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4,612 results for “labelled”
Pre-labeled dissolved inorganic carbon, carbon dioxide, and methane from experiemental plots near Toolik Lake, AK from 2000
Dissolved inorganic carbon, carbon dioxide, and methane in waters from pre-labeled wet sedge plots near Toolik Lake, AK during the summer of 2000.
Pre-labeled dissolved inorganic carbon, carbon dioxide, and methane from experiemental plots near Toolik Lake, AK from 2001
Dissolved inorganic carbon, carbon dioxide, and methane in waters from pre-labeled wet sedge plots near Toolik Lake, AK during the summer of 2001.
Pre-labeled dissolved inorganic carbon, carbon dioxide, and methane from experiemental plots near Toolik Lake, AK from 2003
Dissolved inorganic carbon, carbon dioxide, and methane in waters from pre-labeled wet sedge plots near Toolik Lake, AK during the summer of 2003.
Pre-labeled dissolved inorganic carbon, carbon dioxide, and methane from experiemental plots near Toolik Lake, AK from 2005
Dissolved inorganic carbon, carbon dioxide, and methane in waters from pre-labeled wet sedge plots near Toolik Lake, AK during the summer of 2005.
Pre-labeled dissolved inorganic carbon, carbon dioxide, and methane from experiemental plots near Toolik Lake, AK from 2006
Dissolved inorganic carbon, carbon dioxide, and methane in waters from pre-labeled wet sedge plots near Toolik Lake, AK during the summer of 2006.
Data for Precursor intensity-based label-free quantification software tools for Galaxy Platform.
<p><strong>Precursor intensity-based label-free quantification software tools for proteomic and multi-omic analysis within the Galaxy Platform.</strong></p> <p> </p> <p><strong>ABRF:</strong> Data was generated through the collaborative work of the ABRF Proteomics Research Group (<a href="https://abrf.org/research-group/proteomics-research-group-prg">https://abrf.org/research-group/proteomics-research-group-prg</a>). See Reference for details: Van Riper, S. et al. ‘<a href="http://cbs.umn.edu/sites/cbs.umn.edu/files/public/downloads/2016_ABRF_PRG_Poster_for_ASMS_20160501.pdf">An ABRF-PRG study: Identification of low abundance proteins in a highly complex protein sample</a>’ at the 64th Annual Conference of American Society of Mass Spectrometry and Allied Topics" at San Antonio, TX."</p> <p><strong>UPS:</strong> <strong>MaxLFQ Cox J, Hein MY, Luber CA, Paron I, Nagaraj N, Mann M.<a href="https://www.ncbi.nlm.nih.gov/pubmed/24942700/"> Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.</a> Mol Cell Proteomics. 2014 Sep;13(9):2513-26. doi: 10.1074/mcp.M113.031591. Epub 2014 Jun 17. PubMed PMID: 24942700; PubMed Central PMCID: PMC4159666;</strong></p> <p><strong>PRIDE #5412; ProteomeXchange repository PXD000279: </strong>ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/09/PXD000279</p>
Fig. 45. Canthon xanthopus Blanchard, 1846. A. Lectotype and its labels. B in A monographic revision of the Neotropical dung beetle genus Sylvicanthon Halffter & Martínez, 1977 (Coleoptera: Scarabaeidae: Scarabaeinae: Deltochilini), including a reappraisal of the taxonomic history of 'Canthon sensu lato'
Fig. 45. Canthon xanthopus Blanchard, 1846. A. Lectotype and its labels. B. An ordinary specimen.
