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5,794
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5,794 results for “exposures”
Autism-Related Transcription Factors Underlying the Sex-Specific Effects of Prenatal Bisphenol A Exposure on Transcriptome-Interactome Profiles in the Offspring Prefrontal Cortex
GEO Series GSE229073. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in the mouse brain following early pregnancy exposure to ethanol [CaudatePutamen_Males_P87]
GEO Series GSE87699. Mus musculus. 12 samples. Type: Expression profiling by array.
Analyses of transcriptomic responses to heavy metal exposure in Manila clam collected in Venice lagoon areas characterized by different anthropogenic impact
GEO Series GSE69811. Ruditapes philippinarum. 68 samples. Type: Expression profiling by array.
Cadmium exposure induces SNAIL1 expression via downregulation of miR-30e in human bronchial epithelial cells
GEO Series GSE128263. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene transcription profiles and potential transgenerational epigenetic effects related to Zn exposure history in Daphnia magna
GEO Series GSE22805. Daphnia magna. 27 samples. Type: Expression profiling by array.
Dioxin-like compound exposures and DNA methylation in the Anniston Community Health Survey Phase II
GEO Series GSE149412. Homo sapiens. 292 samples. Type: Methylation profiling by genome tiling array.
Transcriptome analysis of brown fat in young or old mice in cold exposure
GEO Series GSE135391. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Chronic exposure to waterpipe smoke elicits immunomodulatory and carcinogenic effects in the lung II
GEO Series GSE197994. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Effects of acute prenatal exposure to ethanol on microRNA expression are ameliorated by environmental manipulation
GEO Series GSE60900. Rattus norvegicus. 48 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Transcriptional responses of Escherichia coli during recovery from inorganic or organic mercury exposure
GEO Series GSE95575. Escherichia coli str. K-12 substr. MG1655. 30 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles in rat alveolar macrophages exposure to cellulose nanocrystals
GEO Series GSE289408. Rattus norvegicus. 16 samples. Type: Expression profiling by array.
RNA-seq analysis identifies differentially expressed genes regulated by LPS exposure on HNEpC cells
GEO Series GSE241554. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in human peripheral blood 48 hours after exposure to ionizing radiation
GEO Series GSE44201. Homo sapiens. 75 samples. Type: Expression profiling by array.
Searching beyond the streetlight: neonicotinoid exposure alters the neurogenomic state of worker honey bees
GEO Series GSE178742. Apis mellifera. 79 samples. Type: Expression profiling by high throughput sequencing.
Serum miRNAs as potential biomarkers for exposure to embedded military-relevant metals
GEO Series GSE168757. Rattus norvegicus. 138 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Raman data for "A coralline alga gains tolerance to ocean acidification over multiple generations of exposure"
<p>This file contains the Raman data and code for "A coralline alga gains tolerance to ocean acidification over multiple generations of exposure" by Cornwall et al. in Nature Climate Change. Run the file, "run.R" in R to reproduce the analysis.</p> <p>Please see the published paper for methods and details (doi will be provided here when it becomes available).</p>
Host genotype and stable differences in algal symbiont communities explain patterns of thermal stress response of Montipora capitata following thermal pre-exposure and across multiple bleaching events
<p>Data and script supporting "Stable symbiont communities and host genotype underpin complex differences in thermal stress response in <em>Montipora capitata</em>".</p> <p>"Data_MASTER.xlsx" contains raw water temperature, PAM fluorometry F<sub>v</sub>/F<sub>M</sub>, and qPCR data, as well as fragment identification information.</p> <p>"data_processing.R" contains the R script used to clean up, analyze, and visualize the data.</p> <p><strong>Abstract:</strong></p> <p>As sea surface temperatures increase worldwide due to climate change, coral bleaching events are becoming more frequent and severe, resulting in reef degradation. Leveraging the inherent ability of reef-building corals to acclimatize to thermal stress via pre-exposure to protective temperature treatments may become an important tool in improving the resilience of coral reefs to rapid environmental change. We investigated whether historical bleaching phenotype, coral host genotype, and exposure to protective temperature treatments would affect the response of the Hawaiian coral <em>Montipora capitata</em> to natural thermal stress. Fragments were collected from colonies that demonstrated different bleaching responses during the 2014-2015 event in Kāne‘ohe Bay (O‘ahu, Hawai‘i) and exposed to four different artificial temperature pre-treatments (and a control at ambient temperature). After recovery, fragments experienced a natural thermal stress event either in laboratory conditions or their native reef environment. Response to thermal stress was quantified by measuring changes in the algal symbionts’ photochemical efficiency, community composition, and relative density. Historical bleaching phenotype was reflected in stable differences in symbiont community composition, with historically bleached corals containing only <em>Cladocopium</em> symbionts and historically non-bleached corals having mixed symbiont communities dominated by <em>Durusdinium</em>. Mixed-community corals lost more <em>Cladocopium</em> than <em>Cladocopium</em>-only corals during the natural thermal stress event, and preferentially recovered with <em>Durusdinium</em>. Laboratory pre-treatments exposed corals to more thermal stress than anticipated, causing photochemical damage that varied significantly by genotype. While none of the treatments had a protective effect, temperature variation during treatments had a significant detrimental effect on photochemical efficiency during the thermal stress event. These results show that acclimatization potential is affected by fine-scale differences in temperature regime, host genotype, and relatively stable differences in symbiont community composition that underpin historical bleaching phenotypes in <em>M. capitata</em>.</p> <p> </p>
