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245 results for “gestational diabetes mellitus”
Systematic characterization of human placenta-derived miRNAs and identification of autophagy-related miRNAs in gestational diabetes mellitus [miRNA-seq]
GEO Series GSE206042. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNAseq between gestational diabetes mellitus and healthy control groups
GEO Series GSE267259. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Integrated analysis of the transcriptome-wide m6A methylome in gestational diabetes mellitus and healthy control placentas
GEO Series GSE154415. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
THE IMPACT OF SHORT-TERM HYPERGLYCEMIA AND OBESITY ON BIVENTRICULAR AND BIATRIAL MYOCARDIAL FUNCTION ASSESSED BY SPECKLE TRACKING ECHOCARDIOGRAPHY IN A POPULATION OF WOMEN WITH GESTATIONAL DIABETES MELLITUS
<p><strong>Background and aims: </strong>To compare biventricular and biatrial myocardial strain indices assessed by two-dimensional speckle tracking echocardiography (2D-STE) in women with gestational diabetes mellitus (GDM) and those with uncomplicated pregnancy at the third trimester of pregnancy and in post-partum.</p> <p><strong>Methods and results: </strong>30 consecutive GDM women and 30 age-, ethnicity- and gestational week-matched controls without any comorbidity were examined in this prospective case-control study. All women underwent obstetric visit, blood tests and transthoracic echocardiography (TTE) implemented with 2D-STE analysis of all cardiac chambers at 36-38 weeks’ gestation. TTE and 2D-STE were repeated at 6–10 weeks after delivery.</p> <p>At 36-38 weeks’ gestation, GDM women, compared to controls, had significantly higher body mass index (BMI), blood pressure values and inflammatory markers. TTE showed increased left ventricular (LV) mass and impaired LV diastolic function in GDM women, whereas there was no significant difference between the groups in ejection fraction. 2D-STE revealed that biventricular global longitudinal strain (GLS) and biatrial reservoir strain indices were significantly lower in GDM women than controls. Third trimester BMI was inversely correlated with LV-GLS (r=–0.86) and was independently associated with reduced LV-GLS (less negative than –20%) in GDM women in post-partum (OR 1.81, 95%CI 1.14-2.89). A BMI value ≥30 Kg/m<sup>2 </sup>had 100% sensitivity and 99.5% specificity for identifying GDM women with impaired LV-GLS in post-partum (AUC=0.97).</p> <p><strong>Conclusion: </strong>Women with GDM, compared to women with uncomplicated pregnancy, have significantly lower biventricular and biatrial myocardial deformation indices. These abnormalities may be persistent in post-partum in GDM women with obesity.</p>
Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus
<p><strong>OBJECTIVE: </strong>The association between gestational diabetes mellitus (GDM) and common carotid artery (CCA)-intima media thickness (IMT) is still controversial. In the present study, we aimed to compare the CCA-IMT measured in GDM women to that obtained in healthy pregnant women in the third trimester of pregnancy. Secondly, we investigated the main independent predictors of persistent CCA-IMT increase (defined as CCA-IMT ≥0.6 mm) in postpartum period in GDM women.</p> <p><strong>STUDY DESIGN: </strong>30 consecutive GDM women and 30 healthy pregnant women matched for anagraphic age (34.1±4.5 vs 32.8 ± 4.2 yrs, p=0.25), ethnicity (caucasian 56.7 vs 63.3%, p=0.59), gestational age (36.2± 1.7 vs 36.5 ± 1.6 weeks, p=0.48) and cardiovascular risk factors were examined in this prospective case-control study. All women underwent obstetric visit, blood tests, conventional transthoracic echocardiography implemented with two-dimensional speckle tracking echocardiography analysis of left ventricular and left atrial myocardial strain parameters and carotid ultrasound examination at two time points: 36-38 weeks’ gestation and 6-10 weeks after delivery.</p> <p><strong>RESULTS: </strong>At 36.2±1.7 weeks of gestation, CCA-IMT was significantly increased in GDM women than controls (0.81±0.11 vs 0.55 ± 0.12, p <0.001). Twelve GDM women (40% of the total) were found with persistent CCA-IMT increase (0.76±0.14 mm) in postpartum period (8.2±2.2 weeks), whereas the remaining 18 (60% of the total) showed a normalization in CCA-IMT (0.56±0.1 mm). At multivariate logistic regression analysis, third trimester body mass index (BMI) (OR 1.78, 95%CI 1.24-2.54, p = 0.01), glycosylated hemoglobin (HbA1C) (OR 1.51, 95%CI 1.13-1.89, p = 0.03) and neutrophil-to-lymphocyte ratio (NLR) (OR 1.68, 95%CI 1.25-4.65, p = 0.02) resulted to be independently associated with persistent CCA-IMT increase in postpartum period in GDM women. A BMI ≥29.2 Kg/m<sup>2</sup>, an HbA1C ≥37.5 mmol/mol and a NLR ≥5.5 were the best cut-off values for identifying GDM women with persistent CCA-IMT increase in postpartum period.</p> <p><strong>CONCLUSIONS: </strong>GDM is associated with increased CCA-IMT during pregnancy. This increase may be persistent in postpartum period in GDM women with obesity, uncontrolled diabetes and increased inflammatory markers.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.