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481 results for “freezing”
A Phase II Trial to Compare a Liquid-frozen and a Freeze-dried Formulation of IMVAMUNE (MVA-BN®) Smallpox Vaccine in Vaccinia-naïve Healthy Subjects
ClinicalTrials.gov study NCT01668537. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Moving Mindfully for Freezing in Parkinsons
ClinicalTrials.gov study NCT05309083. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Amyloidopathy, Cholinopathy, Dopamine Responsiveness and Freezing of Gait in PD
ClinicalTrials.gov study NCT03647137. IPD Sharing: NO. Countries: 1. Publications: 0.
To Compare Ridge Preservation Technique Using Leukocyte Platelet Rich Fibrin (L-PRF) and Freeze-dried Bone Allograft (FDBA) Layered Technique vs L-PRF/FDBA and L-PRF Alone in Influencing Quantity and
ClinicalTrials.gov study NCT04133363. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: A simple micropump based on a freeze-dried superabsorbent polymer for multiplex solution processing in disposable devices
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Data from: Phenotypic plasticity, but not adaptive tracking, underlies seasonal variation in post-cold hardening freeze tolerance of Drosophila melanogaster
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Distinct patterns of brain Fos expression in Carioca High- and Low-conditioned Freezing Rats
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Data from: QTL mapping of freezing tolerance: links to fitness and adaptive trade-offs
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Data from: Freeze-quenched maize mesophyll and bundle sheath separation uncovers bias in previous tissue-specific RNA-Seq data
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BOREAS Follow-On DSP-04 1994 ERS-1 Level-4 Landscape Freeze/Thaw Maps, Ver. 1.0
The BOREAS DSP-4 team acquired and analyzed imaging radar data from the ESA's ERS-1 over a complete annual cycle at the BOREAS sites in Canada in 1994 to detect shifts in radar backscatter related to varying environmental conditions. Two independent transitions correlating with snow melt and soil thaw onset, and possible canopy thaw were revealed by the data. The results demonstrated that radar provides an ability to observe thaw transitions at the beginning of the growing season, which in turn helps constrain the length of the growing season. The data presented here are gridded maps of landscape freeze/thaw state derived from backscatter change maps. The backscatter change maps were computed from radar backscatter images covering the southern BOREAS sites. The freeze/thaw classifications were determined through application of a change detection threshold based on temporal backscatter change relative to a winter-time frozen reference state. The data are provided as both ASCII text and as binary image (*.gif) format files.
MEaSUREs Northern Hemisphere Polar EASE-Grid 2.0 Daily 6 km Land Freeze/Thaw Status from AMSR-E and AMSR2, Version 1
This data set, part of the NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Program, consists of a Northern Hemisphere daily landscape Freeze/Thaw status at 6 km resolution. The data are derived from observations acquired by the Japan Aerospace Exploration Agency's (JAXA) Advanced Microwave Scanning Radiometer - Earth Observing System (AMSR-E) and the Advanced Microwave Scanning Radiometer 2 (AMSR2).
Multi-omic investigations of mouse liver subjected to simulated spaceflight freezing and storage protocols
This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage protocols used during the Rodent Research-1 (RR-1) payload. Liver samples from twelve-week old female C57BL/6J mice (snap frozen vs. 25 min. slow-frozen and stored for 3 days vs. 1 year) received from the RR-1 project were processed for extraction of RNA DNA and protein. RNA-seq whole genome bisulfite sequencing and mass spectrometry proteomics were performed. These multi-omics datasets will help distinguish the effects of freezing and storage time that could confound the interpretation of the Rodent Research-1 datasets.
Transcriptomic analysis of liver from mice subjected to simulated spaceflight euthanasia freezing and tissue preservation protocols
To understand the molecular mechanisms affected by spaceflight it is essential to achieve high quality sample preservation on-orbit for downstream gene expression analysis. However sample preservation protocols must also be compatible with available equipment and crew time. NASA s Rodent Research (RR) missions have used various methods for euthanasia carcass preservation and tissue preservation. This study extends the sample preservation study performed by GeneLab in GLDS-49 which examined conditions used for the RR-1 mission to include conditions used for multiple RR missions and is designed to help determine factors which may confound data analysis. To determine whether these various factors affect changes in gene expression this ground-based study generated gene expression profiles measured by RNAseq from the livers of 20-21 week-old female C57BL/6J mice. Multiple interacting factors were investigated: 1) To understand how euthanasia protocols affect gene expression when mouse carcasses are slow frozen mice were euthanized by either euthasol injection ketamine/xylazine injection or CO2 inhalation and carcasses slow frozen on dry-ice mimicking carcass preservation in the MELFI on the ISS. Carcasses were thawed and RNA extracted from livers; 2) To understand how carcass preservation protocols affect gene expression mice were euthanized with euthasol and carcasses preserved by flash freezing in liquid nitrogen slow freezing on dry ice or immersion in RNAlater following three-way segmentation. Carcasses were thawed and RNA extracted from livers; 3) To understand how tissue preservation protocols affect gene expression mice were euthanized with euthasol and livers dissected and processed immediately or preserved by flash freezing in liquid nitrogen slow freezing on dry ice or immersion in RNAlater. Liver samples that were processed immediately were homogenized in RLT buffer and then either immediately further processed for RNA extraction or were stored for 70 days at -80C post-homogenization in sample RLT buffer prior to RNA extraction.
