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2,642
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2,642 results for “blindness”
A randomized double-blind Phase IIb trial to evaluate the efficacy of ChAd63-KH for the treatment of post kala-azar dermal leishmaniasis
GEO Series GSE266275. Homo sapiens. 100 samples. Type: Expression profiling by high throughput sequencing.
A Randomized, Double Blinded, Placebo-Controlled Clinical Trial Evaluating the Efficacy and Safety of anti-SARS-CoV-2 Convalescent Plasma in Hospitalized Patients (CONTAIN COVID-19)
<p>This dataset contains de-identified patient data of 941 patients from 21 centers across the United States who were enrolled in the CONTAIN COVID-19 randomized controlled trial that ran from 4/17/2020-3/15/2021. The information in this dataset was used to conduct the analysis reported in the CONTAIN COVID-19 manuscript published in JAMA Internal Medicine (doi: 10.1001/jamainternmed.2021.6850) and includes demographic information, baseline history, baseline medications, baseline laboratory values, clinical status based on the WHO 11-point scale at 14 and 28 days after randomization, antibody titers, randomization arms.</p>
Effects of Dualsite Anodic tDCS on Lower Limbs Function in Patients After Stroke: Randomized, Double-blind, Placebo-controlled, Crossover Trial
<p>https://docs.google.com/spreadsheets/d/1gyZvGAK0t3D83jHWWULAdhNmDYWvHa8nvzGJeLP4oVk/edit#gid=1006784133</p>
Movement-Related Tactile Gating in Blindness
<p>In this work we measured the velocity discrimination threshold of blind and sighted individuals using dynamic stimuli discrimination. Participants had to perceive a sequence of two movements, provided by a wheel, with different speeds and discriminate the faster one. Our experimental conditions were (1) passive touch, in which participants had their finger still while the wheel rotated, and (2) active touch, in which participants move their finger in the opposite direction of the movement of the wheel.</p> <p>The just noticeable difference (JND) and point of subject equality (PSE) are reported for each condition (Passive /Active) of each subject.</p> <p>Subject is the code of each participant, the B that appears at the end of some subject's code indicate that is a blind participant. Age is the age of each participant, condition is if the tactile input was passive or active, sensory_stimulus is always touch, standard_cm_sec is the standard velocity of the wheel (3cm/sec in our case), pse_cm_sec is the value of the point of subject equality (PSE) obtained by the participant, jnd_cm_sec is the value of our dependent variable just noticeable difference (JND) of each participant, vision is if the subject was blind (B) or sighted (S), blind_duration correspond to the number of years of blindness of our blind sample, type_blindness is if the participant is considered late blind (LB), early blind (EB) or a sighted control (SC).</p>
Dataset for the article "Blindly separated spontaneous network-level oscillations predict corticospinal excitability"
<p>This repository contains a dataset supporting results in the manuscript: Ermolova, M., Metsomaa, J., Belardinelli, P., Zrenner, C., & Ziemann, U. (2024). Blindly separated spontaneous network-level oscillations predict corticospinal excitability. <em>Journal of Neural Engineering</em>, <em>21</em>(3), 036041.</p> <p>REFTEP dataset: TMS-EEG experiment on awake healthy human subjects. Single-pulse TMS was applied in resting state over primary motor cortex, with simultaneous EEG recording from the scalp and EMG recording from hand muscles. </p> <p>The dataset is intended for use by the code published at: https://github.com/mariaermolova/CSPAnalysis. The dataset is structured as follows: each .mat file corresponds to a single subject and contains a matlab structure with the following substructs. </p> <p>1. EEG data from 1.5 sec. before each TMS pulse (<em><strong>eeg</strong></em>). The data was preprocessed: bad trials and channels removed, signals detrended, ICA components corresponding to oculographic artefacts removed. </p> <p>2. EEG channel locations on the scalp (<em><strong>chanlocs</strong></em>) and indices of channels removed during preprocessing (<em><strong>removedChannels</strong></em>). </p> <p>3. Peak-to-peak amplitudes of Motor Evoked Potentials for each trial (<em><strong>mepSize</strong></em>) and excitability labels for each trial based on the amplitude of the corresponding MEP (<em><strong>labels</strong></em>). Labels correspond to high (1) vs low (0) MEP amplitude.</p>
A Multicenter, Randomized, Double-blind, Placebo-parallel-controlled Phase II Clinical Study Evaluating the Efficacy and Safety of HRS9531 Injection in Obese Subjects With Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT06595797. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Visilizumab in Subjects With Intravenous Steroid-Refractory Ulcerative Colitis
ClinicalTrials.gov study NCT00502294. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Application of Computer-assisted Navigation in Total Knee Arthroplasty: A Randomized Pair-matched Double-blind Trial
ClinicalTrials.gov study NCT00982956. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Blind Source Separation
Blind source separation in Simulink using STFT and inverse STFT (Signal processing blockset).
