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667 results for “Null”
4EHP and GIGYF1/2 induce translation-coupled messenger RNA decay [Wildtype and ZNF598-null]
GEO Series GSE149279. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice
<p>Fucose, the terminal glycan of the intestinal glycoprotein Mucin2, was shown to have an<br> anti-inflammatory effect in mouse colitis models and modulate immune response due to<br> macrophage polarization changes. In this study we evaluated the effect of 0.05% L-fucose<br> supplementation of drinking water on immune parameters in the intestine of homozygous mutant<br> Muc2 −/− , compared to Muc2 +/+ mice. To get into innate and adaptive immunity mechanisms of<br> gut inflammation, we tested Prkdc SCID Muc2 −/− strain, Muc2 knockout on SCID background, that<br> is characterized by lack of lymphocytes, in comparison with Prkdc SCID mice. We evaluated<br> intestinal cytokine profiling, macrophage and eosinophil infiltration, and expression of Nos2 and<br> Arg1 markers of macrophage activation in all strains. Markers of Th1, Treg and Th17 cells<br> (Tbx21, Foxp3, and Rorc expression) were evaluated in Muc2 −/− and Muc2 +/+ mice.<br> Both Muc2 −/− and Prkdc SCID Muc2 −/− mice demonstrated increased numbers of<br> macrophages, eosinophils, elevated levels of TNFa, GM-CSF, and IL-10 cytokines. In Muc2 −/− <br> mice we observed a wide range of pro-inflammatory cytokines elevated, such as IFN-gamma,<br> IL-1b, IL-12p70, IL-6, M-CSF, G-CSF, IL-17, MCP-1, RANTES, MIP1b, MIP2. Muc2 −/− mice<br> demonstrated increase of Nos2, Tbx21 and Foxp3 genes mRNA, while in Prkdc SCID Muc2 −/− mice<br> Arg1 expression was increased. We found that in Muc2 −/− mice L-fucose reduced macrophage<br> infiltration and IL-1a, TNFa, IFNgamma, IL-6, MCP-1, RANTES, MIP1b levels, decreased<br> Nos2 expression, and induced the expression of Treg marker Foxp3 gene. On the contrary, in<br> Prkdc SCID Muc2 −/− mice L-fucose had no effect on macrophage and eosinophil numbers, but<br> increased TNFa, GM-CSF, IL-12p70, IL-6, IL-15, IL-10, MCP1, G-CSF, IL-3 levels and Nos2<br> gene expression, and decreased Arg1 gene expression.<br> We demonstrated that anti-inflammatory effect of L-fucose observed in Muc2 −/− mice is<br> not reproduced in Prkdc SCID Muc2 −/− , which lack lymphocytes. We conclude that activation of<br> Treg cells is a key event that leads to resolution of inflammation upon L-fucose supplementation<br> in Muc2 −/− mice.</p>
Replication package for: The Null Result Penalty
<p>This replication package produces the exhibits for the paper 'The Null Result Penalty'.</p>
TAS-116 Plus Palbociclib in Breast and Rb-null Cancer
ClinicalTrials.gov study NCT05655598. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Ritonavir-Boosted Danoprevir and RO5024048 in Different Combinations in Null Responder or Treatment-Naïve Patients With Chronic Hepatitis C and Compensated Cirrhosis
ClinicalTrials.gov study NCT01483742. IPD Sharing: Not stated. Countries: 7. Publications: 0.
A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
ClinicalTrials.gov study NCT05094336. IPD Sharing: YES. Countries: 14. Publications: 0.
Miravirsen Study in Null Responder to Pegylated Interferon Alpha Plus Ribavirin Subjects With Chronic Hepatitis C
ClinicalTrials.gov study NCT01727934. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cardiovascular Effects of Incremental Diesel Exhaust Inhalation in Middle-Aged Healthy GSTM1 Null Human Volunteers
ClinicalTrials.gov study NCT01548625. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors
ClinicalTrials.gov study NCT05355753. IPD Sharing: NO. Countries: 1. Publications: 0.
CPG10101 Combination Therapy For The Treatment Of Hepatitis C In Non-Responder (Null And Partial Responder) Hepatitis C Virus (HCV) Genotype 1 Infected Subjects
ClinicalTrials.gov study NCT00277238. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of CHOP + Campath for T-Cell, Null Cell, or Natural Killer (NK)-Cell Lymphoma
ClinicalTrials.gov study NCT00161590. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Miravirsen in Combination With Telaprevir and Ribavirin in Null Responder to Pegylated-Interferon Alpha Plus Ribavirin Subjects With Chronic Hepatitis C Virus Infection
ClinicalTrials.gov study NCT01872936. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Phase II Trial of AZD2014 in TSC1/2 Mutated or TSC1/2 Null GC Patients as Second-line Chemotherapy
ClinicalTrials.gov study NCT03082833. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase II Trial of Vistusertib（AZD2014） Single Agent in TSC1or 2 Null or TSC 1/2 Mutation Solid Cancer Patients Refractory to Standard Chemotherapy
ClinicalTrials.gov study NCT03166176. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase 1/2 Study of AMG 193 in Combination With IDE397 in Participants With Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors
ClinicalTrials.gov study NCT05975073. IPD Sharing: YES. Countries: 7. Publications: 0.
Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition
GEO Series GSE255541. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide gene expression analysis of hNAC1-dependent time course rescue of Nac1 null abnormal reprogrammed cells
GEO Series GSE100350. Mus musculus. 6 samples. Type: Expression profiling by array.
RNA-seq of metformin treatment in primary murine hepatocytes in WT, Raptor Ser-Ala mutant, Tsc2-null, Raptor mutant;Tsc2-null, and Ampk-null cells
GEO Series GSE157048. Mus musculus. 65 samples. Type: Expression profiling by high throughput sequencing.
Regulatory consequences of TARBP2 knock-down in Dicer-null MEFs
GEO Series GSE56949. Mus musculus. 5 samples. Type: Expression profiling by array.
Development of gene sets after deleting Rb or Rb and Pten in p53 null background primary prostate cells
GEO Series GSE68905. Mus musculus. 14 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.