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3,626 results for “vitamins”
Dietary Vitamin D in female rock lizards induces condition-transfer effects in their offspring
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Dietary vitamin A modifies the gut microbiota and intestinal tissue transcriptome, impacting intestinal permeability and the release of inflammatory factors, thereby influencing Aβ pathology
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Data from: An insight into vitamin E and lipid nutrition of the plains-wanderer Pedionomus torquatus
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Supplemental tables from: Antifibrogenic activities of CYP11A1-derived vitamin D3-hydroxyderivatives are dependent on RORγ
<p>Previous studies showed that non-calcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study we tested the role of RORγ, which is expressed in skin, in the action of CYP11A1-derived secosteroids using murine fibroblasts isolated from the skin of wild type (RORg<sup>+/+</sup>), knock out (RORg<sup>-/-</sup>) and heterozygote (RORg<sup>+/-</sup>) mice<span>. CYP11A1-derived </span>20(OH)D3, 20,23(OH)<sub>2</sub>D3, 1,20(OH)<sub>2</sub>D3, and 1,20,23(OH)<sub>3</sub>D3 inhibited proliferation of RORγ<sup>+/+</sup> fibroblasts in a dose-dependent manner with a similar potency to 1,25(OH)<sub>2</sub>D3. Surprisingly, this effect was reversed in RORγ<sup>+/-</sup> and RORγ<sup>-/-</sup> fibroblasts with the most pronounced stimulatory effect seen in RORγ<sup>-/-</sup> fibroblasts. All of the analogs tested inhibited TGF-β1-induced collagen synthesis in RORγ<sup>+/+</sup> fibroblasts and the expression of other fibrosis-related genes. This effect was curtailed or reversed in ROR<span>γ</span><sup>-/-</sup> fibroblasts. These results show that the antiproliferative and antifibrotic activities of the vitamin D hydroxy-derivatives are dependent on a functional RORγ. The dramatic changes in the transcriptomes of fibroblasts of RORg<sup>-/-</sup> versus wild type mice following treatment with 20(OH)D3 or 1,20(OH)<sub>2</sub>D3 provide a molecular basis to explain, at least in part, the observed phenotypic differences</p>
Sphingolipid serum profiling in vitamin D deficient and dyslipidemic obese dimorphic adults
<p>Recent studies on Saudi Arabians indicate a prevalence of dyslipidemia and vitamin D deficiency (25(OH)D) in both normal weight and obese subjects. In the present study the sphingolipid pattern was investigated in 23 normolipidemic normal weight (NW), 46 vitamin D deficient dyslipidemic normal weight (-vitDNW) and 60 vitamin D deficient dyslipidemic obese (-vitDO) men and women by HPTLC-primuline profiling and LC-MS analyses. Results indicate higher levels of total ceramide (Cer) and dihydroceramide (dhCers C18–22) and lower levels of total sphingomyelins (SMs) and dihydrosphingomyelin (dhSM) not only in -vitDO subjects compared to NW, but also in –vitDNW individuals. A dependency on body mass index (BMI) was observed analyzing specific Cer acyl chains levels. Lower levels of C20 and 24 were observed in men and C24.2 in women, respectively. Furthermore, LC-MS analyses display dimorphic changes in NW, -vitDNW and –vitDO subjects. In conclusion, LC-MS data identify the independency of the axis high Cers, dhCers and SMs from obesity <em>per se</em>. Furthermore, it indicates that long chains Cers levels are specific target of weight gain and that circulating Cer and SM levels are linked to sexual dimorphism status and can contribute to predict obese related co-morbidities in men and women.</p>
Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+, K+- ATPase-related neurologic disorders
