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2,348 results for “type 1 diabetes”
Data from: A genome-wide functional genomics approach uncovers genetic determinants of immune phenotypes in type 1 diabetes
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Small things matter: Lack of extra-islet β-cells in Type 1 diabetes
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Risk factors for cardiovascular disease (CVD) in adults with type 1 diabetes: findings from prospective real-life T1D exchange registry
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Impact of COVID-19 lockdown on glycemic control in adults with type 1 diabetes mellitus: information and standardized questions regarding follow-up during lockdown
<p>Aim. To examine the impact of the lockdown caused by COVID-19 pandemic on both the glycemic control and the daily habits of a group of patients with type 1 diabetes mellitus (T1DM) using flash continuous glucose monitoring devices (Flash CGM). </p> <p>Methods. Retrospective analysis based on all the information gathered in virtual consultations from a cohort of 50 adult patients with T1DM with follow-up at our site. We compared their CGM metrics during lockdown with their own previous data before the pandemic occurred, as well as the potential psychological and therapeutic changes.</p> <p>Results. We observed a reduction of the average glucose: 160.26 ± 22.55 mg/dl vs. 150 ± 20.96 mg/dl, p=0.0009, estimated HbA1c: 7.21 ± 0.78% vs. 6.83 ± 0.71%, p=000.5, glucose management indicator (GMI) 7.15 ± 0.57 % vs. 6.88 ± 0.49 %, p=0.0003, and glycemic variability (CV): 40.74 ± 6.66 vs. 36.43 ± 6.09 p<0.0001. Time in range showed an improvement: 57.46 ± 11.85% vs a 65.76 ± 12.09%, p<0.0001, without an increase in percentage of time in hypoglycaemia.</p> <p>Conclusions: COVID-19 lockdown was associated with an improvement in glycemic control in patients with T1DM using CGM.</p>
Self-care activities in pediatric patients with type 1 diabetes mellitus
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Data for publication ''Interactive nutrition education is more effective in terms of improved levels of glycated hemoglobin in adolescent patients with poorly controlled type 1 diabetes – a randomized study''
<p>Data present changes in the most important clinical parameters after 3 and 6 months from the applied educational intervention in the group of children and adolescents with type 1 diabetes.</p>
Data for publication on the impact of two different nutrition education methods on the quality of life of children and adolescents with type 1 diabetes (randomized study)
<p>Data present changes in the quality of life 6 months after the educational intervention applied in the group of children and adolescents with type 1 diabetes.</p>
Peptide Pool Instability of Precancerous Lesion in Rats with Model of Chronic Pancreatitis and/or Without Type 1 Diabetes Mellitus
<p><span><strong>Supplementary table 1. </strong>Data of Shapiro-Wilk (W) normality test and Homogeneity of Variance Test (Levene's F Test).</span></p> <p> </p> <p><span><strong>Supplementary table 2. </strong>Kruskal-Wallis as the overall test (H-values) and posthoc Dunn's test with Bonferroni correction. The corrected α using the Bonferroni correction method is 0.017</span></p>
Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
<p>Data underlying the figures in the publication “Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice”, published in <em>Science</em>, <strong>2020</strong>, 368, 993-1001. <a href="https://science.sciencemag.org/content/368/6494/993">https://science.sciencemag.org/content/368/6494/993</a></p> <p>Table of contents:</p> <p><strong>1. Electrogenetics source data file</strong>; File openable with Graphpad Prism containing the source data for the main <em>Figures: 1-4 </em>(Transgene expression by SEAP measurement), <em>5b, 6a, 6f</em> (Insulin by ELISA), <em>5c, 6b, 6e </em>(NanoLuc luciferase), 7c (NanoLuc luciferase in vivo) and <em>7a, 7d</em> (Glycemia).</p> <p><strong>Transgene expression by SEAP measurement</strong></p> <p>Data for main <em>Figures 1, 2, 3, 4</em>.</p> <p>SEAP (human placental secreted alkaline phosphatase) levels were profiled in cell culture supernatants using a colorimetric assay. 100 µL 2x SEAP assay buffer (20 mM homoarginine, 1 mM MgCl2, 21% diethanolamine, pH 9.8) was mixed with 80 µL heat-inactivated (30 min at 65°C) cell culture supernatant. After the addition of 20 µL substrate solution (120 mM p-nitrophenyl phosphate; cat. no. AC128860100, Thermo Fisher Scientific), the absorbance time course was recorded for 45 min at 405 nm and 37°C using a Tecan Genios PRO plate reader (cat. no. P97084; Tecan Group AG, Maennedorf, Switzerland) and the SEAP levels were determined as follows: first, absorbance change over time (slope) was calculated. According to the Beer–Lambert’s law, absorbance is proportional to the concentration of a colored compound and depends on the light path length (d) and extinction coefficient (ε) (ε for p-nitrophenyl (εpNP) = 18.600 M−1 cm−1). Enzymatic activity EA [U/L] was calculated from the equation: EA = slope × dilution factor × εpNP−1 × d−1 </p> <p>Values in the file present determined SEAP levels.</p> <p><strong>Insulin by ELISA</strong></p> <p>Data for <em>Figures 5b, 6a, 6f</em>.</p> <p>Values in the file present Insulin level as determined by ELISA kit. The assay was performed according to manufacturer’s instructions.</p> <p><strong>NanoLuc luciferase </strong></p> <p>Data for <em>Figures 5c, 6b, 6e</em>.