNA-seq count data required to replicate the analyses presented at: <a href="https://oshlacklab.com/paed-cf-cite-seq/">https://oshlacklab.com/paed-cf-cite-seq/</a> and described in the pre-print titled: <em>"</em>Multimodal single cell analysis of the paediatric lower airway reveals novel immune cell phenotypes in early life health and disease<em>"</em>.<br> Instructions for how to incorporate the raw data into the analysis can be found at: <a href="https://oshlacklab.com/paed-cf-cite-seq/gettingStarted.html">https://oshlacklab.com/paed-cf-cite-seq/gettingStarted.html</a> and the complete analysis code and additional data files can be cloned/downloaded from: <a href="https://github.com/Oshlack/paed-cf-cite-seq">https://github.com/Oshlack/paed-cf-cite-seq</a>.</p>
Data from: A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes
<p><strong>Background: </strong>The large inter-individual variability in immune-cell cell composition and function determines immune responses in general and susceptibility to immune-mediated diseases in particular. While much has been learned about the genetic variants relevant for type 1 diabetes (T1D), the pathophysiological mechanisms through which these variations exert their effects remain unknown.</p> <p><strong>Methods:</strong> Blood samples were collected from 243 patients with T1D of Dutch descent. We applied genetic association analysis on > 200 immune cell traits and >100 cytokine production profiles in response to stimuli measured to identify genetic determinants of immune function, and compared the results obtained in T1D to healthy controls.</p> <p><strong>Results:</strong> Genetic variants that determine susceptibility to T1D significantly affect T cell composition. Specifically, the CCR5+ regulatory T cells associate with T1D through the CCR region, suggesting a shared genetic regulation. Genome-wide quantitative trait loci (QTL) mapping analysis of immune traits revealed 15 genetic loci that influence immune responses in T1D, including 12 that have never been reported in healthy population studies, implying a disease-specific genetic regulation.</p> <p><strong>Conclusion:</strong> This study provides new insights into the genetic factors that affect immunological responses in T1D.</p>
Corresponding spreadsheet to the Paper 'Comparative analysis of pre-Covid19 child immunization rates across 30 European countries and identification of underlying positive societal and system influences'
<p>This study provides a macro-level societal and health system focused analysis of child vaccination rates in 30 European countries, exploring the effect of context on coverage. The importance of demography and health system attributes on health care delivery are recognized in other fields, but generally overlooked in vaccination. The analysis is based on correlating systematic data built up by the Models of Child Health Appraised (MOCHA) Project with data from international sources, so as to exploit a one-off opportunity to set the analysis within an overall integrated study of primary care services for children, and the learning opportunities of the ‘natural European laboratory’. The descriptive analysis shows an overall persistent variation of coverage across vaccines with no specific vaccination having a low rate in all the EU and EEA countries. However, contrasting with this, variation between total uptake per vaccine across Europe suggests that the challenge of low rates is related to country contexts of either policy, delivery, or public perceptions. Econometric analysis aiming to explore whether some population, policy and/or health system characteristics may influence vaccination uptake provides important results - GDP per capita and the level of the population’s higher education engagement are positively linked with higher vaccination coverage, whereas mandatory vaccination policy is related to lower uptake rates. The health system characteristics that have a significant positive effect are a cohesive management structure; a high nurse/doctor ratio; and use of practical care delivery reinforcements such as the home-based record and the presence of child components of e‑health strategies.</p>
Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery
<p>Bariatric surgery is becoming more prevalent as a sustainable weight loss approach, with vertical sleeve gastrectomy (VSG) being the first line of surgical intervention. We and others have shown that obesity exacerbates tumor growth while diet-induced weight loss impairs obesity-driven progression. It remains unknown how bariatric surgery-induced weight loss impacts cancer progression or alters responses to therapy. Using a pre-clinical model of diet induced obesity followed by VSG or diet-induced weight loss, breast cancer progression and immune checkpoint blockade therapy was investigated. Weight loss by bariatric surgery or weight matched dietary intervention before tumor engraftment protected against obesity-exacerbated tumor progression. However, VSG was not as effective as dietary intervention in reducing tumor burden despite achieving similar extent of weight and adiposity loss. Circulating leptin did not associate with changes in tumor burden. Uniquely, tumors in mice that received VSG displayed elevated inflammation and checkpoint ligand PD-L1. Further, mice that received VSG had reduced tumor infiltrating T lymphocytes suggesting an ineffective anti-tumor microenvironment. VSG-associated elevation of PD-L1 prompted us to next investigate the efficacy of immune checkpoint inhibitors in lean, obese, and formerly obese mice that lost weight by VSG or weight matched controls. While obese mice were resistant to immunotherapy, anti-PD-L1 potently impaired tumor progression after VSG through improved anti-tumor immunity. Thus, in formerly obese mice, surgical weight loss followed by immunotherapy reduced breast cancer burden. Further studies are necessary to determine how bariatric surgery sensitizes tumors to immune checkpoint inhibition.</p>
