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Dataset results
353 results for “metabolic pathway”
Pathway analysis identifies altered mitochondrial metabolism, neurotransmission, structural pathways and complement cascade in retina/RPE/choroid in chick model of form-deprivation myopia
GEO Series GSE89325. Gallus gallus. 4 samples. Type: Expression profiling by array.
A microRNA signature identifies four subtypes of triple-negative breast cancer and correlates miR-342-3p as a regulator of the lactate metabolic pathway through silencing the monocarboxylate transport
GEO Series GSE86948. Homo sapiens; synthetic construct. 329 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Hypoxia and oxygenation induce a metabolic switch between the pentose phosphate pathway and glycolysis in glioma stem-like cells
GEO Series GSE45117. Homo sapiens. 20 samples. Type: Expression profiling by array.
Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats
The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed the behavioral and cognitive performances of male Fisher rats 2 months after sham irradiation or total body irradiation with photons in the absence or presence of simulated microgravity. We analyzed the plasma collected 9 months after sham irradiation or total body irradiation for distinct alterations in metabolic pathways and to determine whether changes to metabolic measures were associated with specific behavioral and cognitive measures. A total of 344 male Fischer rats were irradiated with photons (6 MeV; 3, 8, or 10 Gy) in the absence or presence of simulated weightlessness achieved using hindlimb unloading (HU). To identify potential plasma biomarkers of photon radiation exposure or the HU condition for behavioral or cognitive performance, we performed regression analyses. The behavioral effects of HU on activity levels in an open field, measures of anxiety in an elevated plus maze, and anhedonia in the MandM consumption test were more pronounced than those of photon irradiation. Phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism and biosynthesis showed very strong pathway changes, following photon irradiation and HU in animals irradiated with 3 Gy. Here, 29 out of 101 plasma metabolites were associated with 1 out of 13 behavioral measures. In the absence of HU, 22 metabolites were related to behavioral and cognitive measures. In HU animals that were sham-irradiated or irradiated with 8 Gy, one metabolite was related to behavioral and cognitive measures. In HU animals irradiated with 3 Gy, six metabolites were related to behavioral and cognitive measures. These data suggest that it will be possible to develop stable plasma biomarkers of behavioral and cognitive performance, following environmental challenges like HU and radiation exposure. This study derives results from the Open Field, Novel Object Recognition and Anhedonia, and Elevated Plus Maze behavior assays.
Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats
Effects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic rays (GCRs). One of the limitations of previous studies on simulated weightlessness using hindlimb unloading (HU) is that a control HU condition was not included. We characterized the behavioral performance of male Fischer rats 2 months after sham or total body irradiation with a simplified 5-ion 6-mixed-beam exposure representative of GCRs in the absence or presence of HU. Six months later, the plasma, hippocampus, and cortex were processed to determine whether the behavioral effects were associated with long-term alterations in the metabolic pathways. In the open field without and with objects, interactions were observed for radiation × HU. In the plasma of animals that were not under the HU or control HU condition, the riboflavin metabolic pathway was affected most for sham irradiation vs. 0.75 Gy exposure. Analysis of the effects of control HU on plasma in the sham-irradiated animals showed that the alanine, aspartate, glutamate, riboflavin, and glutamine metabolisms as well as arginine biosynthesis were affected. The effects of control HU on the hippocampus in the sham-irradiated animals showed that the phenylalanine, tyrosine, and tryptophan pathway was affected the most. Analysis of effects of 0.75 Gy irradiation on the cortex of control HU animals showed that the glutamine and glutamate metabolic pathway was affected similar to the hippocampus, while the riboflavin pathway was affected in animals that were not under the control HU condition. The effects of control HU on the cortex in sham-irradiated animals showed that the riboflavin metabolic pathway was affected. Animals receiving 0.75 Gy of irradiation showed impaired glutamine and glutamate metabolic pathway, whereas animals receiving 1.5 Gy of irradiation showed impaired riboflavin metabolic pathways. A total of 21 plasma metabolites were correlated with the behavioral measures, indicating that plasma and brain biomarkers associated with behavioral performance are dependent on the environmental conditions experienced. This study derives results from the Open Field and Novel Object Recognition behavior assays.
Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats
A limitation of simulated space radiation studies is that radiation exposure is not the only environmental challenge astronauts face during missions. Therefore, we characterized behavioral and cognitive performance of male WAG/Rij rats 3 months after sham-irradiation or total body irradiation with a simplified 5-ion mixed beam exposure in the absence or presence of simulated weightlessness using hindlimb unloading (HU) alone. Six months following behavioral and cognitive testing or 9 months following sham-irradiation or total body irradiation, plasma and brain tissues (hippocampus and cortex) were processed to determine whether the behavioral and cognitive effects were associated with long-term alterations in metabolic pathways in plasma and brain. Sham HU, but not irradiated HU, rats were impaired in spatial habituation learning. Rats irradiated with 1.5 Gy showed increased depressive-like behaviors. This was seen in the absence but not presence of HU. Thus, HU has differential effects in sham-irradiated and irradiated animals and specific behavioral measures are associated with plasma levels of distinct metabolites 6 months later. The combined effects of HU and radiation on metabolic pathways in plasma and brain illustrate the complex interaction of environmental stressors and highlights the importance of assessing these interactions. This study derives results from the Open Field, Novel Object Recognition and Forced Swim Test behavior assays.
Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction
GEO Series GSE221013. Homo sapiens; Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
BRD4 links carbohydrate and lipid synthetic pathways to a core transcriptional network for a cell-type specific metabolic response (ChIP-Seq 3T3-L1)
GEO Series GSE59158. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
BRD4 links carbohydrate and lipid synthetic pathways to a core transcriptional network for a cell-type specific metabolic response (RNA-Seq 3T3-L1)
GEO Series GSE59159. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Mass spectrometry imaging and single-cell transcriptome reveal metabolic profiles of the postauricular glands of the Bufo gargarizans, and hypothesize Bufotoxin biosynthesis pathways
GEO Series GSE261560. Bufo gargarizans. 1 samples. Type: Expression profiling by high throughput sequencing.
Investigating the Molecular Impact of GGMSC on Redox and Metabolic Pathways in Pancreatic Cancer Cells [HPAF-II]
GEO Series GSE309643. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Propionate stimulates MUC2 expression through metabolism of β-oxidation-like pathway that boosts mitochondrial respiration and resultant induction of HIF-2α activation
GEO Series GSE157016. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Identification of HIF-1 signaling pathway in Pelteobagrus vachelli using RNA-Seq: effects of acute hypoxia and reoxygenation on oxygen sensings, respiratory metabolism and hematology indices
GEO Series GSE80507. Tachysurus vachellii. 1 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with oncogenesis, inflammation, growth and glucose metabolism
GEO Series GSE167100. Homo sapiens. 6 samples. Type: Expression profiling by RT-PCR.
Site-Specific HPV18 Integration Facilitates Cervical Carcinogenesis through metabolic reprogramming-Induced dysfunction of the SpHK1/S1P/S1PR1 pathway-part2
GEO Series GSE285796. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeting Fibroblast growth factor-23 (FGF23)-responsive pathways in the control of phosphate and vitamin D metabolism
GEO Series GSE142113. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Late eating decreases energy expenditure, increases hunger and appetite, and modifies metabolic pathways in adipose tissue [RNA-Seq]
GEO Series GSE190167. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Key metabolism pathways and regulatory mechanisms of high polysaccharide yielding in Hericium erinaceus
GEO Series GSE165264. Hericium erinaceus. 9 samples. Type: Expression profiling by high throughput sequencing.
Ziziphora clinopodioides Lam. Attenuates AS through Modulation of Lipid Metabolism and Oxidative Stress Pathways: Evidence from Multi-Omics Analyses
GEO Series GSE283095. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
BRD4 links carbohydrate and lipid synthetic pathways to a core transcriptional network for a cell-type specific metabolic response (RNA-seq Fat)
GEO Series GSE59161. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.