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2,801
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Dataset results
2,801 results for “diabetes mellitus”
RNA sequence of gestational diabetes mellitus (GDM) and healthy control placentas
GEO Series GSE154414. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Effects of intrauterine hyperglycemia on offspring development in gestational diabetes mellitus based on placental transcriptomics
GEO Series GSE263483. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Systematic characterization of human placenta-derived circRNAs and identification of autophagy-related circRNAs in gestational diabetes mellitus [lncRNA]
GEO Series GSE206041. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Next generation sequencing of circular and lnc RNAs in diabetes mellitus rats after sleeve gastrectomy
GEO Series GSE162022. Rattus norvegicus. 22 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Placenta-derived exosomes of gestational diabetes mellitus affect cell metabolism and cell function via transferring microRNAs
GEO Series GSE234840. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Integrated analysis of the transcriptome-wide m6A methylome in gestational diabetes mellitus and healthy control placentas [meRIP-seq]
GEO Series GSE154413. Homo sapiens. 16 samples. Type: Other.
Microarray analysis among non-alcoholic fatty liver, non-alcoholic steatohepatitis, and type 2 diabetes mellitus rats
GEO Series GSE65220. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Systematic characterization of human placenta-derived miRNAs and identification of autophagy-related miRNAs in gestational diabetes mellitus [miRNA-seq]
GEO Series GSE206042. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA expression profiles of whole blood cells from a Han Chinese population with or without Type-2 Diabetes Mellitus or/and its complications in nephropathy and retinopathy
GEO Series GSE189005. Homo sapiens. 45 samples. Type: Expression profiling by array.
diabetes mellitus and iron metabolic disorders database
<p> </p> <p>The database contains data on patients with diabetes mellitus and disorders of carbohydrate metabolism - </p> <p>anthropometric data, data on the state of metabolic control parameters, data on the state of iron metabolism and lipid metabolism.</p>
Diabesity in Adults With Type 2 Diabetes Mellitus: A Cross-sectional Study Exploring Self-care and Its Determinants.
<p>Baroni I, Caruso R, Dellafiore F, Arrigoni C, Fabrizi D, Luciani M, Rebora P, Ausili D. Diabesity in Adults With Type 2 Diabetes Mellitus: A Cross-sectional Study Exploring Self-care and Its Determinants. Can J Diabetes. 2022 Apr 7:S1499-2671(22)00072-7. doi: 10.1016/j.jcjd.2022.03.009. Epub ahead of print. PMID: 35927172.</p> <p>Abstract</p> <p><strong>Objectives: </strong>The purpose of this study was to describe self-care maintenance, self-care monitoring, self-care management and self-care self-efficacy in adults with type 2 diabetes (T2DM) and body mass index (BMI)<30 kg/m<sup>2</sup> and adults with T2DM and BMI≥30 kg/m<sup>2</sup> ("diabesity"), and to identify their clinical and sociodemographic determinants. Self-care is one of the main treatments for adults with T2DM. However, self-care has been poorly described in people with diabesity, and differences in clinical and sociodemographic determinants of self-care between patients with diabesity and patients with T2DM and BMI<30 kg/m<sup>2</sup> have, to our knowledge, not been assessed.</p> <p><strong>Methods: </strong>A secondary analysis was performed of sociodemographic and clinical data using a multicentre, observational, cross-sectional design, wherein 540 adults diagnosed with T2DM were included in a consecutive and convenience sampling procedure.</p> <p><strong>Results: </strong>Self-care maintenance and management were significantly lower among patients with diabesity (p<0.001 and p=0.025, respectively). Among patients with diabesity, low income (relative risk [RR]=3.27, p=0.01) and presence of diabetic neuropathy (RR=4.16; p=0.03) were strongly associated with inadequate self-care maintenance; completion of high school (RR=0.45; p=0.01), availability of a family caregiver (RR=0.52; p=0.04) and the use of insulin as the main treatment (RR=2.09; p=0.01) decreased the likelihood of inadequate self-care monitoring.</p> <p><strong>Conclusions: </strong>The unfavourable behavioural profile of patients with diabesity could be further worsened by their lower level of confidence in performing adequate self-care.</p>
Synergistic Protective Effects of Ginsenoside Rb1 and Berberine Against Type 2 Diabetes Mellitus via the GDF15/HAMP Signaling Pathway Throughout the Liver Lobules: Insights from Spatial Transcriptomic
GEO Series GSE285791. Mus musculus. 171 samples. Type: Other.
