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283
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ShareScore release 0.9.0
Dataset results
283 results for “Dystonia”
Data set_Network-wide modulation of synaptic plasticity and spike patterns in motor circuits by pallidal deep brain stimulation in a dystonia model
<p>This study utilized deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) to investigate its long-term effects on synaptic activity in motor thalamic and motor cortical neurons in an animal model of generalized dystonia (dtsz hamster). Whole-cell recordings were employed to measure synaptic spike patterns, revealing significant changes in DBS-treated animals compared to sham-treated controls. Specifically, we observed reduced interspike intervals (ISI) and increased postsynaptic current (PSC) frequencies. Fast oscillations were also detected in both thalamic and motor cortical neurons, indicating potential modulation of corticothalamocortical loops by GPi-DBS. Notably, while the overall discharge rates of spontaneous and evoked action potentials remained unchanged, DBS treatment led to increased PSC amplitudes and alterations in inhibitory synaptic currents. These findings suggest that GPi-DBS influences both presynaptic and postsynaptic mechanisms of synaptic plasticity. The results further indicate that GPi-DBS disrupts desynchronized neural activity through axonal and synaptic failures, thereby reorganizing neuronal firing patterns and synaptic connectivity within the motor circuit. This modulation provides mechanistic insights into the therapeutic effects of GPi-DBS in alleviating dystonic symptoms.</p>
Efficacy and Safety of Meditoxin® Injection for Cervical Dystonia in Adults With Cerebral Palsy
ClinicalTrials.gov study NCT01860196. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Enhancing Sensorimotor Processing in Children With Dystonia
ClinicalTrials.gov study NCT05612464. IPD Sharing: YES. Countries: 0. Publications: 0.
Impact Of Physiotherapy And Botox In Improving Functional Outcomes Among Post Stroke Focal Dystonia Patients
ClinicalTrials.gov study NCT03664375. IPD Sharing: YES. Countries: 0. Publications: 0.
Clinical Trial to Compare the Safety and Efficacy of Botulax® Versus Botox® in Patients With Cervical Dystonia
ClinicalTrials.gov study NCT04171258. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Keppra for Cervical Dystonia
ClinicalTrials.gov study NCT00760318. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Efficacy and Safety of MEDITOXIN® in Cervical Dystonia
ClinicalTrials.gov study NCT03905304. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia
ClinicalTrials.gov study NCT03347240. IPD Sharing: NO. Countries: 0. Publications: 0.
Post-marketing Surveillance of Administration of Botulinum Toxin Type B(NerBloc)-Investigation of the Clinical Condition and Safety in Patients With Cervical Dystonia
ClinicalTrials.gov study NCT02175693. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Survey of Sensory and Motor Tricks in Focal Dystonia
ClinicalTrials.gov study NCT00054652. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dystonia Coalition Projects
ClinicalTrials.gov study NCT04156022. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Strategy to Adapt Botulinum Toxin Doses in Dystonia
ClinicalTrials.gov study NCT06386848. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Outcome of Botulinum Toxin Treatment for Oromandibular Dystonia
ClinicalTrials.gov study NCT03363113. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Motor and Premotor Cortex Stimulation for Treatment of Secondary Focal Dystonia With Striato Palliadal Lesion : Evaluation of Safety and Effectiveness
ClinicalTrials.gov study NCT00505323. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Alterations in energy production in a Drosophila model for the X-linked dystonia-parkinsonism-related Taf1 deficiency
GEO Series GSE318289. Drosophila melanogaster. 2 samples. Type: Expression profiling by high throughput sequencing.
Blood expression profiles define penetrance in DYT1 dystonia patients
GEO Series GSE19419. Homo sapiens. 60 samples. Type: Expression profiling by array.
A ROLE FOR DYSTONIA-ASSOCIATED GENES IN SPINAL GABAERGIC INTERNEURON CIRCUITRY
GEO Series GSE99590. Mus musculus. 9 samples. Type: Expression profiling by array.
The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice [CRISPR-Cas9 screen]
GEO Series GSE154728. Mus musculus. 9 samples. Type: Other.
X linked dystonia parkinsonism
GEO Series GSE3064. Homo sapiens. 4 samples. Type: Expression profiling by array.
raw data for Plasticity, genetics and epigenetics in dystonia: An update
<p>Legend of Fig. 13.2. Striatal ACh/DA interactions in dystonia. (A) Schematic representation of simplified striatal circuit showing the inter- actions between ACh, released by cholinergic interneurons (ChI, blue), and dopamine (DA), released by dopaminergic terminals (green). DA, by acting on D2 receptors inhibits firing activity of interneurons and ACh release at synaptic terminals. Released ACh, activates muscarinic M1 receptors on SPNs, exerting a modulatory effect over bidirectional synaptic plasticity at corticostriatal synapses (inset). Moreover, ACh activates also the nicotinic receptors (nACh) on DA terminals that promote DA release. (B) In DYT1 dystonia animal model, stimulation of D2 receptors induces an abnormal excitatory response that causes an anomalous ACh release at SPNs synaptic terminals. Higher level of ACh disrupts the normal activity of M1 muscarinic receptors resulting in turn to abnormal bidirectional synaptic plasticity at corticostriatal synapses (inset).</p>
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