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5,826 results for “Randomized trial”
Pain profile during orthodontic levelling and alignment with fixed appliances reported in randomized trials: a systematic review with meta-analyses
<p>Dataset for all analyses</p>
Raw Data for the article: Donor Simvastatin Treatment Is Safe and Might Improve Outcomes After Liver Transplantation: A Randomized Clinical Trial
<p><strong>Background: </strong>The current curative approaches for ischemia/reperfusion injury on liver transplantation are still under debate for their safety and efficacy in patients with end-stage liver disease. We present the SIMVA statin donor treatment before Liver Transplants study.</p> <p><strong>Methods: </strong>SIMVA statin donor treatment before Liver Transplants is a monocentric, double-blind, randomized, prospective tial aiming to compare the safety and efficacy of preoperative brain-dead donors' treatment with the intragastric administration of 80 mg of simvastatin on liver transplant recipient outcomes in a real-life setting. Primary aim was incidence of patient and graft survival at 90 and 180 d posttransplant; secondary end-points were severe complications.</p> <p><strong>Results: </strong>The trial enrolled 58 adult patients (18-65 y old). The minimum follow-up was 6 mo. No patient or graft was lost at 90 or 180 d in the experimental group (n = 28), whereas patient/graft survival were 93.1% ( P = 0.016) and 89.66% ( P = 0.080) at 90 d and 86.21% ( P = 0.041) and 86.2% ( P = 0.041) at 180 d in the control group (n = 29). The percentage of patients with severe complications (Clavien-Dindo ≥IIIb) was higher in the control group, 55.2% versus 25.0% in the experimental group ( P = 0.0307). The only significant difference in liver tests was a significantly higher gamma-glutamyl transferase and alkaline phosphatase at 15 d ( P = 0.017), ( P = 0.015) in the simvastatin group.</p> <p><strong>Conclusions: </strong>Donor simvastatin treatment is safe, and may significantly improve early graft and patient survival after liver transplantation, although further research is mandatory.</p>
A pragmatic randomized maternal education trial in rural Uganda - Eight years of sustained improvement in child development
<p><strong><span>Background</span> </strong></p> <p><span>Nutrition and stimulation interventions may promote early childhood development, but little is known about the long-term benefits of such interventions, particularly in low- and middle-income countries. We now conducted a follow-up study on a cluster-randomized maternal education trial that was conducted when their children were 6<span>–</span>8 months old, to assess the sustainability of the developmental benefits eight years after the intervention.</span></p> <p><strong><span>Methods and findings</span></strong></p> <p><span>The intervention consisted of education in nutrition, hygiene, oral sanitation and child stimulation. In the current study, we assessed child processing and cognitive abilities using the Kaufman Assessment Battery for Children Second Edition (KABC-II) and attention and inhibitory control using the </span><span>Test of Variables of Attention (TOVA)</span><span>. Using Stata version 17.0, t-tests and multi-level regression were employed to compare scores from KABC-II and </span><span>TOVA tests</span><span> in the two study groups adjusting for clustering effect. The data were analyzed by intention-to-treat. The original trial included 511 mother-child pairs (intervention n=263, control n=248), whereas in the current study, 361 (71%; intervention n=185, control n=176) pairs were available for analyses. T</span><span>he intervention group scored higher than the controls (all P-values<0.001) on all five KABC-II sub-scales, as well as on the KABC-II global score</span><span> (mean difference: </span><span>14, 95% CI: 12–16; P<0.001). </span><span>Furthermore, </span><span>for all five TOVA variables, the intervention group scored higher than the controls in both the visual and auditory tasks (all P-values <0.05).</span> <span> The main limitation is that we were unable to determine the exact individual contribution of each component (nutrition, hygiene and stimulation) of the intervention to the developmental benefits since they were all delivered as a combined package.</span></p> <p><strong><span>Conclusions </span></strong></p> <p><span>The intervention group consistently scored markedly higher on both psychometric tests. Thus, even eight years after the original maternal education intervention, the developmental benefits that we observed at child age of one, two and three years, were sustained.</span></p>
