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5,448 results for “Neuron”
Sensory neurons couple arousal and foraging decisions in C. elegans
<p>Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal's arousal state and a rare decision to leave a patch of bacterial food. Using long-term tracking and behavioral state classification, we find that food leaving decisions in <em>C. elegans</em> are coupled to arousal states across multiple timescales. Leaving emerges probabilistically over minutes from the high arousal roaming state, but is suppressed during the low arousal dwelling state. Immediately before leaving, animals have a brief acceleration in speed that appears as a characteristic signature of this behavioral motif. Neuromodulatory mutants and optogenetic manipulations that increase roaming have a coupled increase in leaving rates, and similarly acute manipulations that inhibit feeding induce both roaming and leaving. By contrast, inactivating a set of chemosensory neurons that depend on the cGMP-gated transduction channel TAX-4 uncouples roaming and leaving dynamics. In addition, <em>tax-4-</em>expressing sensory neurons promote lawn-leaving behaviors that are elicited by feeding inhibition. Our results indicate that sensory neurons responsive to both internal and external cues play an integrative role in arousal and foraging decisions.</p>
Single unit electrophysiology of optogenetically identified dopamine neurons in classical conditioning with probabilistic outcome of reward and punishment
<p>We collected single-unit data (.mat file) from optogenetically identified dopamine neurons in the lateral VTA in mice. These dopamine neurons were recorded while animals performed 4 different variation of classical conditioning tasks with different ratio of probabilistic outcomes of water reward and aversive air puff. In one task, one cue was associated with both water and puff in a probabilistic manner.</p>
raw and preprocessed data included to the paper "Striatum-projecting prefrontal cortex neurons support working memory maintenance"
<p>This Dataset includes matlab variables containing all raw and preprocessed data</p><p>1) fiber photometry experiments (GCaMP and GFP)</p><p>2) miniscope experiments</p><p>3) optogenetics experiments</p><p>4) DLC video analysis for photometry recording, optogenetic inhibition ArchT, optogenetic activation ChR2, optogenetic activation ChR2 + MK801, control experiments for optogenetic inhibition and activation</p><p>5) Source Data Files for all main and supplementary Figures</p><p> </p><p> collected for the paper</p><p> </p><p><strong>"Striatum-projecting prefrontal cortex neurons support working memory maintenance"</strong></p><p>Maria Wilhelm1,2,6, Yaroslav Sych1,7, Aleksejs Fomins1,2, José Luis Alatorre Warren1,8, Christopher Lewis1, Laia Serratosa Capdevila1, Roman Boehringer3, Elizabeth A. Amadei3, Benjamin Grewe2,3,4, Eoin C. O'Connor5, Benjamin J. Hall5,9, Fritjof Helmchen1,2,4*</p><p>1Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.</p><p>2Neuroscience Center Zurich, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland. </p><p>3Institute of Neuroinformatics, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland. </p><p>4University Research Priority Program (URPP) Adaptive Brain Circuits in Development and Learning (AdaBD), University of Zurich, Zurich, Switzerland</p><p>5Neuroscience & Rare Diseases, Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.</p><p>6Present address: Institute for Neuroscience, ETH Zurich, 8057 Zurich, Switzerland. </p><p>7Present address: Institute of Cellular and Integrative Neuroscience, CNRS, University of Strasbourg, Strasbourg, France.</p><p>8Present address: Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo 0317, Norway.</p><p>9Present address: Circuit Biology Department, H. Lundbeck A/S, Valby, Denmark.</p><p>These authors contributed equally: Maria Wilhelm, Yaroslav Sych</p><p>*email: <a href="mailto:helmchen@hifo.uzh.ch">helmchen@hifo.uzh.ch</a></p>
Inhibitory silencing enhances encoding precision of neuronal ensembles
<p>Neuronal ensembles are structured groups of coactive neurons associated with motor, sensory, and behavioral functions. However, how ensembles encode information remains unclear. To explore this, we investigated the responses of layer 2/3 visual cortical neurons in awake mice using two-photon volumetric calcium imaging during visual stimulation. We detected neuronal ensembles employing an unsupervised model-free algorithm. In response to visual stimuli, ensembles exhibited small trial-to-trial variability and high orientation selectivity. During an ensemble occurrence, besides neurons that were significantly activated by the stimulus, we also found neurons whose activity was significantly decreased in response. To distinguish between these two groups of neurons, we introduced the term "onsemble" for the significantly active neurons and "offsemble" for the silenced ones. Calcium decay kinetics in offsemble neurons significantly decreased during stimulus presentation, indicative of selective inhibition. Ensembles predicted visual stimulus orientation better than averaging the activity of individual onsemble or offsemble neurons. We conclude that the combined activation and inhibition of onsemble and offsemble neurons enhances visual encoding. Therefore, ensembles could be functional units representing information in cortical circuits, combining selectively activated and silenced neurons as an emergent and distributed neural code.</p>
Cystagon to Treat Infantile Neuronal Ceroid Lipofuscinosis
ClinicalTrials.gov study NCT00028262. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Premature Fatigue in Veterans With Heart Failure: Neuronal Influences
ClinicalTrials.gov study NCT02209610. IPD Sharing: NO. Countries: 1. Publications: 5.
Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands
ClinicalTrials.gov study NCT02602275. IPD Sharing: NO. Countries: 1. Publications: 7.
Polysomnographic Titration of Non-invasive Ventilation in Motor Neurone Disease
ClinicalTrials.gov study NCT05136222. IPD Sharing: YES. Countries: 1. Publications: 2.
Microembolic Signals and Cerebrospinal Fluid Markers of Neuronal Damage After Surgical Aortic Valve Replacement
ClinicalTrials.gov study NCT01319799. IPD Sharing: NO. Countries: 1. Publications: 6.
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
ClinicalTrials.gov study NCT06976229. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Acute D2 Receptor Blockade Induced Neuronal Network Changes in Human Volunteers
ClinicalTrials.gov study NCT01931059. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Efficacy of Intracerebroventricular BMN 190 in Patients With Late-Infantile Neuronal Ceroid Lipofus
ClinicalTrials.gov study NCT01907087. IPD Sharing: Not stated. Countries: 4. Publications: 4.
Neuronal and Behavioral Effects of Implicit Priming in Obese Individuals
ClinicalTrials.gov study NCT02347527. IPD Sharing: NO. Countries: 1. Publications: 2.
Cellcept for Treatment of Juvenile Neuronal Ceroid Lipofuscinosis
ClinicalTrials.gov study NCT01399047. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Investigating the Impact of Electrical Stimulation on Facial Pain, Jaw Movement and Oral Health in People With Motor Neuron Disease.
ClinicalTrials.gov study NCT07187388. IPD Sharing: YES. Countries: 1. Publications: 3.
Differentiation trajectories of the Hydra nervous system reveal transcriptional regulators of neuronal fate
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Notch directs telencephalic development and neuron fate determination by regulating miRNA levels
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Data from: CRISPR screening by AAV episome-sequencing (CrAAVe-seq): A scalable cell type-specific in vivo platform uncovers neuronal essential genes
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Neuronal activation in the geomagnetic responsive region Cluster N covaries with nocturnal migratory restlessness in white-throated sparrows
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Pronouns reactivate conceptual representations in human hippocampal neurons
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.