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Distinguishing between pan assay interference compounds (PAINS) that are promiscuous or represent dark chemical matter - data set and prediction models
<p>Data sets of promiscuous PAINS (PROM_PAINS) and dark chemical matter PAINS (DCM_PAINS) are provided and support vector machine models built on the basis of original and balanced training data (see readme.txt).<br> </p>
Text-fig. 6—Right fibula of Albertosaurus cf. A. lancensis (LACM 23845), in lateral aspect. Diagonal lines indicate broken surfaces. Bar represents 10 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 6—Right fibula of Albertosaurus cf. A. lancensis (LACM 23845), in lateral aspect. Diagonal lines indicate broken surfaces. Bar represents 10 cm.
Text-fig. 5—Left tibia of Albertosaurus cf. A. lancensis (LACM 23845) in medial aspect. Diagonal lines indicate broken surfaces. Bar represents 5 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 5—Left tibia of Albertosaurus cf. A. lancensis (LACM 23845) in medial aspect. Diagonal lines indicate broken surfaces. Bar represents 5 cm.
Text-fig. 7—Metatarsus and pes of Albertosaurus cf. A. lancensis (LACM 23845). Diagonal lines indicate broken surfaces. Bar represents 10 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 7—Metatarsus and pes of Albertosaurus cf. A. lancensis (LACM 23845). Diagonal lines indicate broken surfaces. Bar represents 10 cm.
Text-fig. 1—Right prefrontal of Albertosaurus cf. A. lancensis (LACM 23845) in dorsal (4), anterior (B), and lateral (C) aspects. The dorsal view shows the prefrontal in articulation with the frontal, that portion of the prefrontal covered by the frontal indicated by the broken line. In B and C the broken region of this prefrontal is reconstructed with the dashed line. Bar represents 1 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 1—Right prefrontal of Albertosaurus cf. A. lancensis (LACM 23845) in dorsal (4), anterior (B), and lateral (C) aspects. The dorsal view shows the prefrontal in articulation with the frontal, that portion of the prefrontal covered by the frontal indicated by the broken line. In B and C the broken region of this prefrontal is reconstructed with the dashed line. Bar represents 1 cm.
Text-fig. 3—Ungual phalanx (4), metacarpal (£) and left ulna (C) of Albertosaurus cf. A. lancensis (LACM 23845) in lateral aspect. Bar represents 5 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 3—Ungual phalanx (4), metacarpal (£) and left ulna (C) of Albertosaurus cf. A. lancensis (LACM 23845) in lateral aspect. Bar represents 5 cm.
Text-fig. 2—The articular surface of the frontal for the prefrontal in anterior view. A, Right frontal of Albertosaurus cf. A. lancensis, LACM 23845. B, Left frontal of Tyrannosaurus sp., MMS 51-2004. The diagonal lines indicate broken surfaces. Abbreviations: ec, endocranial cavity; po, articular surface of frontal for postorbital; prf, articular surface of frontal for prefrontal. MMS 51-2004 includes portions of the laterosphenoid and prootic in addition to the frontal. Bars represent 1 cm. in An albertosaur from the Hell Creek formation of Montana
Text-fig. 2—The articular surface of the frontal for the prefrontal in anterior view. A, Right frontal of Albertosaurus cf. A. lancensis, LACM 23845. B, Left frontal of Tyrannosaurus sp., MMS 51-2004. The diagonal lines indicate broken surfaces. Abbreviations: ec, endocranial cavity; po, articular surface of frontal for postorbital; prf, articular surface of frontal for prefrontal. MMS 51-2004 includes portions of the laterosphenoid and prootic in addition to the frontal. Bars represent 1 cm.