Mass spectrometry output SILAC labelled (F/Y) biological replicate 2 - anti-HLA-A29 antibody DK1G8
<p>Mass spectrometry output from SILAC labelled (F/Y) ERAP2 WT versus (CRISPR Cas9-mediated) ERAP2-KO lymphoblastoid cell line from a Birdshot Uveitis patient (ERAP1 hap10/10 ERAP2 hapA/A). Peptides were eluted from immuno-purifications with anti-HLA-A29 antibody DK1G8. The dataset was used for subsequent filtering and differential expression analysis by <em>limma</em>. </p>
Mass spectrometry output SILAC labelled (F/Y) biological replicate 2 - anti-HLA-ABC antibody W6/32
<p>Mass spectrometry output from SILAC labelled (F/Y) ERAP2 WT versus (CRISPR Cas9-mediated) ERAP2-KO lymphoblastoid cell line from a Birdshot Uveitis patient (ERAP1 hap10/10 ERAP2 hapA/A). Peptides were eluted from immuno-purifications from HLA-A29-negative (DK1G8-negatively selected) fractions with anti-HLA-ABC antibody W6/32. The dataset was used for subsequent filtering and differential expression analysis by <em>limma</em>. </p>
Switch to second-line versus continued first-line antiretroviral therapy for patients with low-level HIV-1 viremia: an open-label randomized controlled trial in Lesotho
<p>These are pseudo-anonymised data from the SESOTHO randomised trial: "Switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL – a multicenter, parallel-group, open-label, randomized clinical study in rural Lesotho". There are two datasets, one containing baseline data (one row per participant) and one containing longitudinal viral load data (one row per participant per visit). The data dictionary explains the data available in each dataset. Between August 2017 and August 2019, 80 eligible and consenting participants were enrolled from eight health facilities in four districts of Lesotho, and followed up for nine months. The protocol was published, DOI: 10.1186/s12879-018-2979-y</p>
Five-years of ocrelizumab in relapsing multiple sclerosis: OPERA studies open-label extension
<p><b>Objective</b></p> <p>To assess over 3 years of follow-up, the effects of maintaining or switching to ocrelizumab (OCR) therapy on clinical and MRI outcomes and safety measures in the open-label extension (OLE) phase of the pooled OPERA studies in relapsing multiple sclerosis.</p> <p><b>Methods</b></p> <p>After 2 years of double-blind, controlled treatment, patients continued OCR (600 mg infusions every 24 weeks) or switched from interferon (IFN) β-1a (44 μg 3 times weekly) to OCR when entering the OLE phase (3 years). Adjusted annualized relapse rate, time to onset of 24-week confirmed disability progression/improvement (CDP/CDI), brain MRI activity (gadolinium-enhanced and new/enlarging T2 lesions), and percentage brain volume change were analyzed.</p> <p><b>Results</b></p> <p>Of patients entering the OLE phase, 88.6% completed Year 5. The cumulative proportion with 24-week CDP was lower in patients who initiated OCR earlier, vs patients initially receiving IFN β-1a (16.1% vs 21.3% at Year 5; <i>p</i>=0.014). Patients continuing OCR maintained, and those switching from IFN β-1a to OCR attained near complete and sustained suppression of new brain MRI lesion activity from Year 3 to 5. Over the OLE phase, patients continuing OCR exhibited less whole brain volume loss from double-blind study baseline vs those switching from IFN β-1a (–1.87% vs –2.15% at Year 5; <i>p</i><0.01). Adverse events were consistent with past reports and no new safety signals emerged with prolonged treatment.</p> <p><b>Conclusion</b></p> <p>Compared with patients switching from IFN β-1a, earlier and continuous OCR treatment up to 5 years provided sustained benefit on clinical and MRI measures of disease progression.</p>
Data set of labeled scenes in a barn in front of automatic milking system
<p>This data set includes supplementary files to our article \emph{"Deep learning image recognition of cow behavior near an automatic milking robot with an open data set"} (Leonardo Santiago Benitez Pereira, Olli Koskela, Ilpo Pölönen, Ilmo Aronen and Iivari Kunttu, in review, 2020). We acquired continuous video data over two-month period of cows in front of Automatic Milking Station (AMS). Each frame of the video is labeled as a single image belonging to one of classes described below.</p> <p>This data set includes 253 files of video data having in total \num{1526473} labeled frames. The data set used in the article consisted of 280 videos, but for privacy reasons, 27 video files including persons were removed from this data set, but their Java Script Object Notation (JSON) label files are left for, e.g., temporal analyses.</p>
On Transferability of Histological Tissue Labels in Computational Pathology
<p>This Zip file contains all Convolutional Neural Network (CNN) models of HistoNet trained on ADP database introduced in</p> <p><em>Hosseini et. al. “On Transferability of Histological Tissue Labels in Computational Pathology.” Accepted in the European Conference on Computer Vision (ECCV), Glasgow, UK, August 2020 </em></p> <p>For more information on the models and how to train them, please refer to <strong>https://github.com/mahdihosseini/HistoLabelTransfer</strong></p> <p> </p>
The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling
<p>Akt is a critical protein kinase that governs cancer cell growth and metabolism. Akt appears to be autoinhibited by an intramolecular interaction between its N-terminal pleckstrin homology (PH) domain and kinase domain, which is relieved by C-tail phosphorylation, but the precise molecular mechanisms remain elusive. Here we use a combination of protein semisynthesis, NMR, and enzymological analysis to characterize structural features of the PH domain in its autoinhibited and activated states. We find that Akt autoinhibition depends on the length/tension of the PH-kinase linker. We identify a role for a dynamic short segment in the PH domain that appears to regulate autoinhibition and PDK1-catalyzed phosphorylation of Thr308 in the activation loop. We determine that Akt allosteric inhibitor MK2206 drives distinct PH domain structural changes compared to baseline autoinhibited Akt. These results highlight how the conformational plasticity of Akt governs the delicate control of its catalytic properties.</p>
