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11,177 results for “identify”
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Monckton, Spencer, <a href="https://orcid.org/0000-0002-9879-9118">https://orcid.org/0000-0002-9879-9118</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Dataset related to article "CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential."
<p>In mice, the ability of naive T (T<sub>N</sub>) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8<sup>+</sup> T<sub>N</sub> cells, defined by the absence or presence of the chemokine receptor CXCR3. The more abundant CXCR3<sup>+</sup> T<sub>N</sub> cell subset displayed an effector-like transcriptional profile and expressed TCRs with physicochemical characteristics indicative of enhanced interactions with peptide-HLA class I Ags. Moreover, CXCR3<sup>+</sup> T<sub>N</sub> cells frequently produced IL-2 and TNF in response to nonspecific activation directly ex vivo and differentiated readily into Ag-specific effector cells in vitro. Comparative analyses further revealed that human CXCR3<sup>+</sup> T<sub>N</sub> cells were transcriptionally equivalent to murine CXCR3<sup>+</sup> T<sub>N</sub> cells, which expressed high levels of CD5. These findings provide support for the notion that effector differentiation is shaped by heterogeneity in the preimmune repertoire of human CD8<sup>+</sup> T cells.</p>
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Schröder, Christof Nikolaus, <a href="https://orcid.org/0000-0002-1359-6961">https://orcid.org/0000-0002-1359-6961</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Raes, Niels, <a href="https://orcid.org/0000-0002-4329-4892">https://orcid.org/0000-0002-4329-4892</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS- CoV-2 infected cells - Proteomic data obtained with Huh-7 cells
<p>Cultured human Huh-7 cells were infected with SARS-CoV-2 and harvested after 24, 48 and 72 h. The extracted proteins were processed in triplicates preparing for mass spectrometric analysis. Data acquisition was completed, including control samples of non-infected cells, following isobaric tandem mass tag (TMT) chemical labeling and on-line fractionation of the 12 combined biological replicates. The resulted vendor specific raw files (Thermo Scientific) of 12 fractions are provided.</p> <p>The data is further analyzed in order to identify regulated proteins upon SARS-CoV-2 infection to understand the underlying biological processes through pathway analysis. Additional details about the study is going to be completed in the manuscript already submitted for publication.</p>
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Prendergast, Kit, <a href="https://orcid.org/0000-0002-1164-6099">https://orcid.org/0000-0002-1164-6099</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Cooper, Jerry, <a href="https://orcid.org/0000-0003-4994-3897">https://orcid.org/0000-0003-4994-3897</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Fig. 1 in Four Achnanthidium species (Bacillariophyta) formerly identified as Achnanthidium minutissimum from the Antarctic Region
Fig. 1. The Antarctic region with the location of the sampled islands and archipelagos.
MarTREC Data Set for Report: Developing and Applying an Analysis Methodology to Identify Flow Generation Influences between Vessel and Truck Shipments
<p>Truck activity is logically connected to vessel activity at a port. In turn, vessel activity is also influenced by truck shipments. Although one might expect a direct and straightforward relation between these two types of shipments, that is rarely the case. For instance, many maritime containers carry consolidated cargos that have multiple and different final destinations. Also, different truck capacities, customs clearance and regulations play a critical role in determining the actual relation between these two types of shipments. This project aims at shedding light on the nuances of maritime and roadway flow relations by quantitatively analyzing the linkages between these two types of shipments.</p> <p>The study performed a statistical analysis to determine the probability distributions of vessel and truck activity, and then explore the correlation of each activity with the other. The analysis yielded coefficients that function as explanatory values for specific truck flows.</p> <p>The ultimate purpose of this study is to provide a clearer and quantitative understanding of the relationship between maritime and truck shipments, and by doing so, to provide tools to develop a system for managing trucks that maximizes efficiency for industry, while minimizing industry’s negative impacts on a region.</p> <p>For this purpose, the study selected the Port Freeport as a case study.</p>
Identifying required APIs for solving Open SourceSoftware issues
<p>Data set to classify skills from a project in GitHub. </p>
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Crayn, Darren, <a href="https://orcid.org/0000-0001-6614-4216">https://orcid.org/0000-0001-6614-4216</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Watkins-Colwell, Greg, <a href="https://orcid.org/0000-0002-7789-9806">https://orcid.org/0000-0002-7789-9806</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Ward, Darren, <a href="https://orcid.org/0000-0002-4509-8553">https://orcid.org/0000-0002-4509-8553</a>. Claims were made on Bloodhound, <a href="http://bloodhound-tracker.net">https://bloodhound-tracker.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Accompanied data files used in the paper "Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis"
<p>lists of source file used in the paper "Analysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis" by Jing Yang, Amanda McGovern, Paul Martin, Kate Duffus, Xiangyu Ge, Peyman Zarrineh, Andrew P Morris, Antony Adamson, Peter Fraser, Magnus Rattray & Stephen Eyre. The paper has been accepted by Nature Communications.</p>
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Shorthouse, David Peter, <a href="https://orcid.org/0000-0001-7618-5230">https://orcid.org/0000-0001-7618-5230</a>. Claims were made on Bionomia, <a href="http://bionomia.net">https://bionomia.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Natural history specimens collected and/or identified and deposited.
