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Dataset results
306 results for “mitral valve”
Target Controlled Infusion of Etomidate or Propofol for Anesthesia of Thoracoscopic Mitral Valve Replacement Surgery
ClinicalTrials.gov study NCT02644980. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Research on the Development and Application of a Preoperative Assessment Model for Transcatheter Mitral Valve Edge-to-Edge Repair Based on Visual Foundation Models
ClinicalTrials.gov study NCT07247890. IPD Sharing: NO. Countries: 0. Publications: 0.
ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral
ClinicalTrials.gov study NCT06167213. IPD Sharing: NO. Countries: 0. Publications: 0.
Observational Study of Prosthetic Tissue Aortic and Mitral Heart Valve
ClinicalTrials.gov study NCT00329667. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Changes in the Tricuspid Valve Complex Induced by Mitral Valve Annuloplasty
ClinicalTrials.gov study NCT02357862. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Effect of Posterior Annulus Elevation Technique in Reducing Residual Regurgitation During Mitral Valve Repair in Children
ClinicalTrials.gov study NCT04518709. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The Choice of Mitral Valve Surgery Type and Mid-term Outcomes in Patients up to 70-years: Results of the AUTHEARTVISIT Study
ClinicalTrials.gov study NCT07168889. IPD Sharing: NO. Countries: 0. Publications: 0.
Atrial Fibrillation Risk After Miniinvasive Mitral Valve Repair
ClinicalTrials.gov study NCT06707506. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Myocardial Protection in Minimally Invasive Mitral Valve Surgery
ClinicalTrials.gov study NCT04231903. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Safety and Efficacy Study of a New Device for Making Neochordae in Mitral Valve Repair
ClinicalTrials.gov study NCT01811537. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Identification of altered salivary microRNAs in Cavalier King Charles Spaniels affected by mitral valve disease at different ACVIM stages
GEO Series GSE307507. Canis lupus familiaris. 25 samples. Type: Non-coding RNA profiling by high throughput sequencing.
mTOR signal in mitral valve diseases
GEO Series GSE293926. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"
<p>This record contains raw data related to the article "Predictive Value of Pre‐Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"</p> <p><strong>Abstract</strong>: The “ideal” management of asymptomatic severe mitral regurgitation (MR) in valve<br> prolapse (MVP) is still debated. The aims of this study were to identify pre‐operatory parameters<br> predictive of residual MR and of early and long‐term favorable remodeling after MVP repair. We<br> included 295 patients who underwent MV repair for MVP with pre‐operatory two‐ and threedimensional<br> transthoracic echocardiography (2DTTE and 3DTTE) and 6‐months (6M) and 3‐years<br> (3Y) follow‐up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures<br> as simple or complex. Pre‐operative echo parameters were compared to post‐operative values at 6M<br> and 3Y. Patients were divided into Group 1 (6M‐MR < 2) and Group 2 (6M‐MR ≥ 2), and predictors<br> of MR 2 were investigated. MVP was simple in 178/295 pts, and 94% underwent simple<br> procedures, while in only 42/117 (36%) of complex MVP a simple procedure was performed. A<br> significant relation among prolapse anatomy, surgical procedures and residual MR was found. Postoperative<br> MR ≥ 2 was present in 9.8%: complex MVP undergoing complex procedures had twice the<br> percentage of MR ≥ 2 vs. simple MVP and simple procedures. MVP complexity resulted<br> independent predictor of 6M‐MR ≥ 2. Favorable cardiac remodeling, initially found in all cases, was<br> maintained only in MR < 2 at 3Y. Pre‐operative 3DTTE MVP morphology identifies pts undergoing<br> simple or complex procedures predicting MR recurrence and favorable cardiac remodeling.</p>
Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair
<p>This record contains raw data related to the article "Machine Learning Prediction Models for Mitral Valve Repairability and Mitral Regurgitation Recurrence in Patients Undergoing Surgical Mitral Valve Repair"</p> <p>Abstract: Background: Mitral valve regurgitation (MR) is the most common valvular heart disease and current variables associated with MR recurrence are still controversial. We aim to develop a machine learning-based prognostic model to predict causes of mitral valve (MV) repair failure and MR recurrence. Methods: 1000 patients who underwent MV repair at our institution between 2008 and 2018 were enrolled. Patients were followed longitudinally for up to three years. Clinical and echocardiographic data were included in the analysis. Endpoints were MV repair surgical failure with consequent MV replacement or moderate/severe MR (>2+) recurrence at one-month and moderate/severe MR recurrence after three years. Results: 817 patients (DS1) had an echocardiographic examination at one-month while 295 (DS2) also had one at three years. Data were randomly divided into training (DS1: n = 654; DS2: n = 206) and validation (DS1: n = 164; DS2 n = 89) cohorts. For intra-operative or early MV repair failure assessment, the best area under the curve (AUC) was 0.75 and the complexity of mitral valve prolapse was the main predictor. In predicting moderate/severe recurrent MR at three years, the best AUC was 0.92 and residual MR at six months was the most<br> important predictor. Conclusions: Machine learning algorithms may improve prognosis after MV repair procedure, thus improving indications for correct candidate selection for MV surgical repair.</p>
Dataset related to the article "Head to Head Comparison between Different 3-Dimensional Echocardiographic Rendering Tools in the Imaging of Percutaneous Edge-to-Edge Mitral Valve Repair"
<p>This record contains raw data related to the article "Head to Head Comparison between Different 3-Dimensional Echocardiographic Rendering Tools in the Imaging of Percutaneous Edge-to-Edge Mitral Valve Repair"</p> <p>MitraClip (MC) is the most common percutaneous treatment for severe mitral regurgitation<br> (MR). An accurate two-dimensional and three-dimensional echocardiographic (3DTEE) imaging is<br> mandatory for the optimal procedural result. Recently transillumination 3DTEE rendering (3DTr) has<br> been introduced integrating a virtual light source into the dataset and with the addition of glass effect<br> (3DGl) allows to adjust tissue transparency improving depth perception and anatomical structure<br> delineation in comparison with the standard 3DTEE (3DSt). The aim of this retrospective study in<br> 30 patients undergoing MC, was to compare 3DSt, 3DTr, and 3DGl in mitral valve (MV) evaluation<br> and procedural result assessment. 3DTEE acquisitions obtained before and after MC were processed<br> with 3DSt, 3DTr, and 3DGl rendering. Each reconstruction was scored for quality and for ability<br> to recognize MV anatomy, MR origin, clip position, dimension and grasping. Imaging quality was<br> judged good or optimal in 52%, 76%, and 96% in 3DSt, 3DTr, and 3DGl reconstructions respectively.<br> In 26/30 patients a diagnostic incremental value was found with 3DTr vs. 3DSt and in 15/26 with<br> 3DGl vs. 3DTr and 3DSt. Only 3DGl with perpendicular cropping of the clip allowed to visualize and<br> measure the grasped portion of each mitral leaflets. 3DTEE imaging during MC may be improved<br> by 3DTr and 3DGl providing a better evaluation of MV, of leaflet grasping and of residual MR jets<br> after MC.</p>
Expression analysis of human aortic valve interstitial cells (hAVICs), mitral valve interstitial cells(hMVICs) and dermal firbroblasts (hDFs)
GEO Series GSE40801. Homo sapiens. 3 samples. Type: Expression profiling by array.
