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702 results for “Longitudinal study”
Data from: Longitudinal study of performance on the Ruff Figural Fluency Test in persons aged 35 years or older
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Data from: Cross-sectional versus longitudinal research: a case study of trees with hollows and marsupials in Australian forests
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Data from: Within guild co-infections influence parasite community membership: a longitudinal study in African Buffalo
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A multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis
<p>Objective: To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns of gray and white matter involvement in clinically or genetically defined subgroups of patients using cross-sectional, longitudinal and multimodal MRI.</p> <p>Methods: We assessed cortical thickness, subcortical volumes and white matter connectivity from T1-weighted and diffusion-weighted MRI in 292 ALS patients (follow-up: n=150) and 156 controls (follow-up: n=72). Linear mixed-effects models were used to assess changes in structural brain measurements over time in patients compared to controls.</p> <p>Results: Patients with a C9orf72 mutation (n=24) showed widespread gray and white matter involvement at baseline, and extensive loss of white matter integrity in the connectome over time. In C9orf72-negative patients, we detected cortical thinning of motor and frontotemporal regions, and loss of white matter integrity of connections linked to the motor cortex. Spinal-onset patients displayed widespread white matter involvement at baseline and gray matter atrophy over time, whereas bulbar-onset patients started out with prominent gray matter involvement. Patients with unaffected cognition or behavior displayed predominantly motor system involvement, while widespread cerebral changes, including frontotemporal regions with progressive white matter involvement over time, were associated with impaired behavior or cognition. Progressive loss of gray and white matter integrity typically occurred in patients with shorter disease durations (<13 months), independent of progression rate.</p> <p>Conclusions: Heterogeneity of phenotype and C9orf72 genotype relates to distinct patterns of cerebral degeneration. We demonstrate that imaging studies have the potential to monitor disease progression and early intervention may be required to limit cerebral degeneration.</p>
Data from: The interrelationship among economic activities, environmental degradation, material consumption, and population health in low-income countries: a longitudinal ecological study
Objectives: The theory of ecological unequal exchange explains how trade and various forms of economic activity create the problem of environmental degradation, and lead to the deterioration of population health. Based on this theory, our study examined the inter-relationship among economic characteristics, ecological footprints, CO2 emissions, infant mortality rates and under-5 mortality rates in low-income countries. Design: A longitudinal ecological study design. Setting: Sixty-six low-income countries from 1980 to 2010 were included in the analyses. Data for each country represented an average of 23 years (N=1497). Data sources: Data were from the World Development Indicators, UN Commodity Trade Statistics Database, Global Footprint Network and Polity IV Project. Analyses: Linear mixed models with a spatial power covariance structure and a correlation that decreased over time were constructed to accommodate the repeated measures. Statistical analyses were conducted separately by sub-Saharan Africa, Latin America and other regions. Results: After controlling for country-level sociodemographic characteristics, debt and manufacturing, economic activities were positively associated with infant mortality rates and under-5 mortality rates in sub-Saharan Africa. By contrast, export intensity and foreign investment were beneficial for reducing infant and under-5 mortality rates in Latin America and other regions. Although the ecological footprints and CO2 emissions did not mediate the relationship between economic characteristics and health outcomes, export intensity increased CO2 emissions, but reduced the ecological footprints in sub-Saharan Africa. By contrast, in Asia, the Middle East and North Africa, although export intensity was positively associated with the ecological footprints and also CO2 emissions, the percentage of exports to high-income countries was negatively associated with the ecological footprints. Conclusions: This study suggested that environmental protection and economic development are important for reducing infant and under-5 mortality rates in low-income countries.
Data from: Brain myo-inositol as a potential marker of amyloid-related pathology: a longitudinal study.
