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339
datasets available to search
ShareScore release 0.9.0
Dataset results
339 results for “In vitro models”
Cancer therapy induced effects on lung organoids as suitable in vitro model [scRNA]
GEO Series GSE277088. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
In vitro model of urothelial cell differentiation using bladder cancer cell lines with various degree of epithelial mesenchymal transition
GEO Series GSE164828. Homo sapiens. 9 samples. Type: Expression profiling by array.
In vitro attachment and symmetry breaking of a human embryo model assembled from primed pluripotent stem cells
GEO Series GSE202542. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Role of folic acid in regulating intestinal flora and short-chain fatty acids based on in vitro fermentation model
GEO Series GSE227224. human feces metagenome. 96 samples. Type: Other.
Identifying modulators of inflammation in an in vitro airway epithelial inflammation model using an arrayed CRISPRi screen
GEO Series GSE271359. Homo sapiens. 186 samples. Type: Expression profiling by high throughput sequencing.
NK cells engineered with a IL-15/IL-15Rα complex and CD19-targeted CAR show in vitro expansion and tumor regression in a murine xenograft model of B-cell leukemia in vivo
GEO Series GSE234733. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
In Vitro Characterization of A4573 Preclinical Radiation-Adapted Model for Ewing Sarcoma
GEO Series GSE98706. Homo sapiens. 2 samples. Type: Expression profiling by array.
Tissue-engineered human psoriatic skin as an in vitro model to study the impact of cytokines
GEO Series GSE67762. Homo sapiens. 6 samples. Type: Expression profiling by array.
Data set for Dermal Biomimicry: Human dermal decellularized ECM Hydrogels as Fidelity-Rich Scaffolds for In Vitro Skin Models.
<p>Data set for the article <strong>Dermal Biomimicry: Human dermal decellularized ECM Hydrogels as Fidelity-Rich Scaffolds for In Vitro Skin Models.</strong></p>
Data set related to the article "An in vitro model for cardiac organoid production: the combined role of geometrical confinement and substrate stiffness"
<p>This record contains raw data related to the article "An in vitro model for cardiac organoid production: the combined role of geometrical confinement and substrate stiffness"</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
A Patient-derived In Vitro - In Vivo Preclinical Model of Renal Cell Carcinoma
GEO Series GSE47356. Homo sapiens. 3 samples. Type: Expression profiling by array.
Anti-inflammatory properties of deep sea water in-vitro and in-vivo models of inflamed intestinal epithelium
GEO Series GSE143378. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
RNA-Sequencing Analysis of Type-I and Type-II Interferon Effects on an In-Vitro Human Thymic Epithelium Model
GEO Series GSE281833. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Proliferation is a driver of quorum sensing in an in vitro model of tissue resident macrophages
GEO Series GSE210175. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Generation of an in vitro 3D Engineered Colorectal Cancer Patient-Derived Xenograft Model
GEO Series GSE151069. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
In Vitro Characterization of SK-ES1 Preclinical Radiation-Adapted Model for Ewing Sarcoma
GEO Series GSE98711. Homo sapiens. 2 samples. Type: Expression profiling by array.
In Vitro Characterization of MHH-ES-1 Preclinical Radiation-Adapted Model for Ewing Sarcoma
GEO Series GSE98709. Homo sapiens. 2 samples. Type: Expression profiling by array.
Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell Transcriptomics
GEO Series GSE233628. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.