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11,745 results for “Disorder”
Effects of a Vibro-Tactile P300 Based Brain-Computer Interface on the Coma Recovery Scale-Revised in Patients With Disorders of Consciousness
<p>Persons diagnosed with disorders of consciousness (DOC) typically suffer from motor and cognitive disabilities. Recent research has shown that non-invasive brain-computer interface (BCI) technology could help assess these patients’ cognitive functions and command following abilities. 20 DOC patients participated in the study and performed 10 vibro-tactile P300 BCI sessions over 10 days with 8–12 runs each day. Vibrotactile tactors were placed on the each patient’s left and right wrists and one foot. Patients were instructed, via earbuds, to concentrate and silently count vibrotactile pulses on either their left or right wrist that presented a target stimulus and to ignore the others. Changes of the BCI classification accuracy were investigated over the 10 days. In addition, the Coma Recovery Scale-Revised (CRS-R) score was measured before and after the 10 vibro-tactile P300 sessions. In the first run, 10 patients had a classification accuracy above chance level (>12.5%). In the best run, every patient reached an accuracy ≥60%. The grand average accuracy in the first session for all patients was 40%. In the best session, the grand average accuracy was 88% and the median accuracy across all sessions was 21%. The CRS-R scores compared before and after 10 VT3 sessions for all 20 patients, are showing significant improvement (<em>p</em> = 0.024). Twelve of the twenty patients showed an improvement of 1 to 7 points in the CRS-R score after the VT3 BCI sessions (mean: 2.6). Six patients did not show a change of the CRS-R and two patients showed a decline in the score by 1 point. Every patient achieved at least 60% accuracy at least once, which indicates successful command following. This shows the importance of repeated measures when DOC patients are assessed. The improvement of the CRS-R score after the 10 VT3 sessions is an important issue for future experiments to test the possible therapeutic applications of vibro-tactile and related BCIs with a larger patient group.</p>
Brain functional connectivity in chronic tic disorders and Gilles de la Tourette syndrome
<p>The pathophysiology of chronic tic disorder (cTD) and Gilles de la Tourette syndrome (GTS) is characterized by the dysfunction of both motor and non - motor cortico - striatal - thalamo - cortical (CSTC) circuitries, which leads to tic release and comorbids. A role of fronto - parietal network (FPN) connectivity breakdown has been postulated for tic pathogenesis, given that the FPN entertain connections with limbic, paralimbic, and CSTC networks. Our study was aimed at characterizing the FPN functional connectivity in cTD and GTS in order to assess the role of its deterioration in tic severity and the degree of comorbids. We recorded scalp EEG during resting state in patients with cTD and GTS. The eLORETA current source densities were analyzed, and the lagged phase synchronization (LPS) was calculated to estimate nonlinear functional connectivity between cortical areas. We found that the FPN functional connectivity in delta band was more detrimental in more severe GTS patients. Also, the sensorimotor functional connectivity in beta2 band was stronger in more severe cTD and GTS patients. FPN functional connectivity deterioration correlated with comorbids presence and severity in patients with GTS. Our data suggest that a FPN disconnection may contribute to the motoric symptomatology and comorbid severity in GTS, whereas sensorimotor disconnection may contribute to tic severity in cTD and GTS. Although preliminary, our study points out a differently disturbed brain connectivity between patients with cTD and GTS. This may serve as diagnostic marker and potentially interesting base to develop pharmacological and noninvasive neuromodulation trials aimed at reducing tic symptomatology.</p>
Table Recognition Benchmark on Biomedical Literature on Neurological Disorders
