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19,342 results for “Sequences”
Sequence data for the article "Targeted reduction of highly abundant transcripts with pseudo-random primers"
<p>Sequence data (Illumina MiSeq runs) for the article "Targeted reduction of highly abundant transcripts with pseudo-random primers". File names indicate unique run identifiers. In the manuscript, shorter names are used:</p> <ul> <li>NC12: 140602_M00528_0019_000000000-A88YD</li> <li>NC17: 140918_M00528_0047_000000000-A8GHU</li> <li>NC22b: 141105_M00528_0062_000000000-AAPC2</li> <li>NCki: 140207_M00528_0069_000000000-A5TY9</li> </ul> <p> </p>
FIGURES 34 37. Lamyctes hellyeri n in A new blind Lamyctes (Chilopoda: Lithobiomorpha) from Tasmania with an analysis of molecular sequence data for the Lamyctes Henicops Group
FIGURES 34 37. Lamyctes hellyeri n. sp. QVMAG 23: 23048, female, pretarsus of leg 14, scales 10 m. 34 36, anterior, posterior, and ventral views; 37, detail of lateral pore and ornament on scutes of main claw.
FIGURES 11 17. Lamyctes hellyeri n in A new blind Lamyctes (Chilopoda: Lithobiomorpha) from Tasmania with an analysis of molecular sequence data for the Lamyctes Henicops Group
FIGURES 11 17. Lamyctes hellyeri n. sp. 11, 14 17, QVMAG 23: 23046, female. 11, anterior part of head shield and basal part of antennae, scale 100 m; 14, sensilla on dorsal side of antenna, scale 10 m; 15 16, antennal articles, dorsal side, scales 50 m; 17, cephalic pleurite with Tömösváry organ, scale 50 m. 12 13, QVMAG 23: 23047, female. 12, ventral view of clypeus and labrum, scale 100 m; 13, labral midpiece and inner parts of sidepieces, scale 30 m.
FIGURES 1 4 in A new blind Lamyctes (Chilopoda: Lithobiomorpha) from Tasmania with an analysis of molecular sequence data for the Lamyctes Henicops Group
FIGURES 1 4. Lamyctes coeculus (Brölemann). 1, 3, AM KS 57961, female, Mellong Range, NSW, Australia. 2, 4, MCZ DNA 100472, female, Cerro San Javier, Tucumán, Argentina. 1 2, ventral view of head, scales 100 m; 3 4, dental margin of maxillipede coxosternite, scales 50 m.
FIGURES 18 25. Lamyctes hellyeri n in A new blind Lamyctes (Chilopoda: Lithobiomorpha) from Tasmania with an analysis of molecular sequence data for the Lamyctes Henicops Group
FIGURES 18 25. Lamyctes hellyeri n. sp. QVMAG 23: 23046, female. 18, ventral view of maxillipede, scale 100 m; 19 20, dental margin of maxillipede coxosternite, scales 50 m, 10 m; 21, tarsus and claw of second maxilla, scale 50 m; 22, distal part of tarsus and claw of second maxilla, scale 10 m; 23, coxal projections and telopods of first maxillae, scale 50 m; 24, first maxillae, scale 100 m; 25, plumose setae on inner margins of telopods of first maxillae, scale 10 m.
