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358
datasets available to search
ShareScore release 0.9.0
Dataset results
358 results for “human skin”
Transcriptional Profile of Aging in Healthy Human Skin
GEO Series GSE18876. Homo sapiens. 98 samples. Type: Expression profiling by array.
To Assess Skin Safety of Test Product(s) by Patch Test on Adult Healthy Human Subjects
ClinicalTrials.gov study NCT07109453. IPD Sharing: NO. Countries: 0. Publications: 0.
Impact of Sex Hormones on Human Skin Immunity in Health and Hidradenitis Suppurativa (SIAP)
ClinicalTrials.gov study NCT07291193. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Clinical Study to Assess the Safety and Effectiveness of Utixira Lotion and Utixira Tablet in Healthy Adult Human Subjects With Dry or Sensitive Skin Prone to Mild to Moderate Pruritus and Urticaria
ClinicalTrials.gov study NCT06924840. IPD Sharing: NO. Countries: 0. Publications: 0.
A Two-week Crossover Evaluation of Two Hand Antiseptic Products on Skin Condition in Healthy Human Subjects
ClinicalTrials.gov study NCT00731042. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Glucocortioids in Human Skeletal Muscle, Adipose Tissue and Skin
ClinicalTrials.gov study NCT06145126. IPD Sharing: Not stated. Countries: 0. Publications: 0.
To Assess Skin Safety of Test Product(s) by Patch Test on Adult Healthy Human Subjects.
ClinicalTrials.gov study NCT07065149. IPD Sharing: NO. Countries: 0. Publications: 0.
Distinct activation of positive and negative regulatory immune genes during an evolving T cell response to diphencyprone (DPCP) in human skin
GEO Series GSE52360. Homo sapiens. 50 samples. Type: Expression profiling by array.
Stabilization of OCT4 synthetic mRNA in adult human skin cells using small molecules
GEO Series GSE40444. Homo sapiens. 8 samples. Type: Expression profiling by array.
scRNA-seq reveals differences in cell states and cell types between human hip, palm, and sole skin
GEO Series GSE202352. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Radiation-induced differentiation of normal human skin fibroblasts.
GEO Series GSE147733. Homo sapiens. 20 samples. Type: Expression profiling by array.
Human Renal Cells and Skin Fibroblast from Individuals with Nephropathic Cystinosis and their Controls
GEO Series GSE190500. Homo sapiens. 36 samples. Type: Expression profiling by array.
The effect of circadian rhythm on gene expression in human skin
GEO Series GSE112660. Homo sapiens. 298 samples. Type: Expression profiling by array.
Extraction of high-quality epidermal RNA after NH4SCN induced dermo-epidermal separation of 4 mm human skin biopsies
GEO Series GSE15101. Homo sapiens. 37 samples. Type: Expression profiling by array.
Gene expression profiling of skin and blood in human acute cutaneous Lyme disease
GEO Series GSE306532. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
UVB drives transcriptomic and epigenetic reprogramming which can be protected by antioxidant sulforaphane in human skin keratinocytes
GEO Series GSE185321. Homo sapiens. 16 samples. Type: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Single-cell transcriptomic analysis of human skin organoids during folliculogenesis
GEO Series GSE231607. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Expression data from human skin biposies (lesional and uninvolved) from psoriatic patients
GEO Series GSE6710. Homo sapiens. 26 samples. Type: Expression profiling by array.
Bystander response to 2.5 Gy of protons in a human 3-dimensional skin model in 16 h after exposure
Bystander mechanisms that originate in the areas surrounding a tissue damage presumably play an important role participating in wound healing and tissue remodeling. Thus identification and characterization of bystander mechanisms will help to development of new treatments of patients with a radiation exposure. In the present study we irradiated 3-dimensional tissue model of human epidermis Epi-200 (Mat-Tek Ashland MA) with 2.5 Gy protons. By exposing only a thin strip across the center of the EPI-200 tissue we have been able to measure global gene expression responses in directly irradiated and bystander cells located at 0.125-0.375 0.375-0.625 0.625-875 mm from the irradiation line. The data were analyzed using BRB-Array Tools (NIH) and further gene ontology analysis and network analysis was performed with Panther (Applied Biosystems) and IPA (Ingenuity) accordingly. Significantly responding genes were identified at all distances and included sets common to both direct and bystander responses. False discovery rate in bystander samples did not exceed 20% (p=0.001) and was sufficiently low in the samples obtained after the whole tissue exposure (0.06-1.16%). Analysis of the fragments cut at the same distance revealed 52 54 and 88 differentially expressed genes. These gene lists overlapped each other had from 3 to 12 genes in common including CLED2 S100A7A. Samples obtained after the whole tissue exposure discovered 949 differentially expressed genes. Moreover the performed gene ontology analysis showed there overrepresentation of TP53 pathway (pathways p=2.04E-02) a common marker of direct irradiation response and also overrepresentation of the following groups of genes: signal transduction (p=4.52E-04) cell communication (p=1.24E-04) and cell cycle in the category of biological processes; DNA helicase activity (p=2.54E-07) receptor binding (p=6.19E-04) calcium ion binding proteins (p=2.57E-03) as the molecular functions. Differentially expresses genes of bystander samples had few categories in common such as cell communication (p=2.36E-03) and signal transduction (p=2.42E-03) among the biological processes and receptor activity (p=4.54E-03) among the molecular functions. Categories specific for the bystander samples included G-protein coupled receptors (p=7.24E-03) and ligand-gated ion channels (p=4.16E-03) suggesting a role of external stimulation and ion trafficking in bystander mechanisms. Radiation induced gene expression in 3-dimensional tissue model Epi-200 was measured in 16 hours after exposure to 2.5 Gy of protons. Four independent experiments were performed for the samples collected at different distances from the irradiation line (125-375 375-625 and 625-875 micrometers) using three tissue fragments per a data point. Moreover three sets of whole tissue irradited samples were also generated for 0 and 2.5 Gy (6 samples total) and used for comparison of bystander and direct responses.
Response of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems which may not fully represent responses in 3-dimensional tissues. To gain insight into low dose responses in tissue we have profiled global gene expression in EPI-200 a 3-dimensional tissue model from MatTek that imitates the structure and function of human epidermis at 4 16 and 24 hours after exposure to high (2.5 Gy) and low (0.1 Gy) doses of low LET protons. Untreated controls and samples exposed to 10 cGy or to 2.5 Gy were analyzed at three different times (4 16 or 24 hours after exposure). Three biological repeats were performed for each condition
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.