Objective: To investigate the association between longitudinal changes in proton magnetic spectroscopy (MRS) metabolites and amyloid pathology in non-demented individuals; to explore the relationship between MRS and cognitive decline. Methods: In this longitudinal multiple time point study (a subset of the Swedish BioFINDER) we included cognitively healthy participants, individuals with subjective cognitive decline and mild cognitive impairment (MCI). MRS was acquired serially in 294 participants (670 individual spectra) from the posterior cingulate/precuneus. Using mixed-effects models, we assessed the association between MRS and baseline amyloid β42 (Aβ), and between MRS and longitudinal MMSE, accounting for APOE, age and sex. Results: While baseline MRS metabolites were similar in Aβ positive (Aβ+) and negative (Aβ-) individuals, in the Aβ+ group, the estimated rate of change was +1.9%/year for myo-inositol/creatine (mI/Cr) and -2.0%/year for N-acetyl-aspartate/myo-inositol (NAA/mI). In the Aβ- group, mI/Cr and NAA/mI yearly change was -0.05% and +1.2%, however this was not significant across time points. MCI Aβ+ group showed the steepest MRS changes, with an estimated rate of +2.93%/year (p=0.07) for mI/Cr and -3.55%/year (p<0.01) for NAA/mI. Further, in the entire cohort, we found that Aβ+ individuals with low baseline NAA/mI had a significantly higher rate of cognitive decline than Aβ+ individuals with high baseline NAA/mI. Conclusions: We demonstrate that the longitudinal change in mI/Cr and NAA/mI is associated with underlying amyloid pathology. MRS may be a useful non-invasive marker of Aβ-related processes over time. Further, we show that in Aβ+ individuals, baseline NAA/mI may predict the rate of future cognitive decline.
Data from: Effect of ultrasonography surveillance in patients with liver cancer: a population-based longitudinal study
Objective Liver cancer is a growing global public health problem. Ultrasonography is an imaging tool widely used for the early diagnosis of liver cancer. However, the effect of ultrasonography surveillance (US) on the survival of patients with liver cancer is unknown. Therefore, this study examined the association between survival and US frequency during the 2 years preceding patients' liver cancer diagnosis. Methods This population-based longitudinal study was conducted in Taiwan, a region with high liver cancer incidence, by using the National Health Insurance Research Database. We compared survival between patients who received US three times or more (≥3 group) and less than three times (<3 group) during the 2 years preceding their liver cancer diagnosis, and identified the predictors for the ≥3 group. Results This study enrolled 4621 patients with liver cancer who had died between 1997 and 2010. The median survival rate was higher in the ≥3 group (1.42 years) than in the <3 group (0.51 years). Five-year survival probability was also significantly higher in the ≥3 group (14.4%) than in the <3 group (7.7%). The multivariate logistic regression results showed that the three most common positive predictors for receiving three or more US sessions were indications of viral hepatitis, gallbladder diseases, and kidney–urinary–bladder diseases; the most common negative predictors for receiving three or more US sessions were male sex and indications of abdominal pain. Conclusion Patients with liver cancer who received US three times or more during the 2 years preceding their liver cancer diagnosis exhibited a higher 5-year survival probability.
Data from: Emotion reactivity is increased 4-6 weeks postpartum in healthy women: a longitudinal fMRI study
Marked endocrine alterations occur after delivery. Most women cope well with these changes, but the postpartum period is associated with an increased risk of depressive episodes. Previous studies of emotion processing have focused on maternal–infant bonding or postpartum depression (PPD), and longitudinal studies of the neural correlates of emotion processing throughout the postpartum period in healthy women are lacking. In this study, 13 women, without signs of post partum depression, underwent fMRI with an emotional face matching task and completed the MADRS-S, STAI-S, and EPDS within 48 h (early postpartum) and 4–6 weeks after delivery (late postpartum). Also, data from a previous study including 15 naturally cycling controls assessed in the luteal and follicular phase of the menstrual cycle was used. Women had lower reactivity in insula, middle frontal gyrus (MFG), and inferior frontal gyrus (IFG) in the early as compared to the late postpartum assessment. Insular reactivity was positively correlated with anxiety in the early postpartum period and with depressive symptoms late postpartum. Reactivity in insula and IFG were greater in postpartum women than in non-pregnant control subjects. Brain reactivity was not correlated with serum estradiol or progesterone levels. Increased reactivity in the insula, IFG, and MFG may reflect normal postpartum adaptation, but correlation with self-rated symptoms of depression and anxiety in these otherwise healthy postpartum women, may also suggest that these changes place susceptible women at increased risk of PPD. These findings contribute to our understanding of the neurobiological aspects of the postpartum period, which might shed light on the mechanisms underlying affective puerperal disorders, such as PPD.
