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Dataset results
2,952 results for “limb”
Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells [RNA-seq]
GEO Series GSE227076. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Expression profiles of wildtype and Shox2 knockout embryonic limbs
GEO Series GSE41945. Mus musculus. 2 samples. Type: Expression profiling by array.
A novel model of chronic limb ischemia with translational significance enables proper evaluation of therapeutic angiogenesis
GEO Series GSE152139. Mus musculus. 8 samples. Type: Expression profiling by array.
MRO CRISM LIMB DATA RECORD V1.0
This dataset is intended to include information on observation conditions of IR and VNIR data cubes from the CRISM instrument on MRO, where the data cubes are pointed at the planet limb. For surface-pointed data cubes, Derived data records are the functional counterpart. The information in LDRs is mapped to the sensor space of non-map-projected data, EDRs and TRDRs.
Alternative splicing regulates the physiological adaptation of the mouse hind limb postural and phasic muscles to microgravity
We sought to comprehensively elucidate the transcriptomic underpinnings of microgravity-induced muscle phenotypes in mice by evaluating both differential gene expression (DGE) and changes in alternative splicing (AS) due to extended spaceflight. Total RNA was isolated from the gastrocnemius and quadriceps, postural and phasic muscles of the hind limb, respectively, of 32-week-old female BALB/c mice exposed to microgravity or ground control conditions for nine weeks. RNA sequencing revealed that DGE and AS varied across postural and phasic muscle types with preferential employment of DGE in the gastrocnemius and AS in the quadriceps. Gene ontology analysis indicated that DGE and AS regulate distinct molecular processes. Various non-differentially expressed transcripts encoding musculoskeletal proteins (Tnnt3, Tnnt1, Neb, Ryr1, and Ttn) and muscle-specific RNA binding splicing regulators (Mbnl1 and Rbfox1) were found to have significant changes in AS that altered critical functional domains of their protein products. In striking contrast, microgravity-induced differentially expressed genes were associated with translation/ribosomal function and lipid metabolism. Our work serves as the first comprehensive investigation of coordinate changes in DGE and AS in large limb muscles across spaceflight. We propose that substantial remodeling of pre-mRNA by AS is a major component of transcriptomic adaptation of skeletal muscle to microgravity. The alternatively spliced genes identified here could be targeted by small molecule splicing regulator therapies to address microgravity-induced changes in muscle during spaceflight.
Truncating variant in MYOF gene is associated with limb-girdle type muscular dystrophy and cardiomyopathy
GEO Series GSE119027. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Sp8 regulatory function in the limb bud ectoderm [RNA-seq]
GEO Series GSE144732. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Mesenchymal Stromal Cells Derived from Human Embryonic Stem Cells, Fetal Limb and Bone Marrow Share a Common Phenotype but are Transcriptionally and Biologically Different [I]
GEO Series GSE100748. Homo sapiens. 80 samples. Type: Expression profiling by array.
Loss of Maenli lncRNA expression causes engrailed-1 dependent congenital limb malformations [scRNA-seq]
GEO Series GSE149368. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the genetics of mammalian limb growth
GEO Series GSE41222. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Modeling human limb skeletal development using human pluripotent stem cell-derived skeletal assembloids [bulkRNA-seq]
GEO Series GSE288042. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Sp8 regulatory function in the limb bud ectoderm [ChIP-seq]
GEO Series GSE144731. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Limb-on-a-Chip: An All-Hydrogel Platform for Scalable and Reproducible Engineering of Neuromuscular Tissues
GEO Series GSE309796. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Enhancing Cell-Based Regenerative Therapies with Peptide-Modified Thermo-responsive Citrate-Based Biomaterials for Treatment of Critical Limb Ischemia
GEO Series GSE263721. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Loss of Maenli lncRNA expression causes engrailed-1 dependent congenital limb malformations [Capture Hi-C]
GEO Series GSE137333. Mus musculus. 11 samples. Type: Other.
Myeloid ALX/FPR2 promotes revascularization during limb ischemia
GEO Series GSE128679. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Influence of DNA-methylation at multiple stages of limb chondrogenesis
GEO Series GSE266119. Gallus gallus. 4 samples. Type: Methylation profiling by high throughput sequencing.
A smooth muscle cell lncRNA controls angiogenesis in chronic limb-threatening ischemia through a miR-143-3p/HHIP signaling axis
GEO Series GSE290218. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Identification of TBX3 and shared HAND2-TBX3 target gene in early mouse limb buds [RNA-seq]
GEO Series GSE192485. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [SM_CHOW_HFSC]
GEO Series GSE196565. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.