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opencc-by-4.0May 2023View details →

Exposure to a Vitamin D Best Practices Toolkit, Model, & E-Tools Increases Knowledge, Confidence, and Translation of Research to Public Health and Practice

Preventable vitamin D deficiency (VDD) is a global health concern. Prevention, early detection, and treatment of vitamin D deficiency aligning with serum 25-hydroxyvitamin D recommendations of 40-60 ng/ml (100-150 nmol/L) by an international panel of 48 vitamin D researchers would result in significant health benefits and cost-savings to individuals and society. However, research shows healthcare professionals lack knowledge and confidence in vitamin D best practices. A vitamin D toolkit was developed, including a model for decision-making support, e-tools, and accompanying resources, and implemented using an online, asynchronous learning management system. The pre-, post-test, and follow-up survey study design aimed to increase nurses’ and dietitians' levels of vitamin D knowledge, confidence, translation of evidence into spheres of practice and influence, and identify translation barriers. Toolkit completion increased participants’ (n=119) knowledge, 31% to 65% (p <0.001) and confidence 2.0 to 3.3 (p<0.001) on a scale of 1-5. Respondents reported using the model (100%) as a framework successfully guiding the translation of vitamin D knowledge into their sphere of influence or practice (94%) and identified translation barriers.  The toolkit should be included in interdisciplinary continuing education, research/quality improvement initiatives, healthcare policy, and institutions of higher learning to increase movement of research to practice.

opencc-by-4.0Jun 2023View details →

Supplementary analysis 1 for Vitamin D status during adolescence and the impact of lifestyle changes – two years follow-up from the Fit Futures Study

Supplementary analysis 1: multiple regression model including BMI instead of physical activity.

The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study

Supplementary file 1

Dataset for BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides.

The dataset published here supports the work in the publication titled "BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B12 uptake in gut Bacteroides." All the initial and final conformation files of the MD simulations are given along with the analyzed data presented in the manuscript.

The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study

Consent form

The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study

Study Questionnaire

Fig. 4. 1H in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 4. 1H NMR spectra (400 MHz, D O) of a crab apple extract fraction (I) and sucrose (II). The circled signal was consistent with the anomeric proton of a β-AAG.

Fig. 7 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 7. Acetylation of 2 under basic conditions gave the unsaturated glycoside 8, but acidic conditions led to the successful acetylation of both 2 and 2a. I. Ac2O, pyridine, 0 ̊C, overnight, 44%. II. Ac2O, HClO4, 0 ̊C, 1 h, 71% (9) and 73% (9a) yield.

Fig. 1 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 1. Structures of AA (1) and the only known naturally occurring derivatives in plants, 2-O-β-D-glucopyranosyl L-ascorbic acid (2) and 6-O-β-D-glucopyranosyl L-ascorbic acid (3). Synthetic 2-O-α-D-glucopyranosyl L-ascorbic acid (4) is commonly used in cosmetic products.

Fig. 2 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 2. Left: PCA (Pareto scaling with 95% confidence interval) of the LC-MS analyses of extracts from four fruit of each of nine apple accessions: green triangles = M. sylvestris, red circles = M. domestica, purple Xs = M. sieversii. Right: PCA of molecular features showing that M. domestica accessions were characterised by polyphenols (red), M. sieversii by fatty acids (blue) and M. sylvestris by dihydrochalcones (green). A molecular feature tentatively identified as an ascorbyl glycoside (top left) was also associated with two M. sylvestris accessions. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 3 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 3. LC-MS chromatograms (Instrument B, method I) of crab apple extract, commercial 2-O-α-D-glucopyranosyl L-ascorbic (4), and two AAGs produced by chemical synthesis, 2-O-β-D-glucopyranosyl L-ascorbic (2) and 2-O-β-D-galactopyranosyl L-ascorbic (2a). The traces are extracted ion chromatograms for m/z 337 [M – H]-. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 9 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 9. LC-MS (Instrument B, method II) extracted ion chromatograms for m/z 655, [M + Na]+, of acetylated AAGs 9 (red, 7.0 min) and 9a (green, 8.1 min), and acetylated and purified crab apple AAG (blue, 7.0 min). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Fig. 8 in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 8. The downfield regions of the 1H NMR spectra for acetylated ascorbyl glycosides (structures in Fig. 7.). I. Peracetyl galactoside 9a, II. Acetylated and purified ascorbyl glycoside from crab apples, III. Peracetyl glucoside 9.

Fig. 6. 1 H in Discovery of a stable vitamin C glycoside in crab apples (Malus sylvestris)

Fig. 6. 1 H NMR spectra of β-glucoside 2 in D O (400 MHz) demonstrating the effect of pH on proton resonances 1′-H and 4-H. Top: one drop of 2 M NaOH added to 2 NMR tube; middle: nothing added; bottom: one drop of conc. HCl added to NMR tube.

opennotspecifiedApr 2020View details →

Fig. 5 in Vitamin E in legume nodules: Occurrence and antioxidant function

Fig. 5. Correlation analyses between α-tocopherol contents, lipid peroxidation and nodule performance in soybean, alfalfa and pea plants. (A) Pearson's correlation analysis between α-tocopherol and thiobarbituric acid-reactive substances (TBARS) contents in leaves, roots and nodules. (B) Pearson's correlation analysis between α-tocopherol and nodule performance, as estimated by 15 N isotope labeling (δ15N) in nodules. P values and correlation coefficients (r) are shown.

opennotspecifiedApr 2020View details →

Fig. 2 in Vitamin E in legume nodules: Occurrence and antioxidant function

Fig. 2. Water deficit stress effects on the relative water content of leaves, roots and nodules and 15N isotope labeling in nodules of soybean, alfalfa and pea plants. (A) Relative water content (RWC) of leaves, roots and nodules of soybean, alfalfa and pea plants (from top to bottom). Data correspond to the mean ± SE of n = 5 individuals. Results of statistics are shown (two-way ANOVA, P <0.05). (B) 15N isotope labeling (δ15N) in nodules of irrigated and water-stressed plants in soybean, alfalfa and pea. Data correspond to the mean ± SE of n = 4. Results of statistics are shown (two-way ANOVA, P <0.05). An asterisk indicates significant differences between water-stressed and irrigated plants. Letters indicate significant differences over time in water-stressed plants (Tukey posthoc test P <0.05). NS, not significant. DAW, days after water withdrawal in water-stressed plants.

opennotspecifiedApr 2020View details →

Fig. 4 in Vitamin E in legume nodules: Occurrence and antioxidant function

Fig. 4. Differential effects of water deficit stress on the extent of lipid peroxidation, estimated as thiobarbituric acid-reactive substances (TBARS) content, in leaves, roots and nodules of soybean, alfalfa and pea plants (from top to bottom). Data correspond to the mean ± SE of n = 5 individuals. Results of statistics are shown (two-way ANOVA, P <0.05). An asterisk indicates significant differences between water-stressed and irrigated plants. Letters indicate significant differences over time in water-stressed plants (Tukey posthoc test P <0.05). NS, not significant. DAW, days after water withdrawal in water-stressed plants.