<p>The dataset contains 1650 tables from 1164 PMC OA articles in the context of neurological disorders. The tables are structured in the International Conference on Document Analysis and Recognition (ICDAR) format.</p> <p>The additional csv file contains a labeling into 3 different complexity classes in the format:</p> <p>class document_id table_id</p> <p>with the classes being:</p> <p>0 = simple<br> 1 = complicated<br> 2 = complex</p> <p>You may use the scripts from <a href="https://github.com/TimAdams84/pmc-downloader">this repository</a> to bulk download PDF sources from PMC.</p> <p>A script for evaluating results against the groundtruth data can be found <a href="https://github.com/mnamysl/benchmarking_table_recogn">here</a>.</p>
Spectral Engineering of Cavity-Protected Polaritons in an Atomic Ensemble with Controlled Disorder
<p>The paradigm of N quantum emitters coupled to a single cavity mode appears in many situations ranging from quantum technologies to polaritonic chemistry. The ideal case of identical emitters is elegantly modeled in terms of symmetric states, and understood in terms of polaritons. In the practically relevant case of an inhomogeneous frequency distribution, this simple picture breaks down and new and surprising features appear. Here we leverage the high degree of control in a strongly coupled cold atom system, where for the first time the ratio between coupling strength and frequency inhomogeneities can be tuned. We directly observe the transition from a disordered regime to a polaritonic one with only two resonances. The latter are much narrower than the frequency distribution, as predicted in the context of ''cavity protection''. We find that the concentration of the photonic weight of the coupled light-matter states is a key parameter for this transition, and demonstrate that a simple parameter based on statistics of transmission count spectra provides a robust experimental proxy for this theoretical quantity. Moreover, we realize a dynamically modulated Tavis-Cumming model to produce a comb of narrow polariton resonances protected from the disorder, with potential applications to quantum networks.</p>
Dataset for "Evolving scattering networks for engineering disorder"
<p>The design of stealthy hyperuniform materials has been a critical topic in realizing bandgap materials without crystalline order. Most previous approaches to constructing SHU materials, such as the collective coordinate method, have assumed the closed system, maintaining the number of particles inside a system during the design process. Here, I upload the dataset for the concept of evolving wave networks. The datasets are applied to introduce the concept of evolving wave networks (dataset for Fig. 2), classify material states according to network parameters (dataset for Fig. 3), generate the stealthy hyperuniformity (SHU) shielding of existing materials (dataset for Fig. 4), realize preferential attachment in evolving wave networks (dataset for Fig. 5), and obtain the following phase diagram of disordered materials (dataset for Fig. 6). </p> <p>raw_data_FigXabc: the file represents the data for the figure X and abc denotes the sub-figure number.</p> <p>raw_data_Fig6_alpha_MMM: the file represents the data for figure 6: SHU states, and MMM denotes the value of alpha that determines the preference / anti-preference.</p> <p>raw_data_Fig6_Crystal_NNN: the file represents the data for figure 6: Crystal states, and NNN denotes the particle number.</p> <p>raw_data_Fig6_Poisson: the file represents the data for figure 6: Poisson state.</p> <p>Each file is composed of two-column data, representing (x,y) positions of particles.</p> <p>While each realization possesses 500 particles (500 row data), [raw_data_Fig3adgj], [raw_data_Fig3behk], [raw_data_Fig4a], [raw_data_Fig4b], [raw_data_Fig4c], [raw_data_Fig4d], [raw_data_Fig4e], [raw_data_Fig4f], [raw_data_Fig5abc], [raw_data_Fig5def], and [raw_data_Fig5ghi] include the data for 100 realizations: 50000 row data.</p> <p>In the data for Fig. 6, the SHU and Poisson states also possess 50000 row data with 100 realizations, while the crystal states have 500 row data with 1 realization.</p> <p> </p>
Traumatic events, post-traumatic stress disorder, and proxy measures for central sensitization in chronic pain patients of a German university outpatient pain clinic