How Confidence in Prior Attitudes, Social Tag Popularity, and Source Credibility Shape Confirmation Bias Toward Antidepressants and Psychotherapy in a Representative German Sample: Randomized Controlled Web-Based Study
<p>ABSTRACT</p> <p>Background: In health-related, Web-based information search, people should select information in line with expert (vs nonexpert) information, independent of their prior attitudes and consequent confirmation bias.</p> <p>Objective: This study aimed to investigate confirmation bias in mental health–related information search, particularly (1) if high confidence worsens confirmation bias, (2) if social tags eliminate the influence of prior attitudes, and (3) if people successfully distinguish high and low source credibility.</p> <p>Methods: In total, 520 participants of a representative sample of the German Web-based population were recruited via a panel company. Among them, 48.1% (250/520) participants completed the fully automated study. Participants provided <em>prior attitudes</em> about antidepressants and psychotherapy. We manipulated (1) <em>confidence</em> in prior attitudes when participants searched for blog posts about the treatment of depression, (2) <em>tag popularity</em> —either psychotherapy or antidepressant tags were more popular, and (3) <em>source credibility</em> with banners indicating high or low expertise of the tagging community. We measured <em>tag</em> and <em>blog post</em> selection, and <em>treatment</em><em>efficacy ratings</em> after navigation.</p> <p>Results: Tag popularity predicted the proportion of selected antidepressant tags (beta=.44, SE 0.11; <em>P</em><.001) and blog posts (beta=.46, SE 0.11; <em>P</em><.001). When confidence was low (−1 SD), participants selected more blog posts consistent with prior attitudes (beta=−.26, SE 0.05; <em>P</em><.001). Moreover, when confidence was low (−1 SD) and source credibility was high (+1 SD), the efficacy ratings of attitude-consistent treatments increased (beta=.34, SE 0.13; <em>P</em>=.01).</p> <p>Conclusions: We found correlational support for defense motivation account underlying confirmation bias in the mental health–related search context. That is, participants tended to select information that supported their prior attitudes, which is not in line with the current scientific evidence. Implications for presenting persuasive Web-based information are also discussed.</p> <p>Trial Registration: ClinicalTrials.gov NCT03899168; https://clinicaltrials.gov/ct2/show/NCT03899168 (Archived by WebCite at http://www.webcitation.org/77Nyot3Do)</p> <p>J Med Internet Res 2019;21(4):e11081</p> <p>doi:10.2196/11081</p>
Text-fig. 10.—A possible hunting set of Hell Creek theropods, drawn to scale. A, Tyrannosaurus rex. B, Albertosaurus lancensis. C, the Jordan theropod. D, Saurornithoides mongoliensis. S. mongoliensis is not present in the Hell Creek, but is used to represent those saurornithoidids and dromaeosaurids present and represented by isolated teeth. A fifth form, Paronychodon lacustris, also represented only by isolated teeth has not been included but was probably intermediate between the saurornithoidids and the Jordan theropod. in A new Theropod Dinosaur from the Upper Cretaceous of Central Montana
Text-fig. 10.—A possible hunting set of Hell Creek theropods, drawn to scale. A, Tyrannosaurus rex. B, Albertosaurus lancensis. C, the Jordan theropod. D, Saurornithoides mongoliensis. S. mongoliensis is not present in the Hell Creek, but is used to represent those saurornithoidids and dromaeosaurids present and represented by isolated teeth. A fifth form, Paronychodon lacustris, also represented only by isolated teeth has not been included but was probably intermediate between the saurornithoidids and the Jordan theropod.
Text-fig. 6.—Endocranial mold of the Jordan theropod (LACM 28471). A, Dorsal view. B, Lateral view. Anterior is to the right. Lined areas represent broken bone surface and the mold is partially reconstructed in dashed lines. Abbreviations: c.h.—cerebral hemispheres, hb.—hindbrain, o.l.—optic lobe, o.n.—olfactory passage. in A new Theropod Dinosaur from the Upper Cretaceous of Central Montana
Text-fig. 6.—Endocranial mold of the Jordan theropod (LACM 28471). A, Dorsal view. B, Lateral view. Anterior is to the right. Lined areas represent broken bone surface and the mold is partially reconstructed in dashed lines. Abbreviations: c.h.—cerebral hemispheres, hb.—hindbrain, o.l.—optic lobe, o.n.—olfactory passage.
Text-fig. 3.—Frontals and parietals of the Jordan theropod (LACM 28471). A. Dorsal view. B. Lateral view. Anterior is to the left. Lined areas represent broken surfaces and elements are partially reconstructed with dashed lines. in A new Theropod Dinosaur from the Upper Cretaceous of Central Montana
Text-fig. 3.—Frontals and parietals of the Jordan theropod (LACM 28471). A. Dorsal view. B. Lateral view. Anterior is to the left. Lined areas represent broken surfaces and elements are partially reconstructed with dashed lines.
