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5,225 results for “volunteers”
Single-center, double-blind, randomized, placebo-controlled, single andmultiple dose escalation study to assess safety and tolerability and pharmacokinetics of HRX215 in healthy male volunteers under food and fasting conditions
<p><a name="_Hlk123284665"></a><a name="_Hlk135557103"></a><span><span>Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. </span></span><span><span>Therapies to restore hepatocyte regeneration are lacking, making liver transplantation the only curative option for end stage liver disease. We here report on the structure-based development and characterization (NMR-spectroscopy) of first-in-class small molecule inhibitors of the dual specific kinase MKK4 (MKK4i). MKK4i increased liver regeneration upon hepatectomy in murine and porcine models, allowed for survival of pigs in a lethal 85% hepatectomy model and showed antisteatotic and antifibrotic effects in liver disease mouse models. A first-in-human phase I trial (EudraCT 2021-000193-28) with the clinical candidate HRX215 was conducted and revealed excellent safety and pharmacokinetics. Clinical trials to probe HRX215 for prevention/treatment of liver failure after extensive oncological liver resections or after transplantation of small grafts are warranted.</span></span></p>
Recordings of aquatic macroinvertebrates by volunteers (2018-2020) and professionals (2013-2019) in the Netherlands
<p>Volunteers have become more and more involved in monitoring the quality of the environment in which they live. Traditionally, water quality monitoring is the field of professionals at water authorities, however, community initiatives have been undertaken to monitor abiotic conditions in waterbodies. To date, biological water quality assessment based on data collected by volunteers remains scarce. A citizen science project on biological water quality assessment was launched in the Netherlands in 2018. In this project, volunteers collect macroinvertebrates from in a nearby waterbody, identify and count the number of specimens, and register their catch through a web portal to instantaneously receive a water quality score based on their data. This study compares the data from the volunteers with the data from professionals focussing on type of sampled waterbody, sampling period, observed animals and water quality.</p> <p>The analyses show that volunteers and professionals seldomly sample the same waterbody, that there is some overlap in sampling period, and that volunteers more frequently sampled smaller water bodies and more urban waters. The citizen science project is thus yielding useful spatially and temporally complementarity data. The assessments by volunteers and professionals likely differ in character and thoroughness. Volunteers collected significantly lower numbers of animals per sample and fewer animals from soft sediments but more mobile individuals from the open water column. As a result, the water quality scores between volunteers and professionals differ. To bridge these differences, new tools and processes may need to be developed to further increase the value of monitoring biological water quality by volunteers for professionals.</p>
Supplementary material 3 from: Anđelković AA, Lawson Handley L, Marchante E, Adriaens T, Brown PMJ, Tricarico E, Verbrugge LNH (2022) A review of volunteers' motivations to monitor and control invasive alien species. NeoBiota 73: 153-175. https://doi.org/10.3897/neobiota.73.79636
List of recommendations for designing projects to ensure maximum recruitment and volunteer retention extracted from the studies used in the analysis (for their full references, please see Suppl. material 1) and their link to our recommendations
Volunteer
<p>The Volunteer dataset includes 2038 volunteers, categorized into 5 classes (alleviation, emergency, environment, neighborhood, and training), with each volunteer's information consisting of two different text segments. This dataset could be used for machine learning jobs such as clustering and classification. We also provided the code to transform the text to vectors for your reference.</p>
Involving Volunteers in Citizen Science: tips for Researchers
<div> <div> <div> <div> </div> </div> </div> </div> <div>The video introduces researchers to the possibilities of recruiting volunteers for citizen science projects.</div>
Data from: Time-lapse imagery and volunteer classifications from the Zooniverse Penguin Watch project
Automated time-lapse cameras can facilitate reliable and consistent monitoring of wild animal populations. In this report, data from 73,802 images taken by 15 different Penguin Watch cameras are presented, capturing the dynamics of penguin (Spheniscidae; Pygoscelis spp.) breeding colonies across the Antarctic Peninsula, South Shetland Islands and South Georgia (03/2012 to 01/2014). Citizen science provides a means by which large and otherwise intractable photographic data sets can be processed, and here we describe the methodology associated with the Zooniverse project Penguin Watch, and provide validation of the method. We present anonymised volunteer classifications for the 73,802 images, alongside the associated metadata (including date/time and temperature information). In addition to the benefits for ecological monitoring, such as easy detection of animal attendance patterns, this type of annotated time-lapse imagery can be employed as a training tool for machi ne learning algorithms to automate data extraction, and we encourage the use of this data set for computer vision development.