RNAseq between gestational diabetes mellitus and healthy control groups
GEO Series GSE267259. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Exploration of SQC formula effect on Type 2 diabetes mellitus by whole transcriptome profile in rats
GEO Series GSE165225. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Gene expression of Skeletal muscle in Tacrolimus-Induced Post-transplantation Diabetes Mellitus model
GEO Series GSE140691. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Integrated analysis of the transcriptome-wide m6A methylome in gestational diabetes mellitus and healthy control placentas
GEO Series GSE154415. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing; Other.
Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via elevated intracellular calcium load
GEO Series GSE287534. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Long-term prognostic role of diabetes mellitus and glycemic control in heart failure patients with reduced ejection fraction: Insights from the MECKI Score database.
<p>Raw data of the paper: </p> <p>Long-term prognostic role of diabetes mellitus and glycemic control in heart failure patients with reduced ejection fraction: Insights from the MECKI Score database.</p> <p><strong>Background. </strong>The prognostic role of diabetes mellitus (DM) in heart failure (HF) patients is undefined, since DM is outweighed by several DM-related variables when confounders are considered. We determined the prognostic role of DM, treatment and glycemic control, in a real-life HF population.</p> <p><strong>Methods. </strong>3927 HF patients included in the Metabolic Exercise Cardiac Kidney Index (MECKI) score database were evaluated with median follow-up of 3.66 years (IQR 1.70-6.67). Data analysis considered survival between DM (n=897) vs. non-DM (n=3030) patients, and, in diabetics, between insulin (n=304), oral antidiabetics (n=479), and dietary only (n=88) treatments. The role of glycemic control was evaluated grouping DM patients according to glycated hemoglobin (HbA1c): <7% (n=266), 7.1-8% (n=133), >8% (n=149). All analyses were performed also adjusting for ejection fraction, renal function, hemoglobin, sodium, exercise peak oxygen uptake, and ventilation/carbon dioxide relationship slope. Study primary endpoint was the composite of cardiovascular death, urgent heart transplantation, or left ventricular assist device implantation. Secondary endpoints were cardiovascular and all causes death.</p> <p><strong>Results. </strong>For all endpoints, upon adjustment for confounders, DM status and insulin treatment or dietary regimen were not significantly associated with adverse long-term prognosis compared to non-DM and oral antidiabetic treated patients, respectively. A worse prognosis was observed in HbA1c >8% patients (Log-Rank p<0.001), even after correction for confounding factors. All results were replicated by hazard ratio analysis.</p> <p><strong>Conclusion. </strong>In HF patients, DM, insulin treatment and dietary regimen are not adverse outcome predictors. The only condition related to long-term prognosis considering potential confounders is poor glycemic control.</p>
THE IMPACT OF SHORT-TERM HYPERGLYCEMIA AND OBESITY ON BIVENTRICULAR AND BIATRIAL MYOCARDIAL FUNCTION ASSESSED BY SPECKLE TRACKING ECHOCARDIOGRAPHY IN A POPULATION OF WOMEN WITH GESTATIONAL DIABETES MELLITUS