<p>This dataset was acquired at Hannover Medical School, Hannover, Germany. The study complied with the Declaration of Helsinki, and was approved by the local ethics committee. All subjects gave written informed consent, and consent to use their data anonymously for research purposes. The study was registered at ClinicalTrials.gov (NCT05190367).</p> <p>Between February 2019 and July 2020, 914 patients who visited our outpatient pain department gave written consent to use their routinely collected data anonymously for research purposes. Participants were divided into four groups depending on their trauma severity: (1) no trauma; (2) accidental trauma (e.g. illness, accident, natural disaster); (3) interpersonal trauma (e.g. assault, rape, war); (4) PTSD (diagnosed according to ICD-10). Patients fulfilling two or more categories were assigned to the highest group.</p> <p>Data were collected using the SymptomMapper application [1]. Participants provided information about their traumas, current pain intensity (visual analogue scale, VAS (0-100) [2]), mean and maximal pain in the last 4 weeks (VAS (0-100)), sleep impairment (VAS (0-100)), acceptable pain (VAS (0-100)), pain disability index (PDI [3]), pain area (digital drawings), pain widespreadness (widespread pain index, WPI [4], derived from drawings), stress (patient health questionnaire, German version, PHQ-D [5]), anxiety (PHQ-D), depression (PHQ-D), and somatization symptoms (PHQ-D).</p> <p>This dataset contains the raw data as well as necessary scripts for reproducing the results of this study.</p> <p> </p> <p>References<br> ##########</p> <p>[1] Neubert TA, Dusch M, Karst M, Beissner F. Designing a Tablet-Based Software App for Mapping Bodily Symptoms: Usability Evaluation and Reproducibility Analysis. JMIR Mhealth Uhealth 2018;6(5):e127.<br> [2] Dworkin RH, Turk DC, Farrar JT et al. Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain 2005;113(1):9-19.<br> [3] Pollard CA. Preliminary Validity Study of the Pain Disability Index. Percept Mot Skills 1984;59(3): 974.<br> [4] Wolfe F, Clauw DJ, Fitzcharles MA et al. The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity. Arthritis Care Res 2010;62(5):600-10.<br> [5] Löwe B, Spitzer RL, Zipfel S, Herzog W. Gesundheitsfragebogen für Patienten (PHQ-D). Manual und Testunterlagen (second edition). Pfizer 2002.</p>
Research Mapping of Trauma Experiences in Autism Spectrum Disorders: A Bibliometric Analysis. Bibliometrix file
<p>This is the Bibliometrix file of the paper entitled: Research Mapping of Trauma Experiences in Autism Spectrum Disorders: A Bibliometric Analysis.</p>
Dataset related toa article: "Dystonia as a prominent feature of TCF20-associated neurodevelopmental disorder: Expanding the phenotype"
<p>Sanger sequences (.abi files) validating variants found with whole exome sequencing</p>
Illustratory figures on brain networks, sex differences, and vulnerability to disorders
<p>These figures were initially created for a PhD thesis but may serve the wider (neuroscientific) community. </p>
Molecular Simulation Data Associated with the Manuscript "Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor"
<p>Molecular Simulation Data Associated with the Manuscript<br> <br> "Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor"<br> <br> by Jie Heng, Yunfei Hu, Guillermo Pérez-Hernández, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixà-González, Changwen Jin, Peter W. Hildebrand, Chunlai Chen & Brian K. Kobilka</p> <p>Nature Communications 2023, <a href="https://doi.org/10.1038/s41467-023-37233-1">https://doi.org/10.1038/s41467-023-37233-1</a><br> <br> The representative molecular dynamics (MD) trajectories shown in the <strong>Supplementary Fig. 8,<br> Variable contacts of the β2AR CT</strong> can be 3D visualized in the browser in the following link:</p> <ul> <li><a href="https://proteinformatics.uni-leipzig.de/mdsrv.html?load=file://base/B2CT/variants.ngl"> https://proteinformatics.uni-leipzig.de/mdsrv.html?load=file://base/B2CT/variants.ngl</a></li> </ul>
Data underpinning "Disorder-induced spin-charge separation in the 1-D Hubbard model"