Brain MR Fingerprinting data of 5 volunteers
<p>Data of brain acquisitions using MR Fringerpringing [1] and reconstructed with an in-house implemented low-rank algorithm. Each .zip file contains the acquisitions of one volunteer on the same weekday during 8 consecutive weeks. The data is provided as MatLab (Mathworks, Natick MA) files. The files have the reconstructed series compressed in time (using SVD compression) and the compression matrix needed to obtain the full-time series reconstruction. A MatLab script is provided to obtain the full-time series from the compressed data.</p> <p><strong>This work was funded by a Research Grant from GE(B-GEHC-05)</strong></p> <p>[1]<a href="https://www.zotero.org/google-docs/?1R2bHF">Jiang Y, Ma D, Seiberlich N, Gulani V, Griswold MA. MR fingerprinting using fast imaging with steady state precession (FISP) with spiral readout. Magnetic Resonance in Medicine 2015;74:1621–31. https://doi.org/10.1002/mrm.25559.</a></p> <p> </p>
Ceftriaxone and Cefotaxime Have Similar Effects on the Intestinal Microbiota in Human Volunteers
<p><strong>Pour ce TP, nous allons déterminer l’impact d’un traitement à la ceftriaxone sur la flore intestinale (<a href="https://aac.asm.org/content/63/6/e02244-18.abstract">https://aac.asm.org/content/63/6/e02244-18.abstract</a>). 22 volontaires sains ont reçu par intraveineuse de la ceftriaxone (1g / 24 h) ou de la cefotaxime ( 1g / 8h) pendant 3 jours. Le consortium CEREMI a collecté des échantillons de selles de ces volontaires et réalisé une étude de métagénomique ciblée sur le gène 16S rRNA. En raison des limitations de vos machines, nous allons analyser les échantillons du groupe B uniquement à 2 temps: Jm1 (un jour avant le traitement) et J4</strong></p>
Study to Assess Adverse Events and Compare How Crushed, Ground, and Intact Oral Tablets Venetoclax Moves Through the Body of Healthy Female Adult Volunteers
ClinicalTrials.gov study NCT05909553. IPD Sharing: NO. Countries: 1. Publications: 1.
Study to Assess Adverse Events and Compare How Oral Ubrogepant and Oral Atogepant Moves Through the Body of Healthy Female Adult Volunteers
ClinicalTrials.gov study NCT05892757. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study To Evaluate The Effect Of Itraconazole On Pharmacokinetics Of PF-06463922 In Healthy Volunteers
ClinicalTrials.gov study NCT02838264. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
ClinicalTrials.gov study NCT03104387. IPD Sharing: NO. Countries: 1. Publications: 15.
A First in Human, Dose Escalation Study to Evaluate the Safety and Tolerability of BBP-671 in Healthy Volunteers and Patients With Propionic Acidemia or Methylmalonic Acidemia
ClinicalTrials.gov study NCT04836494. IPD Sharing: NO. Countries: 1. Publications: 1.
Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge
ClinicalTrials.gov study NCT02639299. IPD Sharing: NO. Countries: 1. Publications: 1.
Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for the Characterization of Volatolome in Clinical Studies
ClinicalTrials.gov study NCT06020521. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Dose Response of Prednisone on Biochemical and Clinical Makers in Adult Healthy Volunteers
ClinicalTrials.gov study NCT02767089. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Multiple Dose FSH-GEX(TM) in Healthy Volunteers
ClinicalTrials.gov study NCT01477073. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Safety, Tolerability, and Pharmacokinetics of REGN3470-3471-3479 in Healthy Adult Volunteers
ClinicalTrials.gov study NCT02777151. IPD Sharing: NO. Countries: 1. Publications: 1.
Non-invasive Neurally Adjusted Ventilatory Assist in Healthy Volunteers
ClinicalTrials.gov study NCT00941044. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers
ClinicalTrials.gov study NCT01082484. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.