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2,738
datasets available to search
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Dataset results
2,738 results for “Multiple sclerosis”
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis [ATAC-seq]
GEO Series GSE283085. Mus musculus. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A novel animal model for secondary progressive multiple sclerosis by oligodendroglia-specific conditional connexin 47 knockout [Affy]
GEO Series GSE121337. Mus musculus. 8 samples. Type: Expression profiling by array.
Mapping the Molecular Signature of Progressive Multiple Sclerosis [194017]
GEO Series GSE290450. Homo sapiens. 78 samples. Type: Expression profiling by high throughput sequencing.
Co-Morbid Multiple Sclerosis and Psoriasis: Clinical Outcomes and Gene Expression
GEO Series GSE141804. Homo sapiens. 55 samples. Type: Expression profiling by array.
Single-nucleus RNA-seq of peripheral blood mononuclear cells from multiple sclerosis patients and healthy controls
GEO Series GSE305477. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Upregulation of selected HERVW loci in Multiple Sclerosis
GEO Series GSE173929. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Multiple sclerosis (oksen-affy-human-488680)
GEO Series GSE8594. Homo sapiens. 10 samples. Type: Expression profiling by array.
Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis
GEO Series GSE203241. Homo sapiens. 59 samples. Type: Expression profiling by array.
Mapping the Molecular Signature of Progressive Multiple Sclerosis [197191]
GEO Series GSE290552. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Mapping the Molecular Signature of Progressive Multiple Sclerosis
GEO Series GSE290554. Homo sapiens. 94 samples. Type: Expression profiling by high throughput sequencing.
Link to dataset related to article "Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis."
<p>Long non-coding RNAs (lncRNAs) are post-transcriptional and epigenetic regulators, whose implication in neurodegenerative and autoimmune diseases remains poorly understood. We analyzed publicly available microarray data sets to identify dysregulated lncRNAs in multiple sclerosis (MS), a neuroinflammatory autoimmune disease. We found a consistent upregulation in MS of the lncRNA MALAT1 (2.7-fold increase; meta-analysis, P = 1.3 × 10-8; 190 cases, 182 controls), known to regulate alternative splicing (AS). We confirmed MALAT1 upregulation in two independent MS cohorts (1.5-fold increase; P < 0.01; 59 cases, 50 controls). We hence performed MALAT1 overexpression/knockdown in cell lines, demonstrating that its modulation impacts on endogenous expression of splicing factors (HNRNPF and HNRNPH1) and on AS of MS-associated genes (IL7R and SP140). Minigene-based splicing assays upon MALAT1 modulation recapitulated IL7R and SP140 isoform unbalances observed in patients. RNA-sequencing of MALAT1-knockdown Jurkat cells further highlighted MALAT1 role in splicing (approximately 1100 significantly-modulated AS events) and revealed its contribution to backsplicing (approximately 50 differentially expressed circular RNAs). Our study proposes a possible novel role for MALAT1 dysregulation and the consequent AS alteration in MS pathogenesis, based on anomalous splicing/backsplicing profiles of MS-relevant genes.</p>
Cognitive reserve in multiple sclerosis
Open the record for dataset details and reuse information.
Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade
<p><strong>Introduction - T</strong>his database includes the raw data linked with the paper <em>Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade.</em></p> <p>In this paper, we reported the HuR protein levels in peripheral blood mononuclear cells (PBMCs) from MS patients before and after dimethyl fumarate (DMF) treatment compared to healthy controls (HC). Considering that HuR may act on different targets playing a protective role against oxidative stress, we had the goal of disclosing whether MnSOD could represent a new molecular target of HuR and the potential influence of DMF treatment on this interaction .</p> <p><strong>Methods - </strong>PBMCs from 20 patients with MS and 20 matched HC were used to evaluate HuR, MnSOD and Nrf2 protein content by Western blot, before and after 12 months of DMF treatment.</p> <p>Immunoprecipitation experiments coupled with RNA extraction in PBMCs were performed to explore whether MnSOD mRNA could be physically bound by HuR and whether this binding could be affected by 12 months of DMF treatment.</p> <p><strong>Results </strong>- In PBMCs, HuR protein interacts with MnSOD transcript both in HC and in MS patients naïve to disease modifying treatment. This interaction is positively affected by 12 months of DMF treatment. PBMCs from MS patients have a lower HuR and MnSOD protein content compared to matched HC (HuR: p<0.01, MnSOD p<0.01). Of interest, 12 months of DMF treatment in MS patients restore the amount of both HuR protein and MnSOD enzyme to the levels observed in HC. We also confirmed that Nrf2 is an HuR target, and we report that its levels are significantly increased in MS patients naïve to disease modifying treatment and remain elevated following DMF administration.</p>
Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis [RNA-seq]
GEO Series GSE283086. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Constraint-Induced Movement Therapy in multiple sclerosis
<p>Dataset related to the journal articole </p> <p>"Constraint-Induced Movement Therapy in multiple sclerosis"</p> <p>de Sire Alessandro, Bigoni Matteo, Priano Lorenzo, Baudo Silvia, Solaro Claudio, MAURO ALESSANDRO</p> <p>NeuroRehabilitation 2019;45(2):247-254.</p>
MRI dataset for susceptibility-based radiomic feature extraction in healthy controls and patients with multiple sclerosis
<p>This dataset include multiparametric MRI brain images and susceptiblity-based radiomic features within a mixed sample of 100 patients with multiple sclerosis and 50 healthy controls. We focused on the normal appearing white matter and its tracts. <br>Imaging and radiomic data are organized according to the Brain Imaging Directory Structure (BIDS) and for each subjects the following data are provided: anatomical T1w and T2w images; DWI after the correction for EPI distortions and susceptibility effects, eddy currents, and signal dropout, b-values and b-vectors and registration matrix to T1w; QSM QSM reconstruction, already registered in T1w space, raw magnitude and phase maps for the 5 echo times and registration matrix to T1w; volumes of interest (normal appearing white matter and tracts, divided for the two hemispheres); 107 radiomic features for each volume of interest. All images were anonymized and de-identified. <br>Additionally, in the database there is the ‘code’ folder containing the available scripts used for the processing (image registration, radiomic feature extraction, and robustness evaluation) and the participants file (containing for each subject the ID number, age, sex, date of scan, clinical condition (‘HC’ and ‘MS’) and the of the DWI sequence used, i.e. single- or multi-shell) and the dataset description.</p> <p>Data were provided by the Functional and Molecular Neuroimaging Unit at IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy. <a href="https://doi.org/10.5281/zenodo.11278906">Here</a> you can find the Data Use Agreement (DUA) to sign before using the dataset, together with the instructions to have the access.</p> <p>More details about image acquisition and processing may be found in Fiscone et al. (2024) Multiparametric MRI database for susceptibility-based radiomic feature extraction and analysis, <em>Scientific Data</em>. Please cite this paper if you use this dataset for publications or presentations. For any further information, please email cristiana.fiscone@gmail.com, davidneil.manners@unibo.it or giovanni.sighinolfi3@unibo.it. </p>
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
<p>This directory contains custom codes and supplementary datasets generated for the study "Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases".</p>
Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial in Germany and the USA
<p>Patient-level data on primary and secondary endpoints of an international multicenter randomized controlled trial of internet-delivered cognitive behavioral therapy (iCBT) to reduce depressive symptoms in multiple sclerosis (MS).</p> <p>ClinicalTrials.gov Identifier: NCT02740361</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.