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zenodo12/100

Dataset (III) related to publication: A cancer-associated K-RAS mutant protein that preferentially binds GDP displays gain-of-function and atypical signaling

Dataset (III) related to publication: <blockquote> A cancer-associated K-RAS mutant protein that preferentially binds GDP displays gain-of-function and atypical signaling </blockquote> Includes raw trajectories of MD-simulations: K-RAS(WT)+GDP replicas 1–10 (each replica 10 micros.) <ul> <li>Individual .zip files contain raw-desmond trajectories (-out.cms files and trj-files)</li> </ul> Other datasets related to this publication: 10.5281/zenodo.5506845 and 10.5281/zenodo.5507212

restrictedSep 2021View details →

zenodo12/100

Dataset (I) related to publication: A cancer-associated K-RAS mutant protein that preferentially binds GDP displays gain-of-function and atypical signaling

Dataset (I) related to publication: <blockquote> A cancer-associated K-RAS mutant protein that preferentially binds GDP displays gain-of-function and atypical signaling </blockquote> Includes raw trajectories of MD-simulations: K-RAS(M67L)+GDP replicas 1–10 (each replica 10 micros.) and K-RAS(M67L)+GDP in complex with RALGDS (1 micros.; SI Movie trajectory) <ul> <li>Individual .zip files contain raw-desmond trajectories (-out.cms files and trj-files)</li> </ul> Other datasets related to this publication: 10.5281/zenodo.5507131 and 10.5281/zenodo.5507212

restrictedSep 2021View details →

zenodo12/100

Dataset of Publication entitled "Prevention of non-ventilator-associated hospital-acquired pneumonia: results of a hybrid effectiveness-implementation trial"

This dataset includes the aggregated data analyzed in the manuscript entitled "Intervention to prevent non-ventilator-associated hospital-acquired pneumonia: results of a hybrid effectiveness-implementation trial" by Wolfensberger A. et al.

restrictedOct 2022View details →

zenodo12/100

Dataset related to the publication Rovai S, Contini M, Sciomer S, Vignati C, Agostoni P. The double anaerobic threshold in heart failure. Int J Cardiol. 2022;353:68-70.

Background: Cardiopulmonary exercise test (CPET) has an important role in assessing heart failure (HF) patients. Among CPET parameters, a pivotal role is attributed to the anaerobic threshold (AT), normally determined by V-slope, ventilatory equivalent and end-tidal methods. In about 10% of healthy subjects, a lack of concordance between these methods has been reported. This event was named double AT (DT). We hypothesized that DT was due to a delay in chemoreflex response. Methods: We reanalyzed CPET data of two cross-over studies in which we compared CPET in stable HF patients treated for two months with bisoprolol and carvedilol. In chronic HF, carvedilol has a greater sympathetic inhibition than bisoprolol, as shown by a lower chemoreflex response. Results: In 87 patients, we identified DT in 46% and 66% of cases during bisoprolol and carvedilol treatment, respectively (p < 0.01). Compared with bisoprolol, carvedilol treatment was associated to a lower peak oxygen uptake (from 17.4 ± 4.3 to 16.4 ± 4.1 mL/min/kg) and oxygen pulse (from 11.8 ± 2.9 to 11.1 ± 2.9 mL/min/kg) suggestive of lower peak cardiac output. Conclusions: DT is frequent in HF and more often with carvedilol than bisoprolol treatment, may be due to a greater inhibition of sympathetic tone and prolonged circulatory time. These findings open an unexplored research field.

restrictedDec 2022View details →

zenodo12/100

Raw data of the publication: Does moderate hyperkalemia influence survival in HF? Insights from the MECKI score data (Int J Cardiol . 2023 Jan 15;371:273-277. doi: 10.1016/j.ijcard.2022.09.030. Epub 2022 Sep 15)

