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3,878 results for “Molecular Data”
Data from: Development and evaluation of a fluorescent antibody-drug conjugate for molecular imaging and targeted therapy of pancreatic cancer
Antibodies are widely available and cost-effective research tools in life science, and antibody conjugates are now extensively used for targeted therapy, immunohistochemical staining, or in vivo diagnostic imaging of cancer. Significant advances in site-specific antibody labeling technologies have enabled the production of highly characterized and homogenous conjugates for biomedical purposes, and some recent studies have utilized site-specific labeling to synthesize bifunctional antibody conjugates with both imaging and drug delivery properties. While these advances are important for the clinical safety and efficacy of such biologics, these techniques can also be difficult, expensive, and time-consuming. Furthermore, antibody-drug conjugates (ADCs) used for tumor treatment generally remain distinct from conjugates used for diagnosis. Thus, there exists a need to develop simple dual-labeling methods for efficient therapeutic and diagnostic evaluation of antibody conjugates in pre-clinical model systems. Here, we present a rapid and simple method utilizing commercially available reagents for synthesizing a dual-labeled fluorescent ADC. Further, we demonstrate the fluorescent ADC's utility for simultaneous targeted therapy and molecular imaging of cancer both in vitro and in vivo. Employing non-site-specific, amine-reactive chemistry, our novel biopharmaceutical theranostic is a monoclonal antibody specific for a carcinoembryonic antigen (CEA) biomarker conjugated to both paclitaxel and a near-infrared (NIR), polyethylene glycol modified (PEGylated) fluorophore (DyLight™ 680-4xPEG). Using in vitro systems, we demonstrate that this fluorescent ADC selectively binds a CEA-positive pancreatic cancer cell line (BxPC-3) in immunofluorescent staining and flow cytometry, exhibits efficient internalization kinetics, and is cytotoxic. Model studies using a xenograft of BxPC-3 cells in athymic mice also show the fluorescent ADC's efficacy in detecting tumors in vivo and inhibiting tumor growth more effectively than equimolar amounts of unconjugated drug. Overall, our results demonstrate that non-selective, amine-targeting chemistry is an effective dual-labeling method for synthesizing and evaluating a bifunctional fluorescent antibody-drug conjugate, allowing concurrent detection, monitoring and treatment of cancer.
Data from: State-space reduction and equivalence class sampling for a molecular self-assembly model
Direct simulation of a model with a large state space will generate enormous volumes of data, much of which is not relevant to the questions under study. In this paper, we consider a molecular self-assembly model as a typical example of a large state-space model, and present a method for selectively retrieving 'target information' from this model. This method partitions the state space into equivalence classes, as identified by an appropriate equivalence relation. The set of equivalence classes H, which serves as a reduced state space, contains none of the superfluous information of the original model. After construction and characterization of a Markov chain with state space H, the target information is efficiently retrieved via Markov chain Monte Carlo sampling. This approach represents a new breed of simulation techniques which are highly optimized for studying molecular self-assembly and, moreover, serves as a valuable guideline for analysis of other large state-space models.
Data from: Phylogeny of digitaria sections Trichachne and Trichophorae (Poaceae, Panicoideae, Paniceae): a morphological and molecular analysis. New circumscription and synopsis
The present study provides evidence for taxonomic delimitation of Digitaria sect. Trichachne based on morphological data (micro- and macromorphology) and molecular data. A phylogenetic analysis was performed using 121 morphological characters and ITS sequences of 22 species and one variety of Digitaria plus three outgroups. In all topologies (based on morphological, molecular, and combined data) Digitaria sect. Trichophorae was non-monophyletic and nested within D. sect. Trichachne. Digitaria sect. Trichophorae is thus synonymized under D. sect. Trichachne and the circumscription of D. sect. Trichachne is emended. Diagnostic morphological characters related to spikelet structure are described and documented with SEM. A key to taxa belonging to D. sect. Trichachne is provided, as well as a synopsis including synonymy, iconography, geographical distribution, and ecology. The neotype of Trichachne sacchariflora Nees is herein designated. Complete illustrations of Digitaria eggersii, D. hitchcockii, and D. patens are provided. The phylogenetic placement of the Australian species D. brownii differed among trees resulting from different data sets, thus it is provisionally not included in D. sect. Trichachne in spite of its morphological similarity. Furthermore, Megaloprotachne albescens is formally transferred to Digitaria, as Digitaria albescens .
FIGURE 22 in Morphological and molecular data reveal the cryptic diversity among populations of Aegla paulensis (Decapoda, Anomura, Aeglidae), with descriptions of four new species and comments on dispersal routes and conservation status
FIGURE 22. Dorsal view of Aegla jundiai n. sp., female holotype (MZUSP 13493). Bar = 2.0 mm.
FIGURE 20 in Morphological and molecular data reveal the cryptic diversity among populations of Aegla paulensis (Decapoda, Anomura, Aeglidae), with descriptions of four new species and comments on dispersal routes and conservation status
FIGURE 20. Dorsal view of Aegla jaragua n. sp., male holotype (MZUSP 34376). Bar = 3.0 mm.