The evolution of immune function in decorated crickets
<p>While dietary macronutrients are known to regulate insect immunity, few studies have examined their evolutionary effects. Here, we evaluate this relationship in the cricket<em> Gryllodes sigillatus</em> by maintaining replicate populations on four diets differing in protein (P) to carbohydrate (C) ratio (P- or C-biased) and nutritional content (low- or high-nutrition) for >37 generations. We split each population into two; one maintained on their evolution diet and the other switched to their ancestral diet. We also maintained populations exclusively on the ancestral diet (baseline). After three generations, we measured three immune parameters in males and females from each population. Immunity was higher on P-biased than C-biased diets and on low- versus high-nutrition diets, although the latter was most likely driven by compensatory feeding. These patterns persisted in populations switched to their ancestral diet, indicating genetic divergence. Crickets evolving on C-biased diets had lower immunity than the baseline, whereas their P-biased counterparts had similar or higher immunity than the baseline, indicating that populations evolved with dietary manipulation. While females exhibited superior immunity for all assays, the sexes showed similar immune changes across diets. Our work highlights the important role that macronutrient intake plays in the evolution of immunity in the sexes.</p>
Data from: Microglia are necessary to regulate sleep after an immune challenge
<p>Microglia play a critical role in the neuroimmune response, but little is known about the role of microglia in sleep following an inflammatory trigger. Nevertheless, decades of research have been predicated on the assumption that an inflammatory trigger increases sleep through microglial activation. We hypothesized that mice (n = 30) with depleted microglia would sleep less following administration of lipopolysaccharide (LPS) to induce inflammation. Brains were collected and microglial morphology was assessed using quantitative skeletal analyses, and physiological parameters were recorded using non-invasive piezoelectric cages. Mice fed PLX5622 (PLX) diet for 3 weeks had a transient increase in sleep that dissipated by week 2. Subsequently, following a first LPS injection (0.4 mg/kg), mice with depleted microglia slept more than mice on control diet. All mice were returned to normal rodent chow to repopulate microglia in the PLX group (10 days). Nominal differences in sleep existed during the microglia repopulation period. However, following a second LPS injection, mice with repopulated microglia slept similarly to control mice during the dark period but with longer bouts during the light period. Comparing sleep after the first LPS injection to sleep after the second LPS injection, controls exhibited temporal changes in sleep patterns with no change in cumulative minutes slept, whereas in mice with repopulated microglia cumulative sleep decreased during the dark period across all days. Microglia repopulated after PLX also had a reactive morphology with fewer branch endpoints per cell. We conclude that microglia are necessary to regulate sleep after an immune challenge.</p>
Dataset related to article "'Understanding fibrosis pathogenesis via modelling macrophage-fibroblast interplay in immune-metabolic context"
<p>This record contains raw data related to article “ 'Understanding fibrosis pathogenesis via modelling macrophage-fibroblast interplay in immune-metabolic context"</p> <p>Abstract not avaible at the moment</p>
Malignant pleural effusion LADC immunity 700 gene dataset
<p>MPE cytologic cell blocks of 83 LADC patients were analysed for the mRNA expression of 770 cancer-immune genes by the NanoString nCounter platform.</p>
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
<p>The biological determinants underlying the range of COVID-19 clinical manifestations are not fully understood. Here, over 1400 plasma proteins and 2600 single-cell immune features comprising cell phenotype, endogenous signaling activity, and signaling responses to inflammatory ligands are cross-sectionally assessed in peripheral blood from 97 patients with mild, moderate, and severe COVID-19 and 40 uninfected patients. Using an integrated computational approach to analyze the combined plasma and single-cell proteomic data, we identify and independently validate a multivariate model classifying COVID-19 severity (multi-class AUC<sub>training</sub> = 0.799, p-value = 4.2e-6; multi-class AUC<sub>validation</sub> = 0.773, p-value = 7.7e-6). Examination of informative model features reveals novel biological signatures of COVID-19 severity, including the dysregulation of JAK/STAT, MAPK/mTOR, and NF-κB immune signaling networks in addition to recapitulating known hallmarks of COVID-19. These results provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for prevention and/or treatment of COVID-19 progression.</p>
