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663
datasets available to search
ShareScore release 0.9.0
Dataset results
663 results for “tumor targeting”
Targeting an alternate Wilms Tumor Antigen-1 peptide bypasses immunoproteasome dependency
GEO Series GSE190501. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Targeted DNA Sequencing of Circulating Tumor Cell-Enriched Samples from Stage II/III NSCLC Patients
<p>Targeted DNA sequencing of circulating tumor cell (CTC) enriched blood samples from stage II/III non-small cell lung cancer (NSCLC) patients prior to undergoing chemoradiation and immunotherapy treatment. The CTC samples were enriched using a label-free microfluidic platform, the Labyrinth. Following enrichment, the samples were fixed in 80% methanol or ethanol and stored at -80C or -20C, respectively. DNA was extracted from the samples using Qiagen's DNA/RNA AllPrep kit and submitted to the Univeristy of Michigan's Advanced Genomics Core (AGC) to perform targeted DNA sequencing using Illumina's TruSight Oncology (TSO) 500 assay. The TSO 500 assay consists of a 523 gene panel of specific oncogenes. Following sequecing, the pair-end fastq files were locally processed through the TSO 500 analysis pipeline (version: ruo-2.2.0.12) to produce the CombinedVariantOutput files per patient. Each file contains a list of all variants detected within the patient. For each variant, the following information is provided: gene name, chromosome, genomic position, reference call, alternative call, allele frequency, depth, p-dot notation, c-dot notation, consequence of variant, and the number of affected exons.</p>
Potent anti-tumor immunity and reversal of CD8 T cell exhaustion by spatially and functionally targeting Treg cells in the tumor microenvironment
<p>1×10<sup>6</sup> of splenic GFP<sup>+</sup> Tregs were purified from WT (n=4) and KO mice (n=4) via FACS isolation. RNA was extracted using RNeasy Micro Kit (Qiagen) following its standard protocol and RNA degradation and contamination was monitored on 1% agarose gels. For RNA sequencing, libraries were prepared using NEBNext® Ultra TM RNA Library Prep Kit for Illumina® (NEB, USA) following manufacturer’s recommendations and index codes were added to attribute sequences to each sample. The clustering of the index-coded samples was performed on a cBot Cluster Generation System using PE Cluster Kit cBot-HS (Illumina) according to the manufacturer’s instructions. After cluster generation, the library preparations were sequenced on an Illumina platform and paired-end reads were generated. All samples were prepared at the same time and sequenced on the same lane. Original image data file from high-throughput sequencing platforms (like Illumina) is transformed to sequenced reads (called Raw Data or Raw Reads) by CASAVA base recognition (Base Calling). Raw data in FASTQ format were processed through fastp. In this step, clean data (clean reads) were obtained by removing reads containing adapter and poly-N sequences and reads with low quality from raw data. All the downstream analyses were based on the clean data with high quality. Reference mouse genome and gene model annotation files were downloaded from genome website browser (NCBI/UCSC/Ensembl). Paired-end clean reads were mapped against the reference genome using the Spliced Transcripts Alignment to a Reference (STAR) software. FeatureCounts was used to count the read numbers mapped of each gene. And then RPKM (Reads Per Kilobase of exon model per Million mapped reads) of each gene was calculated based on the length of the gene and reads count mapped to this gene. The FPKM gene expression matrix, R code, DEG list, and targeted gene list are uploaded in this project.</p>
Prospective Collection of Tumor Biopsy and Plasma Samples From Cancer Patients Treated With Molecular Targeted Therapies or Immunotherapy
ClinicalTrials.gov study NCT03835520. IPD Sharing: NO. Countries: 1. Publications: 0.
Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment
ClinicalTrials.gov study NCT05600933. IPD Sharing: YES. Countries: 1. Publications: 0.
PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor
ClinicalTrials.gov study NCT05803746. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Application of PET Imaging Targeting CLDN18.2 in Malignant Tumors
ClinicalTrials.gov study NCT07301814. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors
ClinicalTrials.gov study NCT05518253. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study Evaluating the Activity of Anti-cancer Treatments Targeting Tumor Molecular Alterations/Characteristics in Advanced / Metastatic Tumors.
ClinicalTrials.gov study NCT04116541. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of JNJ-79032421 Targeting Mesothelin for Advanced Stage Solid Tumors
ClinicalTrials.gov study NCT06255665. IPD Sharing: YES. Countries: 1. Publications: 0.
DLL3 CAR-T Therapy Targeting Brain Tumors
ClinicalTrials.gov study NCT07180927. IPD Sharing: NO. Countries: 1. Publications: 0.
Targeted Alpha-Particle Therapy for Advanced Somatostatin Receptor Type 2 (SSTR2) Positive Neuroendocrine Tumors
ClinicalTrials.gov study NCT05636618. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
HER2 Targeted HypoSti.CAR-T Cells in HER2 Positive Advanced Solid Tumors
ClinicalTrials.gov study NCT05681650. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MMP14(MT1-MMP) Targeting Bicyclic Peptide Probe for PET Imaging in Solid Tumors
ClinicalTrials.gov study NCT06719856. IPD Sharing: NO. Countries: 1. Publications: 0.
Application of 68GA-labeled CD73 Targeting Probe PET/CT Imaging in the Diagnosis of Malignant Tumor
ClinicalTrials.gov study NCT06844110. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of a Novel Technique for the Discovery of New, Tumor-specific Targets for the Deployment of Innovative Immunotherapeutics Against Cancer.
ClinicalTrials.gov study NCT06629233. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tumor TARGET Prostate Cancer
ClinicalTrials.gov study NCT01802242. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Dual-targeting Tracer TATE-RGD for the Diagnosis of SSTR- and RGD- Positive Tumors
ClinicalTrials.gov study NCT06632860. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors
ClinicalTrials.gov study NCT06394622. IPD Sharing: NO. Countries: 1. Publications: 0.
A Tissue Collection Study in Patients Who Respond to Immune Checkpoint Inhibitors to Identify Targets of Tumor-Reactive T Cells.
ClinicalTrials.gov study NCT05230186. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.