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295
datasets available to search
ShareScore release 0.9.0
Dataset results
295 results for “midbrain”
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [MERFISH]
GEO Series GSE271118. synthetic construct; Homo sapiens. 21 samples. Type: Other.
profiling of midbrain from arthritic DBA/1 mice vs. control DBA/1 mice
GEO Series GSE7284. Mus musculus. 10 samples. Type: Expression profiling by array.
Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
GEO Series GSE180913. Mus musculus. 394 samples. Type: Expression profiling by high throughput sequencing.
The single cell transcriptomic profiling in iPSC derived Midbrain Organoid of POLG Disease
GEO Series GSE241743. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Differential gene expression analysis on forebrain,midbrain and hindbrain tissues dissected from 3 biological replicates of P-25 wild type and Fmr1CRE knockin mutant mice
GEO Series GSE180066. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Effects of Lin28a overexpression on gene expression changes during culturing neural stem cells (NSCs) derived from mouse embryonic ventral midbrain (VM)
GEO Series GSE77851. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Other.
Differentiation of astrocytes with characteristics of ventral midbrain from human embryonic stem cells
GEO Series GSE203345. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional profiling of neurons in the midbrain of a Lhx5-TRAP (DT154) mouse line
GEO Series GSE137078. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [scRNA-Seq]
GEO Series GSE271116. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
ChIP-Seq for LXR in the mouse substantia nigra midbrain dopaminergic cell line SN4741 treated with the synthetic LXR ligand GW3965 for 1.5 hours
GEO Series GSE66118. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression changes in IC GABA receptors in the auditory midbrain of young adult and aging presbycusis mice.
GEO Series GSE49522. Mus musculus. 39 samples. Type: Expression profiling by array.
RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021
GEO Series GSE66160. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Study of mechanisms by which Liver X Receptors regulate mouse midbrain dopaminergic neuron development
GEO Series GSE66197. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Parkinson's disease midbrain organoids link GBA1 to Lewy pathology"
<p>This record contains data related to the article "Parkinson’s disease midbrain organoids link GBA1 to Lewy pathology".</p> <p><strong>Abstract</strong></p> <p>Aggregation of α-synuclein protein in “Lewy bodies” or “Lewy neurites” is a defining hallmark of Parkinson’s disease neuropathology. Mutations in <em>GBA1</em>, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent genetic risk factor for Parkinson’s disease. However, a defined link between mutations in <em>GBA1</em> and α-synuclein pathology is yet to be determined, largely because of the absence of experimental models able to recapitulate the key neuropathological signatures of the disease. Here, we present an innovative midbrain organoid culture system derived from subjects with <em>GBA1</em>-related Parkinson’s disease as the first patient-based model able to reproduce fundamental neuropathological features of the disease. We show that retention of mutant glucocerebrosidase in the endoplasmic reticulum and increased glucosylceramide levels are determinants of α-synuclein aggregation into inclusions resembling Lewy bodies and Lewy neurites in both mono- and biallelic <em>GBA1</em> mutated midbrain organoids. In this process, the entity of glucocerebrosidase activity reduction acts as an accelerating factor in the progression of α-synuclein pathology by favoring the conversion of soluble α-synuclein to its insoluble forms. We provide evidence that α-synuclein extracted from Parkinson’s samples displays seeding activity <em>in vitro</em> and, following inoculation in unaffected organoids, propagates the pathology. Finally, we demonstrate pharmacological rescue of pathological phenotypes with molecules engaging in the glucocerebrosidase pathway, suggesting that midbrain organoids could represent valuable <em>in vitro</em> platforms for drug testing in Parkinson’s disease and potentially other Lewy body disorders still lacking a definitive therapy.</p> <p> </p>
Single-cell transcriptomics revealed molecular vulnerability in a human midbrain-like organoid model of Parkinson's Disease [RNA-Seq]
GEO Series GSE271115. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.