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440 results for “neuroprotection”
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
<p>Raw data for Figure 2. Readme file with info regarding the data. Zip file is about 40 GB as contains all raw images used for quantification presented in figure 2 and in supplementary 7</p>
Raw MRI imaging for "In Vivo Neuroprotection in Ischemic Stroke by Activated Protein C Requires β-Arrestin 2"
<p><span>The protease, activated protein C (APC) and its variants provide pharmacological benefits in many murine preclinical injury models, including neuroprotection for ischemic stroke and mortality reduction for sepsis.<span> </span>The <em>in vivo</em> mechanism of action for APC in ischemic stroke and sepsis injury models, similar to extensive in vitro studies using cultured cells, involves protease activated receptor (PAR) 1-mediated biased signaling. Cell culture studies showed that APC/PAR1 signaling requires β-Arrestin 2, an intracellular scaffold protein, and that β-Arrestin 2-dependent, APC-initiated signaling can distinctly alter a wide variety of intracellular signaling pathways.<span> </span>It is unclear whether <em>in vitro</em> studies can be extrapolated to <em>in vivo</em> mechanisms of action.<span> </span>This study employed a proximal transient Middle Cerebral Artery Occlusion model to study the neuroprotective actions of the signaling-selective APC variant, 3K3A-APC, in β-arrestin 2 deficient (<em>Arrb2</em><sup>-/-</sup>) mice. Based on the size and shape of brain injury areas, 3K3A-APC significantly limited brain injury in control mice to a relatively small, localized area whereas these protective effects were lost in <em>Arrb2<sup>-/-</sup></em> mice. Thus, these data indicate that the major <em>in vitro</em> mechanism of action that requires β-arrestin 2 for APC/PAR1 biased signaling is central to the <em>in vivo</em> mechanism of action for APC’s neuroprotection. </span></p>
Figure 1 from: Kokanova-Nedialkova Z, Aluani D, Tzankova V, Nedialkov P (2021) Simultaneous quantification of the major flavonoids from wild spinach by UHPLC-HRMS and their neuroprotective effects in a model of H2O2-induced oxidative stress on SH-SY5Y cells. Pharmacia 68(3): 657-664. https://doi.org/10.3897/pharmacia.68.e71030
Figure 1 A chromatogram of the standard mixture of flavonoids.
Perioperative Neuroprotection of Stellate Ganglion Block
ClinicalTrials.gov study NCT02275247. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Coenzyme Q10 for Neuroprotection in Paclitaxel-Induced Neuropathy
ClinicalTrials.gov study NCT07307911. IPD Sharing: NO. Countries: 1. Publications: 0.
Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia
ClinicalTrials.gov study NCT02621944. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neuroprotective Effect of Dexomitomidine
ClinicalTrials.gov study NCT05487742. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigating the Neuroprotective Effect of Cop-1 (Copaxone) in Acute Primary Angle Closure
ClinicalTrials.gov study NCT01936129. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Traumatic Neuroprotection and Epilepsy Prevention of Valproate Acid
ClinicalTrials.gov study NCT02027987. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Magnesium Sulfate for Fetal Neuroprotection
ClinicalTrials.gov study NCT04401852. IPD Sharing: NO. Countries: 1. Publications: 0.
NEUROprotection Via optimizINg Cerebral Blood Flow afTer cArdiaC arresT (NEURO-INTACT) Study
ClinicalTrials.gov study NCT05679739. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dexmedetomidine and Neuroprotection in Children Undergoing General Anesthesia
ClinicalTrials.gov study NCT03234660. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neuroprotectant for Hypertensive Intracerebral Hemorrhage
ClinicalTrials.gov study NCT03546283. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
ClinicalTrials.gov study NCT07181564. IPD Sharing: NO. Countries: 1. Publications: 0.
Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery
ClinicalTrials.gov study NCT07316868. IPD Sharing: YES. Countries: 1. Publications: 0.
Comparative Effectiveness of Neuroprotectants on Acute Ischemic Stroke
ClinicalTrials.gov study NCT01556854. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neuroprotective Effect of Neurotropin on Chronic OXA-induced Neurotoxicity in Stage II and Stage III CRC Patients
ClinicalTrials.gov study NCT07320950. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Functional and Neuroprotective Effects of Restoring Lower Limb Sensation After Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT04658693. IPD Sharing: NO. Countries: 1. Publications: 0.
The Neuroprotective Effect of Lamotrigine and Interferon Beta 1a in Patients With Relapsing-Remitting Multiple Sclerosis
ClinicalTrials.gov study NCT00917839. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT04518540. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.