Data set from Ferrulli A, Macrì C, Terruzzi I, Massarini S, Ambrogi F, Adamo M, Milani V, Luzi L. Weight loss induced by deep transcranial magnetic stimulation in obesity: A randomized, double-blind, sham-controlled study. Diabetes Obes Metab. 2019 Aug;21(8):1849-1860. doi: 10.1111/dom.13741. Epub 2019 May 15. PMID: 30957981.
<p>Data set from Ferrulli A, Macrì C, Terruzzi I, Massarini S, Ambrogi F, Adamo M, Milani V, Luzi L. Weight loss induced by deep transcranial magnetic stimulation in obesity: A randomized, double-blind, sham-controlled study. Diabetes Obes Metab. 2019 Aug;21(8):1849-1860. doi: 10.1111/dom.13741. Epub 2019 May 15. PMID: 30957981.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Aim: </strong> To test the hypothesis that deep transcranial magnetic stimulation (dTMS) reduces food craving and causes weight loss via neuromodulation.</p> <p><strong>Materials and methods: </strong> This pilot study was designed as a randomized, double-blind, sham-controlled study. A total of 33 obese people (nine men, 24 women, mean age 48.1 ± 10.6 years, body mass index [BMI] 36.9 ± 4.7 kg/m<sup>2</sup> ) were randomized and completed the study: 13 participants underwent a 5-week treatment with high-frequency (HF) dTMS (18 Hz; HF group), 10 were treated with low-frequency (LF) dTMS (1 Hz; LF group), and 10 were sham-treated (sham group). Food craving, and metabolic and neuro-endocrine variables were evaluated at baseline, after the 5-week treatment, and at follow-up visits (1 month, 6 months, 1 year after the end of treatment).</p> <p><strong>Results: </strong> The mixed-model analysis for repeated measures showed a significant interaction of time and groups for body weight (P = 0.001) and BMI (P = 0.001), with a significant body weight (-7.83 ± 2.28 kg; P = 0.0009) and BMI (-2.83 ± 0.83, P = 0.0009) decrease in the HF versus the sham group. A decreasing trend in food craving in the HF versus the LF and sham groups (P = 0.073) was observed. A significant improvement of metabolic and physical activity variables was found (P < 0.05) in the HF group.</p> <p><strong>Conclusions: </strong> We demonstrated the safety and efficacy of dTMS, in addition to physical exercise and a hypocaloric diet, in reducing body weight for up to 1 year in obese people. We hypothesize that a possible mechanism of HF dTMS treatment is modulation of the dopaminergic pathway and stimulation of physical activity.</p> <p> </p>
Analysis of inflammatory predictors and differences in gene expression in patients with Cognitive Impairment Mild responders and non-responders to Neurostimulation: a randomized, double-blind clinical trial
<p>https://docs.google.com/spreadsheets/d/1jUrBFxUs57HBCj-y0NkID1kzdnsLPpr9/edit#gid=788062431</p> <p>Mild cognitive impairment (MCI) refers to the transition state between the cognitive changes of normal aging and early dementia, but it does not notably interfere with activities of daily living. MCI is believed to be a prodromal stage of dementia that causes severe cognitive dysfunction, so its identification for early intervention is considered an important therapeutic strategy.<br> In this context, non-pharmacological interventions, such as Transcranial Direct Current Stimulation (tDCS), which uses direct electrical currents to stimulate specific parts of the brain, have been used to clinically improve these patients. Biochemical processes have been linked to the pathogenesis of MCI and dementia, including chronic inflammation, dysregulation of membrane lipids, disruption of neurotransmitter pathways, and mutations in specific genes. Therefore, the general objective of this study is to evaluate the inflammatory and gene expression profile of patients with MCI, responders and non-responders to tDCS. This is a randomized, double-blind, sham-controlled clinical trial (ClinicalTrials.org: NCT04934423).