<p><strong><span><span><span><span><span><span><span><span><span><span><span>Raw data, a2Ca3-dKO phenotype and dystonic spell of a3-HT</span></span></span></span></span></span></span></span></span></span></span></strong></p> <p><strong><span><span><span><span><span><span><span><span><span><span><span>We found brain haemorrhage phenotype of Atp1a2 and Atp1a3 doule knockout (α2α3-dKO) foetuses. Here we present two kinds of α2α3-dKO line, α2-Nα3-dKO andα2-Cα3-dKO, both show brain haemorrhage upon birth. They were similar to that of homozygous knockout of the gene encoding ascorbic acid (ASC orNvitamin C) transporter, SVCT2 (SVCT2-KO). We made SVCT2-knockout mouse line by CRIPR/CAS9 method. We present SVCT2-KO, showing brain hemorrage as α2α3-dKO. The α2α3-dKO and SVCT2-KO brain showed significantly decreased level of ASC compared with the wild-type (WT) and single knockout (here, raw data). We found that the ASC content in the basal ganglia and cerebellum was significantly lower in the adult <i>Atp1a3 </i>heterozygous knockout mouse (α3-HT) than in the WT (here, raw data). We did not observe increased oxidative stress in them (here raw data). Interestingly, we observed a significant decrease in the ASC level in the basal ganglia and cerebellum of α3-HTin the peripartum period, during which mice are under physiological stress(here, raw data). Here, we show dystonic spell of α3-HT in peripartum. These observations indicate that the α2 and α3 subunits independently contribute to the ASC level in the foetal brain and that the α3 subunit contributes to ASC transport in the adult basal ganglia and cerebellum. We propose that decreases in ASC levels may affect neural network development and are linked to the pathophysiology of <i>ATP1A2- </i>and <i>ATP1A3</i>-related neurologic disorders.</span></span></span></span></span></span></span></span></span></span></span></strong></p>
Effect of vitamin D supplementation in patients with chronic hepatitis C after direct-acting antiviral treatment: a randomized, double-blind, placebo-controlled trial
<p><b>Background: </b>Replacement of vitamin D (VD) among patients with chronic hepatitis C (CHC) before viral eradication has demonstrated a protective effect on serum markers associated with hepatic fibrogenesis. We therefore hypothesized that VD may facilitate further fibrosis amelioration following curative treatment with direct-acting antivirals (DAA). </p> <p><b>Methods: </b>This study was a randomized, double-blind, placebo-controlled trial conducted between February 2018 and August 2018. Patients with CHC and VD deficiency were randomized in a 1:1 ratio to either receive ergicalciferol or placebo over 6 weeks. Biochemical analysis indicators, including 25-hydroxyvitamin D (25(OH)D), fibrogenic markers [(transforming growth factor beta 1 (TGF-β1) and tissue inhibitors of matrix metalloproteinases 1 (TIMP-1)], and fibrolytic markers [matrix metalloproteinase 9 (MMP-9) and amino terminal type III procollagen peptide (P3NP)], were assessed at baseline and at 6 weeks. Serum 25(OH)D was analyzed by a chemiluminescence immunoassay. Serum hepatic fibrogenesis markers were measured using a quantitative sandwich enzyme-linked immunosorbent assay.</p> <p><b>Results: </b>Seventy-five patients with CHC and VD deficiency were randomly assigned to VD (n=37) and placebo (n=38) groups. At the end of the study, the mean serum 25(OH)D level had risen to a normal level in the VD group, but was still deficient in the placebo group (41.8±9.1 vs. 18.1±4.6 ng/mL, p<0.001). Upon restoration of the VD level, there were no significant mean differences in the change from baseline for TGF-β1 (-0.6 ng/mL (95% confidence interval (95%CI) -2.8 – 1.7), p=0.63), TIMP-1 (-5.5 ng/mL (95%CI -26.4 – 15.3), p=0.60), MMP-9 (122.9 ng/mL (95%CI -69.0 – 314.8), p=0.21), and P3NP (-0.1 ng/mL (95%CI -2.4 – 2.2), p=0.92) between the VD and placebo groups. </p> <p><b>Conclusion: </b>Short-term VD supplementation after DAA treatment in patients with CHC does not improve serum fibrogenesis markers and may not expedite the residual liver fibrosis healing process. Future studies are warranted to evaluate the long-term effect of VD supplementation on hepatic fibrosis regression.</p>
Data from: Vitamin D receptor gene expression and function in a South African population: ethnicity, vitamin D and FokI