Immunosenescence in the wild? A longitudinal study in a long‐lived seabird
<p>1. Longitudinal studies of various vertebrate populations have demonstrated senescent declines in reproductive performance and survival probability to be almost ubiquitous. Longitudinal studies of potential underlying proximate mechanisms, however, are still scarce. <br> 2. Due to its critical function in the maintenance of health and viability, the immune system is among the potential (mediators of) proximate mechanisms that could underlie senescence. <br> 3. Here, we studied three innate immune parameters - hemagglutination titre, haemolysis titre and haptoglobin concentration - in a population of common terns (Sterna hirundo) known to undergo actuarial senescence. We repeatedly sampled birds of known sex and age across 11 years and used random regression models to (i) quantify how immune parameters vary among individuals, and (ii) describe within-individual age-specific changes in, and potential trade-offs between, immune parameters.<br> 4. Our models revealed no differences between males and females in hemagglutination titre and haptoglobin concentration, and very low among-individual variation in these parameters in general. Within individuals, hemagglutination titre increased with age, while haptoglobin concentration did not change. We found no indication for selective (dis)appearance in relation to hemagglutination titre or haptoglobin concentration, nor for the existence of a trade-off between them. Haemolysis was absent in the majority (76%) of samples.<br> 5. Common terns do not exhibit clear senescence in hemagglutination titre and haptoglobin concentration and show very little among-individual variation in these parameters in general. This may be explained by canalisation of the immune parameters or by the colonial breeding behaviour of our study species, but more longitudinal studies are needed to facilitate investigation of links between species' characteristics and immunosenescence in wild animals.</p>
Supplementary Website, Data, and Scripts for the Paper "Hierarchical and Hybrid Organizational Structures in Open-Source Software Projects: A Longitudinal Study"
<p>Supplementary website containing result plots and data, anonymized raw data, and scripts used to produce the results of the paper "Hierarchical and Hybrid Organizational Structures in Open-Source Software Projects: A Longitudinal Study".</p>
Database of Study SARS-CoV-2 Antibody Level after Homologous and Heterologous Booster Vaccines an 18-month Longitudinal Observational Cohort Study in Indonesia (Ardyanto et el., 2024)
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Continuous Digital Monitoring of Walking Speed in Frail Elderly Patients: Noninterventional Validation Study and Longitudinal Clinical Trial (Data for interventional clinical trial)
<p>Digital technologies and advanced analytics have drastically improved our ability to capture and interpret health relevant data from patients. However, to date, limited data and results have been published detailing real-world patient compliance, demonstrating accuracy in target indications or examining what novel insights and clinical value can be derived. Here we present novel, digital mobility data from two studies: an independent, non-interventional validation study with elderly, naturally slow walking subjects, and a global, multi-site phase IIb clinical trial involving patients with age-related muscle loss and slow walking speed (sarcopenia). Based on these data, we validate the accuracy of a novel algorithm for capturing in-clinic and real-world gait speed in frail, slow-walking adults. We demonstrate the feasibility of continuous monitoring with a wearable inertial sensor in elderly adults in real-world settings, and propose minimum thresholds for compliance required for robust capture of gait behaviors in this population. We also show how simple, inferred contextual information, describing the length of a given walking bout, can explain some of the variation in real-world gait speed, and use this information to demonstrate for the first time a relationship between in-clinic performance and real-world gait speed behavior. This work lays a foundation for exploration of the clinical relevance and value of such measures and is a first step in building a more complete chain of evidence between standardized physical performance assessment, real-world behavior, and subjective perceptions of mobility, independence and health.</p> <p>This dataset contains data collected during the interventional clinical trial: derived data from raw accelerometry data, and summary performance data.</p> <p>The full dataset, including raw accelerometry data, is available here: <a href="https://mueller-et-al-2019.s3.amazonaws.com/index.html">https://mueller-et-al-2019.s3.amazonaws.com/index.html</a></p>
Fig. 3. P in A longitudinal molecular study of the ecology of malaria infections in freeranging mandrills
Fig. 3. P. gonderi parasitaemia across male mandrills with different SIV statuses. SIV-: SIV-negative males; SIV+: SIV-positive males; PI: males in primo-infection. Means and standard errors of the mean calculated from raw values are represented. P-values were obtained using differences of least squares means across the three categories (LMM).