Text-fig. 4.—Right surangular fragment of the Jordan theropod (LACM 28471). Lined areas represent broken surfaces. in A new Theropod Dinosaur from the Upper Cretaceous of Central Montana
Text-fig. 4.—Right surangular fragment of the Jordan theropod (LACM 28471). Lined areas represent broken surfaces.
Text-fig. 5. Reconstruction of aeduellids from the Bohemian Massif. 1 – Spinarichthys dispersus (FRITSCH, 1895) (after Štamberg 1986). 2 – Neslovicella elongata ŠTAMBERG, 2010 (after Štamberg 2010). 3 – Neslovicella rzehaki ŠTAMBERG, 2007 (after Štamberg 2007). 4 – Bourbonnella hirsuta ŠTAMBERG, 2007 (after Štamberg, 2007). Scale bar represents 20 mm. in Knowledge Of The Carboniferous And Permian Actinopterygian Fishes Of The Bohemian Massif - 100 Years After Antonín Frič
Text-fig. 5. Reconstruction of aeduellids from the Bohemian Massif. 1 – Spinarichthys dispersus (FRITSCH, 1895) (after Štamberg 1986). 2 – Neslovicella elongata ŠTAMBERG, 2010 (after Štamberg 2010). 3 – Neslovicella rzehaki ŠTAMBERG, 2007 (after Štamberg 2007). 4 – Bourbonnella hirsuta ŠTAMBERG, 2007 (after Štamberg, 2007). Scale bar represents 20 mm.
Text-fig. 2. Reconstruction of some Westphalian and Stephanian actinopterygians. Figs 1 – 5 after Štamberg (1991), Fig. 6 after Westoll (1944). Scale bars represent 20 mm. 1 – Acrolepis gigas (FRIČ, 1877), 2 – "Elonichthys" krejcii (FRITSCH, 1895), figured after the original holotype of Acrolepis sphaerosideritarum FRITSCH, 1895, 3 – "Elonichthys" krejcii (FRITSCH, 1895), figured after the original holotype of Acrolepis krejcii FRITSCH, 1895, 4 – Sphaerolepis kounoviensis FRIČ, 1877, 5 – Sceletophorus biserialis FRITSCH, 1894, 6 – Pyritocephalus sculptus (FRIČ, 1875). in Knowledge Of The Carboniferous And Permian Actinopterygian Fishes Of The Bohemian Massif - 100 Years After Antonín Frič
Text-fig. 2. Reconstruction of some Westphalian and Stephanian actinopterygians. Figs 1 – 5 after Štamberg (1991), Fig. 6 after Westoll (1944). Scale bars represent 20 mm. 1 – Acrolepis gigas (FRIČ, 1877), 2 – "Elonichthys" krejcii (FRITSCH, 1895), figured after the original holotype of Acrolepis sphaerosideritarum FRITSCH, 1895, 3 – "Elonichthys" krejcii (FRITSCH, 1895), figured after the original holotype of Acrolepis krejcii FRITSCH, 1895, 4 – Sphaerolepis kounoviensis FRIČ, 1877, 5 – Sceletophorus biserialis FRITSCH, 1894, 6 – Pyritocephalus sculptus (FRIČ, 1875).