<p>Many-body localisation is believed to be generically unstable in quantum systems with continuous non-Abelian symmetries, even in the presence of strong disorder. Breaking these symmetries can stabilise the localised phase, leading to the emergence of an extensive number of quasi-locally conserved quantities known as local integrals of motion, or l-bits. Using a sophisticated non-perturbative technique based on continuous unitary transforms, we investigate the one-dimensional Hubbard model subject to both spin and charge disorder, compute the associated l-bits and demonstrate that the disorder gives rise to a novel form of spin-charge separation. We examine the role of symmetries in delocalising the spin and charge degrees of freedom, and show that while symmetries generally lead to delocalisation through multi-particle resonant processes, certain subsets of states appear stable.</p>
Global prevalence of autism spectrum disorder
<p>The diagram show the global autism spectrum disorder</p>
Raw data for: Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulates lipid-dependent channel activity
<p>This repository contains raw data and code related to "Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulates lipid-dependent channel activity" by Goretzki et al.</p> <p>Included are molecular dynamics parameter files, initial structures after system equilibration, production trajectories, and final structures of simulations of:<br> 1. coarse-grained IDRs on membrane, and force and position data for restrained c-termini. Trajectories are subsampled with one frame every 50 ns.<br> 2. The tetrameric TRPV4 core in a POPC in atomistic resolution. Trajectories are sampled with one frame every 1 ns. <br> 3. The isolated ARD in solution in atomistic resolution. Trajectories are subsampled with one frame every 1 ns.</p> <p>Contact information:<br> Name: Stefan L. Schaefer<br> Institution: Department of Theoretical Biophysics, Max Planck Institute of Biophysics<br> Address: Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany<br> Email: stefan.schaefer@biophys.mpg.de</p> <p>Name: Ainara Claveras Cabezudo<br> Institution: Department of Theoretical Biophysics, Max Planck Institute of Biophysics<br> Address: Max-von-Laue-Str. 3, 60438 Frankfurt am Main, Germany<br> Email: ainara.claveras@biophys.mpg.de</p>
Intrinsically Disordered Regions Promote Protein Refoldability and Facilitate Retrieval from Biomolecular Condensates–Peptide Quantifications
<p>Many eukaryotic proteins contain intrinsically disordered regions (IDRs) that intersperse globular folded domains, in contrast with bacterial proteins which are typically highly globular. Recent years have seen great progress in identifying biological functions associated with these elusive protein sequence: in specific cases, they mediate liquid- liquid phase separation, perform molecular recognition, or act as sensors to changes in the environment. Nevertheless, only a small number of IDRs have annotated functions despite their presence in 64% of yeast proteins, stimulating some to question what ‘general purpose’ they may serve. Here, by interrogating the refoldability of two fungal proteomes (Saccharomyces cerevisiae and Neurosporra crassa), we show that IDRs render their host proteins more refoldable from the denatured state, allowing them to cohere more closely to Anfinsen’s thermodynamic hypothesis. The data provide an exceptionally clear picture of which biophysical and topological characteristics enable refoldability. Moreover, we find that almost all yeast proteins that partition into stress granules during heat shock are refoldable, a finding that holds for other condensates such as P-bodies and the nucleolus. Finally, we find that the Hsp104 unfoldase is the principal actor in mediating disassembly of heat stress granules and that the efficiency with which condensed proteins are returned to the soluble phase is also well explained by refoldability. Hence, these studies establish spontaneous refoldability as an adaptive trait that endows proteins with the capacity to reform their native soluble structures following their extraction from condensates. Altogether, our results provide an intuitive model for the function of IDRs in many multidomain proteins and clarifies their relationship to the phenomenon of biomolecular condensation.