Significance of longitudinal muscle loss in predicting the maintenance efficacy of durvalumab treatment following con-current chemoradiotherapy in patients with NSCLC: a retro-spective study Supplementary Figure
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COVID-19: Longitudinal immune correlates studies icddr,b (GH-VAP-SI-55)
<p><span>The goal of this project is to characterize the humoral immune response to SARS-COV-2 in COVID-19+ individuals in a longitudinal cohort in Bangladesh. </span></p> <p><span>We used plasma samples to run the Olink inflammation panel.</span></p>
Carriers of a single cystic fibrosis transmembrane conductance regulator pathogenic variant and COVID-19 in pregnancy: A retrospective longitudinal cohort study
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Longitudinal white-matter abnormalities in sports-related concussion: a diffusion MRI study of the NCAA-DoD CARE Consortium
<p><b>Objective</b></p> <p>To study longitudinal recovery trajectories of white-matter after sports-related concussion (SRC), we performed diffusion tensor imaging (DTI) on collegiate athletes who sustained SRC. </p> <p><b>Methods </b></p> <p>Collegiate athletes (n=219, 82 concussed athletes, 68 contact-sport controls, and 69 non-contact-sport controls) were included from the Concussion Assessment, Research and Education (CARE) Consortium. The participants completed clinical assessments and DTI at four time points: 24-48-hours post-injury, asymptomatic state, seven days following return-to-play, and six-months post-injury. Tract-based spatial statistics were used to investigate group differences in DTI metrics and identify white-matter areas with persistent abnormalities. Generalized linear mixed models were used to study longitudinal changes and associations between outcome measures and DTI metrics. Cox proportional hazards model was used to study effects of white-matter abnormalities on recovery time. </p> <p><b>Results</b></p> <p>In the white matter of concussed athletes, DTI-derived mean diffusivity was significantly higher than the controls at 24-48 hours post-injury and beyond the point when the concussed athletes became asymptomatic. While the extent of affected white matter decreased over time, part of the corpus callosum had persistent group-differences across all the time points. Furthermore, greater elevation of mean diffusivity at acute concussion was associated with worse clinical outcome measures (i.e., Brief-Symptom-Inventory scores and symptom-severity scores) and prolonged recovery time. No significant differences in DTI metrics were observed between the contact-sport and non-contact-sport controls. </p> <p><b>Conclusions</b></p> <p>Changes in white matter were evident after SRC at six-months post-injury, but were not observed in contact-sport exposure. Further, the persistent white-matter abnormalities were associated with clinical outcomes and delayed recovery time.</p>
Urinary Function and Multimorbidity Risks: A Longitudinal Study in Beijing Community-Dwelling Elderly
ClinicalTrials.gov study NCT07357714. IPD Sharing: NO. Countries: 1. Publications: 0.
Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosoma
ClinicalTrials.gov study NCT03977584. IPD Sharing: YES. Countries: 1. Publications: 0.
FEmale Metabolic Risk and Androgens: an Irish Longitudinal (FEMAIL) Study
ClinicalTrials.gov study NCT04912648. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.