Polymorphisms of the vitamin D receptor gene (VDR) have been associated inconsistently with various diseases, across populations of diverse origin. The T(f) allele of the functional SNP FokI, in exon 2 of VDR, results in a longer vitamin D receptor protein (VDR) isoform, proposed to be less active. Genetic association of VDR with disease is likely confounded by ethnicity and environmental factors such as plasma 25(OH)D3 status. We hypothesized that VDR expression, VDR level and transactivation of target genes, CAMP and CYP24A1, depend on vitamin D, ethnicity and FokI genotype. Healthy volunteers participated in the study (African, n = 40 and White, n = 20). Plasma 25(OH)D3 levels were quantified by LC-MS and monocytes cultured, with or without 1,25(OH)2D3. Gene expression and protein level was quantified using qRT-PCR and flow cytometry, respectively. Mean plasma 25(OH)D3 status was normal and not significantly different between ethnicities. Neither 25(OH)D3 status nor 1,25(OH)2D3 supplementation significantly influenced expression or level of VDR. Africans had significantly higher mean VDR protein levels (P<0.050), nonetheless transactivated less CAMP expression than Whites. Genotyping the FokI polymorphism by pyrosequencing together with HapMap data, showed a significantly higher (P<0.050) frequency of the CC genotype in Africans than in Whites. FokI genotype, however, did not influence VDR expression or VDR level, but influenced overall transactivation of CAMP and 1,25(OH)2D3-elicited CYP24A1 induction; the latter, interacting with ethnicity. In conclusion, differential VDR expression relates to ethnicity, rather than 25(OH)D3 status and FokI genotype. Instead, VDR transactivation of CAMP is influenced by FokI genotype and, together with ethnicity, influence 1,25(OH)2D3-elicited CYP24A1 expression. Thus, the expression and role of VDR to transactivate target genes is determined not only by genetics, but also by ethnicity and environment involving complex interactions which may confound disease association.
Data from: Vitamin D status among Thai school children and the association with 1,25-dihydroxyvitamin D and parathyroid hormone levels
In several low latitude countries, vitamin D deficiency is emerging as a public health issue. Adequate vitamin D is essential for bone health in rapidly growing children. In the Thai population, little is known about serum 25-hydroxyvitamin D [25(OH)D] status of infants and children. Moreover, the association between 25(OH)D and the biological active form of 1,25-dihydroxyvitamin D [1,25(OH)]2D is not clear. The specific aims of this study were to characterize circulating serum 25(OH)D, 1,25(OH)2D and their determinants including parathyroid hormone (PTH), age, sex, height and body mass index (BMI) in 529 school-aged Thai children aged 6–14 y. Adjusted linear regression analysis was performed to examine the impact of age and BMI, and its interaction with sex, on serum 25(OH)D concentrations and 1,25(OH)2D concentrations. Serum 25(OH)D, 1,25(OH)2D and PTH concentrations (geometric mean ± geometric SD) were 72.7±1.2 nmol/L, 199.1±1.3 pmol/L and 35.0±1.5 ng/L, respectively. Only 4% (21 of 529) participants had a serum 25(OH)D level below 50 nmol/L. There was statistically significant evidence for an interaction between sex and age with regard to 25(OH)D concentrations. Specifically, 25(OH)D concentrations were 19% higher in males. Moreover, females experienced a statistically significant 4% decline in serum 25(OH)D levels for each increasing year of age (P = 0.001); no decline was seen in male participants with increasing age (P = 0.93). When BMI, age, sex, height and serum 25(OH)D were individually regressed on 1,25(OH)2D, height and sex were associated with 1,25(OH)2D with females exhibiting statistically significantly higher serum 1,25(OH)2D levels compared with males (P<0.001). Serum 1,25(OH)2D among our sample of children exhibiting fairly sufficient vitamin D status were higher than previous reports suggesting an adaptive mechanism to maximize calcium absorption.