Text-fig. 1. Amblypterus latus AGASSIZ, 1833. Pen and ink drawing (A) and photo (B) of the skull in lateral view. Mb. F. 3809b, scale bar represents 10 mm. Cl – cleithrum; Dent – dentalosplenial; Dhy – dermohyal; Dpt – dermopterotic; Dsph –dermosphenotic; Extl – extrascapular lateral; Fr –frontal; Gu – gular; Infs – infraorbital superior; Ju – jugal; La – lacrimal; Mx – maxilla; Na – nasal; Op – operculum; Pa – parietal; Pmx – premaxillar; Pop – preoperculum; Pp – postparietal; Pt – posttemporal; Rbr – branchiostegal rays; Sbo – suborbital; Scl – supracleithrum; Soant – supraorbital anterior; Sop – suboperculum; Spi – spiracular; sr – sclerotical ring. in New Data On The Osteology Of The Actinopterygian Fish Amblypterus And The Relationship Between Amblypterus And Paramblypterus
Text-fig. 1. Amblypterus latus AGASSIZ, 1833. Pen and ink drawing (A) and photo (B) of the skull in lateral view. Mb. F. 3809b, scale bar represents 10 mm. Cl – cleithrum; Dent – dentalosplenial; Dhy – dermohyal; Dpt – dermopterotic; Dsph –dermosphenotic; Extl – extrascapular lateral; Fr –frontal; Gu – gular; Infs – infraorbital superior; Ju – jugal; La – lacrimal; Mx – maxilla; Na – nasal; Op – operculum; Pa – parietal; Pmx – premaxillar; Pop – preoperculum; Pp – postparietal; Pt – posttemporal; Rbr – branchiostegal rays; Sbo – suborbital; Scl – supracleithrum; Soant – supraorbital anterior; Sop – suboperculum; Spi – spiracular; sr – sclerotical ring.
Fig. 14 All scales represent 100 in Taxonomic Record Of The Oligocene Benthic Foraminifera From The Vima Formation (Transylvanian Basin, Romania)
Fig. 14 All scales represent 100 μm. 1. Fursenkoina schreibersiana (Czjzek). Same specimen, a. apertural view, b. lateral view, same scale, sample F14, Rupelian. 2,3. Fursenkoina mustoni (Andreae). 2a-b. same specimen, a. apertural view, b. lateral view, same scale, sample F3, Rupelian; 3. sample F3, Rupelian. 4. Fursenkoina sp. Same specimen, a. apertural view, b. lateral view, same scale, sample F3, Rupelian. 5-10. Fursenkoina halkyardi (Cushman). 5. same specimen, a. apertural view, b. lateral view, same scale; 6. same specimen, a. apertural view, b. lateral view; same scale. 5-10. sample FB01, Chattian. 11. Pleurostomella incrassata Hantken. Same specimen, a. lateral view, b. apertural view, same scale, sample F5, Rupelian. 12-14. Stilostomella adolphina (d'Orbigny). 12. sample FB20, Chattian; 13. sample F14, Rupelian; 14. sample F18, Rupelian. 15, 17, 18, 21. Stilostomella emaciata (Reuss). 15. sample F9, Rupelian; 17. sample F9, Rupelian; 18. sample F21, Rupelian; 21. sample F25, Rupelian. 16. Siphonodosaria consobrina (d'Orbigny). Sample F3, Rupelian. 19. Stilostomella pauperata (d'Orbigny). Sample F21, Rupelian. 20. Stilostomella bradyi (Cushman). Sample F5, Rupelian.
Fig. 17 All scales represent 100 in Taxonomic Record Of The Oligocene Benthic Foraminifera From The Vima Formation (Transylvanian Basin, Romania)
Fig. 17 All scales represent 100 μm. 1-2. Heterolepa praecincta (Karrer). 1a-c. same specimen, a. umbilical view, b. peripherial view, c. spiral view, same scale, sample F14, Rupelian; 2a-c. same specimen, a. umbilical view, b. peripherial view, c. spiral view, same scale, sample FB20, Chattian. 3-4. Heterolepa eocaena (Gümbel). 3a-b. same specimen, a. umbilical view, b. spiral view, same scale, sample F12, Rupelian; 4a-b. same specimen, a. umbilical view, b. spiral view, same scale, sample FB21, Chattian. 5. Gyroidinoides octocameratus (Cushman & Hanna). Same specimen, a. umbilical view, b. peripherial view, c. spiral view, same scale, sample FB21, Chattian. 6. Gyroidinoides mamillatus (Andreae). Same specimen, a. umbilical view, b. peripherial view, c. spiral view, same scale, sample F5, Rupelian. 7-8. Hansenisca soldanii (d'Orbigny). 7a-c. same specimen, a. umbilical view, b. peripherial view, c. spiral view, same scale, sample F14, Rupelian; 8.
