Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,678
datasets available to search
ShareScore release 0.9.0
Dataset results
2,678 results for “cell signaling”
SRSF1 knockdown alleviates the ribosomal stress-induced inhibition of cell proliferation through the MAPK signaling pathway
GEO Series GSE218461. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Wnt/β-catenin signaling activation induces differentiation in human limbal epithelial stem cells cultured ex vivo
GEO Series GSE234403. Homo sapiens. 12 samples. Type: Expression profiling by array.
Mincle-mediated signaling leads to characteristic gene expressions in rat mast cells
GEO Series GSE80416. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Vesicle-Associated Membrane Protein-Associated Protein B Promotes Osteogenic Differentiation in Aortic Valve Interstitial Cells via Activation of the SMAD Signaling Pathway
GEO Series GSE282962. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Bi-directional c-Kit–mKitL signalling promotes tumour endothelial cell differentiation and triple-negative breast cancer progression
GEO Series GSE154000. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
RNAseq assessment of early IL-33-mediated signaling on donor T cells in mourse GVHD model
GEO Series GSE197775. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Treg cell by tumor-associated macrophage ROS and inflammatory signaling through T-cell NF-κB c-Rel drives pathogenesis of lung adenocarcinomas
GEO Series GSE132460. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates
GEO Series GSE94092. Mus musculus. 28 samples. Type: Expression profiling by array.
SLC6A3 Dopaminergic Signaling Subverts Spliceosomal Fidelity to Promote Immune Checkpoint Inhibitor Resistance in Clear Cell Renal Cell Carcinoma [1]
GEO Series GSE316468. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Data set from the article Vianello E, Marrocco-Trischitta Massimiliano M, Dozio E, Bandera F, Tacchini L, Canciani E, Dellavia C, Schmitz G, Lorenzo M, Corsi Romanelli Massimiliano M. Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. J Mol Cell Cardiol. 2019 Jul;132:210-218. doi: 10.1016/j.yjmcc.2019.05.012. Epub 2019 May 15. Erratum in: J Mol Cell Cardiol. 2019 Aug;133:112. PMID: 31102584.
<p>Data set from the article Vianello E, Marrocco-Trischitta Massimiliano M, Dozio E, Bandera F, Tacchini L, Canciani E, Dellavia C, Schmitz G, Lorenzo M, Corsi Romanelli Massimiliano M. Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling. J Mol Cell Cardiol. 2019 Jul;132:210-218. doi: 10.1016/j.yjmcc.2019.05.012. Epub 2019 May 15. Erratum in: J Mol Cell Cardiol. 2019 Aug;133:112. PMID: 31102584.</p> <p>This is the abstract:</p> <p><strong>Aims: </strong>Genetic and environmental factors all interact in the risk of progression of valvular dysfunctions. Previous studies reported a relation between valve diseases and epicardial adipose tissue (EAT) thickness. The aim of this study was to verify the possible relationship between the molecular pattern of EAT related to IL-13 fibrogenic cytokine expression and valve dysfunction.</p> <p><strong>Methods and results: </strong>A valvular heart disease (VHD) population was stratified according to their median EAT thickness (7 mm). The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification.</p> <p><strong>Conclusion: </strong>IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.</p> <p> </p>
Signalling networks govern immune cell avoidance in colorectal cancer
<p>Please refer to https://doi.org/10.5281/zenodo.7015015 instead!</p>
Dataset related to the article " Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"
<p>This record contains raw data related to the article “Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca<sup>2+</sup> Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"</p> <p>Abstract</p> <p>Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca<sup>2+</sup> release. NAADP-induced lysosomal Ca<sup>2+</sup> release may be amplified by the endoplasmic reticulum (ER) through the Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release (CICR) mechanism. NAADP-induced intracellular Ca<sup>2+</sup> signals were shown to modulate a growing number of functions in the cardiovascular system, but their occurrence and role in cardiac mesenchymal stromal cells (C-MSCs) is still unknown. Herein, we found that exogenous delivery of NAADP-AM induced a robust Ca<sup>2+</sup> signal that was abolished by disrupting the lysosomal Ca<sup>2+</sup> store with Gly-Phe β-naphthylamide, nigericin, and bafilomycin A1, and blocking TPC1 and TPC2, that are both expressed at protein level in C-MSCs. Furthermore, NAADP-induced EL Ca<sup>2+</sup> release resulted in the Ca<sup>2+</sup>-dependent recruitment of ER-embedded InsP<sub>3</sub>Rs and SOCE activation. Transmission electron microscopy revealed clearly visible membrane contact sites between lysosome and ER membranes, which are predicted to provide the sub-cellular framework for lysosomal Ca<sup>2+</sup> to recruit ER-embedded InsP<sub>3</sub>Rs through CICR. NAADP-induced EL Ca<sup>2+</sup> mobilization via EL TPC was found to trigger the intracellular Ca<sup>2+</sup> signals whereby Fetal Bovine Serum (FBS) induces C-MSC proliferation. Furthermore, NAADP-evoked Ca<sup>2+</sup> release was required to mediate FBS-induced extracellular signal-regulated kinase (ERK), but not Akt, phosphorylation in C-MSCs. These finding support the notion that NAADP-induced TPC activation could be targeted to boost proliferation in C-MSCs and pave the way for future studies assessing whether aberrant NAADP signaling in C-MSCs could be involved in cardiac disorders.</p>
Supplementary processed data for Chandler et al. Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of a murine model of WT1 kidney disease
<p><strong><em>Summary datafiles for Chandler et al.</em></strong></p> <ul> <li>Processed single-cell RNA sequencing data, derived from murine glomeruli (isolated using the dynabead technique) from <em>n = 2</em> wild-type <em>Wt1<sup>+/+</sup></em> (Ctrl) and <em>n = 2</em> mutant <em>Wt1<sup>R394W/+</sup></em> (Mut) littermates of WT1 glomerulopathy, followed by 10x Genomics Chromium v3 platform.</li> <li>Please refer to associated scripts for analysis of the data: <a href="https://github.com/daniyal-jafree1995/collaborations/blob/main/Chandleretal_2022_WT1glomerulopathyscRNAseq.R">https://github.com/daniyal-jafree1995/collaborations/blob/main/Chandleretal_2022_WT1glomerulopathyscRNAseq.R</a> </li> <li>File descriptions as below: <ul> <li>barcodes.tsv.gz - barcodes file required for input to Read10X function in Seurat</li> <li>features.tsv.gz - features file required for input to Read10X function in Seurat</li> <li>matrix.mtx.gz - matrix file required for input to Read10X function in Seurat</li> <li>WT1_scRNAseq.rds - RDS file containing processed and annotated Seurat object for downstream analysis</li> </ul> </li> </ul>
YAP orchestrates heterotypic endothelial cell communication via HGF/c-MET signaling in liver tumorigenesis
GEO Series GSE128044. Mus musculus. 20 samples. Type: Expression profiling by array.
Arid1a loss potentiates pancreatic beta-cell regeneration through activation of EGF signaling
GEO Series GSE199229. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Reduced antigen-triggered BCR signaling in Fcmr-deficient B cells
GEO Series GSE298232. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Functional Role of Gab1 and MAPK Signaling in Hair Cycle and Stem Cell Quisecence
GEO Series GSE35780. Mus musculus. 44 samples. Type: Expression profiling by array.
SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis
GEO Series GSE256405. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing; Other.
GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells
GEO Series GSE200800. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
JAG2 signaling induces differentiation of CD14+ monocytes into Langerhans Cell Histiocytosis-like cells
GEO Series GSE114181. Homo sapiens. 26 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.