Global Annual Freezing and Thawing Indices, Version 1
The total annual freezing and thawing indices are defined as thecumulative number of degree-days when air temperatures are below andabove zero degrees Celsius. The total annual freezing index has beenwidely used to predict permafrost distribution; estimate themaximum thickness of sea, lake, and river ice, and the maximum depth ofground-frost penetration; and classify snow types. The annual totalthawing index has been used to predict permafrost distribution and toestimate the maximum depth of thaw in frozen ground. Both totalfreezing and thawing indices are important parameters for engineeringdesign in cold regions.Data coverage is global. The data set contains the total annual freezing and thawing indices with a spatial resolution of 0.5 degreeslatitude by 0.5 degrees longitude. Two data files are available, forthe freeze and thaw indices respectively, in flat binary format. Eachfile is approximately 1 MB in size. The total annual freezing andthawing indexes were calculated based upon the monthly mean airtemperature by Legates and Willmott (1990).
Transcriptional analysis of soleus from mice preserved with the Rapid Freeze hardware
Data from the NASA Rodent Research-1 (RR-1) mission showed that gene-expression levels in mouse livers are different depending on what tissue preservation protocol is used and that slow freezing is not an effective method for preserving signals in gene-expression data. In response to these and other observations the Rapid Freeze hardware was built for use on the International Space Station. The Rapid Freeze hardware freezes mouse tissues (Glovebox freezer) and whole carcasses (Cryochiller) at rates closely mimicking those attained with immersion in liquid nitrogen. Because this hardware will be used extensively on future rodent research missions it is crucial to understand whether or not it preserves signals in gene expression data in order to maximize the value of these rare and expensive spaceflight experiments. Therefore this study was designed with three goals: 1) To evaluate the temperature profile of the Cryochiller and Glovebox freezer cartridges (Rapid Freeze hardware) over time during mock on-orbit procedures; 2) To determine the freezing profiles of tissues and carcasses using Rapid Freeze hardware at both optimal and sub-optimal temperatures (to mimic on-orbit operations) compared with those frozen in liquid nitrogen (the laboratory gold standard) or frozen at -80 C (the current standard method); 3) To identify gene expression changes in a) tissues that were frozen via the Glovebox freezer and b) tissues dissected from whole or partial carcasses that were frozen via the Cryochiller versus tissues that were frozen via control methods (liquid nitrogen or -80C slow freeze) to assess how the Rapid Freeze hardware compares with laboratory gold standard practices and our current standard methods.
Transcriptomic analysis of quadriceps from mice subjected to simulated spaceflight euthanasia freezing and tissue preservation protocols
To understand the molecular mechanisms affected by spaceflight it is essential to achieve high quality sample preservation on-orbit for downstream gene expression analysis. However sample preservation protocols must also be compatible with available equipment and crew time. NASA s Rodent Research (RR) missions have used various methods for euthanasia carcass preservation and tissue preservation. This study extends the sample preservation study performed by GeneLab in GLDS-49 which examined conditions used for the RR-1 mission to include conditions used for multiple RR missions and is designed to help determine factors which may confound data analysis. To determine whether these various factors affect changes in gene expression this ground-based study generated gene expression profiles measured by RNAseq from the quadriceps of 20-21 week-old female C57BL/6J mice. Multiple interacting factors were investigated: 1) To understand how euthanasia protocols affect gene expression when mouse carcasses are slow frozen mice were euthanized by either euthasol injection ketamine/xylazine injection or CO2 inhalation and carcasses slow frozen on dry-ice mimicking carcass preservation in the MELFI on the ISS. Carcasses were thawed and RNA extracted from quadriceps; 2) To understand how carcass preservation protocols affect gene expression mice were euthanized with euthasol and carcasses preserved by flash freezing in liquid nitrogen slow freezing on dry ice or immersion in RNAlater following three-way segmentation. Carcasses were thawed and RNA extracted from quadriceps; 3) To understand how tissue preservation protocols affect gene expression mice were euthanized with euthasol and quadriceps immediately dissected and preserved by flash freezing in liquid nitrogen slow freezing on dry ice or immersion in RNAlater.