</p> <p>NanoLuc® luciferase was quantified in cell culture supernatants using the Nano-Glo® Luciferase Assay System (cat. no. N1110; Promega, Duebendorf, Switzerland). In brief, 7.5 µL of cell culture supernatant was added per well of a black 384-well plate and mixed with 7.5 µL substrate-containing assay buffer. Total luminescence was quantified using a Tecan Genios PRO plate reader (Tecan Group AG).</p> <p>Values in the file present measured luminescence levels.</p> <p><strong>NanoLuc luciferase in vivo </strong></p> <p>Data for <em>Figure 7c.</em></p> <p>Aliquots of 15 µL of whole-blood samples were diluted in 5 μL of 50 mM EDTA and frozen at -20 °C until NanoLuc® quantification as described above.</p> <p>Values in the file present measured luminescence levels normalized to time point 0 (Normalization individually for each mouse).</p> <p><strong>Glycemia </strong></p> <p>Data for <em>Figures 7a, 7d</em>.</p> <p>Blood glucose level was determined using a glucometer (Contour®Next, Bayer Healthcare, Leverkusen, Germany).</p> <p>Values in the file present measured glucose levels.</p> <p><strong>2. Figure 7b</strong>; Data for <em>Figure 7b</em>. File openable with Graphpad Prism.</p> <p>Blood glucose level was determined using a glucometer (Contour®Next, Bayer Healthcare, Leverkusen, Germany).</p> <p>Values in the file present measured glucose levels.</p> <p><strong>3. Figure 6c and 6d</strong>; Excel file with the data for <em>Figures 6c, 6d</em>.</p> <p>NanoLuc® luciferase was quantified in cell culture supernatants using the Nano-Glo® Luciferase Assay System (cat. no. N1110; Promega, Duebendorf, Switzerland). In brief, 7.5 µL of cell culture supernatant was added per well of a black 384-well plate and mixed with 7.5 µL substrate-containing assay buffer. Total luminescence was quantified using a Tecan Genios PRO plate reader (Tecan Group AG).</p> <p>Values in the file present measured luminescence levels.</p>
Hypoglycemia-induced electrocardiogram changes in a rodent model of type 1 diabetes
<p>Retrospective data was obtained from studies conducted by Reno et al. Adult male Sprague-Dawley rats (weight, 250–300 g; Charles River Laboratories, Malvern, PA) were housed individually in temperature- and light-controlled environments and fed ad libitum a standard chow diet and water. Rats underwent surgery for carotid artery and jugular vein cannulation as previously described. ECG leads were also placed subcutaneously during surgery. One wire was placed over the lower left rib cage and one was placed over the right supraclavicular fossa. A reference wire was placed over the back. Two days after cannulation, one set of rats received intraperitoneal injections of streptozotocin (65 mg/kg; Sigma, St. Louis, MO) to induce diabetes (n = 37). A second group of rats received sodium citrate buffer and acted as a control, non-diabetic group (n = 54). Blood glucose was measured from the tail vein with a glucometer (Ascensia Contour; Bayer HealthCare, Mishawaka, IN) to ensure diabetes. Rats were diabetic for two weeks prior to the hypoglycemic clamp. Overnight fasted, awake, unrestrained non-diabetic and diabetic rats underwent hyperinsulinemic (0.2 units ⋅ kg−1 ⋅ min−1; Humulin R), severe hypoglycemic (10–15 mg/dL) single step clamps with continuous ECGs for 3 hours, as previously described ECGs were recorded every millisecond (ms) using PowerLab 26T software (LabChart; ADInstruments, Colorado Springs, CO). Arterial blood was used to determine glucose levels during the clamp with a glucometer (Ascensia Contour BG monitors; Bayer Healthcare Mishawaka, IN) every 15-minutes.</p> <p> </p> <p>Reno CM, Daphna-Iken D, Chen YS, VanderWeele J, Jethi K, Fisher SJ. Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation. Diabetes. 2013;62(10):3570-81.</p> <p> </p> <p>Reno CM, VanderWeele J, Bayles J, Litvin M, Skinner A, Jordan A, et al. Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. Diabetes. 2017;66(12):3091-7.</p> <p> </p> <p> </p> <p> </p>
Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study
<p>Association between a glucagon-like peptide 1 receptor genetic polymorphism and therapeutic response to sitagliptin in a sample of type 2 diabetic patients: an observational study</p>
Feasibility Study of 2000 IU Per Day of Vitamin D for the Primary Prevention of Type 1 Diabetes
ClinicalTrials.gov study NCT00141986. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Acetazolamide in Persons With Type 1 Diabetes - Dose Finding
ClinicalTrials.gov study NCT05473364. IPD Sharing: NO. Countries: 1. Publications: 1.
GIP and GLP-1 in Type 1 Diabetes
ClinicalTrials.gov study NCT01739283. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Motivational Interviewing in Children With Type 1 Diabetes
ClinicalTrials.gov study NCT06424574. IPD Sharing: NO. Countries: 1. Publications: 3.
Markers of Bone Status in Diabetes Mellitus (Type 1 and Type 2)
ClinicalTrials.gov study NCT01870557. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Activation Innate Immune System in Type 1 Diabetes
ClinicalTrials.gov study NCT03441919. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Monotherapy With Rapamycin in Long-standing Type 1 Diabetes
ClinicalTrials.gov study NCT02803892. IPD Sharing: YES. Countries: 1. Publications: 1.
Food Literacy and Type 1 Diabetes
ClinicalTrials.gov study NCT03588234. IPD Sharing: NO. Countries: 1. Publications: 4.
Closing the Loop in Young Children With Type 1 Diabetes
ClinicalTrials.gov study NCT01557634. IPD Sharing: Not stated. Countries: 1. Publications: 3.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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