Data from: A large-scale field study examining effects of exposure to clothianidin seed-treated canola on honey bee colony health, development, and overwintering success
In summer 2012, we initiated a large-scale field experiment in southern Ontario, Canada, to determine whether exposure to clothianidin seed-treated canola (oil seed rape) has any adverse impacts on honey bees. Colonies were placed in clothianidin seed-treated or control canola fields during bloom, and thereafter were moved to an apiary with no surrounding crops grown from seeds treated with neonicotinoids. Colony weight gain, honey production, pest incidence, bee mortality, number of adults, and amount of sealed brood were assessed in each colony throughout summer and autumn. Samples of honey, beeswax, pollen, and nectar were regularly collected, and samples were analyzed for clothianidin residues. Several of these endpoints were also measured in spring 2013. Overall, colonies were vigorous during and after the exposure period, and we found no effects of exposure to clothianidin seed-treated canola on any endpoint measures. Bees foraged heavily on the test fields during peak bloom and residue analysis indicated that honey bees were exposed to low levels (0.5–2 ppb) of clothianidin in pollen. Low levels of clothianidin were detected in a few pollen samples collected toward the end of the bloom from control hives, illustrating the difficulty of conducting a perfectly controlled field study with free-ranging honey bees in agricultural landscapes. Overwintering success did not differ significantly between treatment and control hives, and was similar to overwintering colony loss rates reported for the winter of 2012–2013 for beekeepers in Ontario and Canada. Our results suggest that exposure to canola grown from seed treated with clothianidin poses low risk to honey bees.
Data from: Sex allocation theory reveals a hidden cost of neonicotinoid exposure in a parasitoid wasp
Sex allocation theory has proved to be one the most successful theories in evolutionary ecology. However, its role in more applied aspects of ecology has been limited. Here we show how sex allocation theory helps uncover an otherwise hidden cost of neonicotinoid exposure in the parasitoid wasp Nasonia vitripennis. Female N. vitripennis allocate the sex of their offspring in line with Local Mate Competition (LMC) theory. Neonicotinoids are an economically important class of insecticides, but their deployment remains controversial, with evidence linking them to the decline of beneficial species. We demonstrate for the first time to our knowledge, that neonicotinoids disrupt the crucial reproductive behaviour of facultative sex allocation at sub-lethal, field-relevant doses in N. vitripennis. The quantitative predictions we can make from LMC theory show that females exposed to neonicotinoids are less able to allocate sex optimally and that this failure imposes a significant fitness cost. Our work highlights that understanding the ecological consequences of neonicotinoid deployment requires not just measures of mortality or even fecundity reduction among non-target species, but also measures that capture broader fitness costs, in this case offspring sex allocation. Our work also highlights new avenues for exploring how females obtain information when allocating sex under LMC.
Data from: Understanding willingness to use oral pre-exposure prophylaxis for HIV prevention among men who have sex with men in China
Background: Oral pre-exposure prophylaxis (PrEP) is recommended as an additional prevention choice for men who have sex with men (MSM) at substantial risk of HIV. The aim of this study was to evaluate the extent, and reasons, for MSM's willingness to use oral PrEP in Wuhan and Shanghai, China. Methods: Between May and December 2015, a cross-sectional survey was conducted among 487 MSM recruited through snowball sampling in physical locations frequented by MSM and through social media applications. Exploratory factor analysis was used to group reasons for being willing or not willing to use PrEP. Chi-square tests were used to explore bivariate associations between groupings of reasons for being willing or unwilling to use PrEP, and key sociodemographic and sexual-behavioral characteristics of MSM. Results: Overall, 71.3% of respondents were willing to use PrEP. The most commonly reported reasons for being willing to use PrEP were preventing HIV infection (91.6%), taking responsibility for own sexual health (72.6%) and protecting family members from harm (59.4%). The main reasons for being unwilling to use PrEP were being worried about side effects (72.9%), the necessity of taking PrEP for long periods of time (54.3%) and cost (40.4%). Individual characteristics that influenced the type of reasons given for being willing or unwilling to use PrEP included being married to a woman, having a regular sex partner, rates of condom use with regular and casual sex partners, and the number of casual sex partners. Conclusion: The introduction of PrEP in China could benefit from promotion campaigns that emphasize its role in preventing HIV infection, in taking responsibility for own sexual health, and in protecting family members from potential harm. To reduce uptake barriers, it will be essential to provide accurate information to potential PrEP users about the mild and short-term nature of side effects, and the possibility of taking PrEP only during particular periods of life when the risk of HIV exposure might be highest.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.