Transcriptional analysis of livers from mice preserved with the Rapid Freeze hardware
Data from the NASA Rodent Research-1 (RR-1) mission showed that gene-expression levels in mouse livers are different depending on what tissue preservation protocol is used and that slow freezing is not an effective method for preserving signals in gene-expression data. In response to these and other observations the Rapid Freeze hardware was built for use on the International Space Station. The Rapid Freeze hardware freezes mouse tissues (Glovebox freezer) and whole carcasses (Cryochiller) at rates closely mimicking those attained with immersion in liquid nitrogen. Because this hardware will be used extensively on future rodent research missions it is crucial to understand whether or not it preserves signals in gene expression data in order to maximize the value of these rare and expensive spaceflight experiments. Therefore this study was designed with three goals: 1) To evaluate the temperature profile of the Cryochiller and Glovebox freezer cartridges (Rapid Freeze hardware) over time during mock on-orbit procedures; 2) To determine the freezing profiles of tissues and carcasses using Rapid Freeze hardware at both optimal and sub-optimal temperatures (to mimic on-orbit operations) compared with those frozen in liquid nitrogen (the laboratory gold standard) or frozen at -80 C (the current standard method); 3) To identify gene expression changes in a) tissues that were frozen via the Glovebox freezer and b) tissues dissected from whole or partial carcasses that were frozen via the Cryochiller versus tissues that were frozen via control methods (liquid nitrogen or -80C slow freeze) to assess how the Rapid Freeze hardware compares with laboratory gold standard practices and our current standard methods.
BOREAS RSS-17 1994 ERS-1 Level-3 Freeze/Thaw Backscatter Change Images
The BOREAS RSS-17 team acquired and analyzed imaging radar data from the ESA's ERS-1 over a complete annual cycle at the BOREAS sites in Canada in 1994 to detect shifts in radar backscatter related to varying environmental conditions. Two independent transitions corresponding to soil thaw and possible canopy thaw were revealed by the data. The results demonstrated that radar provides an ability to observe thaw transitions at the beginning of the growing season, which in turn helps constrain the length of the growing season. The data set presented here includes change maps derived from radar backscatter images that were mosaicked together to cover the southern BOREAS sites. The image values used for calculating the changes are given relative to the reference mosaic image. Due to copyright issues, the 01-March-1994 reference image is not included on the CD-ROM and is not publically available. See the accompanying guide document for information about how to possibly acquire the data. The data are stored in binary image format files.
MEaSUREs Polar EASE-Grid 2.0 Daily 6 km Land Freeze/Thaw Status from AMSR-E and AMSR2, Version 2
This data set, part of the NASA Making Earth System Data Records for Use in Research Environments (MEaSUREs) Program, reports the global, daily freeze/thaw status of the landscape at 6 km resolution on EASE-Grid 2.0 Northern Hemisphere and Southern Hemisphere polar grids. The data are derived from observations acquired by the Japan Aerospace Exploration Agency's (JAXA) Advanced Microwave Scanning Radiometer - Earth Observing System (AMSR-E) and the Advanced Microwave Scanning Radiometer 2 (AMSR2).
Probabilistic Freeze-Thaw Record for the Northern Hemisphere, 2016-2020
This dataset provides a probabilistic freeze/thaw (FT) data record from 2016 to 2020 for the Northern Hemisphere derived using a deep learning model (U-Net). The model was informed by satellite multi-frequency microwave brightness temperature retrievals from the NASA SMAP (Soil Moisture Active Passive) and JAXA AMSR2 (Advanced Microwave Scanning Radiometer 2) radiometers, and trained using daily soil temperature observations from Northern Hemisphere weather stations and global reanalysis data (ERA-5). Unlike other available FT data records that provide only a binary classification of frozen or non-frozen conditions, this product includes both binary FT and continuous variable estimates of the probability of thawed conditions. This product is designed to complement other established binary FT data records, including the NASA FT Earth System Data Record and SMAP Level 3 FT operational products, by providing a probabilistic FT variable with enhanced accuracy and sensitivity to near-surface (<=5 cm depth) soil FT condition. The data are provided in cloud optimized GeoTIFF (COG) format.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.