</p> <p>This dataset provides peptide quantifications (and their respective P-values) from three separate types of experiments used to support the claims in this study.</p> <p>1. Peptide quantifications from global refolding reactions, assessed with limited-proteolysis mass spectrometry (LiP-MS), carried out on two fungal organisms (S. cerevisiae [yeast] & N. crassa), at three refolding times, repeated on three separate iterations (for yeast).</p> <p>2. Peptide quantifications from LiP-MS experiments conducted on yeast extracts during heat shock or recovery from heat shock</p> <p>3. Annotations for peptides in #1 that are associated with linker regions between folded domains.</p>
Deidentified public survey data for: Patterns and perceptions of nicotine use among U.S. adolescents and young adults receiving medication treatment for opioid use disorder
<p>Nicotine use among U.S. youth is cause for concern, as previous studies have shown that nicotine use in adolescence increases the risk of developing substance use disorders later in life. This exploratory study aimed to understand patterns of nicotine use and perceptions of various nicotine products among adolescents and young adults (AYA) receiving medication treatment for opioid use disorder (MOUD). We administered an adapted version of the National Youth Tobacco Survey via REDCap to AYA (n=32) receiving outpatient care in the Medication-Assisted Treatment of Addiction at Nationwide Children's Hospital in Columbus, Ohio, U.S.A. Thirty (97%) participants had tried a combustible cigarette and 27 (90%) had tried an electronic cigarette. By age 13, nineteen (61%) participants had tried combustible cigarettes and eight (25%) had tried opioids. Twenty-two (71%) participants reported smoking combustible cigarettes every day for the past 30 days, and 15 (48%) reported smoking more than 10 cigarettes per day on average. Only ten (32%) participants reported e-cigarette use in the last 30 days. Participants universally agreed that tobacco products are dangerous, and twenty (67%) current tobacco users reported that they planned to quit in the next year. Nicotine use patterns among AYA receiving MOUD differ from that previously shown in the general population, primarily by high prevalence of nicotine use in early adolescence and high current combustible cigarette use. Interventions such as universal screening for nicotine use before age 13 and tailored smoking cessation programs for AYA with OUD may help optimize care for these individuals.</p>
AsdKB: A Chinese Knowledge Base for the Early Screening and Diagnosis of Autism Spectrum Disorder
<p><strong>Instance</strong></p> <ul> <li>Instance triples</li> </ul> <p><strong>Mapping</strong></p> <ul> <li>mapping.owl: ontology mapping to UMLS and ADAR</li> </ul> <p><strong>Ontology</strong></p> <ul> <li>ontology.owl: AsdKB ontology</li> </ul> <p><strong>For more details, please refer to <a href="https://github.com/SilenceSnake/ASDKB">http://w3id.org/asdkb</a></strong></p>
Contrasting the magnetism in La2−xSrxFeCoO6(x=0,1,2) double perovskites: The role of electronic and cationic disorder
<p>Data sets for original figures in the article 'Contrasting the magnetism in La<sub>2−x</sub>Sr<sub>x</sub>FeCoO<sub>6 </sub>(x=0,1,2) double perovskites: The role of electronic and cationic disorder' published in <a href="https://doi.org/10.1103/PhysRevB.99.184411">Phys. Rev. B <strong>99</strong>, 184411 (2019)</a>. The file name of each xls file corresponds to the figure number in the published article. The files can be opened using the Excel program. If there are sub-figures, or multiple frames in each figure, the data of each sub-figure is stored in separate sheets within one xls file. The files with the file extension 'vesta' can be opened using the freely available program <a href="https://jp-minerals.org/vesta/en/">VESTA</a>.</p>
Synthetic control of correlated disorder in UiO-66 frameworks
<p>Raw data associated to the Figures 2, 3, 4, 5 and 7 in the main text.</p>
Fig. 1 in Genetics and biochemistry of cobalamin disorders
Fig. 1. Light trap.
Development of a Resiliency Training Program for Parents of Children With Autism Spectrum Disorder
ClinicalTrials.gov study NCT02995408. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.