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269
datasets available to search
ShareScore release 0.9.0
Dataset results
269 results for “machinery”
The regulartory role of ZCCHC24 in splicing machinery
GEO Series GSE66632. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Nucleolar Stress-inducing Compounds Influence rDNA occupancy of RNA Polymerase I Transcription Machinery
GEO Series GSE284654. Homo sapiens. 64 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Nano-immunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer’s disease treatment
GEO Series GSE285608. Mus. 15 samples. Type: Expression profiling by high throughput sequencing.
HIV-1 TAT SUPPRESSES THE TCR/CD3 MACHINERY IN HUMAN CD4+ T CELLS [Tat]
GEO Series GSE33705. Homo sapiens. 6 samples. Type: Expression profiling by array.
CDK13 phosphorylates the translational machinery and promotes tumorigenic protein synthesis
GEO Series GSE224287. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Functional splicing network reveals extensive regulatory plasticity of the core Spliceosomal machinery
GEO Series GSE56605. Homo sapiens. 18 samples. Type: Expression profiling by array.
Soluble αKlotho interacts with Hsp90aa1 to inhibit the chaperone machinery-mediated Hif1α stabilization and alleviate CKD-induced vascular calcification
GEO Series GSE280375. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcript leader elements contribute to competitive discrimination of mRNAs by the translational machinery
GEO Series GSE98788. Saccharomyces cerevisiae. 9 samples. Type: Other.
Alterations of the Sialylation Machinery in Brugada Syndrome
<p>Ghiroldi A, Ciconte G, Creo P, Tarantino A, Melgari D, D'Imperio S, Piccoli M, Cirillo F, Micaglio E, Monasky MM, Frosio A, Locati ET, Vicedomini G, Rivolta I, Pappone C, Anastasia L. Alterations of the Sialylation Machinery in Brugada Syndrome. Int J Mol Sci. 2022 Oct 29;23(21):13154. doi: 10.3390/ijms232113154. PMID: 36361941; PMCID: PMC9655504.</p> <p>Brugada Syndrome (BrS) is an inherited arrhythmogenic disorder with an increased risk of sudden cardiac death. Recent evidence suggests that BrS should be considered as an oligogenic or polygenic condition. Mutations in genes associated with BrS are found in about one-third of patients and they mainly disrupt the cardiac sodium channel NaV1.5, which is considered the main cause of the disease. However, voltage-gated channel's activity could be impacted by post-translational modifications such as sialylation, but their role in BrS remains unknown. Thus, we analyzed high risk BrS patients (<em>n</em> = 42) and healthy controls (<em>n</em> = 42) to assess an involvement of sialylation in BrS. Significant alterations in gene expression and protein sialylation were detected in Peripheral Blood Mononuclear Cells (PBMCs) from BrS patients. These changes were significantly associated with the phenotypic expression of the disease, as the size of the arrhythmogenic substrate and the duration of epicardial electrical abnormalities. Moreover, protein desialylation caused a reduction in the sodium current in an in vitro NaV1.5-overexpressing model. Dysregulation of the sialylation machinery provides definitive evidence that BrS affects extracardiac tissues, suggesting an underlying cause of the disease. Moreover, detection of these changes at the systemic level and their correlation with the clinical phenotype hint at the existence of a biomarker signature for BrS.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.