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2,830
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2,830 results for “Radiation therapy”
Hypofractionated Pre-operative Radiation Therapy for Soft Tissue Sarcomas of the Extremity and Chest-wall
ClinicalTrials.gov study NCT02634710. IPD Sharing: NO. Countries: 1. Publications: 1.
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy
ClinicalTrials.gov study NCT06667362. IPD Sharing: NO. Countries: 1. Publications: 1.
Randomized Salvage Radiation Therapy Plus Enzalutamide Post Prostatectomy
ClinicalTrials.gov study NCT02203695. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Radiation Therapy With or Without Chemotherapy in Reducing Mouth Dryness in Patients With Nasopharyngeal Cancer
ClinicalTrials.gov study NCT00057785. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy
ClinicalTrials.gov study NCT01156142. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies
ClinicalTrials.gov study NCT03217747. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Adjuvant Radiation Therapy With Ifosfamide in Patients With Mixed Mesodermal Tumors of the Uterus
ClinicalTrials.gov study NCT00231842. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study of Radiation-Enhanced Allogeneic Cell Therapy for Progressive Hematologic Malignancy After Allogeneic Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT00984165. IPD Sharing: NO. Countries: 1. Publications: 3.
Whole-Brain Radiation Therapy With or Without Hippocampal Avoidance in Limited Stage or Extensive Stage Small Cell Lung Cancer
ClinicalTrials.gov study NCT02635009. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Use of Cone Beam Kilovoltage Imaging in Patients Receiving Radiation Therapy for Head and Neck Cancer
ClinicalTrials.gov study NCT00358007. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer
ClinicalTrials.gov study NCT01302834. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy
ClinicalTrials.gov study NCT00053898. IPD Sharing: Not stated. Countries: 3. Publications: 4.
Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia: A Pilot Study
ClinicalTrials.gov study NCT03597360. IPD Sharing: NO. Countries: 1. Publications: 17.
Disulfiram/Copper With Concurrent Radiation Therapy and Temozolomide in Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT02715609. IPD Sharing: NO. Countries: 1. Publications: 0.
Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma
ClinicalTrials.gov study NCT00895622. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Data from: Probabilistic interfractional motion carbon ion radiation therapy dose distribution for prostate cancer shows rectum sparing with moderate target coverage degradation
Purpose: This observational study investigates the influence of interfractional motion on clinical target volume (CTV) coverage, planning target volume (PTV) margins, and rectum tissue sparing in carbon ion radiation therapy (CIRT). It reports dose coverage to target structures and organs at risk in the presence of interfractional motion, investigates rectal tissue sparing, and provides recommendations for further lowering the rate of toxicity. We also propose probabilistic DVH for consideration in treatment planning to represent probable dose to the clinic's patient population. Methods: At Gunma University Hospital intensity-modulated x-ray therapy (IMXT, aka IMRT) prostate cancer patients are positioned on a table which is shifted twice based on cone-beam computed tomography (CBCT) to align bones and then align prostate tissue to isocenter. These shifts thereby contain interfractional motion. 1306 such tableshifts from 85 patients were collected. Normal probability distributions were fit to the difference between bone-matching and prostate-matching CBCT-to-planning CT tableshifts (i.e. interfractional motion). Between 2011 and 2016 CIRT prostate patients were treated with PTV1 and PTV2 margins as follows: PTV1 extends the prostate contour by 10/10, 5/10, 6/6 mm in the right/left, posterior/anterior, and superior/inferior directions, respectively, and the proximal seminal vesicles contour by 5 mm superiorly and inferiorly, 3 mm right and left. PTV2 reduces PTV1 posteriorly along a straight line to exclude the rectum and reduces the superior and inferior margins by 6 mm. From those treated with these margins, 40 patients' beam data were selected to create probable interfractional motion: The previously fit normal probability distributions were randomly sampled 2000 times per patient and beams shifted to simulate this motion. These shifted dose distributions were scaled down proportionately in magnitude and summed to obtain probable blurred dose distributions. Results: Probable dose to rectum is substantially less than planned for doses higher than 10 Gy(RBE). Absolute DVH show that mean clinical target volumes are about 138-670 cm3 smaller for a given probable dose than planned doses higher than 57 Gy(RBE) after accounting for standard error. Cumulative DVH show mean CTV fraction receiving a given probable dose is less than the mean fraction receiving the corresponding planned dose for doses larger than 52 Gy(RBE), up to 19% less at 57.4 Gy(RBE). Our PTV1 margins generally cover 95% of interfractional motion but seminal vesicles and inferior prostate receive less dose than planned due to insufficient PTV2 margins. Conclusion: Assuming rigidly shifting interfractional motion around the prostate region and neglecting minor changes in soft tissue stopping power, interfractional motion resulted in underdosing or tissue sparing in all cases. Given our low rates of relapse and recurrence, it appears less curative dose is needed than previously thought or else the target may be smaller than previously thought. In-room CT may be useful to lower dose, shrink target margins, conduct PET auto-activation dose verification studies and account for interfractional motion.
PortPy: Planning and Optimization for Radiation Therapy
<p>PortPy (<strong>P</strong>lanning and <strong>O</strong>ptimization for <strong>R</strong>adiation <strong>T</strong>herapy) is a community effort to develop an open source python library to facilitate the development and clinical translation of radiotherapy cancer treatment planning algorithms. PortPy includes:</p> <p>1. Research-ready data and code to promote <em>benchmarking</em>, <em>transparency</em>, <em>reproducibility </em>and <em>community</em>-<em>driven </em>development</p> <p>2. Interface to an open-source optimization package <a href="https://www.cvxpy.org/">CVXPy</a> for easy/quick prototyping and out-of-the-box access to commercial/open-source optimization engines (e.g., Mosek, Gorubi, CPLEX, IPOPT)</p> <p>3. Visualization modules to visualize relevant plan information (e.g, dose volume histograms, dose distribution, fluence map)</p> <p>4. Evaluation modules to quantify plan quality with respect to established clinical metrics (e.g., RTOG metrics, dose conformality, tumor control probability, normal tissue control probability)</p> <p>Data needed for optimization and algorithm development (e.g., a set of beams/beamlets/voxels, dose contribution of each beamlet to each voxel) are provided for a set of pre-specified machine parameters (e.g., beam/colimator/couch angles). We initially provide these data for a set of publicly available dataset from TCIA. We hope to expand our dataset in the future. The data needed for optimization is extracted from the research version of Eclipse<sup>TM</sup> treatment planning system (<a href="https://www.varian.com/">Varian Medical Systems</a>) using its API.</p>
SEM images of control and SDF treated teeth after radiation therapy
<p>SEM images of control and SDF treated teeth after radiation therapy</p>
Intraoperative Radiation Therapy for Resectable Pancreas Cancer
ClinicalTrials.gov study NCT02599662. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Radiation Therapy Plus Chemotherapy in Treating Patients With Supratentorial Glioblastoma Multiforme
ClinicalTrials.gov study NCT00002545. IPD Sharing: Not stated. Countries: 2. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.