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262
datasets available to search
ShareScore release 0.9.0
Dataset results
262 results for “tumor heterogeneity”
A Functional Role of OLIG2 in Tumor Heterogeneity of MYC-amplified Medulloblastoma
GEO Series GSE188887. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A quadrivalent in vivo CAR-macrophage serve as cell vaccine to repress solid tumors and overcome tumor heterogeneity through antigen spreading
GEO Series GSE316356. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors [gene expression]
GEO Series GSE79058. Homo sapiens. 76 samples. Type: Expression profiling by array.
Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG III
GEO Series GSE146312. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors
GEO Series GSE79171. Homo sapiens. 160 samples. Type: Expression profiling by array; Genome variation profiling by array.
Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors [gene copy number]
GEO Series GSE79170. Homo sapiens. 84 samples. Type: Genome variation profiling by array.
Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG V
GEO Series GSE146314. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG VI
GEO Series GSE146315. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Archetype tasks link intratumoral heterogeneity to plasticity in recalcitrant small cell lung cancer [Human tumor]
GEO Series GSE193960. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Other solid tumors
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000012.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Non-rhabdomyosarcoma soft tissue sarcomas
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000013.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Wilms tumor
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000014.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Ewing sarcoma
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000015.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Rhabdoid tumor
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000016.
Profiling the transcriptional heterogeneity of diverse pediatric solid tumors - Osteosarcoma
For more information, including a more complete description, data generator contact information, and reference, please see: https://scpca.alexslemonade.org/projects/SCPCP000023.
Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG IV
GEO Series GSE146313. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Tumor heterogeneity, hypoxia, and immune markers in surgically resected non-small-cell lung cancer"
<p>This record contains raw data related to article "Tumor heterogeneity, hypoxia, and immune markers in surgically resected non-small-cell lung cancer"</p> <p>OBJECTIVES:</p> <p>This study aimed to determine the prognostic role of textural features and their association with metabolic parameters, hypoxia, and cancer-related immune markers in non-small-cell lung cancer (NSCLC) patients.</p> <p>PATIENTS AND METHODS:</p> <p>The trial was registered at http://www.clinicaltrials.gov (<a href="http://clinicaltrials.gov/show/NCT02519062">NCT02519062</a>). From January 2010 to May 2014, 44 patients (male : female=33 : 11; median age: 69.5 years), referred to our Institution for NSCLC resection, were enrolled. Tumor specimens were assessed for HIF-1α, CD68-TAMs, CD8-TILs, PD-1-TILs, and PD-L1 expressions. All patients underwent fluorine-18-fluorodeoxyglucose (F-FDG) PET before surgery. Semiquantitative parameters included maximum standardized uptake value (SUVmax), SUVpeak, SUVmean, metabolic tumor volume, and total lesion glycolysis, whereas for heterogeneity, we considered tumor sphericity, skewness, kurtosis, entropy, and energy. Parameters were correlated with disease-free survival (DFS) considering a median follow-up of 22.7 months.</p> <p>RESULTS:</p> <p>SUVmax (cutoff: 7.9; P=0.015), SUVpeak (cutoff: 6.7; P=0.013), SUVmean (cutoff: 5.5; P=0.028), metabolic tumor volume (cutoff: 3.6 cm; P=0.027), and entropy (cutoff: 1.89; P=0.045) showed a statistically significant association with DFS. Also, a high expression of cytoplasmic HIF-1α (score 3) was associated with DFS (hazard ratio: 0.09; P=0.003). All F-FDG PET variables differed significantly in tumors with high or low entropy (≤1.89). Also, a significantly higher level of mean CD8-TILs was observed in tumors with higher entropy (P=0.041).Using identified prognostic factors, we developed a scoring system, which was confirmed to be associated with DFS (P<0.004). On receiver operating characteristics analysis, a score above 3 was defined as the optimal cutoff point.</p> <p>CONCLUSION:</p> <p>Tumor heterogeneity, metabolic parameters, and high expression of hypoxia were found to be prognostic factors in NSCLC patients who were candidates for surgery. Higher levels of entropy appear to be associated with increased density of CD8-TILs. The combination of investigated prognostic factors enabled the development of a potential scoring system associated with DFS</p>
Understanding tumor heterogeneity in HNSCC by gene-expression
GEO Series GSE313289. Homo sapiens. 100 samples. Type: Expression profiling by array.
Emergent metastatic heterogeneity of primary tumor cells is restricted by the Ig-transmembrane protein VSIG I
GEO Series GSE146310. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
MesoHET (Multi-site tumor sampling highlights molecular intra-tumor heterogeneity in malignant pleural mesothelioma)
GEO Series GSE175769. Homo sapiens. 10 samples. Type: Methylation profiling by genome tiling array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.