Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
4,157
datasets available to search
ShareScore release 0.9.0
Dataset results
4,157 results for “Survival.”
Mycobacterium tuberculosis transcription factor, EmbR regulates expression of virulence factors that aid in ex vivo and in vivo survival
GEO Series GSE154673. Mycobacterium tuberculosis. 8 samples. Type: Expression profiling by high throughput sequencing.
Seminal fluid compromises visual perception in honeybee queens reducing their survival during additional mating flights
GEO Series GSE127185. Apis mellifera. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1]
GEO Series GSE35910. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The epigenetic reader protein SPIN1 controls proliferation and survival of liposarcoma by modulating the RET signaling pathway
GEO Series GSE57502. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
analysis of expression profiles and differential allelic expression of third-instar larvae (L3) that survived treatment with OP insecticide.
GEO Series GSE145822. Cochliomyia hominivorax. 4 samples. Type: Expression profiling by high throughput sequencing.
PPP2R1A mutations portend improved survival after cancer immunotherapy
GEO Series GSE276284. Homo sapiens. 43 samples. Type: Expression profiling by high throughput sequencing.
Acquired Genomic Copy Number Aberrations and Survival in Adult Acute Myelogenous Leukemia
GEO Series GSE23452. Homo sapiens. 226 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
Organogenesis relies on the SoxC transcription factors for the survival of neural and mesenchymal progenitors
GEO Series GSE20740. Mus musculus. 8 samples. Type: Expression profiling by array.
Survival of cells with deregulated MYC requires UVSSA-dependent regulation of RNAPII dynamics
GEO Series GSE121960. Homo sapiens. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The contribution of stress-tolerant endosymbiotic dinoflagellate Durusdinium to Pocillopora acuta survival in a highly urbanized reef system
<p><strong>Online Resource 1</strong> BLAST results for <em>cp23S </em>Symbiodineaceae sequences.</p> <p>Online Resource 2 BLAST results for <em>ITS2 </em>Symbiodineaceae sequences.</p> <p><strong>Online Resource 3 </strong>Summary of EDGE analysis showing DETs across genotypes and treatment comparisons with corresponding fold change values, FDR and protein matches.</p> <p><strong>Online Resource 4 </strong>Summary of DEGs across genotypes and treatment comparisons with corresponding fold change values.</p>
Grey seal pup survival for Skomer Island, Marloes Peninsula and Ramsey Island in Wales, UK.
<p>Dataset and R code associated with the submitted manuscript: Census data aggregation decisions can affect population-level inference in heterogeneous populations</p> <p> </p>
Data from: Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer
<p>Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceutical CDK inhibitors. Insights into the biological consequences of CDK inhibition in specific tumor types have led to the successful development of CDK4/6 inhibitors as treatments for certain types of breast cancer. More recently, the development of a new generation of pharmaceutical inhibitors of CDK enzymes that regulate the transcription of key oncogenic and pro-survival proteins, including CDK2 and CDK9, have entered clinical development. Here, we provide the first disclosure of the chemical structure of fadraciclib (CYC065), a CDK inhibitor and clinical candidate designed by further optimization from the aminopurine scaffold of seliciclib. We describe its synthesis and mechanistic characterization. Fadraciclib exhibits improved potency and selectivity for CDK2 and CDK9 compared to seliciclib, and also displays high selectivity across the kinome. We show that the mechanism of action of fadraciclib is consistent with potent inhibition of CDK9-mediated transcription, decreasing levels of RNA polymerase II C-terminal domain serine 2 phosphorylation, the pro-survival protein Myeloid Cell Leukemia 1 (MCL1) and MYC oncoprotein, and inducing rapid apoptosis in cancer cells. This cellular potency and mechanism of action translate to promising anti-cancer activity in human leukemia mouse xenograft models. Studies of leukemia cell line sensitivity identify mixed lineage leukemia (<i>MLL</i>) gene status and the level of B-cell lymphoma 2 (BCL2) family proteins as potential markers for selection of patients with greater sensitivity to CYC605. We show that the combination of fadraciclib with BCL2 inhibitors, including venetoclax, is synergistic in leukemic cell models, as predicted from simultaneous inhibition of MCL1 and BCL2 pro-survival pathways. Fadraciclib preclinical pharmacology data support its therapeutic potential in CDK9- or CDK2-dependent cancers and as a rational combination with BCL2 inhibitors in hematological malignancies. Fadraciclib is currently in Phase 1 clinical studies in patients with advanced solid tumors (<a href="https://clinicaltrials.gov/ct2/show/NCT02552953?cond=CYC065&rank=2">NCT02552953</a>) and also in combination with venetoclax in patients with relapsed or refractory chronic lymphocytic leukemia (CLL) (<a href="https://clinicaltrials.gov/ct2/show/NCT03739554?cond=CYC065&rank=1">NCT03739554</a>) and relapsed refractory acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) (<a href="https://clinicaltrials.gov/ct2/show/NCT04017546?cond=CYC065&draw=1&rank=2">NCT04017546</a>)</p>