Thallium(I) exposure perturbs the gut microbiota and metabolic profile as well as the regional immune function of C57BL/6 J mice
<p><span>Intestinal microbes</span><span> regulate the development of diseases induced by environmental exposure. Thallium (Tl) is a highly toxic heavy metal</span><span>, </span><span>and its toxicity is rarely discussed in relation to gut microbes. Herein, we showed that Tl(I) exposure (10 ppm for two weeks) affected the alpha diversity of bacteria in </span><span>the ileum, colon, and </span><span>feces, but had little effect on the beta diversity of bacteria through 16S rRNA sequencing. LEfSe analysis revealed that Tl(I) exposure changed the abundance of intestinal microbiota along the digestive tract. Cecum metabolomic detection and analysis showed that Tl(I) exposure altered the abundance and composition of metabolites. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that Tl(I) exposure impaired amino acid, lipid, purine metabolism, and G protein-coupled receptor signalling pathways. A consistency test revealed a strong correlation, and a Pearson's correlation analysis showed an extensive interaction, between microorganisms and metabolites. Analysis of the intestinal immunity revealed that Tl(I) exposure suppressed the immune responses, which also had regional differences. These results identify the perturbation of the intestinal microenvironment by Tl exposure and provide a new explanation for Tl toxicity.</span></p>
Do departure and flight route decisions correlate with immune parameters in migratory songbirds?
<p>Many songbirds migrate twice a year to exploit seasonally available resources. These journeys are energetically demanding and the energy reserves of these small birds are limited. Accordingly, most of the time migrating is spent during stopovers that serve to rest, replenish resources and recover. While external influences, like prevailing weather conditions and resource availability, are well studied with regard to stopover behavior and departure decisions, studies on how birds' individual physiological conditions and stopover decisions may be linked are scarce.</p> <p>We used a large-scale radio-telemetry network covering the German Bight (SE North Sea) to study how birds' immunological constitution at stopover may correlate with departure and flight behavior in five species of short- to medium-distance migratory songbirds. We measured markers of the innate (bacterial killing activity, lysozyme concentration, natural antibodies, and complement titers) and acquired immune function (immunoglobulin Y) in the birds' plasma. After sampling, we tracked the birds' behavior in terms of stopover duration as well as flight routes and flight distances within the telemetry network after departure.</p> <p>We found that stopover durations were positively related to natural antibodies and immunoglobulin Y across species and to the bacterial killing ability solely in song thrushes in spring, while no relations became apparent in fall. Flight distances were linked positively to immunoglobulin Y concentrations in both spring and fall, though not in all of the investigated species. Coastal and offshore-oriented routes were taken independent of the birds' immune status.</p> <p>Our study for the first time shows that the migratory behavior of songbirds in the wild is correlated with their immune status, not only during but also beyond stopover. Further, birds with increased complement titers and Immunoglobulin Y concentrations, either due to recent infection or greater investment in their immune function, took additional time at their stopover sites, probably to reach their breeding grounds in good condition. During the less time-constrained fall season, stopovers were generally prolonged, independent from the birds' immune status, and any delays taken to improve immune status are most likely not detrimental in terms of fitness.</p>
Ecological determinants of variation in phenotypic selection on quantitative immune defence traits
Immune defence is an important determinant of organismal fitness. While theoretical models based on trade-offs in resource allocation predict quantitative immune traits to be subject to stabilizing selection due to associated energetic costs and self-harm, empirical studies report mainly positive directional selection. This discrepancy may arise from multiple ecological factors that vary in nature and could influence selection. We examined if selection on immune activity varies depending on immune challenge/infection risk, between immune traits, and among populations in the freshwater snail Lymnaea stagnalis. We assessed selection on the phenoloxidase-like and antibacterial activity of snail haemolymph while manipulating the level of immune challenge imposed by environmental microbes. We did this using snails from multiple populations and also quantified within-population family-level variation (i.e., evolutionary potential) in the snails' immune activity. We found that the strength of immune challenge and the examined immune trait determined selection on the snails' immune function. Thus, variation in infection risk can be an important factor in maintaining genetic variation in defence traits. Additionally, immune traits showed low among-population differentiation but high within-population genetic variation. This pattern could arise if natural snail populations are exposed to higher temporal than spatial variation in infection risk.