Background: The prognostic role of moderate hyperkalemia in reduced ejection fraction (HFrEF) patients is still controversial. Despite this, it affects the use of renin-angiotensin-aldosterone system inhibitors (RAASi) with therapy down-titration or discontinuation. Objectives: Aim of the study was to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF optimally treated patients. Methods and results: We retrospectively analyzed MECKI (Metabolic Exercise test data combined with Cardiac and Kidney Indexes) database, with median follow-up of 4.2 [IQR 1.9-7.5] years. Data on K+ levels were available in 7087 cases. Patients with K+ plasma level ≥ 5.6 mEq/L and < 4 mEq/L were excluded. Remaining patients were categorized into normal >4 and < 5 mEq/L (n = 4826, 68%) and moderately high ≥5.0 and ≤ 5.5 mEq/L (n = 496, 7%) K+. Then patients were matched by propensity score in 484 couplets of patients. MECKI score value was 7% [IQR 3.1-14.1%] and 7.3% [IQR 3.4-15%] (p = 0.678) in patients with normal and moderately high K+ values while cardiovascular mortality events at two years follow-up were 41 (4.2%) and 33 (3.4%) (p = 0.333) in each group respectively. Conclusions: Moderate hyperkalemia does not influence patients' outcome in a large cohort of ambulatory HFrEF patients.

restrictedDec 2022View details →

zenodo12/100

Data for the publication: Struggles for democracy: strategies and resources of initiatives for non-citizen voting rights at local level in Europe

The uploaded files present research material of the project: Initiatives for Non-Citizen Voting Rights in Three European Countries (nccr - on the move, Switzerland) and of the publication:  Sontag, K., Herzog, M. & Lässer, S. Struggles for democracy: strategies and resources of initiatives for non-citizen voting rights at local levels in Europe. CMS 10, 17 (2022). https://doi.org/10.1186/s40878-022-00286-0 The dataset contains survey questionnaires, links to webpages, metadata of interviews and a user manual.

restrictedJan 2023View details →

zenodo12/100

Database of publication "Compressed sensing (CS) MP2RAGE versus standard MPRAGE: A comparison of derived brain volume measurements"

Database of publication "Compressed sensing (CS) MP2RAGE versus standard MPRAGE: A comparison of derived brain volume measurements", by M.P. Ferraro, L. Gualco, M. Costagli et al., Physica Medica 103 (2022) 166 174 https://doi.org/10.1016/j.ejmp.2022.10.023

restrictedFeb 2023View details →

zenodo12/100

unarXive: All arXiv Publications Pre-Processed for NLP, Including Structured Full-Text and Citation Network (full)

<h2>Description</h2>unarXive is a scholarly data set containing publications' structured full-text, annotated in-text citations, linked non-text content (mathematical notation, figure/table captions) and a citation network.The data is generated from all LaTeX sources on <a href="https://arxiv.org/">arXiv</a> and therefore of higher quality than data generated from PDF files.Typical uses are<ul><li>Training of ML models (citation recommendation, summarization, LLMs)</li><li>Citation context analysis</li><li>Bibliographic analyses</li></ul><h2>Access</h2>┏━━━━━━━━━━━━━━━━━━━━━━━━━━┓ ┃  <a href="https://github.com/IllDepence/unarXive/raw/master/doc/unarXive_data_sample.tar.gz">D O W N L O A D   S A M P L E</a>   ┃ ┗━━━━━━━━━━━━━━━━━━━━━━━━━━┛To download the whole data set send an access request and note the following:<blockquote>Note: this Zenodo record is the "full" version of unarXive, which was generated from all of arXiv.org including non-permissively licensed papers. Make sure that your use of the data is compliant with the paper's licensing terms.¹ Alternatively you can use the <a href="https://doi.org/10.5281/zenodo.7752615">unarXive open subset</a>.¹ For information on papers' licenses use <a href="https://info.arxiv.org/help/bulk_data/index.html">arXiv's bulk metadata access</a>.</blockquote>The code for generating the data set is <a href="https://github.com/IllDepence/unarXive">publicly available</a>.

restrictedMar 2023View details →

zenodo12/100

MICRE - ACP publication - co-located EAMv1 and observation data at Macquarie Island and python scripts for analysis

We simulate immersion-mode INP concentrations using the Energy Exascale Earth System Model version 1 (E3SMv1) by combining simulated aerosols with recently developed deterministic INP parameterizations and the native classical nucleation theory (CNT) for mineral dust in E3SMv1. Here, we provide Python scripts, co-located model data, and MICRE INP observations.