Data from: Temperature-dependent development and survival of an invasive genotype of wheat curl mite, Aceria tosichella
<p><strong>Filename: Development.xlsx</strong></p> <p>Variables:</p> <p>1. id_spec - specimen ID<br> 2. temp - temperature of incubation<br> 3. trial - replication ID<br> 4. larv - number of days needed to reach larva stage <br> 5. q_larv - number of days needed to reach quiescent larva stage <br> 6. nymph - number of days needed to reach nymph stage <br> 7. q_nymph - number of days needed to reach quiescent nymph stage <br> 8. adult - number of days needed to reach adult stage <br> 9. egg - number of days needed to oviposit egg of next generation </p> <p><strong>Filename: Survival.xlsx</strong></p> <p>Variables:</p> <p>1. id_spec - specimen ID<br> 2. temp - temperature of incubation<br> 3. time - number of days when individual was observed alive<br> 4. stage - developmental stage which individual reached before death<br> 5. sex - sex of an individual (F - female; M - male; NA - unknown)<br> 6. status - 0 - censored observation; 1 - observed event of death</p>
The Clinical Characteristics and Survival Profiles of Wilms Tumor in the United Arab Emirates: A Single-center Retrospective Analysis
<p>The dataset of a research article titled: "The Clinical Characteristics and Survival Profiles of Wilms Tumor in the United Arab Emirates: A Single-center Retrospective Analysis"</p>
Data from: When perception reflects reality: non-native grass invasion alters small mammal risk landscapes and survival
1. Modification of habitat structure due to invasive plants can alter the risk landscape for wildlife by, for example, changing the quality or availability of refuge habitat. Whether perceived risk corresponds with actual fitness outcomes, however, remains an important open question. We simultaneously measured how habitat changes due to a common invasive grass (cheatgrass, <i>Bromus tectorum</i>) affected the perceived risk, habitat selection, and apparent survival of a small mammal, enabling us to assess how well perceived risk influenced important behaviors and reflected actual risk. 2. We measured perceived risk by nocturnal rodents using a giving-up density foraging experiment with paired shrub (safe) and open (risky) foraging trays in cheatgrass and native habitats. We also evaluated microhabitat selection across a cheatgrass gradient as an additional assay of perceived risk and behavioral responses for deer mice (<i>Peromyscus maniculatus</i>) at two spatial scales of habitat availability. Finally, we used mark-recapture analysis to quantify deer mouse apparent survival across a cheatgrass gradient while accounting for detection probability and other habitat features. 3. In the foraging experiment, shrubs were more important as protective cover in cheatgrass dominated habitats, suggesting that cheatgrass increased perceived predation risk. Additionally, deer mice avoided cheatgrass and selected shrubs, and marginally avoided native grass, at two spatial scales. 4. Deer mouse apparent survival varied with a cheatgrass-shrub interaction, corresponding with our foraging experiment results, and providing a rare example of a native plant mediating the effects of an invasive plant on wildlife. 5. By synthesizing the results of three individual lines of evidence (foraging behavior, habitat selection, and apparent survival), we provide a rare example of linkage between behavioral responses of animals indicative of perceived predation risk and actual fitness outcomes. Moreover, our results suggest that exotic grass invasions can influence wildlife populations by altering risk landscapes and survival.
Data from: Protein deprivation decreases male survival and the intensity of sexual antagonism in southern field crickets Gryllus bimaculatus
Recent theory predicts that the magnitude of sexual antagonism should depend on how well populations are adapted to their environment. We tested this idea experimentally by comparing intersexual genetic correlations for adult survival in pedigreed populations of southern field crickets (Gryllus bimaculatus) raised on naturally balanced (free-choice) vs. imbalanced (protein-deprived) diets. We tested for (1) sex differences in nutritional intake and preference, (2) sex-specific effects of protein deprivation on survival and (3) diet dependence of the level of sexual antagonism. Adult males and females consumed a similar amount of protein, but protein deprivation decreased male survival but not female survival. Protein deprivation appeared to decrease the degree of sexual antagonism as intersexual genetic correlations were significantly lower than 1 only for the complementary free-choice diet group but close to 1 for the protein-deficient diet group. Our findings thereby implied that variation in nutritional environments can alter the magnitude of sexual antagonism. This research represents an important step towards understanding the relationship between sexual antagonism and adaptation in heterogeneous environments.
Data from: Rain downpours affect survival and development of insect herbivores: the specter of climate change?