Dataset related to the article "Multimodality imaging assessment of mitral annular disjunction in mitral valve prolapse"
<p>This record contains raw data related to the article "Multimodality imaging assessment of mitral annular disjunction in mitral valve prolapse".</p> <p><strong>Objective </strong>Mitral annular disjunction (MAD) is an abnormality linked to mitral valve prolapse (MVP), possibly associated with malignant ventricular arrhythmias. We assessed the agreement among different imaging techniques for MAD identification and measurement.</p> <p><strong>Methods </strong>131 patients with MVP and significant mitral regurgitation undergoing transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) were retrospectively enrolled. Transoesophageal echocardiography (TOE) was available in 106 patients. MAD was evaluated in standard long-axis views (four-chamber, two-chamber, three-chamber) by each technique.</p> <p><strong>Results </strong>Considering any-length MAD, MAD prevalence was 17.3%, 25.5%, 42.0% by TTE, TOE and CMR, respectively (p<0.05). The agreement on MAD identification was moderate between TTE and CMR (κ=0.54, 95% CI 0.49 to 0.59) and good between TOE and CMR (κ=0.79, 95% CI 0.74 to 0.84). Assuming CMR as reference and according to different cut-off values for MAD (≥2 mm, ≥4 mm, ≥6 mm), specificity (95% CI) of TTE and TOE was 99.6 (99.0 to 100.0)% and 98.7 (97.4 to 100.0)%; 99.3 (98.4 to 100.0)% and 97.6 (95.8 to 99.4)%; 97.8 (96.2 to 99.3)% and 93.2 (90.3 to 96.1)%, respectively; sensitivity (95% CI) was 43.1 (37.8 to 48.4)% and 74.5 (69.4 to 79.5)%; 54.0 (48.7 to 59.3)% and 88.9 (85.2 to 92.5)%; 88.0 (84.5 o 91.5)% and 100.0 (100.0 to 100.0)%, respectively. MAD length was 8.0 (7.0-10.0), 7.0 (5.0-8.0], 5.0 (4.0-7.0) mm, respectively by TTE, TOE and CMR. Agreement on MAD measurement was moderate between TTE and CMR (ρ=0.73) and strong between TOE and CMR (ρ=0.86).</p> <p><strong>Conclusions </strong>An integrated imaging approach could be necessary for a comprehensive assessment of patients with MVP and symptoms suggestive for arrhythmias. If echocardiography is fundamental for the anatomic and haemodynamic characterisation of the MV disease, CMR may better identify small length MAD as well as myocardial fibrosis.</p>
Dataset related to the article 'Diagnostic Accuracy of Transillumination in Mitral Valve Prolapse: Side-by-Side Comparison of Standard Transthoracic Three-Dimensional Echocardiography against Surgical Findings'
<p>This record contains raw data related to the article 'Diagnostic Accuracy of Transillumination in Mitral Valve Prolapse: Side-by-Side Comparison of Standard Transthoracic Three-Dimensional Echocardiography against Surgical Findings'</p> <p>In patients with mitral valve (MV) prolapse (MVP) eligible for surgery, three-dimensional echocardiography (3DE) is routinely used for pre-operative assessment. Despite the worldwide use of transesophageal echocardiography in this context, transthoracic echocardiography (TTE) allows accurate noninvasive evaluation of MV anatomy and pathology in patients with good acoustic windows. Transillumination (TI) is a new 3D tool that improves the visualization of cardiac structures due to shadow effects achieved by the use of a virtual light source. We aimed to compare the diagnostic accuracy of TTE TI side-by-side with standard 3DE (s3DE) display in patients undergoing surgery for MVP, using surgical valve inspection as a reference standard.</p> <p>We prospectively studied 59 patients with good acoustic windows on TTE, undergoing surgery for MVP. The study was approved by the institutional review board with a written informed consent. 3D MV analysis, including evaluation of scallops, chordal rupture and cleft was performed using s3DE and TI. Data were acquired by two experienced operators using zoomed acquisition mode over 4 to 6 cardiac cycles and processed by adjusting gain, brightness and smoothing. For TI images, the virtual light source was set in the left ventricle to enhance MV visualization. At the end of each TTE study, a first reader analyzed post-processed s3DE images and, one week later, the TI images. Surgical findings of MV anatomy were collected and agreement was expressed using Cohen’s concordance coefficient kappa, sensitivity, specificity, negative and positive predictive