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274
datasets available to search
ShareScore release 0.9.0
Dataset results
274 results for “phenotypic response”
Transcriptomic profiling reveals a role for pro-survival and stress responsive genes in suppressing fly parkin phenotypes.
GEO Series GSE232950. Drosophila melanogaster. 11 samples. Type: Expression profiling by high throughput sequencing.
Multiple Environmental Stressors Induce Complex Transcriptomic Responses Indicative of Phenotypic Outcomes in Western Fence Lizard
GEO Series GSE116026. Sceloporus occidentalis. 120 samples. Type: Expression profiling by array.
Concentration-response gene expression analysis in zebrafish reveals phenotypically-anchored transcriptional responses to retene
GEO Series GSE203258. Danio rerio. 32 samples. Type: Expression profiling by high throughput sequencing.
CCSER1 transcriptomic analysis reveals a role in neurodevelopmental phenotypes and alcohol response.
GEO Series GSE282155. Danio rerio. 29 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial signatures shape phenotype switching and apoptosis in response to PLK1 and RSK inhibitiors in melanoma
GEO Series GSE264686. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Phenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
GEO Series GSE35990. Entamoeba histolytica. 8 samples. Type: Expression profiling by array.
Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS differ in their dependence on the phosphorylation of the response regulator BvrR
<p><em>Brucella abortus</em> is a zoonotic pathogen whose ability to survive intracellularly at the endoplasmic reticulum is essential for its virulence. The two-component system BvrR/BvrS is essential for intracellular survival due to the transcriptional control of the type IV secretion system VirB and its transcriptional regulator VjbR. In addition, this system is a master regulator of several traits including membrane conformation by controlling proteins such as Omp25. To understand the regulatory strategies used by BvrR we generated dominant positive and negative versions of this response regulator which, in addition to the wild type version, were introduced in a BvrR- background. We then characterized BvrRS-controlled phenotypes and the expression of proteins controlled by the system. We found two regulatory patterns exerted by BvrR. The first pattern was represented by resistance to polymyxin and expression of Omp25 (membrane conformation) which were restored to normal levels by the dominant positive and the wild type version, but not the dominant negative version, of BvrR. The second pattern was represented by intracellular survival and expression of VjbR and VirB (virulence) which were, again, fully complemented by wild type and the dominant versions of BvrR but, significantly restored by complementation with the dominant negative version of the response regulator. These results suggested a differential binding of unphosphorylated BvrR with promoters of the genes it controls. We confirmed this hypothesis by showing that the dominant negative version of BvrR was not able to interact with the promoter of <em>omp25</em> but was able to interact with the promoter of <em>vjbR</em>. Furthermore, a global transcriptional analysis indicated that some genes respond to the presence of the dominant negative version of BvrR. Thus, BvrR possesses diverse strategies to exert transcriptional control on the genes it regulates and as consequence on the phenotypes controlled by this response regulator.</p> <p>Here, we include the raw count data (rawcounts.txt) for all analyzed samples, as well as the experimental designed used to perform the statistical results (target.txt).</p>
Identification of primate renal salt-responsive gene networks that differ by blood pressure phenotype
GEO Series GSE18484. Homo sapiens; Papio hamadryas. 4 samples. Type: Expression profiling by array.
Persistent Bordetella bronchiseptica carriage is associated with broad phenotypic alterations of peripheral CD4+CD25+ T cells and differentially affects immune responses to secondary non-infectious an
GEO Series GSE116913. Mus musculus. 8 samples. Type: Expression profiling by array.
Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy.
GEO Series GSE249637. Homo sapiens. 84 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by array.
Phenotype and RNA-Seq-Based Transcriptome Profiling of Staphylococcus aureus biofilms in response to Tea tree oil
GEO Series GSE85787. Staphylococcus aureus. 4 samples. Type: Expression profiling by high throughput sequencing.
Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy. [RNA-Seq]
GEO Series GSE249544. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Phenotypical states modulate sensitivity and transcriptional reprogramming in patient-derived glioblastoma cells in response to temozolomide and radiation therapy. [array]
GEO Series GSE249636. Homo sapiens. 36 samples. Type: Methylation profiling by array.
Phenotype and expression profile analysis of Staphylococcus aureus biofilms and planktonic cells in response to Licochalcone A
GEO Series GSE58938. Staphylococcus aureus. 8 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.