FIGURE 18 in Morphological and molecular data reveal the cryptic diversity among populations of Aegla paulensis (Decapoda, Anomura, Aeglidae), with descriptions of four new species and comments on dispersal routes and conservation status
FIGURE 18. Dorsal view of Aegla japi n. sp., male holotype (MZUSP 34374). Bar = 3.0 mm.
FIGURE 16 in Morphological and molecular data reveal the cryptic diversity among populations of Aegla paulensis (Decapoda, Anomura, Aeglidae), with descriptions of four new species and comments on dispersal routes and conservation status
FIGURE 16. Dorsal view of Aegla vanini n. sp., male holotype (MZUSP 34371). Bar = 3.0 mm.
FIGURE 6 in Kakadudessus tomweiri, a new genus and species of diving beetle from tropical northern Australia, based on molecular phylogenetic and morphological data (Coleoptera, Dytiscidae, Bidessini)
FIGURE 6. Kakadudessus tomweiri sp.n., distribution.
FIGURE 5 in A new frog of the genus Pristimantis (Amphibia: Strabomantidae) from the high Andes of Southeastern Ecuador, discovered using morphological and molecular data
FIGURE 5. Oscillogram and sonagram of the advertisement call of Pristimantis bambu (QCAZ 47558).
FIGURE 1 in A new frog of the genus Pristimantis (Amphibia: Strabomantidae) from the high Andes of Southeastern Ecuador, discovered using morphological and molecular data
FIGURE 1. Adult male holotype of Pristimantis bambu, QCAZ 46740, SVL 20.0 mm.
FIGURE 5 in Description of a new species of the genus Xenophrys Günther, 1864 (Amphibia: Anura: Megophryidae) from Mount Jinggang, China, based on molecular and morphological data
FIGURE 5. Habitat of X. jinggangensis at the type locality. Photo Jian Zhao on 5 December 2011.
FIGURE 3 in Pachybrachis holerorum (Coleoptera: Chrysomelidae: Cryptocephalinae), a new species from the Apennines, Italy, identified by integration of morphological and molecular data
FIGURE 3. Pachybrachis holerorum Montagna & Sassi, dorso-lateral view.
FIGURE 6 in A revision of the genus Conicofrontia Hampson (Lepidoptera, Noctuidae, Apameini, Sesamiina), with description of a new species: new insights from morphological, ecological and molecular data
FIGURE 6. Distribution map of sampled Conicofrontia and Hygrostola specimens.
FIGURE 1 in A revision of the genus Conicofrontia Hampson (Lepidoptera, Noctuidae, Apameini, Sesamiina), with description of a new species: new insights from morphological, ecological and molecular data
FIGURE 1. Adults of Conicofrontia species (C. bipartita and C. diamesa). Scale bar = 10 mm.
FIGURE 2 in A revision of the genus Conicofrontia Hampson (Lepidoptera, Noctuidae, Apameini, Sesamiina), with description of a new species: new insights from morphological, ecological and molecular data
FIGURE 2. Adults of Conicofrontia species (C. lilomwa and C. sesamoides). Scale bar = 10 mm.
FIGURE 4 in A revision of the genus Conicofrontia Hampson (Lepidoptera, Noctuidae, Apameini, Sesamiina), with description of a new species: new insights from morphological, ecological and molecular data
FIGURE 4. Last instar larvae of Conicofrontia species. Scale bar = 10 mm.
FIGURE 4 in Redescription of Alitta succinea (Leuckart, 1847) and reinstatement of A. acutifolia (Ehlers, 1901) n. comb. based upon morphological and molecular data (Polychaeta: Nereididae)
FIGURE 4. Neighbor-joining tree of COI sequences of Alitta species using T92+G.
FIGURE 9 in A new species of Cymodoce Leach, 1814 (Crustacea: Isopoda: Sphaeromatidae) based on morphological and molecular data, with a key to the Northern Indian Ocean species
FIGURE 9. Cymodoce waegelei sp. nov., holotype (ZMH-K-42594); A–E, pereopods 3–7.
FIGURE 3. Cymodoce tribullis Harrison & Holdich 1984 in A new species of Cymodoce Leach, 1814 (Crustacea: Isopoda: Sphaeromatidae) based on morphological and molecular data, with a key to the Northern Indian Ocean species
FIGURE 3. Cymodoce tribullis Harrison & Holdich 1984, paratype (QM W9643); A–E, pereopods 3–7.
FIGURE 10 in A new species of Cymodoce Leach, 1814 (Crustacea: Isopoda: Sphaeromatidae) based on morphological and molecular data, with a key to the Northern Indian Ocean species
FIGURE 10. Cymodoce waegelei sp. nov., holotype (ZMH-K-42594); A–E, pleopods 1–5; F, penes.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.