value (NPV, PPV) and overall accuracy. A second reader, blinded to all prior measurements, repeated TI analysis to assess reproducibility using intraclass correlation coefficients (ICC). </p> <p>No differences were noted in etiological diagnosis (Myxomatous vs Fibroelastic Deficiency) between the two 3DE techniques and surgery. Based on s3DE, 53 patients (90%) were diagnosed with P<sub>2</sub> flail secondary to chordal rupture (N=51, 86%) or elongation (N=2, 14%). A cleft was diagnosed in 10 cases (17%), mostly located in the posterior leaflet. Based on TI, 53 patients (88%) were diagnosed with P<sub>2</sub> flail secondary to chordal rupture (N=48, 81%) or elongation (N=5, 19%). In 9 patients (15%) a cleft was found, mainly located in the posterior leaflet.</p> <p>The reproducibility of TI was good for prolapse detection (ICC=0.78) and chordal rupture localization (ICC= 0.73) and fair for cleft identification (ICC= 0.66). Overall, compared to the surgical reference, TI was significantly more accurate than s3DE for the identification of prolapse (94% vs 89%), chordal rupture (98% vs 92%) and cleft localization (87% vs 54%).</p> <p>Specifically, s3DE correctly detected the flail in the majority of patients (N=57, 97%); in 20 patients (34%), at least one scallop was erroneously diagnosed as prolapsing, while in 4 patients (7%), a second prolapsing scallop was missed by s3DE. In 2 cases (3%) the real flail was missed. Agreement between s3DE and surgery in prolapse identification was poor (kappa=0.30). By TI, the flail was correctly diagnosed in 57 cases (97%), while in 7 patients (12%) there was an over-diagnosis and in 4 cases (7%) an under-diagnosis. In 1 patient (2%), the flail was missed by TI. The agreement between TI and surgery in prolapse detection was considerably better (kappa=0.60). A significant difference (p<0.05) was found between s3DE and TI in sensitivity (87% vs 91%), specificity (92% vs 97%), PPV (75% vs 87%) and NPV (96% vs 98%) in scallop’s prolapse identification.</p> <p>Chordal rupture was diagnosed in 51 patients (86%) by s3DE, compared to 45 (76%) cases confirmed by surgery. Among these 45 patients, s3DE correctly identified rupture position in 41 (91%). The agreement between s3DE and surgery was moderate (kappa=0.43). In contrast, TI identified chordal rupture in 48 cases (81%); among 45 patients confirmed by surgery TI detected the correct rupture position in 44 (98%), resulting in a very good agreement (kappa=0.86). Compared to s3DE, TI showed a significant difference (p<0.05) in sensitivity (89% vs 98%), specificity (95% vs 99%), PPV (74% vs 94%) and NPV (96% vs 99%) in chordal rupture recognition.</p> <p>The agreement with surgery in terms of localization of cleft by s3DE was poor (k=0.17). Surgical valve inspection reported 8 cases (14%) with MV cleft (2 cleft of the anterior leaflet and 6 indentations of the posterior leaflet), only one was correctly diagnosed by s3DE, mainly due to signal drop-out. Concordance between TI and surgery in cleft localization was good (kappa=0.67); TI correctly diagnosed 6 out of 8 clefts. For cleft identification, sensitivity (13% vs 75%), specificity (96% vs 99%), PPV (10% vs 67%), and NPV (97% vs 99%) were significantly better (p<0.05) for TI compared to s3DE.</p> <p>Based on our results, in patients undergoing surgery for MVP, TI has the potential to improve the diagnostic accuracy of TTE in anatomical analysis of the MV compared to s3DE, and may thus contribute towards improved personalized presurgical planning.</p> <p> </p>
Dataset related to the article "Rest and exercise oxygen uptake and cardiac output changes 6 months after successful transcatheter mitral valve repair"