Graphing and tabulating next-generation sequencing and genotyping data
<p>Making figures and tables for publication. Each zip archive contains input data, shell script to initiate and log R script, one R script for generating several graphs and tables, and the output graphs and tables themselves.</p> <p>Data was generated by whole-genome resequencing of 22 individual D.melanogaster from Sussex-LHM population and 2 from the Sussex RG line, followed by read-mapping, then genotyping with Haplotype Caller and Genomestrip.</p> <p>Locations for raw data, code, logs, extended QC data:</p> <p>Sequence reads NCBI SRA268956</p> <p>NCBI dbSNP https://www.ncbi.nlm.nih.gov/projects/SNP/snp_viewBatch.cgi?sbid=1062461</p> <p>NCBI dbVar accession number pre-release nstd134</p> <p> </p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p> <p> </p>
Read-mapping for next-generation sequencing data (Drosophila melanogaster)
<p>Code, logs and quality-control data for whole-genome resequencing of Sussex-LH<sub>M</sub> and RG <em>Drosophila melanogaster</em>.</p> <p>Mapping code is in the archive lhm_mapping_scripts.zip</p> <p>Mapping logs are in the in the archive lhm_mapping_logs.zip</p> <p>Other zip archives contain the quality control data.</p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p>
Read-mapping for next-generation sequencing data (Wolbachia)
<p>Code, log files and QC data. NCBI SRA accession number SRP091004. Note that sequencing Wolbachia was not a central aim of the project, and was undertaken in order to maximise the amount of information that could be extracted from the raw genome sequence data targetted at the fruit-fly host.</p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p>
Genotype reproducibility testing in next-generation sequencing data
<p>Code, log and results summary for testing the reproducibility of genotypes with three pairs of hemiclones in the Sussex LH<sub>M </sub><em>D.melanogaster </em>population sample. Discovery and genotyping of genomic sequence variants was done using GATK HaplotypeCaller, and Genomestrip. Numerical comparison of genotype calls within each pairs of hemiclone individuals was performed using GATK GenotypeConcordance.</p> <p> </p> <p>The pre-print manuscript for this data is available on biorxiv: "Whole genome resequencing of a laboratory-adapted Drosophila melanogaster population sample" http://biorxiv.org/content/early/2016/10/17/081554 doi: http://dx.doi.org/10.1101/081554</p>
FIGURE 2 in A new species of Auriculostoma (Trematoda: Allocreadiidae) from the intestine of Brycon guatemalensis (Characiformes: Bryconidae) from the Usumacinta River Basin, Mexico, based on morphology and 28 S rDNA sequences, with a key to species of the genus
FIGURE 2. Scanning electron micrographs of Auriculostoma lobata n. sp. (A) Anterior end with oral sucker bearing muscular lobe on either side, genital atrium and ventral sucker. (B) Pair of muscular lobes with a short posterior ‘‘ free’ ’ end, and 4 apical dome-like papillae (white arrows). (C) Lateral view of muscular lobe. (D) Distribution of dome-like papillae over oral sucker, 6 anterior (white arrows), 4 on the inner surface (white triangle), and 5 on the outer surface (white arrows).
16S rRNA sequences data set of Dicronocephalus species in this study.
Explanation note: This 16S rRNA data includes 46 individual sequences of the examined Dicronocephalus species in this study.
COI sequences dataset of Dicronocephalus species in this study.
Explanation note: This COI data includes 50 individual sequences of the examined Dicronocephalus species and subspecies in this study
Inbred Strain Variant Database (ISVdb): A repository for probabilistically informed sequence differences among the Collaborative Cross strains and their founders
<p>Data files for the development of a database for storing (and a GUI for retrieving) the imputed variants for 72 Collaborative Cross strains of mice. Files include the inputs for the imputation, as well as the final results. See File_S1_Readme for more details on the included files.</p>
Direct chromosome-length haplotyping by single-cell sequencing.
