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294
datasets available to search
ShareScore release 0.9.0
Dataset results
294 results for “photoreceptors”
Epigenetic and transcriptional changes in aging mouse rod photoreceptors [WGBS]
GEO Series GSE134872. Mus musculus. 11 samples. Type: Methylation profiling by high throughput sequencing.
The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia.
GEO Series GSE10577. Mus musculus. 12 samples. Type: Expression profiling by array.
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina
The purpose of this study was to determine whether the spaceflight environment induces oxidative damage on ocular structure and how gene expression profiles change during spaceflight.
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress related damage in the murine retina (RR-9)
Extended spaceflight has been shown to adversely affect astronaut visual acuity. The purpose of this study was to determine whether spaceflight alters gene expression profiles and induces oxidative damage in the retina. Ten week old adult C57BL/6 male mice were flown aboard the ISS for 35 days and returned to Earth alive. Ground control mice were maintained on Earth under identical environmental conditions. Within 38 (+/−4) hours after splashdown, mice ocular tissues were collected for analysis. RNA sequencing detected 600 differentially expressed genes (DEGs) in murine spaceflight retinas, which were enriched for genes related to visual perception, the phototransduction pathway, and numerous retina and photoreceptor phenotype categories. Twelve DEGs were associated with retinitis pigmentosa, characterized by dystrophy of the photoreceptor layer rods and cones. Differentially expressed transcription factors indicated changes in chromatin structure, offering clues to the observed phenotypic changes. Immunofluorescence assays showed degradation of cone photoreceptors and increased retinal oxidative stress. Total retinal, retinal pigment epithelium, and choroid layer thickness were significantly lower after spaceflight. These results indicate that retinal performance may decrease over extended periods of spaceflight and cause visual impairment. This dataset is from the micro-computed tomography, immunostaining, and histology assays.
Single-cell gene expression profiles of hESC-derived retinal organoid progenitor cells and photoreceptor precursors from deep full-length scRNA-seq.
GEO Series GSE207824. Homo sapiens. 925 samples. Type: Expression profiling by high throughput sequencing.
Transplantation of human iPSC-derived cone photoreceptor sheets in the sub-retinal space of a minipig model of severe photoreceptor degeneration
GEO Series GSE228436. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Loss of PILRB gene at age-related macular degeneration associated PILRB/PILRA locus impairs photoreceptor function in mouse retina
GEO Series GSE264349. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Photostimulation Promotes Maturation of Human Stem Cell-Derived Photoreceptors
GEO Series GSE299921. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Retinal Gene and Protein Expression Associated with CNTF-Induced Deconstruction of Photoreceptor Outer Segments in normal and CNGB3-achromatopsia dogs
GEO Series GSE49659. Canis lupus familiaris. 20 samples. Type: Expression profiling by array.
Cellular and molecular characterisation of cone photoreceptor migration in normal and degenerate murine retinae
GEO Series GSE288930. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic adaptation prolongs photoreceptor survival during retinal degeneration
GEO Series GSE136880. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Ablating VHL in Rod Photoreceptors Modulates RPE Glycolysis and Improves Preclinical Model of Retinitis Pigmentosa
GEO Series GSE287734. Mus musculus. 17 samples. Type: Expression profiling by high throughput sequencing.
The long noncoding RNA Peanut promotes neurogenesis and rod photoreceptor differentiation during postnatal retinal development.
GEO Series GSE310182. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration
GEO Series GSE186612. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells [2w Retina]
GEO Series GSE184815. Mus musculus. 8 samples. Type: Expression profiling by array.
Knockdown of the transcription regulators Spt5 and dom in Drosophila photoreceptors results in premature retinal degeneration and transcriptional signature similar to old flies
GEO Series GSE225499. Drosophila melanogaster. 30 samples. Type: Expression profiling by high throughput sequencing.
Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells
GEO Series GSE184818. Mus musculus. 16 samples. Type: Expression profiling by array.
Mitochondrial fusion controls the development of specialized mitochondrial structure and metabolism in rod photoreceptor cells
GEO Series GSE297370. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Sox15 is a novel retinal developmental gene that promotes cone photoreceptor differentiation through inhibition of alternative rod photoreceptor fates
GEO Series GSE283880. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing.
Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells [P8 photoreceptor]
GEO Series GSE184817. Mus musculus. 8 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.