Labeling and tracking of immune cells in ex vivo human skin
<p>Example imaging datasets linked to the publication 'Labeling and tracking of immune cells in ex vivo human skin' (doi: 10.1038/s41596-020-00435-8).</p> <p>Additional information filenames:<br> - m = ex vivo murine skin<br> - h = ex vivo human skin<br> - mCD8= anti-murine CD8-AF594 nanobody staining (red)<br> - hCD8= anti-human CD8-AF594 nanobody staining (red)<br> - Hoechst= Hoechst 33342 staining (grey)<br> - CD1a= anti-hCD1a-AF488 staining (green)<br> - CD103= anti-hCD103-AF488 staining (green)<br> - SHG = second harmonic generation (cyan)</p> <p>Imaris x64 v9.2.0.</p>
Labeled banana bunch dataset
<p>Dataset of multiple labeled images for training a neural network.</p>
Data from: Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: two open-label, randomized, safety trials
Background: Primaquine (PQ) actively clears mature Plasmodium falciparum gametocytes but in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals can cause hemolysis. We assessed the safety of low-dose PQ in combination with artemether-lumefantrine (AL) or dihydroartemisinin-piperaquine (DP) in G6PDd African males with asymptomatic P. falciparum malaria. Methods and findings: In Burkina Faso, G6PDd adult males were randomized to treatment with AL alone (n = 10) or with PQ at 0.25 (n = 20) or 0.40 mg/kg (n = 20) dosage; G6PD-normal males received AL plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. In The Gambia, G6PDd adult males and boys received DP alone (n = 10) or with 0.25 mg/kg PQ (n = 20); G6PD-normal males received DP plus 0.25 (n = 10) or 0.40 mg/kg (n = 10) PQ. The primary study endpoint was change in hemoglobin concentration during the 28-day follow-up. Cytochrome P-450 isoenzyme 2D6 (CYP2D6) metabolizer status, gametocyte carriage, haptoglobin, lactate dehydrogenase levels and reticulocyte counts were also determined. In Burkina Faso, the mean maximum absolute change in hemoglobin was -2.13 g/dL (95% confidence interval [CI], -2.78, -1.49) in G6PDd individuals randomized to 0.25 PQ mg/kg and -2.29 g/dL (95% CI, -2.79, -1.79) in those receiving 0.40 PQ mg/kg. In The Gambia, the mean maximum absolute change in hemoglobin concentration was -1.83 g/dL (95% CI, -2.19, -1.47) in G6PDd individuals receiving 0.25 PQ mg/kg. After adjustment for baseline concentrations, hemoglobin reductions in G6PDd individuals in Burkina Faso were more pronounced compared to those in G6PD-normal individuals receiving the same PQ doses (P = 0.062 and P = 0.022, respectively). Hemoglobin levels normalized during follow-up. Abnormal haptoglobin and lactate dehydrogenase levels provided additional evidence of mild transient hemolysis post-PQ. Conclusions: Single low-dose PQ in combination with AL and DP was associated with mild and transient reductions in hemoglobin. None of the study participants developed moderate or severe anemia; there were no severe adverse events. This indicates that single low-dose PQ is safe in G6PDd African males when used with artemisinin-based combination therapy.
Sex affects immunolabeling for histone 3 K27me3 in the trophectoderm of the bovine blastocyst but not labeling for histone 3 K18ac
<p>The mammalian embryo displays sexual dimorphism in the preimplantation period. Moreover, competence of the embryo to develop is dependent on the sire from which the embryo is derived and can be modified by embryokines produced by the endometrium such as colony stimulating factor 2 (CSF2). The preimplantation period is characterized by large changes in epigenetic modifications of DNA and histones. It is possible, therefore, that effects of sex, sire, and embryo regulatory molecules are mediated by changes in epigenetic modifications. Here it was tested whether global levels of two histone modifications in the trophectoderm of the bovine blastocyst were affected by sex, sire, and CSF2. It was found that amounts of immunolabeled H3K27me3 were greater (P=0.030) for male embryos than female embryos. Additionally, labeling for H3K27me3 and H3K18ac depended upon the bull from which embryos were derived. Although CSF2 reduced the proportion of embryos developing to the blastocyst, there was no effect of CSF2 on labeling for H3K27me3 or H3K18ac. Results indicate that the blastocyst trophoctoderm can be modified epigenetically by embryo sex and paternal inheritance through alterations in histone epigenetic marks.</p>
Classifying Handedness in Chiral Nanomaterials Using Label Noise-Robust Deep Learning
<p>Images of individual Te chiral nanoparticles and labels of their handedness for classifier training.</p>
Data from: Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
<p>The lenticular fiber cells are comprised of extremely long-lived proteins while still maintaining an active biochemical state. Dysregulation of these activities has been implicated in age-related cataracts, and other lens diseases. However, the lenticular protein dynamics underlying health and disease is unclear. We sought to measure the global protein turnover rates in the eye using dietary nitrogen-15 (15N)-labeling of mice between 3 and 15 weeks of age. By performing mass spectrometry we measured the 14N- to 15N-peptide ratios of 248 lens proteins, including Crystallin, Aquaporin, Collagen and Laminin of the lens capsule, and enzymes that catalyze glycolysis as well as oxidation and reduction reactions. Unexpectedly, like the crystallin proteins, many of these enzymes are also exceedingly long-lived. The slow replacement of these enzymes in spite of young age of the mice suggests their potential roles in age-related metabolic changes in the lens.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.