Fig. 12 All scales represent 100 in Taxonomic Record Of The Oligocene Benthic Foraminifera From The Vima Formation (Transylvanian Basin, Romania)
Fig. 12 All scales represent 100 μm. 1,8. Bulimina coprolithoides Andreae. 1a-b. same specimen, a. apertural view, b. lateral view, same scale, sample F14, Rupelian; 8. sample F33, Rupelian/Chattian. 2. Bulimina elongata d'Orbigny. Same specimen, a. apertural view, b. lateral view, same scale, sample F17, Rupelian. 3-5. Caucasina oligocaenica Khalilov. 3a-b. same specimen, a. apertural view, b. lateral view, same scale, sample F14, Rupelian; 4. sample F3, Rupelian; 5. sample F12, Rupelian. 6-7. Bulimina alsatica Cushman & Parker. 6a-b. same specimen, a. apertural view, b. lateral view, same scale, sample F7, Rupelian; 7. sample F5, Rupelian. 9. Bulimina schischkinskayae Samoylova. Sample F27, Rupelian. 10. Bulimina alazanensis Cushman. Sample F18, Rupelian. 11. Bulimina striata striata d'Orbigny. Same specimen, a. apertural view, b. lateral view, same scale, sample F7, Rupelian. 12. Bulimina arndti Hagn. Same specimen, a. apertural view, b. lateral view, same scale, FB19, Chattian. 13. Praeglobobulimina pupoides (d'Orbigny). Sample F25, Rupelian.
Fig. 10 All scales represent 100 in Taxonomic Record Of The Oligocene Benthic Foraminifera From The Vima Formation (Transylvanian Basin, Romania)
Fig. 10 All scales represent 100 μm. 1. Vaginulinopsis cumulicostatus (Gümbel). Same specimen, a. apertural view, b. lateral view, same scale, sample F10, Rupelian. 2. Vaginulinopsis mexicana (Nuttall). Same specimen, a. apertural view, b. lateral view, same scale, sample F10, Rupelian. 3. Lagena tenuis (Bornemann). Sample FB17, Chattian. 4. Pseudofissurina kapellensis (Spiegler). Same specimen, a. apertural view, b. lateral view, same scale, sample FB17, Chattian. 5. Favulina hexagona (Williamson). Sample F26, Rupelian. 6. Glandulina ovula d'Orbigny. Sample FB20, Chattian. 7. Bolivina beyrichi carinata Hantken. Same specimen, a. apertural view, b. lateral view, same scale, sample F21, Rupelian. 8. Bolivina beyrichi beyrichi Reuss. Sample F9, Rupelian. 9. Bolivina plicatella Cushman. Sample FB17, Chattian. 10-11. Bolivina crenulata Cushman. 10. sample F33, Rupelian/Chattian; 11a-b. same specimen, a. apertural
Fig. 9 All scales represent 100 in Taxonomic Record Of The Oligocene Benthic Foraminifera From The Vima Formation (Transylvanian Basin, Romania)
Fig. 9 All scales represent 100 μm. 1. Saracenaria arcuata (d'Orbigny). Same specimen, a. lateral view, b. apertural view, same scale, sample F3, Rupelian. 2-3. Frondovaginulina tenuissima (Hantken). 2. sample F17, Rupelian; 3. sample F28, Rupelian. 4. Percultazonaria fragaria (Gümbel). Same specimen, a. apertural view, b. lateral view, same scale, sample FB20, Chattian. 5-6. Amphicoryna spinicosta (d'Orbigny). 5. sample F13, Rupelian; 6. same specimen, a. apertural view, b. lateral view, same scale, sample FB21, Chattian. 7. Amphicoryna armata (Neugeboren). Sample F21, Rupelian. 8. Amphicoryna crassa (Hantken). Sample F10, Rupelian. 9. Marginulina behmi (Reuss). Same specimen, a. apertural view, b. lateral view, c. peripherial view, same scale, sample FB21, Chattian. 10. Hemirobulina recta (Hantken). Sample F12, Rupelian. 11. Hemirobulina hantkeni (Bandy). Same specimen, a. apertural view, b. lateral view, same scale, sample FB21, Chattian.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.