Systematic comparison of Mendelian randomization studies and randomized controlled trials using electronic databases
<p><strong>Supplementary Dataset 1. </strong>Select ClinicalTrials.Gov data fields for the RCT studies identified as the<br> <em>main </em>dataset.<br> <strong>Supplementary Dataset 2.</strong> Select ClinicalTrials.Gov data fields for the RCT studies identified as the<br> <em>literature </em>dataset.<br> <strong>Supplementary Dataset 3.</strong> Comparison of frequency of RCT general features between the <em>Main</em><br> dataset and background of all RCTs available in ClinicalTrials.Gov.</p> <p><strong>Supplementary Dataset 4. </strong>PubMed and SemMedDB data for published MR and RCT studies.<br> <strong>Supplementary Dataset 5. </strong>Case series of MR and RCT studies with matching exposures<br> (interventions) and outcomes (conditions).</p>
A Prospective Randomized Trial of Static-Progressive Versus Dynamic Splinting for Post-Traumatic Elbow Stiffness
ClinicalTrials.gov study NCT01241916. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy of Preoperative Diclofenac Potassium- Acetaminophen Combination on Anesthetic Success in Patients With Symptomatic Irreversible Pulpitis: a Randomized Controlled Trial
ClinicalTrials.gov study NCT04593160. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Prospective, Randomized Trial of Basiliximab (Simulect) in the Prophylaxis of High-Risk Keratoplasty Patients
ClinicalTrials.gov study NCT00409656. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Randomized Contralateral Clinical Trial With Single-piece (SN60WF) vs. Three Piece (MA60AC) AcrySof Intraocular Lenses (IOLs) on Development of Posterior Chamber Opacification (PCO).
ClinicalTrials.gov study NCT00758745. IPD Sharing: Not stated. Countries: 1. Publications: 0.
RandOmized Study Exploring the Combination of radioTherapy With Two Types of Acupuncture Treatment: The ROSETTA Trial
ClinicalTrials.gov study NCT02674646. IPD Sharing: NO. Countries: 0. Publications: 1.
Vale+Tú Salud: Corner-Based Randomized Trial to Test a Latino Day Laborer Program Adapted to Prevent COVID-19
ClinicalTrials.gov study NCT06146361. IPD Sharing: NO. Countries: 1. Publications: 0.
Empowering Veterans to Actively Communicate and Engage in Shared Decision Making in Medical Visits, A Randomized Controlled Trial
ClinicalTrials.gov study NCT05169359. IPD Sharing: YES. Countries: 1. Publications: 0.
Comparison of the GMA-TULIP and I-gel Laryngeal Mask for Airway Management in General Anaesthesia: a Randomized Controlled Trial
ClinicalTrials.gov study NCT07019961. IPD Sharing: YES. Countries: 1. Publications: 0.
Site-randomized Trial of an Expanded Social Network Recruitment to HIV Testing (E-SNRHT) Intervention to Locate Undiagnosed Cases and Reduce HIV-related Stigma
ClinicalTrials.gov study NCT06857071. IPD Sharing: YES. Countries: 1. Publications: 0.
A Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms
ClinicalTrials.gov study NCT00441896. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effectiveness of Video Monitoring and Care Transition for Heart Failure Patients (EVIT-HF): Randomized Clinical Trial
ClinicalTrials.gov study NCT06731166. IPD Sharing: NO. Countries: 0. Publications: 0.
Comparing Effectiveness of Duloxetine and Desipramine in Patients With Chronic Pain: A Pragmatic Trial Using Point of Care Randomization
ClinicalTrials.gov study NCT03548454. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized, Controlled Trial of Hyperosmotlar Saline for Rotator Cuff Repair Irrigation Solution
ClinicalTrials.gov study NCT03738735. IPD Sharing: NO. Countries: 0. Publications: 2.
The Effect of Bulk Filling Flowable Composite on Caries Recurrence in Deep Marginal Elevation: a Randomized Clinical Trial
ClinicalTrials.gov study NCT06900868. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
ClinicalTrials.gov study NCT01590979. IPD Sharing: NO. Countries: 1. Publications: 0.
Low-dose Evaluation of Aspirin After STEMI Patients With PCI: A Multicenter, Double-blind, Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT06756945. IPD Sharing: Not stated. Countries: 0. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.