Data from: Effects of manipulated food availability and seasonality on innate immune function in a passerine
<p>1. The innate immune system is essential for survival, yet many immune traits are highly variable between and within individuals. In recent years, attention has shifted to the role of environmental factors in modulating this variation. A key environmental factor is food availability, which plays a major role in shaping life-histories, and may affect resource allocation to immune function through its effect on nutritional state.</p> <p>2. We developed a technique to permanently increase foraging costs in seed-eating birds, and leveraged this technique to study the effects of food availability on the innate immune system over a three-year period in 230 zebra finches housed in outdoor aviaries. The immune components we studied were haptoglobin, ovotransferrin, nitric oxide, natural antibodies through agglutination, complement-mediated lysis, and killing capacity of <em>Escherichia</em> <em>coli</em> and <em>Candida</em> <em>albicans</em>, covering a broad spectrum of the innate immune system. We explored effects of food availability in conjunction with other potentially important variables: season, age, sex, and manipulated natal brood size.</p> <p>3. Increased foraging costs affected multiple components of the immune system, albeit in a variable way. Nitric oxide and agglutination levels were lower under harsh foraging conditions, while Escherichia coli killing capacity was increased. Agglutination levels also varied seasonally, but only at low foraging costs. <em>C</em>. <em>albicans</em>' killing capacity was lower in winter, and even more so for animals in harsh foraging conditions that were raised in large broods. Effects of food availability on ovotransferrin were also seasonal, and only apparent in males. Haptoglobin levels were independent of foraging costs and season.</p> <p>4. Males had higher levels of immune function than females for 3 of the measured immune traits. Innate immune function was independent of age and manipulated natal brood size.</p> <p>5. Our finding that food availability affects innate immune function suggests that fitness effects of food availability may at least partially be mediated by effects on the immune system. However, food availability effects on innate immunity varied in direction between traits, illustrating the complexity of the immune system and precluding conclusions on the level of disease resistance.</p>
Do changes in body mass alter white blood cell profiles and immune function in Australian cane toads (Rhinella marina)?
<p><span>Variation in food resources can result in dramatic fluctuations in the body condition of animals dependent on those resources. Decreases in body mass can disrupt patterns of energy allocation and impose stress, thereby altering immune function. In this study we investigated links between changes in body mass of captive cane toads (Rhinella marina), their circulating white blood cell populations, and their performance in immune assays. Captive toads that lost weight over a 3-month period had increased levels of monocytes and heterophils and reduced levels of eosinophils. Basophil and lymphocyte levels were unrelated to changes in mass. Because individuals that lost mass had higher heterophil levels but stable lymphocyte levels, the ratio of these cell types was also higher, partially consistent with a stress response. Phagocytic ability of whole blood was higher in toads that lost mass, due to increased circulating levels of phagocytic cells. Other measures of immune performance were unrelated to mass change. These results highlight the challenges faced by invasive species as they expand their range into novel environments which may impose substantial seasonal changes in food availability that were not present in the native range. Individuals facing energy restrictions may shift their immune function towards more economical and general avenues of combating pathogens. </span></p>
An ssGSEA Based Immune-related Gene Prognostic Signature Combining Immune Infiltration and Immune Checkpoint for Breast Cancer Patients
<p>This is the gene expression and related clinical data of breast cancer patients obtained from TCGA. Original codes and data from GEO database could be found in GitHub via link "https://github.com/Grevilblois/R-codes-for-manuscript".</p>
Multi-organ CD45+ immune cell atlas
