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296
datasets available to search
ShareScore release 0.9.0
Dataset results
296 results for “TP53”
TP53 loss and TET2 deficiency cooperate to drive lineage-plastic leukemogenesis by transforming progenitors and establishing immune suppressive environment
GEO Series GSE217867. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
TP53 wild type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
GEO Series GSE189152. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of TP53-proficient and deficient PCNAWT/WT;FancG+/+ (WT) and PCNAK164R/K164R;FancG-/- (DM) MEFs
GEO Series GSE165989. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Differential expression analysis of colorectal carcinoma cells (defunct TP53 versus active TP53) using MAT
GEO Series GSE29831. Homo sapiens. 28 samples. Type: Expression profiling by genome tiling array.
Characterizing TP53 and PPM1D Mutations as Resistance Drivers to Radiation Therapy in Diffuse Intrinsic Pontine Gliomas
Pediatric high-grade gliomas (pHGGs), encompassing diffuse midline gliomas (DMGs) and hemispheric tumors, represent the most common cause of cancer-related deaths in children age 0-14 years. Over the last decade, several landmark papers have revealed recurrent single nucleotide variants (SNVs) in the core histones H3.3 and H3.1, co-occurring with alterations in the TP53 signaling pathway and receptor tyrosine kinases (RTKs). However, the contribution of structural variants (SVs) to gliomagenesis has not been systematically explored. We performed a comprehensive analysis of whole genome sequencing (WGS) data on pediatric high-grade gliomas (pHGGs) from 179 children, including 61 hemispheric tumors and 118 diffuse midline gliomas, or DMGs, of which 61 are novel to this study. Among the DMGs, 84 (71%) were from pre-treatment biopsies including 33 obtained from the first multi-institutional North American clinical trial to incorporate diagnostic biopsies. This represents the largest cohort of pretreatment DMGs with whole genome sequencing to date. This large cohort of whole genome sequences provides an unparalleled opportunity to assess significantly recurrent structural variants in pHGG and their associations with driver SNVs and SCNAs.
Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers
GEO Series GSE306117. Homo sapiens. 74 samples. Type: Expression profiling by high throughput sequencing.
Expression analysis of colorectal carcinoma cells with overexpressed TP53 using TAS
GEO Series GSE29840. Homo sapiens. 14 samples. Type: Expression profiling by genome tiling array.
tp53 R217H and R242H Mutant Zebrafish Display Dysfunctional p53 Hallmarks and Recapitulate LFS Phenotypes [RNA-seq]
GEO Series GSE267760. Danio rerio. 24 samples. Type: Expression profiling by high throughput sequencing.
Immune recovery in tumor microenvironment of TP53-mutated AML following venetoclax combination therapy
GEO Series GSE306339. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression analysis of colorectal carcinoma cells with overexpressed TP53 using MAT
GEO Series GSE29830. Homo sapiens. 14 samples. Type: Expression profiling by genome tiling array.
Expression analysis of colorectal carcinoma cells with defunct TP53 using TileShuffle
GEO Series GSE29844. Homo sapiens. 14 samples. Type: Expression profiling by genome tiling array.
Differential expression analysis of colorectal carcinoma cells (defunct TP53 versus active TP53) using TileShuffle
GEO Series GSE29970. Homo sapiens. 28 samples. Type: Expression profiling by genome tiling array.
Development of an osteosarcoma model with MYCN amplification and TP53 mutation in hiPS cell-derived neural crest cells
GEO Series GSE201511. Homo sapiens. 12 samples. Type: Expression profiling by array.
Differential expression analysis of colorectal carcinoma cells (defunct TP53 versus active TP53) using TAS
GEO Series GSE29841. Homo sapiens. 28 samples. Type: Expression profiling by genome tiling array.
Tet2 and Tp53 cooperate to promote leukemia and modulate response to inflammation
GEO Series GSE305295. Mus musculus. 18 samples. Type: Methylation profiling by high throughput sequencing; Other.
Application of a NanoString Technology-based TP53 Functional Assay for Prediction of Chemotherapy Response of Muscle-invasive Bladder Cancer
GEO Series GSE80711. Homo sapiens. 48 samples. Type: Other.
Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53 [ATAC-Seq]
GEO Series GSE241888. Homo sapiens; Chlorocebus sabaeus. 114 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
TP53 signature predicts survival outcome in triple-negative breast cancer with neoadjuvant chemotherapy
GEO Series GSE190275. Homo sapiens. 60 samples. Type: Expression profiling by array.
Relation between TP53 GOF mutation and Osimertinib treatment in EGFR mutant lung cancer: ChIP-seq
GEO Series GSE253478. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ancient ubiquitous protein 1 (AUP1) is a prognostic biomarker connected with TP53 mutation and the inflamed microenvironments in glioma
GEO Series GSE227721. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.