<br> Neuropsychological tests and a sociodemographic and clinical questionnaire will be used to assess and characterize the subjects. Participants captured by the Laboratory of Studies in Aging and Neurosciences of the Federal University of Paraíba will be divided into 02 groups, each with 25 patients, totaling 50 volunteers: Active – participants who will receive real anodic current; Sham – participants who will receive simulated stimulation. Participants enrolled by eligibility criteria will be randomly allocated in a simple 1:1 ratio. The equipment parameters will be customized by Computational Modeling with the help of the Non-Invasive Brain Stimulation Simulation Program and the measurement of the head circumference. The electroencephalogram and the evaluation of polymorphisms of the genes Alpha synuclein and Neuroregulin, as well as the inflammatory mediators IL-6, Il-10 and TNF-α, will be considered as possible predictors of response. The project was evaluated by the Research Ethics Committee of the Federal University of Paraíba, obtaining the following CAAE registration: 40675220.0.0000.5188. It is expected to find improvements in the scores of general cognition and memory tests after the intervention protocol of neurostimulation with an individual dose in the group that will receive the active current, compared to the simulated neurostimulation group. As well as finding differences in the Inflammatory and Genetic profiles of those responders and non-responders to Neurostimulation.</p>
Anodal transcranial direct current stimulation in chronic migraine and medication overuse headache: A pilot double-blind randomized sham-controlled trial
<p>This dataset includes raw data from the article “Anodal transcranial direct current stimulation in chronic migraine and medication overuse headache: A pilot double-blind randomized sham-controlled trial”.</p> <p>In this study, we enrolled 20 patients with chronic migraine (CM) and medication overuse headache (MOH). They were hospitalized for a 7-day detoxification treatment and were randomly assigned to anodal tDCS or sham stimulation delivered over the primary motor cortex contralateral to the prevalent migraine pain side every day for 5 days. Clinical data were recorded at baseline (T0), after 1 month (T2) and 6 months (T3). EEG recording was performed at T0, at the end of the tDCS/Sham treatment, and at T2.</p> <p>At T2 and T3, we found a significant reduction in monthly migraine days (p = 0.001), which were more pronounced in the tDCS group when compared to the sham group (p = 0.016). At T2, we found a significant increase of alpha rhythm in occipital leads, which was significantly higher in tDCS group when compared to sham group. In conclusion, tDCS showed adjuvant effects to detoxification in the management of patients with CM and MOH. The EEG recording showed a significant potentiation of alpha rhythm, which may represent a correlate of the underlying changes in cortico-thalamic connections.</p>
Test Double Blind
<p>Test upload for double blind review</p>
Dataset concerning A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment
<p>This is the processed data for the manuscript " Rodella C, Bernini S, Panzarasa S, Sinforiani E, Picascia M, Quaglini S, Cavallini E, Vecchi T, Tassorelli C, Bottiroli S. A double-blind randomized controlled trial combining cognitive training (CoRe) and neurostimulation (tDCS) in the early stages of cognitive impairment. Aging Clin Exp Res. 2021 Jun 22. Epub ahead of print".</p> <p>Dataset refers to a Randomized Controlled Trial aimed to evaluate the effectiveness of a combined treatment protocol associating a computerized cognitive training (CoRe) with anodal transcranial direct current stimulation (tDCS) in early phases of cognitive impairment. The dataset contains cognitive performances in neuropsychological tests (raw scores) at baseline (T0), post-intervention (T1) and 6-months later (T2). Data highlights the efficacy of combining cognitive training and neurostimulation.</p>