Vitamin D Deficiency and Pregnancy Outcome: A longitudinal Interventional Study
<p><strong><u><span>ABSTRACT</span></u></strong><span>:</span></p> <p><strong><span>Introduction:</span></strong><span> <span>Vitamin D is a fat-soluble vitamin responsible for increasing the absorption of calcium, magnesium, phosphate, and multiple other biological effects. Deficiency of vitamin D is a common global problem, especially in females. It is naturally produced by the body on exposure to sunlight. Deficiency of vitamin D in pregnancy predisposes to pre-eclampsia, GDM, preterm birth to the mother, hypocalcemic tetany, low birth weight, and congenital rickets in the fetus. In general, 10 (400) units of vitamin D are recommended for all pregnant women per day.</span></span><span> <strong><span>Materials and methods:</span></strong> The study was conducted in the OBGY department of MGM Medical College, Aurangabad, Maharashtra, between August 2022 to August 2023. A complete procedure was explained to all the second-trimester pregnant women willing to participate in this study, and informed written consent was obtained from them. Their detailed history was taken and subjected to an estimation of 25 hydroxyvitamin D and serum calcium. <strong><span>Results:</span></strong> A high prevalence of vitamin D deficiency is found (81%). In teenage pregnancy, the occurrence of vitamin D deficiency is higher. In our study, vitamin D deficiency was more prevalent in rural areas thanurban areas. It was more in the Muslim population. A sedentary life is prone to vitamin D deficiency. The incidence of GDM, pre-eclampsia, and low birth weight was significantly lower in tested and treated patients. Empirical vitamin D supplementation should be given to each pregnant patient.</span></p> <p><strong><em><span> </span></em></strong></p> <p><strong><em><span>Keywords: GDM, Preeclampsia, prevalence, teenage pregnancy, low birth weight.</span></em></strong></p> <p><span> </span></p>
A comparative study between Vitamin K1 and K2 on vascular calcification in hemodialysis patients: a randomized controlled trial
<p><span><span><strong>Background: </strong>Vascular calcification is a common complication of end stage renal disease patients, an important cause of cardiovascular disease and all-cause mortality. Vitamin K is essential for the activation of matrix Gla protein (MGP), a powerful inhibitor of tissue calcification. Different forms of vitamin K have been proposed to have a good impact on vascular calcification. However, clinical data are still limited on efficacy and safety of different forms of vitamin K.</span></span></p> <p><span><span><strong>Methods : </strong>A prospective, randomized, placebo-controlled study that included 120 eligible hemodialysis patients who were randomly assigned to either vitamin k1 group (10 mg phytomenadione thrice weekly) or vitamin k2 group (90 ug daily) or placebo group for 3 months. Serum MGP, calcium, phosphorus, their product, and intact parathyroid hormone (iPTH) levels, were all assessed at baseline and at the end of the study.</span></span></p> <p><span><span><b>Results:</b> There were significant increase in percentages of change in MGP levels in Vitamin k2 group (700%) compared to (78%) in Vitamin k1 & (40%) in placebo groups. No correlations observed between calcium, phosphorous and PTH and MGP levels at baseline or after treatment. None of the treatment group patients experienced any adverse effects.</span></span></p> <p><span><span><strong>Conclusion: </strong>Vitamin k supplementation was tolerable and effective with k2 form showing superiority over k1 in their impact on MGP levels among hemodialysis patients.</span></span></p> <p><span><span><b>ClinicalTrials.gov registration number:</b><b> NCT04477811</b><b>.</b></span></span></p> <p><span><span> </span></span></p>
The dose makes the poison: feeding of antibiotic-treated winter honey bees, Apis mellifera, with probiotics and b-vitamins
<div> <p><span>Honey stores of </span><em><span>Apis mellifera</span></em><span> colonies are replaced with sugar water by beekeepers, which may result in malnutrition. Nutritional supplements have been developed, but the importance of bacterial probiotics and vitamins is poorly understood. Given that supplementary feeding with vitamins and probiotics enhances worker weight and longevity, this would suggest a feasible approach to mitigate winter colony losses. Here, we conducted a laboratory hoarding cage study with freshly emerged winter bees, which were treated with the antibiotic tetracycline to reduce gut bacteria and subsequently assigned to feeding regimes: sucrose only, sucrose + pollen, probiotics (low and high dosage), probiotics + pollen (low and high dosage), or b-vitamins (low and high dosage), (N=8 treatments, 29 workers/cage x8 replicates). In parallel, controls remained on their frame (=Frame) to establish their gut microbiota and were subsequently fed with sucrose only or sucrose + pollen (N=2 treatments, 29 workers/cage x4 replicates). Higher body weights were found in workers fed pollen, and in notably the Frame Sucrose + Pollen group, confirming a role of gut bacteria in protein digestion. Furthermore, both Frame groups and the antibiotic-treated workers fed with probiotic low + pollen survived longer than all other groups, highlighting an inherent host-microbial relationship. In contrast, high dosages of both probiotic and b-vitamins significantly reduced life span compared to their low concentration counterparts, probably due to dysbiosis and toxicity, suggesting that the outcome was dose-dependent. These results highlight that bacterial supplementation can alter longevity with advisable caution since harmful concentrations appear to exist.</span> </p> </div>
Dataset of skin pigmentation related variants and interaction effects on serum vitamin D
<p>This dataset contains all SNPs-gene and phenotype analyzed in article <span><span><span>entitled</span></span></span> "<em>Skin pigmentation related variants in Mexican population and interaction effects on serum 25(OH)D concentration and vitamin D deficiency</em>".</p> <p> </p>
Do all infants need vitamin D supplementation?