Natural history specimen data collected and/or identified by Cody Thompson, <a href="https://orcid.org/0000-0002-6686-6056">https://orcid.org/0000-0002-6686-6056</a>. Claims were made on Bionomia, <a href="http://bionomia.net">https://bionomia.net</a> using specimen data from the Global Biodiversity Information Facility, <a href="https://gbif.org">https://gbif.org</a>.
Codes used to identify hospital complications in validation of Charlson comorbidity index ICD-10 for the US
<p>Codes used to identify hospital complications in validation of Charlson comorbidity index ICD-10 for the US.</p>
Demographic analysis of invasible habitat fraction identifies context-dependent roles of resource availability and biotic resistance in determining invasion success
<p>Theories of plant invasions predict that plant communities should be more easily invaded when resources increase and/or competition decreases. We tested this with an experimentally introduced plant population by manipulating precipitation and resident community biomass. We used a spatially-explicit demographic approach to develop a new population-level metric of invasibility that quantifies the invasible habitat fraction (IHF) across the landscape.</p> <p>The existing community was essentially uninvasible (median IHF ≈ 0%), but experimental manipulations greatly increased the range of outcomes, with maximum observed IHF values over 50%. However, changes in invasibility were often context-dependent, resulting in some outcomes that aligned with existing theory, and others that were not readily predicted. Moreover, variation in invasibility was often driven by specific sets of invader demographic vital rates.</p> <p>Removing competitors revealed the capacity for strong biotic resistance, but this interacted with precipitation such that little biotic resistance was detected under drought conditions. Adding precipitation typically had little positive effect on invasibility, and moderate drought relief led to relatively high invasibility. However, the latter was driven to a large extent by interactions with mammal herbivory that otherwise inhibited invasion in one year.</p> <p><i>Synthesis</i>. Our findings show that interactions between abiotic and biotic factors, as well as legacy effects, can strongly mediate invasibility. This study also highlights the importance of incorporating spatial heterogeneity into population-level assessments of invasion, as initial population declines do not necessarily indicate resistance to invasion.</p>
Sex-linked markers by genome-wide RAD sequencing to identify XX/XY Sex Chromosomes in the spiny frog (Quasipaa boulengeri)
<p><span>We use genotyping by sequencing as an approach to identify sex-linked markers in the spiny frog <i>Quasipaa boulengeri</i> with 43 wild-collected adults from a single site. The GBS methodology identified 2 loci on sex differences in allele frequencies, 50 loci on sex differences in heterozygosity, and 523 loci on male-limited occurrence, altogether associated with males heterogamety, indicating an XX-XY system. The sex specificity of five markers was further validated by PCR amplification with a large number of additional individuals from 26 various populations in this species. A total of 27 sex linkage markers were matched to Dmrt1 gene, a ubiquitous role in sex determination and differentiation from flies and nematodes to mammals. Chromosome 1, that harboring Dmrt1, has further been assigned to a highly potential candidate sex chromosome in anurans. Five sex-linked SNP makers explored 3 sex reversals out of 133 individuals here, sparsely showing sex reversal detected in wild amphibian populations. </span></p>
Dataset for: Image-based screen capturing misfolding status of Niemann-Pick type C1 identifies potential candidates for chaperone drugs
<p>Niemann-Pick disease type C is a rare, fatal neurodegenerative disorder characterized by massive intracellular accumulation of cholesterol. In most cases, loss-of-function mutations in NPC1 gene that encodes for a lysosomal cholesterol transporter NPC1 are responsible for the disease, and more than half of the mutations are considered to interfere with biogenesis or folding of the protein. Previously we have identified a series of oxysterol derivatives and phenanthridine-6-one derivatives as pharmacological chaperones, small molecules that rescue folding defective phenotypes of a mutated NPC1, and opened an avenue to develop chaperone therapy for Niemann-Pick disease type C. Here, we established an improved image-based screen for NPC1 chaperones and performed drug-repurposing screening to identify some azole antifungals, including itraconazole and posaconazole, and a kinase inhibitor lapatinib as probable pharmacological chaperones. Photo-crosslinking probes of the compounds allowed us to detect direct binding of itraconazole to a representative folding-defective mutant, NPC1-I1061T. Competitive photo-crosslinking experiments suggested that oxysterol-based chaperones and itraconazole share the same or nearby binding site(s), and sensitivity of the crosslinking to P691S mutation on the sterol-sensing domain supported currently proposed hypothesis that their binding sites are located near the domain. Although the azoles were less effective in reducing cholesterol accumulation than the oxysterol-derived chaperone or an HDAC inhibitor LBH-589, our findings should offer new starting points for developing better pharmacological chaperones for NPC1 through medicinal chemistry efforts.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.