Data related to article EFFICACY OF MINDFULNESS ADDED TO TREATMENT AS USUAL IN PATIENTS WITH CHRONIC MIGRAINE AND MEDICATION OVERUSE HEADACHE: A PHASE-III SINGLE-BLIND RANDOMIZED-CONTROLLED TRIAL (THE MIND-CM STUDY) - submitted
<p>DATA ON PATIENTS INCLUDED IN THE MIND-CM STUDY. TWO ARMS (TAU AND TAU+MIND), AND FOUR EVALUATIONS: BASELINE, 3-MONTHS, 6-MONTHS AND 12-MONTS FOLLOW-UP.</p>
Clinical assessment of the TechArm system on visually impaired and blind children during uni- and multi-sensory perception tasks
<p>Introduction</p> <p>This dataset includes the raw data linked with the paper “Clinical assessment of the TechArm system on visually impaired and blind children during uni- and multi-sensory perception tasks ”.</p> <p>In this paper, we validated the TechArm system on a pediatric population of visually impaired (low-vision and blind), and sighted children.</p> <p>Raw data concerning sighted children are collected in the first sheet, while raw data for visually impaired children are in the second sheet. Encoding is available in the third sheet.</p> <p>Methods</p> <p>8 blind children (B, mean age 10.50 ± 4.21 y.o.), 23 children with low vision (LV, mean age 92 9.87 ± 3.09 y.o.), and 23 age-matched sighted children (S, mean age 9.83 ± 3.01 y.o.) were enrolled in the study. Four TechArm units were used to deliver uni- (audio or tactile) or multi-sensory stimulation (audio-tactile) on the participant’s arm, and subject was asked to evaluate the number of active units (see Martolini et al, Brain Sciences, 2021 for a presentation of the protocol).</p> <p>Results (in brief)</p> <p>Results showed no significant difference among groups (normal or impaired vision). Overall, we observed the best performance in tactile condition, while auditory accuracy was around chance level. Also, we found that the audio-tactile condition is better than the audio condition alone, suggesting that multisensory stimulation is beneficial when perceptual accuracy and precision are low. Interestingly, we observed that for low-vision children the accuracy in audio condition improved proportionally to the severity of the visual impairment. Our findings confirmed the TechArm system's effectiveness in assessing perceptual competencies in sighted and visually impaired children, and its potential to be used to develop personalized rehabilitation programs for people with visual and sensory impairments.</p>
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of an HIV-1 Pseudovirion Vaccine
ClinicalTrials.gov study NCT00000835. IPD Sharing: Not stated. Countries: 0. Publications: 0.
EFFECT OF A NOVEL PROBIOTIC PREPARATION ON INDUCTION AND MAINTENANCE OF REMISSION IN ULCERATIVE COLITIS PATIENTS: A DOUBLE-BLIND PLACEBO CONTROLLED TRIAL
GEO Series GSE50594. Homo sapiens. 54 samples. Type: Expression profiling by array.
The Role of Sensory Perception, Emotionality and Lifeworld in Auditory Word Processing: Evidence from Congenital Blindness and Synesthesia
<p>Data set of Papadopoulos, J., Domahs, F., & Kauschke, C. (2017). The Role of Sensory Perception, Emotionality and Lifeworld in Word Processing: Evidence from Congenital Blindness and Synesthesia.<em> Journal of Psycholinguistic Research</em>. Online first: DOI 10.1007/s10936-017-9511-1.</p> <p>Data on request.</p>
Test upload to verify restricted access and double blind review
<p>Test upload to verify Zenodo's restricted access and double blind review</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.