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247 results for “adaptive immunity”
Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"
<p>This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". </p> <p>A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their protumoral functions is actively pursued, with the purpose of relieving this state of immunesuppression. We previously reported that trabectedin, a registered antitumor compound, selectively reduces monocytes and TAMs in treated tumors. However, its putative effects on the adaptive immunity are still unclear. In this study, we investigated whether treatment of tumor-bearing mice with trabectedin modulates the presence and functional activity of T-lymphocytes. In treated tumors, there was a significant upregulation of T cell-associated genes, including CD3, CD8, perforin, granzyme B, and IFN-responsive genes (MX1, CXCL10, and PD-1), indicating that T lymphocytes were activated after treatment. Notably, the mRNA levels of the Pdcd1 gene, coding for PD-1, were strongly increased. Using a fibrosarcoma model poorly responsive to PD-1-immunotherapy, treatment with trabectedin prior to anti-PD-1 resulted in improved antitumor efficacy. In conclusion, pretreatment with trabectedin enhances the therapeutic response to checkpoint inhibitor-based immunotherapy. These findings provide a good rational for the combination of trabectedin with immunotherapy regimens.</p> <p> </p>
Integration of tumor-specific dendritic cell and antibody therapy within tumor drives innate and adaptive anti-cancer immunity [Immunology_NanoString]
GEO Series GSE302764. Mus musculus. 18 samples. Type: Expression profiling by array.
Meningeal immune signaling supports emotional adaptation following threat
GEO Series GSE276662. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
GEO Series GSE132036. Mus musculus. 9 samples. Type: Other; Expression profiling by high throughput sequencing.
Integration of tumor-specific dendritic cell and antibody therapy within tumor drives innate and adaptive anti-cancer immunity [Metabolic_Pathways_NanoString]
GEO Series GSE302735. Mus musculus. 18 samples. Type: Expression profiling by array.
Computational modelling of the cellular interplay in Rheumatoid Arthritis. Deciphering the role of innate and adaptive immunity in cartilage destruction and bone erosion
<p>Immune dysregulation was first implicated in the pathogenesis of Rheumatoid Arthritis (RA) by the discovery of anti-immunoglobulin G (IgG) antibodies known as rheumatoid factors. However, concepts of how immune responses contribute to disease have evolved dramatically over the last 50 years. Many cells and their cytokines play critical roles in the development of RA. The synovial compartment is infiltrated by leukocytes and the synovial fluid is inundated with pro-inflammatory mediators that are produced to induce an inflammatory cascade, which is characterized by interactions of fibroblast-like synoviocytes with the cells of the innate immune system, including monocytes, macrophages, mast cells, dendritic cell as well as cells of adaptive immune system such as T cells and B cells. The fulminant stage contains hyperplastic synovium, cartilage damage, bone erosion, and systemic consequence.</p> <p>The objective of my project is to construct a computational model able to decipher the interplay between cells of the innate and adaptive immunity in RA, that eventually leads to bone and cartilage breakdown.</p> <p>To do so, we will start by creating separate maps for T cells, B cells, macrophages, fibroblasts, osteoblasts and osteoclasts. We will use different data mining tools, appropriate data bases such as KEGG (Kanehisa et al, 2000), REACTOME (Fabregat et al, 2018) as well as internal data generated within Sanofi. We will exploit the graph editor CellDesigner (Funahashi et al, 2003) and the platform Minerva (Gawron et al, 2016) for automatic annotation and reference of the cell specific maps. We will benefit greatly from a global, fully annotated RA specific map (Singh et al, 2018, Singh et al, 2020). This map features interactions implicated in RA coming from various cell types, but due to the extensive annotations the user can opt for cell specific interactions and extract the corresponding network. We are also going to use public datasets of expression data (microarrays, RNAseq, RNAseq single cell), data concerning metabolic pathways from MetaCyc and Sanofi’s proprietary datasets to enrich and expand existing pathway resources. These maps will be used to generate cell specific dynamic models using the tool CaSQ (Aghamiri et al, 2020). The next step is the creation of a multicellular model to understand how the different cells interact, contributing to the emergent behavior of the system. We will prioritize signature pathways for each cell type and combine them to build a logical model that will represent the intra- and intercellular relationships.</p> <p> </p>
Memory CD4 T cells help adaptive immunity with minimal immunopathology
GEO Series GSE92474. Mus musculus. 6 samples. Type: Expression profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.