restrictedMar 2023View details →

zenodo12/100

Datasset to the publication: Application and challenges of TCR and BCR sequencing to investigate T and B cell clonality in abdominal aortic aneurysm

Title: Application and challenges of TCR and BCR sequencing to investigate T and B cell clonality in abdominal aortic aneurysm Abstract: Background: Abdominal aortic aneurysm (AAA) is a life-threatening cardiovascular disease.32 Although its pathogenesis is still poorly understood, recent evidence suggests that AAA displays33 characteristics of an autoimmune disease. Particularly T cells responding to AAA-related antigens in34 the aortic wall may contribute to the initial immune response. Single-cell RNA (scRNA) T- and B- cell35 receptor (TCR and BCR) sequencing is a powerful tool to investigate clonality. However, difficulties36 such as limited numbers of isolated cells must be considered during implementation and data analysis,37 making biological interpretation challenging. Here, we perform a representative single cell immune38 repertoire analysis in experimental murine AAA and show a reliable bioinformatic processing pipeline39 highlighting opportunities and limitations of this approach.40 Methods: We performed scRNA TCR and BCR sequencing of isolated lymphocytes from the41 infrarenal aorta of male C57BL/6J mice 3, 7, 15, and 28 days after AAA induction via elastase42 perfusion of the aorta. Sham-operated mice at day 3 and 28 as well as non-operated mice served as43 controls.44 Results: Comparison of complementarity-determining region (CDR3) length distribution of 179 B45 cells and 796 T cells revealed neither differences between AAA and control nor between the disease46 stages. We found no clonal expansion of B cells in AAA. For T cells, we identified expanded clones47 in 11 of 16 AAA samples and in 1 of 8 control samples. Immune receptor repertoire comparison48 indicated that only few clones were shared between the individual AAA samples. The most frequently49 used V-genes in the TCR beta chain in AAA were TRBV3, TRBV19, and the splicing variant50 TRBV12-2+TRBV13-2.51 Conclusion: We found no clonal expansion of TCRs or BCRs in elastase-induced AAA in mice at52 different disease stages. Our findings imply that a more precise characterization of TCR and BCR53 distribution requires a more extensive number of lymphocytes to prevent undersampling and to54 potentially detect rare clones. In summary, this paper examines TCR and BCR sequencing results,55 identifies limitations and pitfalls, and offers guidance for future studies.     The Raw Data can be found here: https://zenodo.org/doi/10.5281/zenodo.10725979

restrictedMay 2023View details →

zenodo12/100

Dataset related to the publication by Pan et al.: A randomized clinical trial of two-staged tourniquet strategy for total knee arthroplasty

Dataset related to the publication by Pan et al. 2023. A randomized clinical trial of two-staged tourniquet strategy for total knee arthroplasty

restrictedMay 2023View details →

zenodo12/100

H2020 DeepCube UC2: Climate Induced Migration in Africa Public Datacube

This is the public datacube for UC2 climate induced migration in Africa (2015-2023) The input data includes varied data sources, environmental and climatic variables from Earth Observation data and relevant socioeconomic data sources accounting for the main drivers of drought displacement in Somalia. The Earth Observation data cube includes variables from ERA5 Land such as 2m Temperature, Potential Evaporation, Total Precipitation and the Volumetric soil water layers, the ESA CCI land cover map and the precipitation dataset captured from Climate Hazards Center InfraRed Precipitation with Station data (CHIRPS). The precipitation data from CHIRPS and the Potential Evaporation from ERA5 are used to compute the Standardized Precipitation and Evaporation Index (SPEI) that is a robust indicator for drought conditions accounting for both precipitation and temperature extremes. Regarding socioeconomic sources, the food security dimension is represented by market prices variables in different local markets like the price of livestock (for instance, Cattle, Camel, etc.) and harvest products (e.g., wheat, rice, maize, etc.). We also include the violent conflict data captured from the Armed Conflict Location & Event Data Project (ACLED) given the close link existing between droughts and conflict in Somalia. Finally, the dataset of Internal Displacement Somalia is obtained via the United Nations High Commissioner for Refugees (UNHCR) Protection & Return Monitoring Network (PRMN).

restrictedJul 2023View details →

nasa12/100