Changes in the frequency, duration, and intensity of rainfall events are among the abiotic effects predicted under anthropogenic global warming. Heavy downpours may profoundly affect the development and survival of small organisms such as insects. Here, we examined direct (physically on the insects) and indirect (plant‐mediated) effects of simulated downpours on the performance of caterpillars of two lepidopteran herbivores (Plutella xylostella and Pieris brassicae) feeding on black mustard (Brassica nigra) plants. Host plants were exposed to different rainfall regimes both before and while caterpillars were feeding on the plants in an attempt to separate direct and indirect (plant‐mediated) effects of rainfall on insect survival and development. In two independent experiments, downpours were simulated as a single long (20 min) or as three short (5 min) daily events. Downpours had a strong negative direct effect on the survival of P. xylostella, but not on that of P. brassicae. Direct effects of downpours consistently increased development time of both herbivore species, whereas effects on body mass depended on herbivore species and downpour frequency. Caterpillar disturbance by rain and recorded microclimatic cooling by 5°C may explain extended immature development. Indirect, plant‐mediated effects of downpours on the herbivores were generally small, despite the fact that sugar concentrations were reduced and herbivore induction of secondary metabolites (glucosinolates) was enhanced in plants exposed to rain. Changes in the frequency of precipitation events due to climate change may impact the survival and development of insect herbivores differentially. Broader effects of downpours on insects and other arthropods up the food chain could seriously impair and disrupt trophic interactions, ultimately destabilizing communities.
Data from: Effects of forestry-driven changes to groundcover and soil moisture on amphibian desiccation, dispersal, and survival
Over 80% of amphibian species that are declining are forest dependent. Forestry practices are a major cause of forest alterations globally, and it is well documented that clearcutting can contribute to amphibian declines. However, there might be adverse effects of forestry practices other than clearcutting. For example, planting overstory trees in rows (plantations) can change groundcover microhabitats and soil moisture levels, but the effects of this common practice on amphibian populations are not well studied. We compared the impacts of common intensive pine plantation operations to naturally regenerated pine forests on the desiccation, movement rates, behavior, and survival of > 900 juvenile Southern toads (Anaxyrus terrestris). Pine plantations had significantly more accumulation of conifer needles and less exposed soil, herbaceous groundcover, broadleaf litter, and soil moisture than natural pine forests despite the greater canopy cover at plantations. Litter cover explained 85% of groundcover microhabitat variance among forest types and predicted minimum soil moisture levels. When toads were held in small outdoor enclosures that constrained microhabitat selection, 24-h desiccation rates and 72-h mortality were significantly greater in pine plantation than in naturally regenerated pine forest because of lower soil moisture, especially during low rainfall periods. In large outdoor pens where juvenile amphibians could select microhabitats, movement was strongly directed down slope and increased with precipitation. However, initial speeds were positively associated with pine density, likely because toads were trying to evacuate from the drier high-pine-density areas. High-intensity silviculture practices that eliminate herbaceous or vegetative groundcover, such as roller chopping and scalping, increase amphibian desiccation because planted conifers dry the upper soil layer. Our study highlights the importance of prioritizing lower intensity silviculture practices or lower pine densities to retain groundcover microhabitat that serves as amphibian refugia from dry conditions that are predicted to increase in frequency with climate change.
Data from: The impact of bottlenecks on microbial survival, adaptation and phenotypic switching in host-pathogen interactions
Microbial pathogens and viruses can often maintain sufficient population diversity to evade a wide range of host immune responses. However, when populations experience bottlenecks, as occurs frequently during initiation of new infections, pathogens require specialized mechanisms to regenerate diversity. We address the evolution of such mechanisms, known as stochastic phenotype switches, which are prevalent in pathogenic bacteria. We analyze a model of pathogen diversification in a changing host environment that accounts for selective bottlenecks, wherein different phenotypes have distinct transmission probabilities between hosts. We show that under stringent bottlenecks, such that only one phenotype can initiate new infections, there exists a threshold stochastic switching rate below which all pathogen lineages go extinct, and above which survival is a near certainty. We determine how quickly stochastic switching rates can evolve by computing a fitness landscape for the evolutionary dynamics of switching rates, and analyzing its dependence on both the stringency of bottlenecks and the duration of within-host growth periods. We show that increasing the stringency of bottlenecks or decreasing the period of growth results in faster adaptation of switching rates. Our model provides strong theoretical evidence that bottlenecks play a critical role in accelerating the evolutionary dynamics of pathogens.
Data from: Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in human first trimester HTR-8/SVneo trophoblast cells and placental villous explants exposed to 2% O2. Specific MMP inhibitors established the requirement for MMP2 in HBEGF shedding and upregulation. Because α-amanitin inhibited the upregulation of HBEGF, differentially expressed genes were identified by next-generation sequencing of RNA from trophoblast cells cultured at 2% O2 for 0, 1, 2 and 4 h. Nine genes, all containing HIF-response elements, were upregulated at 1 h, but only HSPA6 (HSP70B') remained elevated at 2–4 h. The HSP70 chaperone inhibitor VER 155008 blocked upregulation of both MMP2 and HBEGF at 2% O2, and increased apoptosis. However, both HBEGF upregulation and apoptosis were rescued by exogenous MMP2. Proximity ligation assays demonstrated interactions between HSP70 and MMP2, and between MMP2 and HBEGF, supporting the concept that MMP2-mediated shedding of HBEGF, initiated by HSP70, contributes to trophoblast survival at the low O2 concentrations encountered during the first trimester, and is essential for successful pregnancy outcomes. Trophoblast survival during human placentation, when oxygenation is minimal, required HSP70 activity, which mediated MMP2 accumulation and the transactivation of anti-apoptotic ERBB signaling by HBEGF shedding.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.