<p>A high prevalence of vitamin D deficiency (VDD) in children has been observed worldwide, but there are few studies on the nutritional status of vitamin D (VD) in healthy infants. The main cause of deficiency in healthy children is breastfeeding without supplementation and lack or insufficiency of sun exposure. The aims of this study were to determine serum concentrations of 25(OH)D and verify its association with parathyroid hormone (PTH) concentrations and use of VD supplementation in healthy infants aged ≥ 6 to ≤ 24 months attended at two Primary Health Care Units in Ribeirão Preto city, São Paulo, Brazil. A cross-sectional, observational and analytical study was performed in which serum concentrations of 25(OH)D, PTH, alkaline phosphatase (AP), calcium (Ca), phosphorus (P) and albumin were determined in 155 healthy infants. Information on sun exposure, sociodemographic aspects of mothers and clinical and nutritional characteristics of infants were obtained through interviews with responsible infants’s legal representatives. Ten infants (6%) presented deficient 25(OH)D serum concentration (≤20ng/ml) and 46 (30%), insufficient (21 to 29ng/ml). No changes in serum P, Ca and albumin concentrations were detected. Only one infant had an increase in PTH serum concentrations. 35% (55/155) of infants had high AP e 40% (22/55) presented insufficient serum concentrations of 25(OH)D but none presented deficient ones. There was a weak association between serum concentrations of 25(OH)D and PTH and an association between serum concentrations of 25(OH)D and P when adjusted for sex, age and BMI. There were no associations between inadequate serum concentrations of 25(OH)D (deficient ou insufficient), sun exposure and VD supplementation. This study found a low prevalence of deficient 25(OH)D serum concentration and high prevalence of insufficient ones which was not associated with changes in serum PTH, AP, P, Ca and albumin concentrations, VD supplementation and the formula volume intake.</p>
Factors associated with vitamin D levels in Mongolian patients with multiple sclerosis
<p>Data to reproduce the results included in the manuscript "<span>Factors </span><span>a</span><span>ssociated with </span><span>v</span><span>itamin D </span><span>l</span><span>evels in Mongolian </span><span>p</span><span>atients with </span><span>m</span><span>ultiple </span><span>s</span><span>clerosis"</span></p>
Enhancement of vitamin B6 production driven by omics analysis combined with fermentation optimization
<p>Transcriptome analysis of the mutant strain E. coli in response to PN overproduction from 6 h to 16 h;</p> <p>Metabolic analysis of the mutant strain E. coli in response to PN overproduction between the early and late stages of fermentation</p>
Underlying data for In vivo assessment of the relationship between oral lichen planus and antioxidant status of vitamins A, C, and E in diabetic and hypertensive patients: An observational study
<p>Underlying data for In vivo assessment of the relationship between oral lichen planus and antioxidant status of vitamins A, C, and E in diabetic and hypertensive patients: An observational study</p>
STROBE checklist for: In vivo assessment of the relationship between oral lichen planus and antioxidant status of vitamins A, C, and E in diabetic and hypertensive patients: An observational study
<p>STROBE checklist for: In vivo assessment of the relationship between oral lichen planus and antioxidant status of vitamins A, C, and E in diabetic and hypertensive patients: An observational study</p>
Measurement of renal failure biomarkers for the: Nephroprotective Effect of Vitamin D Against Levofloxacin-Induced Renal Injury: an observational study
<p>Measurement of renal failure biomarkers for the: Nephroprotective Effect of Vitamin D Against Levofloxacin-Induced Renal Injury: an observational study</p>
The ARRIVE Essential 10: author checklist – Nephroprotective Effect of Vitamin D Against Levofloxacin-Induced Renal Injury: an observational study.
<p>The ARRIVE Essential 10: author checklist – Nephroprotective Effect of Vitamin D Against Levofloxacin-Induced Renal Injury: an observational study.</p>
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