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735 results for “Nausea”
Olanzapine Combined With Fosaprepitant, Ondansetron, and Dexamethasone for Preventing Nausea and Vomiting in Patients With Testicular Cancer
ClinicalTrials.gov study NCT05244577. IPD Sharing: NO. Countries: 1. Publications: 9.
Data from: Ambulatory versus inpatient management of severe nausea and vomiting of pregnancy: a randomized control trial with patient preference arm
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Supplementary Files-14-nausea
<p>Supplementary File to the Cochrane Review “Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis”.</p> <p>Supplementary Files-14-nausea_p1-70, Raw data-14-nausea</p>
Data from: 8-way randomized controlled trial of doxylamine, pyridoxine and dicyclomine for nausea and vomiting during pregnancy: restoration of unpublished information
Objectives: We report information about an unpublished 1970s study ("8-way" Bendectin Study) that aimed to evaluate the relative therapeutic efficacy of doxylamine, pyridoxine, and dicyclomine in the management of nausea and vomiting during pregnancy. We are publishing the trial's findings according to the restoring invisible and abandoned trials (RIAT) initiative because the trial was never published. Design: Double blinded, multi-centred, randomized placebo-controlled study. Setting: 14 clinics in the United States. Participants: 2308 patients in the first 12 weeks of pregnancy with complaints of nausea or vomiting were enrolled. Interventions: Each patient was randomized to one of eight arms: placebo, doxylamine/pyridoxine/dicylcomine, doxylamine/pyridoxine, dicylomine/pyridoxine, doxylamine, dicyclomine/pyridoxine, pyridoxine and dicyclomine. Each patient was instructed to take 2 tablets at bedtime and 1 additional tablet in the afternoon or morning if needed, for 7 nights. Outcomes: Reported outcomes included the number of hours of nausea reported by patients, the frequency of vomiting reported by patients and the overall efficacy of medication as judged by physicians. Results: Data from 1599 (69% of those randomized) participants were analyzed. Based on the available summary data of physician evaluation of symptoms and ignoring missing data and data integrity issues, the proportion of participants who were "evaluated moderate or excellent" was greater in each of the seven active treatment groups when compared with placebo (57%): doxylamine/pyridoxine/dicylcomine (14% absolute difference versus placebo; 95% CI: 4 to 24), doxylamine/pyridoxine (21; 95% CI 11 to 30), dicylomine/pyridoxine (21; 95% CI 11 to 30), doxylamine (20; 95% CI 10 to 29), dicyclomine/pyridoxine (4; 95% CI -6 to 14), pyridoxine (9; 95% CI -1 to 19) and dicyclomine (4; 95% CI -6 to 14). Based on incomplete information, the most common adverse events were apparently drowsiness and fatigue. There is a high risk of bias in these previously unpublished results given the high attrition rate in a 7 day trial, the lack of prespecified outcomes or analyses, and the exclusion of some data because of questionable data integrity. Conclusion: The available information about this "8-way Bendectin" trial indicates it should not be used to support the efficacy of doxylamine, pyridoxine or dicyclomine for the treatment of nausea and vomiting during pregnancy because of a high risk of bias.
Aprepitant, Granisetron, & Dexamethasone in Preventing Nausea & Vomiting in Pts. Receiving Cyclophosphamide Before a Stem Cell Transplant
ClinicalTrials.gov study NCT00293384. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effects of Preoperative Scopolamine Patch Application on the Postoperative Nausea and Vomiting in MVD Surgery
ClinicalTrials.gov study NCT02968082. IPD Sharing: NO. Countries: 0. Publications: 4.
NEPA to Prevent Chemotherapy Induced Nausea and Vomiting in Patients With Breast Cancer
ClinicalTrials.gov study NCT03862144. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study of Aprepitant (MK-0869) for Chemotherapy-Induced Nausea and Vomiting (CINV) in Adolescent Participants (MK-0869-097)
ClinicalTrials.gov study NCT00080444. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effects of Aromatherapy on Nausea Levels
ClinicalTrials.gov study NCT04882501. IPD Sharing: NO. Countries: 1. Publications: 0.
Aloxi for Prevention of Chemotherapy Induced Nausea and Vomiting in Malignant Glioma Patients Receiving Irinotecan With Bevacizumab
ClinicalTrials.gov study NCT00636805. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Management of Nausea and Vomiting Chemotherapy-induced in Normandy
ClinicalTrials.gov study NCT01440465. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy
ClinicalTrials.gov study NCT04118322. IPD Sharing: YES. Countries: 1. Publications: 0.
Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV) Associated With Highly Emetogenic Chemotherapy (0869-801)(COMPLETED)
ClinicalTrials.gov study NCT00090207. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Granisetron Transdermal Patch for Prevention of Postoperative Nausea and Vomiting
ClinicalTrials.gov study NCT02457195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting
ClinicalTrials.gov study NCT01031498. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Osteopathic Manipulative Treatment for Post-Operative Nausea and Vomiting
ClinicalTrials.gov study NCT00387361. IPD Sharing: Not stated. Countries: 0. Publications: 3.
An Efficacy and Safety Study of Intravenous Palonosetron Administered as an Infusion and as a Bolus for the Prevention of Nausea and Vomiting
ClinicalTrials.gov study NCT02557035. IPD Sharing: Not stated. Countries: 9. Publications: 0.
Domperidone for the Treatment of Chronic Nausea and Vomiting Secondary to Gastroparesis
ClinicalTrials.gov study NCT01711918. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Nexium Study To Suppress Nausea During Chemotherapy
ClinicalTrials.gov study NCT00206440. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reletex Versus Standard of Care Therapy for Post-Operative Nausea Control in Patients Undergoing Foregut Surgery
ClinicalTrials.gov study NCT01510379. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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