<p><strong>Aims: </strong>Changes in peak exercise oxygen uptake (VO<sub>2</sub> ) and cardiac output (CO) 6 months after successful percutaneous edge-to-edge mitral valve repair (pMVR) in severe primary (PMR) and functional mitral regurgitation (FMR) patients are unknown. The aim of the study was to assess the efficacy of pMVR at rest by echocardiography, VO<sub>2</sub> and CO (inert gas rebreathing) measurement and during cardiopulmonary exercise test with CO measurement.</p> <p><strong>Methods and results: </strong>We evaluated 145 and 115 patients at rest and 98 and 66 during exercise before and after pMVR, respectively. After successful pMVR, significant reductions in MR and NYHA class were observed in FMR and PMR patients. Cardiac ultrasound showed reverse remodelling (left ventricular end-diastolic volume from 158 ± 63 mL to 147 ± 64, P < 0.001; ejection fraction from 51 ± 15 to 48 ± 14, P < 0.001; pulmonary artery systolic pressure (PASP) from 43 ± 13 to 38 ± 8 mmHg, P < 0.001) in the entire population. These changes were significant in PMR (n = 62) and a trend in FMR (n = 53), except for PASP, which decreased in both groups. At rest, CO and stroke volume (SV) increased in FMR with a concomitant reduction in arteriovenous O<sub>2</sub> content difference [ΔC(a-v)O<sub>2</sub> ]. Peak exercise, CO and SV increased significantly in both groups (CO from 5.5 ± 1.4 L/min to 6.3 ± 1.5 and from 6.2 ± 2.4 to 6.7 ± 2.0, SV from 57 ± 19 mL to 66 ± 20 and from 62 ± 20 to 69 ± 20, in FMR and PMR, respectively), whereas peak VO<sub>2</sub> was unchanged and ΔC(a-v)O<sub>2</sub> decreased.</p> <p><strong>Conclusions: </strong>These data confirm pMVR-induced clinical improvement and reverse ventricular remodelling at a 6-month analysis and show, in spite of an increase in CO, an unchanged exercise performance, which is achieved through a 'more physiological' blood flow distribution and O<sub>2</sub> extraction behaviour. Direct rest and exercise CO should be measured to assess pMVR efficacy.</p> <p><strong>Keywords: </strong>Cardiac output; Exercise; Oxygen uptake; Percutaneous edge-to-edge mitral valve repair; Transcatheter mitral valve repair.</p>
Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair: Mid-Term Outcomes From the CUTTING-EDGE International Registry
<p>Dataset from Kaneko T, Hirji S, Zaid S, Lange R, Kempfert J, Conradi L, Hagl C, Borger MA, Taramasso M, Nguyen TC, Ailawadi G, Shah AS, Smith RL, Anselmi A, Romano MA, Ben Ali W, Ramlawi B, Grubb KJ, Robinson NB, Pirelli L, Chu MWA, Andreas M, Obadia JF, Gennari M, Garatti A, Tchetche D, Nazif TM, Bapat VN, Modine T, Denti P, Tang GHL; CUTTING-EDGE Investigators. Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair: Mid-Term Outcomes From the CUTTING-EDGE International Registry. JACC Cardiovasc Interv. 2021 Sep 27;14(18):2010-2021. doi: 10.1016/j.jcin.2021.07.029. PMID: 34556275.</p> <p>Abstract</p> <p><strong>Objectives: </strong>The aim of this study was to determine clinical and echocardiographic characteristics, mechanisms of failure, and outcomes of mitral valve (MV) surgery after transcatheter edge-to-edge repair (TEER).</p> <p><strong>Background: </strong>Although >100,000 mitral TEER procedures have been performed worldwide, longitudinal data on MV surgery after TEER are lacking.</p> <p><strong>Methods: </strong>Data from the multicenter, international CUTTING-EDGE registry were retrospectively analyzed. Clinical and echocardiographic outcomes were evaluated. Median follow-up duration was 9.0 months (interquartile range [IQR]: 1.2-25.7 months) after MV surgery, and follow-up was 96.1% complete at 30 days and 81.1% complete at 1 year.</p> <p><strong>Results: </strong>From July 2009 to July 2020, 332 patients across 34 centers underwent MV surgery after TEER. The mean age was 73.8 ± 10.1 years, median Society of Thoracic Surgeons risk for MV repair at initial TEER was 4.0 (IQR: 2.3-7.3), and primary/mixed and secondary mitral regurgitation were present in 59.0% and 38.5%, respectively. The median interval from TEER to surgery was 3.5 months (IQR: 0.5-11.9 months), with overall median Society of Thoracic Surgeons risk of 4.8% for MV replacement (IQR: 2.8%-8.4%). The primary indication for surgery was recurrent mitral regurgitation (33.5%), and MV replacement and concomitant tricuspid surgery were performed in 92.5% and 42.2% of patients, respectively. The 30-day and 1-year mortality rates were 16.6% and 31.3%, respectively. On Kaplan-Meier analysis, the actuarial estimates of mortality were 24.1% at 1 year and 31.7% at 3 years after MV surgery.</p> <p><strong>Conclusions: </strong>In this first report of the CUTTING-EDGE registry, the mortality and morbidity risks of MV surgery after TEER were not negligible, and only <10% of patients underwent MV repair. These registry data provide valuable insights for further research to improve these outcomes.</p>
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