<p><strong>Background and aims: </strong>To compare biventricular and biatrial myocardial strain indices assessed by two-dimensional speckle tracking echocardiography (2D-STE) in women with gestational diabetes mellitus (GDM) and those with uncomplicated pregnancy at the third trimester of pregnancy and in post-partum.</p> <p><strong>Methods and results: </strong>30 consecutive GDM women and 30 age-, ethnicity- and gestational week-matched controls without any comorbidity were examined in this prospective case-control study. All women underwent obstetric visit, blood tests and transthoracic echocardiography (TTE) implemented with 2D-STE analysis of all cardiac chambers at 36-38 weeks’ gestation. TTE and 2D-STE were repeated at 6–10 weeks after delivery.</p> <p>At 36-38 weeks’ gestation, GDM women, compared to controls, had significantly higher body mass index (BMI), blood pressure values and inflammatory markers. TTE showed increased left ventricular (LV) mass and impaired LV diastolic function in GDM women, whereas there was no significant difference between the groups in ejection fraction. 2D-STE revealed that biventricular global longitudinal strain (GLS) and biatrial reservoir strain indices were significantly lower in GDM women than controls. Third trimester BMI was inversely correlated with LV-GLS (r=–0.86) and was independently associated with reduced LV-GLS (less negative than –20%) in GDM women in post-partum (OR 1.81, 95%CI 1.14-2.89). A BMI value ≥30 Kg/m<sup>2 </sup>had 100% sensitivity and 99.5% specificity for identifying GDM women with impaired LV-GLS in post-partum (AUC=0.97).</p> <p><strong>Conclusion: </strong>Women with GDM, compared to women with uncomplicated pregnancy, have significantly lower biventricular and biatrial myocardial deformation indices. These abnormalities may be persistent in post-partum in GDM women with obesity.</p>
Prognostic indicators of persistent carotid intima-media thickness increase in postpartum period in a population of normotensive women with gestational diabetes mellitus
<p><strong>OBJECTIVE: </strong>The association between gestational diabetes mellitus (GDM) and common carotid artery (CCA)-intima media thickness (IMT) is still controversial. In the present study, we aimed to compare the CCA-IMT measured in GDM women to that obtained in healthy pregnant women in the third trimester of pregnancy. Secondly, we investigated the main independent predictors of persistent CCA-IMT increase (defined as CCA-IMT ≥0.6 mm) in postpartum period in GDM women.</p> <p><strong>STUDY DESIGN: </strong>30 consecutive GDM women and 30 healthy pregnant women matched for anagraphic age (34.1±4.5 vs 32.8 ± 4.2 yrs, p=0.25), ethnicity (caucasian 56.7 vs 63.3%, p=0.59), gestational age (36.2± 1.7 vs 36.5 ± 1.6 weeks, p=0.48) and cardiovascular risk factors were examined in this prospective case-control study. All women underwent obstetric visit, blood tests, conventional transthoracic echocardiography implemented with two-dimensional speckle tracking echocardiography analysis of left ventricular and left atrial myocardial strain parameters and carotid ultrasound examination at two time points: 36-38 weeks’ gestation and 6-10 weeks after delivery.</p> <p><strong>RESULTS: </strong>At 36.2±1.7 weeks of gestation, CCA-IMT was significantly increased in GDM women than controls (0.81±0.11 vs 0.55 ± 0.12, p <0.001). Twelve GDM women (40% of the total) were found with persistent CCA-IMT increase (0.76±0.14 mm) in postpartum period (8.2±2.2 weeks), whereas the remaining 18 (60% of the total) showed a normalization in CCA-IMT (0.56±0.1 mm). At multivariate logistic regression analysis, third trimester body mass index (BMI) (OR 1.78, 95%CI 1.24-2.54, p = 0.01), glycosylated hemoglobin (HbA1C) (OR 1.51, 95%CI 1.13-1.89, p = 0.03) and neutrophil-to-lymphocyte ratio (NLR) (OR 1.68, 95%CI 1.25-4.65, p = 0.02) resulted to be independently associated with persistent CCA-IMT increase in postpartum period in GDM women. A BMI ≥29.2 Kg/m<sup>2</sup>, an HbA1C ≥37.5 mmol/mol and a NLR ≥5.5 were the best cut-off values for identifying GDM women with persistent CCA-IMT increase in postpartum period.</p> <p><strong>CONCLUSIONS: </strong>GDM is associated with increased CCA-IMT during pregnancy. This increase may be persistent in postpartum period in GDM women with obesity, uncontrolled diabetes and increased inflammatory markers.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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