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315
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ShareScore release 0.9.0
Dataset results
315 results for “MTOR”
Expanded Access for ABI-009 in Patients With Advanced PEComa and Patients With a Malignancy With Relevant Genetic Mutations or mTOR Pathway Activation
ClinicalTrials.gov study NCT03817515. IPD Sharing: Not stated. Countries: 0. Publications: 0.
m6A RNA modification cooperates with alternative polyadenylation to control T cell homeostasis via mTOR signaling
GEO Series GSE202164. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Chronic Exposure to Palmitic Acid Downregulates AKT in Beta-Cells through Activation of mTOR
GEO Series GSE183778. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Autophagy and lysosomal dysfunction in Tay Sachs disease are restored by mTOR modulation
GEO Series GSE184906. Homo sapiens. 12 samples. Type: Expression profiling by array.
Inhibiting the mammalian target of rapamycin (mTOR) as an adjunctive therapy for cerebral malaria
GEO Series GSE64702. Mus musculus. 64 samples. Type: Expression profiling by array.
Impact of mTOR inhibition on RNA expression in AT/RT
GEO Series GSE198514. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
GEO Series GSE246152. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Claspin is required for growth recovery from serum starvation through regulating the PI3K-PDK1-mTOR pathway
GEO Series GSE200669. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression data from mouse lung squamous cell carcinoma isolated from KrasG12D;Lkb1 mice treated with Vehicle or with catalytic mTOR inhibitor MLN128 for 8 weeks
GEO Series GSE110108. Mus musculus. 6 samples. Type: Expression profiling by array.
GDF-15 is a biomarker of aggressiveness and is down-regulated by the mTOR inhibitor sirolimus through ATF4 and ATF5 suppression in epithelioid hemangioendothelioma.
GEO Series GSE246235. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway
GEO Series GSE300699. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Database of NGS results of MTOR gene of intensive fattening lambs of sheep breeds raised in Latvia in 2022 within the framework of project of the Latvian Council of Science LZP-2021/1-0489 project
<p>Project of The Latvian Council of Science (LCS) - LZP-2021/1-0489 project: “<strong>Development of an innovative approach to identify biological determinants involved in the between-animal variation in feed efficiency in sheep farming</strong>.”</p> <p><strong>The aim of the project</strong> is to determine whether the feed efficiency status of Latvian meat sheep breeds could be predicted using a panel of genetic and molecular markers previously found to be associated with divergent Feed efficiency status in a training population of lambs when fed the same diet.</p> <p><strong>Novelty</strong>: to determine the parameters predicting the most productive result of lamb rearing, we set out to develop the cheapest and most effective method for determining markers of feed efficiency - based on molecular and genetic markers obtained from the blood of live lambs.</p> <p><strong>About the project:</strong></p> <p>The costs associated with lambing (buying or keeping sheep) and preparing or purchasing feed are the two largest components of variable costs in sheep raising. Feed costs are high due to poor grain growing conditions in major producing countries, the use of feed grains in ethanol production, and increased competition for land in crop production compared to urban development. Feed efficiency in growing lambs (i.e., the animal’s ability to reach a market or adult body weight (BW) with the least amount of feed intake) is a key factor in the sheep industry. Improving Feed efficiency reduces production costs. Improving Feed efficiency by 5% can bring economic benefits that are up to four times higher than a 5% increase in average daily gain (ADG).</p> <p>Traditionally, meat breeding programs have focused on outputs due mainly to the routine availability of phenotypic data on outputs or correlated traits. Currently, no marker has successfully explained enough of the variability in feed efficiency that they were used as part of a routine improvement program, as well as, according to our data, no genetic parameters for performance and feed efficiency traits are available for sheep. The physiological determinants of feed efficiency or putative biomarkers used to analyze animal-to-animal variation in live lambs could be used as a cost-effective and rapid tool for genetic selection or management decisions.</p> <p>As with other complex traits (also referred to as quantitative or polygenic traits), Feed efficiency is controlled by many genes which are involved in several molecular mechanisms and pathways causing animal-to-animal genetic variation in different biological functions. GWAS results suggested genes impacting lipid and energy metabolism as markers of Feed efficiency. Detection of many variants in these genes is necessary to predict or identify efficient animals accurately.</p> <p>Mammalian cell growth, in general, and particularly in cells of the conceptus, is regulated by growth factors and the availability of nutrients. The mechanistic mammalian target of rapamycin (MTOR/FRAP1) cell signaling pathway plays an important role in regulating cell growth and metabolism in response to growth factors and nutritional status to affect biological and physiological responses of cells and organs. MTOR is an evolutionarily conserved serine/threonine kinase. The MTOR pathway is a ‘‘nutrient-sensing system’’ stimulated by molecules that include SPP1, insulin-like growth factor 2 (IGF2), glucose and selected amino acids. The MTOR cell signaling pathway is a prominent component of the peri-implantation intra-uterine environment in sheep.</p> <p><strong>About the data of the project:</strong></p> <p>LZP-2021/1-0489 project data on lamb samples of the year 2022, or the A22 group, which consists of 76 intensively fattened lambs from six breeds.</p> <p>Exons (57) of the MTOR gene and their flanking intron regions were sequenced using Illumina NGS technology (AmpliSeq). The MTOR gene has been sequenced in lambs of Latvia (in sheep research in Latvia) for the first time.</p> <p>Information about 77 loci was found comparing with the last reference sequences ARS_UI_Ramb_v2.0. Forty-four (44) loci form seventeen groups with complete linkage disequilibrium between polymorphisms. Four new SNP (without ID number) were found.</p> <p>The database contains information on each locus for each lamb and the distribution of alleles and genotypes for each locus across all 76 samples. The data will be used in (1) analysis of Latvian sheep and (2) analysis of association with feed efficiency.</p> <p> </p> <p>The data is the<strong> joint property</strong> of the participants of the LCS project: the University of Latvia and the Latvian University of Life Sciences and Technologies.</p>
Comparing the Transcriptomes of Wild Type and Zp3-Cre mediated Mtor-Oocyte-Conditional Knockout (CKO) Mouse Metaphase II oocytes by RNA-Seq Analysis
GEO Series GSE98548. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The 40S-LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity
GEO Series GSE186779. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Histologic image related to article "Is Focal Cortical Dysplasia/Epilepsy Caused by Somatic MTOR Mutations Always a Unilateral Disorder?"
<p>image of histological sample resulting from patient n. 2 </p>
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