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286
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ShareScore release 0.9.0
Dataset results
286 results for “sex expression”
The gene expression of the brain/pituitary from oxt/oxtr1 homozygous mutants and WT medaka in both sexes
GEO Series GSE139158. Oryzias latipes. 18 samples. Type: Expression profiling by high throughput sequencing.
Sex-biased expression of miRNAs by microarray in critically endangered Amur sturgeon
GEO Series GSE62787. Acipenser sturio; Acipenser schrenckii. 2 samples. Type: Non-coding RNA profiling by array.
Sex-related changes in LDH-A expression differently impact on immune response in melanoma
<p><span>Marta Iozzo1, Giuseppina Comito1, Luigi Ippolito1, Giada Sandrini2, Elisa Pardella1, Erica Pranzini1,<strong> </strong>Mariaelena Capone3, Gabriele Madonna3, Paolo Antonio Ascierto3, Paola Chiarugi1, Elisa Giannoni1.</span></p> <p><span>1 Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy</span></p> <p><span>2 Institute of Oncology Research (IOR), Università della Svizzera Italiana (USI), Bellinzona, Switzerland</span></p> <p><span>3 Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131, Naples, Italy </span></p> <p> </p> <p>Abstract<br>Melanoma incidence and mortality are higher in male patients than female ones, likely associated to the sex dimorphism in immune responses. Pro- and anti-tumor immune immunity are altered by the metabolic changes occurring in the tumor microenvironment.<br>Here, we identified the lactate dehydrogenase A (LDH-A), the key enzyme deputed to the lactate production, as a crucial metabolic player discriminating sex-related melanoma immune responses both in in vitro and in patient-derived specimens. Specifically, LDH-A-associated higher lactate secretion in male melanoma cells leads to a significant enrichment in pro-tumoral regulatory T cells (Treg) with a decrease in the number and activity of anti-tumor CD8+ T cells. Remarkably, pharmacological and genetic impairment of LDH-A in male melanoma cells are able to phenocopy female ones in terms of Treg and CD8+ infiltration. In keeping, in vivo pharmacological targeting of LDH-A in melanoma-bearing male mice significantly impairs tumor growth and lung colonization, and this correlates with a concomitant modulation of Treg and CD8+ T cells infiltration. Taken together, our findings underline sex-related differences in the melanoma LDH-A-promoting immune reshaping and suggest LDH-A targeting as an effective strategy to abolish the sex-gap in melanoma progression.</p> <p> </p>
Neonatal intermittent hypoxia exposure sex-specifically augments rat microglial cytokine expression acutely and long-term
GEO Series GSE126946. Rattus norvegicus. 24 samples. Type: Expression profiling by high throughput sequencing.
Spatial Transcriptomics of C. elegans Males and Hermaphrodites Identifies Sex-Specific Differences in Gene Expression Patterns
GEO Series GSE114723. Caenorhabditis elegans. 10 samples. Type: Expression profiling by high throughput sequencing.
Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens
GEO Series GSE266315. Mus musculus. 91 samples. Type: Other.
Sex differences in the expression and function of hepatic very low-density lipoprotein receptor during protein deficiency in mice
GEO Series GSE259313. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Sex-specific gene expression in the mouse heart
GEO Series GSE4793. Mus musculus. 8 samples. Type: Expression profiling by array.
Sex-associated Early-life Innate Immune Response is Transcriptionally Regulated by Epigenetic Control of Type-I IFN-inducible Gene Expression
GEO Series GSE195836. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effect of Hyp, low phosphate diet and sex on mRNA gene expression in the mouse kidney
GEO Series GSE5243. Mus musculus. 48 samples. Type: Expression profiling by array.
Aedes aegypti sex specific gene expression
GEO Series GSE7813. Aedes aegypti. 3 samples. Type: Expression profiling by array.
Sex-linked differences in glyco-gene expression in thymocytes
GEO Series GSE27054. Homo sapiens; Mus musculus. 6 samples. Type: Expression profiling by array.
Sex-specific gene expression in the human left ventricle
GEO Series GSE4795. Homo sapiens. 8 samples. Type: Expression profiling by array.
Transcript expression analysis of Drosophila melanogaster reveals sex-specific alternative splicing of qtc gene
GEO Series GSE180626. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
Effect of cross sex hormones on gene expression in Mattek reconstructed vaginal tissue model
GEO Series GSE317796. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Sex-specific expression during asexual development of Neurospora crassa under constant light condition
GEO Series GSE26209. Neurospora crassa. 26 samples. Type: Expression profiling by array.
Sex specific gene expression patterns in cortico-limbic structures associate with psychiatric disorders
GEO Series GSE162419. Rattus norvegicus. 194 samples. Type: Expression profiling by high throughput sequencing.
Geographical and host plant influences on transcriptional variation in Drosophila mojavensis: mapping gene expression differences in both sexes
GEO Series GSE78852. Drosophila mojavensis. 127 samples. Type: Expression profiling by array.
Influence of Sex on Basal and Dickkopf-1 Regulated Gene Expression in the Bovine Morula
GEO Series GSE60098. Bos taurus. 20 samples. Type: Expression profiling by array.
Sex-specific Variation in Signaling Pathways and Gene Expression Patterns in Human Leukocytes in Response to Endotoxin and Exercise
GEO Series GSE83578. Homo sapiens. 64 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.