<p>Selected Strand-seq libraries from PMID:27646535 study. Data were originally shared on the European Nucleotide Archive (http://www.ebi.ac.uk/ena) under the accession number: PRJEB14185</p>
Data from: CIDER-Seq: unbiased virus enrichment and single-read, full length genome sequencing
<p>Raw and finished sequence data produced in the study: </p> <p>Mehta D, Hirsch-Hoffmann M, Patrignani A, Gruissem W, Vanderschuren H (2017) CIDER-Seq: unbiased virus enrichment and single-read, full length genome sequencing. <em><strong>bioRxiv</strong></em>. doi: https://doi.org/10.1101/168724</p>
Research data supporting "Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils"
<p>Research data supporting the publication:</p> <p>Wang, S.-T. et al., 2017, Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils, ACS Nano, http://dx.doi.org/10.1021/acsnano.7b02325</p>
BioDemuX.jl: A High-Performance Julia-based Tool for Accurate Sequence Demultiplexing
<p>This repository contains all the in silico test data required for executing demultiplexing, as described in the associated publication.</p>
Data for methylome sequencing: Enriching and Profiling Methylomes for Tumor Classification and Liquid Biopsies
<p>We benchmarked and demonstrated the versatility of FLEXseq (Fragment Ligation EXclusive methylation sequencing) across different sample types: genomic DNA from the K562 (leukemia) cell line, DNA mix-in titrations of four immune cell types (B cells, T cells, monocytes, and neutrophils), DNA titrations of three cancer cell lines (breast invasive carcinoma [BRCA], colon adenocarcinoma [COAD], and glioblastoma [GBM]) mixed with those four immune cell mixtures separately, input titrations of cell-free (cf) DNA from one plasma sample and DNA from formalin-fixed paraffin-embedded (FFPE) tissues, cfDNA from 106 cerebrospinal fluids (CSF) and 42 other body fluids, and DNA from 37 FFPE tissues.</p> <p>We sequenced all the samples mentioned above using FLEXseq. Paired-end reads were quality and length trimmed with cutadapt version 3.5, and all high-quality sequencing reads were then aligned to the hg38 reference genome using Bismark v0.23.0. We then filtered out reads with unmethylated cytosine in the non-CpG context with filter_non_conversion function. Next, we used the bismark_methylation_extractor function to extract the methylation calls (removing single-nucleotide polymorphisms [SNP]).</p> <p>We also used the bam2pat function from wgbs_tools, to convert bam files into .pat files for deconvolution, keeping reads covering at least three CpG sites. The .pat files preserve fragment-level data and were de-identified by removing SNPs using the mask_pat function. </p> <p>We used CNVkit (v0.9.10) to analyze and visualize genome-wide copy numbers. Our inputs into CNVkit were Bismark/Bowtie 2 aligned BAM files deduplicated by Bismark based on end positions and fragment lengths. We then generated log2copy ratio plots for all body fluid and FFPE samples based on the pooled reference and visualized them across all bins using the DNAcopy R package.</p> <p> </p>
Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
<p>scRNA sequencing datasets used in the paper titled 'Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells' published in Nature Communications<br> <br> https://www.nature.com/articles/s41467-020-18155-8</p>
Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context
<p><span>The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtubule-binding activity. However, the structural relationship between aggregation propensity and biological activity remains unclear. We employed a multi-disciplinary approach, including computational modeling, NMR, cross-linking mass spectrometry, and cell models to engineer tau sequences that modulate its structural ensemble. Our findings show that substitutions near the conserved 'PGGG' </span><span>β</span><span>-turn motif informed by tau isoform context reduce tau aggregation in vitro and cells and can even counteract aggregation from disease-associated proline-to-serine mutations. Engineered tau sequences maintain microtubule binding and explain why 3R isoforms exhibit reduced pathogenesis compared to 4R. We propose a simple mechanism to reduce the formation of pathogenic tau species while preserving biological function, thus offering insights for therapeutic strategies aimed at reducing tau protein misfolding in neurodegenerative diseases.</span></p> <p><strong>Description of Source Data and Supplementary Data</strong>: All MD, NMR (peptide and tauRD), ThT, XL-MS, MT stabilization, MT:tau modeling, and cell-based aggregation data are available in the Source_Data directory as Data S1, Data S2, Data S3, Data S4, Data S5, Data S6, Data S7, and Data S8, respectively. Supplementary Data for raw MD trajectory files, structure files for MSM modeling and validation file, and tau:MT modeling are available as "Supplementary_Data_MD_Trajectories_Structures", "Supplementary_Data_MSM_models_Structures" and "Supplementary_Data_MT-tau_complex_models", respectively."</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.