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256
datasets available to search
ShareScore release 0.9.0
Dataset results
256 results for “sporadic”
Expression data from hyperplastic polyps and normal colonic mucosa from patients with familial and sporadic HPPS
GEO Series GSE19963. Homo sapiens. 9 samples. Type: Expression profiling by array.
Gene expression profiling of sporadic neuroblastoma
GEO Series GSE5779. Homo sapiens. 40 samples. Type: Expression profiling by array.
Persistent epigenome anomalies in induced pluripotent stem cells from late-onset sporadic Alzheimer’s disease cases
GEO Series GSE255985. Homo sapiens. 58 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Array comparative genomic hybridization analysis reveals a limited number of genomic alterations in familial adenomatous polyposis-associated and sporadic desmoid tumors
GEO Series GSE28458. Homo sapiens. 55 samples. Type: Genome variation profiling by genome tiling array.
RNA molecular signature profiling in PBMCs of sporadic ALS patients: HSP70 overexpression is associated with nuclear SOD1
GEO Series GSE183204. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
a-synuclein accumulation in an iPSC derived model of early onset sporadic Parkinson’s Disease reveals novel drug targets
GEO Series GSE120746. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Autophagy enhancement ameliorates tau burden and neurofilament pathology in sporadic PSP-RS neurons
GEO Series GSE313924. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Genomic profiling of colorectal cancer from patients with Lynch syndrome and Familial colorectal cancer type X with comparison to sporadic microsatelite stable and instable colorectal cancer
GEO Series GSE38405. Homo sapiens. 91 samples. Type: Genome variation profiling by genome tiling array.
HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex
<p><strong>The database includes </strong>the raw of the article “HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex”.</p> <p><strong>In detail, the database contains</strong> data obtained by the following evaluations: i) RNA electrophoretic mobility shift assay (REMSA) to detect the formation of a complex between HuD recombinant protein and SOD1 ARE sequences. ii) multiplex qRT-PCR to evaluate if oxidative stress levels, i.e H2O2 treatment, induces a shift in the alternative polyadenylation (APA) site usage in SOD1 3'UTR.</p> <p><strong>Aim of the work</strong> was to investigate the potential involvement of HuD (ELAVL4) one of the neuronal members of the ELAVL family, in SOD1 regulation during oxidative stress and in sporadic ALS patients (sALS).</p> <p>Using differentiated SH-SY5Y cells along with brain tissues from sALS patients, we evaluated HuD-dependent regulation of SOD1 mRNA. By means in vitro binding and mRNA decay assays we observed that HuD specifically binds to SOD1 ARE motifs promoting mRNA stabilization. In SH-SY5Y cells, we faound that the overexpression of full-length HuD increased SOD1 mRNA and protein levels; moreover HuD regulation of SOD1 mRNA we found that this regulation is related to oxidative stress, as shown after H2O2 exposure. H2O2 exposure also induced a shift in the APA site usage in SOD1 3'UTR, increasing the levels of a long variant bearing HuD binding sites. We validated this data using a specific siRNA. In the motor cortex from sALS patients, we found increases in SOD1 and HuD mRNAs and proteins, accompanied by greater HuD binding to this mRNA as confirmed by RNA-immunoprecipitation (RIP) assays.</p> <p><strong>To conclude,</strong> these results point a role of HuD in the post-transcriptional regulation of SOD1 expression in neurons after oxidative stress and in sALS brain tissues, thus suggesting an involvement in ALS pathogenesis.</p>
Lysosomes dysfunction causes mitophagy impairment in PBMCs of sporadic ALS patients
<p>The database includes the raw data of the article “Lysosomes dysfunction causes mitophagy impairment in PBMCs of sporadic ALS patients”. Aim of this work was to investigate mitophagy pathway in PBMCs of ssporadic amyotrophic lateral sclerosis (sALS) patients and how the pathway can be tuned by using chemicals.</p> <p>The database contains the data obtained by the following evaluations: a) flow cytometry for the evaluation of mitochondria health, b) western blot analysis of protein involved in mitophagy and mitochondrial dynamism, c) immunofluorescence analysis of autophagosomes and lysosomes accumulation.</p> <p>We evidenced that that the presence of morphologically altered mitochondria and an inefficient turnover of damaged mitochondria in PBMCs of sALS patients relies on an impairment of the mitophagy pathway. In particular, we found that the induction of mTOR-independent autophagy pathway leads to a decrease of lysosomes level, suggesting a more sensitivity of sALS PBMCs to the effect of trehalose. Such evidences suggest that trehalose could represent an effective treatment for ALS patients.</p>
Heterogeneous transcriptional landscapes in human sporadic parathyroid adenomas
Open the record for dataset details and reuse information.
Characterization of N6-Methyladenosine lncRNAs in sporadic congenital cataract and age-related cataract
GEO Series GSE221970. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Human induced pluripotent stem cells derived from a sporadic Alzheimer's disease patient
GEO Series GSE31163. Homo sapiens. 8 samples. Type: Expression profiling by array.
Sporadic vs. Post-Chernobyl Papillary vs. Anaplastic Thyroid Cancers
GEO Series GSE29265. Homo sapiens. 49 samples. Type: Expression profiling by array.
Dataset related to article: "Early Age of Onset Is an Independent Predictor for a Worse Response to Neoadjuvant Therapies in Sporadic Rectal Cancer Patients"
<p>This record contains raw data related to article: "Early Age of Onset Is an Independent Predictor for a Worse Response to Neoadjuvant Therapies in Sporadic Rectal Cancer Patients"</p><p>The incidence of rectal cancer (RC) is increasing in the population aged ≤ 49 (early-onset RC-EORC). EORC patients are more likely to present with locally advanced disease at diagnosis than late-onset RC (LORC; aged ≥ 50) patients. As a consequence, more EORC patients undergo neoadjuvant therapies. The response to treatment in EORC patients is still unknown. This study aims to explore the effect of age of onset on the pathological response to neoadjuvant therapies in sporadic locally advanced RC (LARC) patients. Based on an institutional prospectively maintained database, LARC patients undergoing neoadjuvant therapies and radical surgery between January 2010 and December 2022 were allocated to the EORC and LORC groups. The primary endpoint was the rate of incomplete response (Dworak 0-2). A total of 326 LORC and 79 EORC patients were included. Pre-neoadjuvant tumor features were comparable. A significantly higher rate of incomplete response was observed in EORC patients (49% vs. 35%; <i>p</i> = 0.028). From multivariable analysis, early age of onset, smoking and extramural invasion presented as independent risk factors for a worse response. This study demonstrates that an early age of onset is related to a worse response and calls for different multimodal strategies in this group of patients.</p>
dataset related to article "Sporadic and von Hippel–Lindau Related Hemangioblastomas of Brain and Spinal Cord: Multimodal Imaging for Intraoperative Strategy"
<p>Datasheet containing clinicla anonimyzed information on patients involved in study at title</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.