<p><em>File Description</em></p> <p><strong>MultiOrgan_MetaAtlas_total_level3_qc.rds:</strong> an rds file containing a Seurat object 114275 cells (RNA integrated assays, PCA and UMAP reductions and quality metrics)</p> <p><strong>MultiOrgan_MetaAtlas_total_level3_qc.h5ad: </strong>an h5 file containing the single cell object as the above</p> <p><strong>MultiOrgan_MetaAtlas_total_level3_qc_metadata.csv</strong>: a table containing the metadata for each cell</p> <p> </p> <p><em>Methodology </em></p> <p>162 loom files were downloaded from the 12 different projects of the HCA consortium. In more detail, we focused on 14 different organs: prostate gland, eye, heart, skeletal muscle organ, blood, liver, spleen, brain, kidney, colon, esophagus, lung, thymus, and bone marrow. The files were transformed into Seurat objects with the function as.Seurat() from Seurat package in R. After incorporating metadata information, each object was screened for immune cells based on the expression of the CD45 immune marker. Specifically, cells were considered immune cells if they exhibited at least one read of the PTPRC - CD45 surface marker gene. Finally, the Seurat object was transformed into a .h5 object for Python users.</p> <p> </p> <p><em>Metadata</em></p> <p>All the files contain the following donor metadata variables:</p> <ul> <li>Tissue: Organ/tissues</li> <li>Project: Project of HCA</li> <li>Library_prep: single cell technology</li> <li>Sample_ID: assigned patient identifiers</li> <li>Tissue_part: specific location of the sampling</li> <li>Sex: the donor's sex</li> <li>Age: the donor's age</li> <li>percent.mt: Calculation of mitochondrial proportion</li> <li>percent.ribo: Calculation of ribosomal proportion</li> <li>annotation_level1: characterization of cells into the main immune compartments</li> <li>annotation_level2: focusing on each annotation_level1 category and performing in-depth characterization of the immune</li> <li>cells</li> <li>annotation_level3: focusing on the different subtypes of macrophages and the Tregs compartment</li> <li>The columns scDblFinder.class_rna, scDblFinder.score_rna, scDblFinder.weighted_rna, scDblFinder.cxds_score_rna are related</li> <li>to metrics for doublet detection using scDblFinder</li> <li>The columns S.Score, G2M.Score and Phase are related to cell cycling</li> </ul>
Heritability and genome-wide association study of vaccine-induced immune response in Beagles: A pilot study
<p>Both genetic and non-genetic factors contribute to individual variation in the immune response to vaccination. Understanding how genetic background influences variation in both the magnitude and persistence of vaccine-induced immunity is vital for improving vaccine development and identifying possible causes of vaccine failure. Dogs provide a relevant biomedical model for investigating mammalian vaccine genetics; canine breed structure and long linkage disequilibrium simplify genetic studies in this species compared to humans. The objective of this study was to estimate the heritability of the antibody response to vaccination against viral and bacterial pathogens and to identify genes driving variation of the immune response to vaccination in Beagles. Sixty puppies were immunized following a standard vaccination schedule with an attenuated combination vaccine containing antigens for canine adenovirus type 2, canine distemper virus, canine parainfluenza virus, canine parvovirus, and four strains of <em>Leptospira</em> bacteria. Serum antibody measurements for each viral and bacterial component were measured at multiple time points. Heritability estimations and GWAS were conducted using SNP genotypes at 279,902 markers together with serum antibody titer phenotypes. The heritability estimates were: (1) to <em>Leptospira</em> antigens, ranging from 0.178 to 0.628; and (2) to viral antigens, ranging from 0.199 to 0.588. There was not a significant difference between the overall heritability of vaccine-induced immune response to <em>Leptospira</em> antigens compared to viral antigens. Genetic architecture indicates that SNPs of low to high effect contribute to immune response to vaccination. GWAS identified two genetic markers associated with vaccine-induced immune response phenotypes. Collectively, these findings indicate that genetic regulation of the immune response to vaccination is antigen-specific and influenced by multiple genes of small effect.</p>
Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity
<p>Isocitrate Dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores anti-tumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. IDH1-mutant solid tumors show striking, selective hypermethylation and silencing of the cytoplasmic dsDNA sensor, CGAS, compromising innate immune signaling. mIDH1 inhibition restores DNA demethylation, derepressing CGAS and transposable element (TE) subclasses. dsDNA produced by TE-reverse transcriptase activates cGAS, triggering viral mimicry and stimulating anti-tumor immunity. Thus, we demonstrate that mIDH1 epigenetically suppresses innate immunity and link endogenous reverse transcriptase activity to the mechanism of action of an FDA-approved oncology drug.</p>
Imaging mass cytometry analysis of brain tissues with CNS immune-related adverse events during anti-PD-1 cancer immunotherapy
<p><span>Dataset accompanying the manuscript "Anti-PD-1 cancer immunotherapy induces CNS immune-related adverse events by Spleen tyrosine kinase activation in microglia".</span></p> <p><span>The Metadata.xls file includes the metadata, the raw image data is saved as .txt file, the segmented cellular expression data is available as csv files. </span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.